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      • KCI등재

        Micro-CT System for Small Animal Imaging

        남기용,김경우,김재희,손현화,유종현,강성훈,천권수,박성훈,윤권하,Nam, Ki-Yong,Kim, Kyong-Woo,Kim, Jae-Hee,Son, Hyun-Hwa,Ryu, Jeong-Hyun,Kang, Seoung-Hoon,Chon, Kwon-Su,Park, Seong-Hoon,Yoon, Kwon-Ha Korean Society of Medical Physics 2008 의학물리 Vol.19 No.2

        살아있는 마우스 영상화를 목적으로 겐트리 회전형과 평판영상검출기를 기반으로 한 고분해능 마이크로 컴퓨터단층촬영 장치를 개발하였다. 이 장치는 주로, 마이크로 크기 광원사이즈를 갖는 X-선 광원, Csl (TI)과 결합된 평판형 상보성 금속산화 반도체 영상검출기(CMOS), 선형이송 카우치, 위치정보 엔코더와 결합된 겐트리, 그리고 영상데이터 처리를 위한 병렬처리 시스템으로 구성되었다. 본 장치는 겐트리 회전형으로 설계되었는데, 이는 살아있는 마우스를 CT 영상을 얻는데 있어서 마우스 움직임에 기인한 영상결점의 최소화에 유리하고 촬영하는 동안 쥐의 호흡마취시행에 여러 가지 장점을 갖기 때문이다. CT팬텀을 이용하여 개발한 CT장치의 공간해상도, 영상대비도 그리고 영상균일도를 평가하였다. 결과로써, 본 장치의 공간해상도는 MTF 곡선으로부터 10%에 해당하는 약 11.3 cycles/mm을 얻었으며, 마우스에 대한 방사선 피폭선량은 81.5 mGy의 결과를 얻었다. 저대비 영상팬텀을 이용한 영상실험에서 분해가능 최소영상대비차는 약 46 CT였다. $55{\times}55{\times}X100\;{\mu}^3$의 복셀(voxel) 크기에서 영상의 불균일도는 약 70 CT 임을 얻었다. 또한 본 연구에서는 살아있는 마우스의 몸체, 뼈, 그리고 간에 대한 영상 테스트 결과를 제시하였다. We developed a high-resolution micro-CT system based on rotational gantry and flat-panel detector for live mouse imaging. This system is composed primarily of an x-ray source with micro-focal spot size, a CMOS (complementary metal oxide semiconductor) flat panel detector coupled with Csl (TI) (thallium-doped cesium iodide) scintillator, a linearly moving couch, a rotational gantry coupled with positioning encoder, and a parallel processing system for image data. This system was designed to be of the gantry-rotation type which has several advantages in obtaining CT images of live mice, namely, the relative ease of minimizing the motion artifact of the mice and the capability of administering respiratory anesthesia during scanning. We evaluated the spatial resolution, image contrast, and uniformity of the CT system using CT phantoms. As the results, the spatial resolution of the system was approximately the 11.3 cycles/mm at 10% of the MTF curve, and the radiation dose to the mice was 81.5 mGy. The minimal resolving contrast was found to be less than 46 CT numbers on low-contrast phantom imaging test. We found that the image non-uniformity was approximately 70 CT numbers at a voxel size of ${\sim}55{\times}55{\times}X100\;{\mu}^3$. We present the image test results of the skull and lung, and body of the live mice.

      • 걷기의 생리학적 분석 - 체력 증진을 위한 운동 -

        남기용(Nam, Kee-Yong),장신요(Chang, Shin-Yo),신동훈(Shin, Dong-Hoon),성낙응(Sung, Nak-Eung),엄륭의(Earm, Yung-E) 대한생리학회 1970 대한생리학회지 Vol.4 No.1

        Studies on the analysis of walking were performed on 33 male subjects. A prescription of physical exercise (walking at a speed of greater than 6 km/hr for more than one hour daily) for the promotion of individual health is presented on the basis of walking analysis. Presumptions were made that adequate physical exercise does promote health and is beneficial for the healthy life and increases the life span. These presumptions were derived from the numerous experimental literatures. The literatures support indirectly the presumptions. The following results were obtained and prescription of physical exercise is presented. 1. Oxygen uptake in a walking on a treadmill at a speed of 4 km/hr was only 3 times of the resting oxygen uptake. This kind of moderate exercise did not stimulate the cardiopulmonary system adequately. Heart rate at a 4 km/hr walking was 101 beats/min in boys of less than 20 years old and 83 beats/min in adults. Oxygen uptake at a 6 km/hr walking exceeded 4 times of the resting oxygen uptake. It was interpreted that walking at 6 km/hr stimulated the cardiopulmonary system for the promotion of health. Heart rate at this speed was greater than 110 beats/min in boys and greater than 100 beats/min in adults. 2. Heart rates in a walking of 10 km/hr were 172 beats/min in boys, and 143 beats/min in adults, respectively. Maximal heart rates were 185 beats/min in boys, 180 in office clerks, and 168 beats/min in construction site laboreres. 3. The correlation between heart rate and oxygen uptake was high, namely, r>0.95. Subsequently heart rate could be used as a measure of degree of intensity of physical exercise instead of the cumbersome oxygen uptake measurement. 4. The prescription of physical exercise for the promotion of health is: Daily walking for more than one hour at a speed of greater than 6 km/hr. Bodily functions in this daily walking are in boys (body weight, 50 kg): heart rates of 110 beats/min; breathing frequency, 28/min; oxygen uptake, greater than 4 times of the resting uptake; pulmonary ventilation, 351/min; stride, 124 strides/min; cumulative number of strides for one hour, 7,440 strides, and energy expenditure of more than 300 kcal. In adults (body weight, 60 kg) the bodily functions are: heart rates of 100 beats/min, breathing frequency, 28/min; oxygen uptake, greater than 4 times of the resting uptake; Pulmonary ventilation, 301/min; stride, 127 strides/min; cumulative number of strides for one hour, 7,670 strides, and energy expenditure of more than 300 kcal.

      • 다양한 질의어 환경하에서의 뷰 매핑 메카니즘에 관한 연구

        남기용(Keeyung Nam),배해영(Haeyoung Bae),이철희(Chulhee Lee) 한국정보과학회 1989 한국정보과학회 학술발표논문집 Vol.16 No.2

        뷰(view)는 베이스 테이블로부터 유도된 가상 테이블(virtual table)이다. 뷰에 관한 연산을 포함하는 질의는 베이스 테이블에 관한 동등한 연산을 포함하는 질의로 변환되는 매핑(mapping) 과정을 요구한다. 본 논문에서는 다양한 질의어(KQL, SQL, QUEL)를 지원하는 관계 데이타베이스 관리 시스템에서 뷰에 관한 질의를 효율적으로 처리하기 위하여 canonical form 파스 트리를 이용하여 하나의 처리기에서 매핑이 이루어질 수 있는 View Mapping Processor가 설계되었으며, 한글을 기본으로한 관계 데이타베이스 관리 시스템인 KORED에 구현되었다.

      • 격심한 운동후 심장박동수에 미치는 인삼 총배당체의 회복 촉진작용

        이재곤,남기용,Lee, Jae-Kon,Nam, Kee-Yong 대한생리학회 1974 대한생리학회지 Vol.8 No.2

        In 24 men and 12 women recovery of heart rate after strenuous exercise was observed before and after administration of total ginseng glycosides. In men 100 mg of ginseng glycosides were given twice with a 3 hour interval on the day of treadmill test and in women two more administrations of ginseng glycosides were added on the day before the exercise test. The action of ginseng glycosides was interpreted as an adaptogen, i.e., to enhance the recovery to the physiological equilibrium from the displace4 state. Recovery of heart rate to the pre-exercise state was observed for 20 minutes after strenuous exercise of 2 minutes duration on a treadmill (8 km/hr, 15% grade). In men the recovery of heart rate was enhanced$(P<.2{\sim}.4)$ after ginseng glycosides administration. In women the acceleration of recovery heart rate was highly significant $(P<.01{\sim}.05)$ after ginseng glycosides administration. In men and women recovery heart rate at 3 minute of recovery period after ginseng glycosides equaled to the value at 6 minute of recovery period before ginseng administration.

      • 사람의 피부두겹 및 총지방량에 관한 연주 -제1편 총지방량의 계절적 변동-

        조윤식,남기용,Cho, Yoon-Sik,Nam, Kee-Yong 대한생리학회 1969 대한생리학회지 Vol.3 No.1

        Skinfold thickness measurement and total body fat calculation were made in summer (July) and winter (December or January) On 70 medical students (age: 20 yr),8 national team basketball players (age: 20 yr), and 9 middle-age men. Skinfold thickness measurements were made on 4 sites, namely, back, arm, waist and abdomen. The mean skinfold thickness (mm) of the 4 sites was substituted into the following formulae. For adult of 20 years old: % Fat=0.911x+8.1, and for middle-aged men % Fat=1.199x+1.41. In young medical students and ball players body weight decreased, mean skinfold thickness increased in winter season. As a result total body fat .(% body weight) increased in winter In middle-aged men both body weight and mean skinfold thickness increased in winter and resulted in an increase in the total body fat. The detailed data are as follows: 1. In medical students summer: winter values were: body weight, 59.7 :58.9 kg; mean skinfold thickness, 7.85 : 8.12 mm; and total body fat, 15.0 : 15.5% body weight (P<.30). 2. In national team basketball players summer: winter values were: body weight, 73.5 : 69.1 kg; mean skinfold thickness, 7.2 : 7.5 mm; total body fat, 11.6 : 12.1% (P:NS). 3. In middle-aged men summer vs winter values were: body weight, 61.5 : 63.0 kg; mean skinfold thickness, 10.3 : 11.8 mm; total body fat, 17.2 : 18.0% (P:NS). 4. Skinfold thickness on back showed no seasonal variation and on abdomen the thickness increased in winter. 5. It was concluded that the predominant factor in increasing total body fat in winter is the decrease in body exercise in the winter time.

      • 헤마토크?????? 비율이 낮은 사람에 있어서 최대 산소 부채와 과잉젖산 사이의 관계

        김대성,남기용,Kim, Dai-Sung,Nam, Kee-Yong 대한생리학회 1968 대한생리학회지 Vol.2 No.2

        Maximal oxygen debt, lactate and excess lactate were measured in 13 men with low hematocrit ratio before and after maximal exercise. Maximal exercise run was performed on a treadmill and the duration of run was 2 minutes 45 seconds in each subject. Hematocrit ratio ranged between 35 and 47%, the mean being 39.8%. The following results were obtained. 1. Maximal oxygen debt expressed on basis of body weight increased as the hematocrit ratio decreased. The correlation coefficient between the two was r= -0.770. 2. The time necessary for decreasing to 50% of total maximal $O_2$ debt(half time) became longer as the hematocrit ratio decreased. In normal men the half time was about 4 minutes and at the longest it was 12 minutes in men with the lowest hematocrit ratio. 3. The lactate concentration reached its peak value after 3 minutes of recovery. Thereafter, the time course of decrease in lactate concentration coincided roughly with that of respiratory oxygen debt curve. To reach to the resting level, however, it took longer time than that of respiratory oxygen debt. 4. Resting concentrations of lactate was 1.28 mM/l, pyruvate 0.13 mM/l and L/P ratio was 9.8. Peak value of ${\Delta}L$ after exercise reached to the value of 10.4 mM/l and ${\Delta}L/P$ reached 26.0. Peak excess lactate after exercise was 6.34 mM/l. 5. The part of oxygen debt accounted for by the oxygen equivalent of excess lactate was only 38.4%. A better relationship between lactate and oxygen debt was observed and the part of oxygen debt accounted for by the oxygen equivalent of lactate was 63.3%. 6. Peak value of lactate after maximal exercise increased as the hematocrit ratio decreased. 7. Respiratory oxygen debt of 100 ml/kg was accounted for by lactate more than 60% and only 30% was by excess lactate. 8. Excess lactate was not a good index of respiratory oxygen debt.

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