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高慶淑,成樂應 서울大學校 保健大學院 1974 公衆保健雜誌 Vol.11 No.2
In order to observe the obesity among primary school children in Seoul, the author studied the anthropometric survey, serum total cholesterol, skinfold thickness and causes of obesity with the samples of 36 obese and 62 nonobese groups. The results obtained were as follows: 1) Thc data demonstrated that more than 2 percent of the children in this primary school turned out to be obesity. 2) Thc difference in the total cholesterol content in serum of the obese children was not significant in comparison with the nonobese group. 3) The mean values of body weight chest-girth and skinfold-thickness of the obese children were higher than those of the nonobese group. 4) As the results of the study, inactivity familial history and the excess caloric intake are considered to be the possible factors for development of obesity among children.
膽道閉塞과 副腎剔除 白鼠에서 Hydrocortisone 投與가 2-Acetylaminofluorene의 Hydroxylation에 미치는 影響
洪永淑,成樂應 梨花女子大學校 韓國生活科學硏究院 1981 韓國生活科學硏究院 論叢 Vol.27 No.-
AAF의 대사물질인 N-hydroxy-AAF는 간암을 일으키는 물질이다. AAF의 대사과정은 hepatic microsomal enzyme에 의해서 이루어 진다. 이런 발암물질 형성에 hydrccoritsone이 미치는 영향을 구명하고자 이실험을 시도하였다. 담도폐색, 부신척제, 담도폐색과 부신척제를 동시에 한 군, 부신척제와 hydrocortisone을 투여한 군 그리고 담도폐색과 부신척제를 동시에 한 군에 hydrocortisone을 12일간 투여한 숫컷과 암컷 흰쥐에서 hepatic microsomal enzyme system에 의한 AAF의 hydroxlation형성을 측정한 결과는 다음과 같다. 1. 담도폐색군에서 N-hydroxy-AAF의 형성은 대조군보다 숫컷 흰주에서 52%, 암컷 흰쥐에서 75% 감소하였다. 2. 부신척제군에서 N-hydroxy-AAF의 형성은 숫컷은 43% 암컷은 57%가 감소하였다. 그러나 hydrocortisone을 투여하였을 때는 약 20% 증가하였다. 3. 담도폐색과 부신척제를 동시에 수술한 군에서 숫컷은 66%, 암컷은 35%의 N-hydroxy-AAF형성이 감소하였다, 그러나 hydrocortis-one을 투여하였을 때도 N-hydroxy-AAF형성은 증가하지 않았다. 4. Hydrocortisone만을 투여하였을 때 N-hydroxy-AAF의 형성은 숫컷이 19%와 암컷이 16% 증가하였다. 이상의 결과들로 부신피질 호르몬은 간암 발생을 위하여 꼭 필요한 인자라는 것과 부신척제와 담도폐색 흰쥐에서는 간암 발생을 저해한다는 것을 시사하는 것이다. The formation of N-hydroxy-2-acetylaninofluorene (N-hydroxy-AAF) by bile-duct ligated male and female rats were reduced to about 50 and 75 per cent respectively. Adrenalectomized male and female rats decreased about 40 and 57 per cent formation of N-hydroxy-AAF than unoperated rate. Administration of adrenocorticotropic hormone for 12 days largely incre-ased the formation of N-hydroxy-AAF by adrenalectomized rats. In adrenalectomized-bile-duct ligated male and female rats, the formation of N-hydroxy-AAF was reduced to 66 and 35 per cent respcctively. Administration of hydrocortisone did not affect on the formation of N-hydroxy-AAF by the dougle operated rats. Administration of hydrocortisone alone caused the increase of the formation of N-hydroxy-AAF by about 20 per cent. These results indicate that adrenalectomy does not affect the breakdown or further metabo lism of N-hydroxy-AAF. Therefore, it appears that adrenal hormones regulate the format-ion of N-hydroxy-AAF. It is suggested that one of the roles of adrenal hormones in promoting hepatic carcino-genesis by 2-acetylaminofluorne in the rat, as shown by other investigatiors, may promote the formation of maintanance of higher levels of the N-hydroxy derivatives.
Cholesterol 投與가 白鼠血淸 및 肝組織內 各種 酵素活性에 미치는 影響
庾定鎬,成樂應 中央醫學社 1969 中央醫學 Vol.16 No.1
The changes in total cholesterol level, beta-glucuronidase and transaminase activities, vitamin B6 level and alkaline phosphatase activity were each traced in the serum and liver tissue of the rats prior to and 2, 4 and 8 weeks after the administration of standard diet. containing 1, cholesterol to the animal. The results obtained were as follows. 1. The total cholesterol level in the serum rose from 67±7mg% of control to 215± 17mg% at the 8th week on cholesterol feeding:in the liver the rise was from 2. 56 ±0. 1mg. /g w. w. to 11.05±1. 05mg. /g w. w. 2. The cholesterol biosynthetic activity of the liver as measured by acetate-l-C-14 incorporation was considerably depressed by exogenous cholesterol i.e., from .1985 cpm/g. of control to 115 cpm/g. at the 8th week. 3. Both in liver and serum the beta-glucuronidase activity increased until the 4th week, then decreased rapidly at the 8th week on cholesterol-diet. 4. In the liver both GOT and GPT activities were stationary, whereas in the serum a gradual elevation of the enzyme activities were noted. On the other hand the serum and liver contents of vitamin B6 which has to do with the transaminase activities, were lowered. 5. The alkaline phosphatase activity of the serum and liver was gradually increasing on the administration of cholesterol diet.