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Impact of Bisoprolol on Ventricular Arrhythmias in Experimental Myocardial Infarction
김현국,임경섭,김성수,나주영 전남대학교 의과학연구소 2021 전남의대학술지 Vol.57 No.2
Following acute myocardial infarction (AMI), early use of beta-blockers (BBs) reduced the incidences of ventricular arrhythmia (VA) and death in the pre reperfusion era. However, some studies have reported a worsening of clinical outcomes and therefore, this study used a porcine model of AMI to evaluate the efficacy of bisoprolol on VAs and mortality. Twenty pigs were divided into two groups with one group using oral bisoprolol which was given for 3 hours before the experiment and then maintained for 7 days. A loop recorder was implanted, AMI was induced by balloon occlusion for 60 min, and then, reperfusion. One week later, the echocardiography and loop recorder data were analyzed in the surviving animals. Bisoprolol did not increase the heart rate (62.9±14.5 vs 79.0±20.3; p=0.048), lower the rate of premature ventricular contractions (PVC) (0.8±0.8 vs 11.0±12.8; p=0.021) or tend to lower recurrent VA (0.6±0.5 vs 1.1±1.1; p=0.131) during coronary artery occlusion. After reperfusion, bisoprolol did reduce VA in the early AMI period (0.1±0.3 vs 4.2±4.6; p=0.001) and it was not associated with the extent of myocardial recovery. In this porcine model, early oral bisoprolol might help reduce the incidences of PVC and recurrent VA and determine whether effects are more pronounced during the early AMI period. Our results suggest that bisoprolol might help reduce lethal VA and cardiac death following AMI in this reperfusion era.
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김현국,서봉국,임충선 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.75 No.-
The production of cyclic carbonates from CO2 and epoxides has been extensively studied. We investigatedthe formation of a cyclic carbonate promoted by metal- and halide-free silica-supported alkanolamines. Moreover, we compared the obtained turnover numbers with those of the corresponding homogeneouscatalysts and confirmed that the reusability of the proposed heterogeneous catalysts was enhanced bythe utilization of polymer-type structures with amine/epoxy reaction around the silica. A cycliccarbonate yield of 70% and selectivity of 97% were achieved at 120 C and 10 bar afterfive-fold reuse of thecatalyst.
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