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겨우살이(Viscacae, Loranthancae)의 成分이 白鼠肝組織內 Cholesterol 生合成過程에 미치는 影響
成樂應 梨花女子大學校 醫科大學 醫科學硏究所 1979 EMJ (Ewha medical journal) Vol.2 No.1
Rats being fed with 1% Viscaceae powder containing diet for 10 weeks, total cholesterol in serum and liver tissue decreased by 17% and neutral fat decreased by 10%. And also, hepatic HMG-CoA reductase activity had a tendency to decrease by 43% in the 1% Viscaceae fed group. In saponin fraction of Viscaceae fed group and in alkaloidal fraction of Viscaceae fed group, it had a tendency to decrease by 65%, and 86% expectively.
담도폐색 흰쥐에서 Cholic Acid와 Phenobarbital 투여 대한 Hepatic Microsomal Cytochrome P-450 Apoprotein의 변화
성낙응,김복희,홍영숙,최금자 梨花女子大學校 醫科大學 醫科學硏究所 1980 EMJ (Ewha medical journal) Vol.3 No.4
We have investigated in rat liver whether different forms of cytochrome P-450 are alterated in hepatic disorders associated with impaired drug metabolism. Total hepatic cytochrome P-450 is decreased after either bile duct ligation or the administration of estradiol. In contrast, phenobarbital administrated alone increase hepatic content of cytochrome P-450, and when administrated with estradiol the reduction in cytochrome P-450 was prevented. Four forms of microsomal cytochrome P-450 apoproteins, ranging in molecular weight from 50 000 to 58,000, were tentatively identified in a sodium dodecyl sulfate(SDS)-6M urea polyaocrylamide gel electrophoresis system. Phenobrbital administration icreased primarily band Ⅳ(50,000 daltons). Bile duct ilgation was associated with a marked reduction in bands Ⅱ and Ⅲ while bands Ⅱ and Ⅲ were decreased with estradiol benzoate administration. Sumultaneous administration of phenobarbital and estradiol demonstrated a return of band Ⅰ and an increase in density of bands Ⅲ and Ⅳ. Simultaneous administration of cholic acid and estradiol demonstrated a return of band Ⅰ and not altered in band Ⅲ and Ⅳ. These studies support the hypothesis that multiple forms of cytochrome P-450 are present in liver microsomal membranes and that alterations in spenific apoproteins may be associated with an increase or a decrease in the functional properties of cytochrome P-450.
흰쥐에 Vitamin Antioxidant 투여가 2-Acetylaminofluorene hydroxylation에 미치는 발암 억제작용
성낙응,홍영숙 梨花女子大學校 醫科大學 醫科學硏究所 1982 EMJ (Ewha medical journal) Vol.5 No.3
The principal role of cytochrome P-450 in many other mixed function oxidase reactions including hydroxylations or oxidative dealkylations of various drugs, fatty acids, steroids, pesticides, and carcinogens. In order to elucidate the effect of various vitamin antioxidants on hepatic microsomal cytochrome P-450 and AAF hydroxylation, vitamin antioxidants, including vitamiin A acetate, L-ascorbic acid and DL-α-tocopherol were administered to rats. The results of this study show that the inhibition of cytochrome P-450 level and AAF hydroxylation by vitamin antioxidants may be related to their ability to prevent the in vivo activation of AAF to carcinogenic N-hydroxylation. Vitamin antioxidants, because of their effectiveness in inhibiting chemical carcinogenesis, may become useful chemoprophylatic agents against environmental carcinogens.
겨우살이(Viscaceae, Loranthaceae)의 백서조직내 Cholesterol대사에 미치는 영향
成樂應 梨花女子大學校 醫科大學 醫科學硏究所 1978 EMJ (Ewha medical journal) Vol.1 No.1
Rat were fed with diets containing 1%, 2%, 5%, and 10% Viscaceae powder respectively for 8 weeks. The following results were obtained. 1) In the group of 1% diet, the fat contents of serum and liver decreased, but in the other groups increased. 2) Viscaceae has a tendency to effect on the prequancy and the growth of fetus.
산화방지제 BHT, BHA가 간세포내 Mixed Function Oxygenase 활성에 미치는 영향
성낙응 梨花女子大學校 醫科大學 醫科學硏究所 1989 EMJ (Ewha medical journal) Vol.12 No.1
To evaluate the effect of BHA and BHT on liver tissue, BHA and BHT, 100㎎ and 200㎎/㎏ B.W. respectively, were given to experimental animals for 4 months. Microsomal cytochrome P-450, cytochrome b_5, cytochrome C reductase activity and lipid peroxidation of liver tissue of experimental animal were measured. The results were as follow ; 1) Cytochrome P-450 increased significantly in experimental group given BHA but cytochrome b5 did not. 2) Cytochrome oxidnse activity increased moderately in BHA group but decreased in BHT group. From these finding, it can be assumed, that BHA and BHT has no great effect on human tissue.