MSG 비만 모델의 구축

장응찬 경북대학교 체육과학연구소 1997 체육과학연구지 Vol.13 No.-

흰쥐에서 트레드밀 운동이 인슐린 분비에 미치는 영향

장응찬,박덕일,이수천 한국운동영양학회 1997 Physical Activity and Nutrition (Phys Act Nutr) Vol.1 No.2

The purpose of this study was to investigate the effects of exercise upon insulin secretion through male Sprague-Dawlay rats. That is to say, it was to determine whether exercise reduces insulin secretion or not. The rats were randomly divided into seven exercise-trained rats(SG) and seven sedentary rats(SG), and EG was subjected to a six weeks physical training by means of treadmill running four days per week. The experiment on EG was carried out in the state of overnight fast forty-eight hours after the exercise in order to eliminate the effect of the last bout of the exercise. This study was successively performed by three stages to find out insulin secretion response to stimuli for 130 minutes. At first, arginine bolus was injected in basal level, and insulin secretion response to arginine stimulus was evaluated 40 minutes after the injection. Next, hyperglycemic clamp procedure was introduced for 20 minutes, and insulin secretion response to glucose stimulus was evaluated Finally, arginine was additionally infused in the state of a hyperglycemic clamp(stage 2), and insulin secretion response to synergism of both glucose and arginine stimuli was evaluated. The results were as follows. When arginine bolus was injected in basal level, plasma insulin concentration in EG was lower than that in SG. Secretory response of insulin in EG during hyperglycemic clamp was lower than that in SG. When arginine was additionally injected in the state of a hyperglycemic clamp, plasma insulin concentration in EG was lower than that in SG. From the above results, the reduced plasma insulin concentrations in response to these stimuli in EG could be explained either by a blunted sensitivity of the β-cell or by a reduced capacity of the β-cell tp secrete insulin in vivo.

학술발표 : 현대인의 건강증진방안 : MSG 로 유도한 비만 쥐의 구축

장응찬(Eung Chan Jang),권오선(Oh Sun Kwon),이수천(Soo Chun Lee) 한국운동영양학회 2001 한국운동영양학회 학술발표논문집 Vol.- No.9

97년도 춘계학술대회 : 학술발표 : 운동이 인슐린분비 및 작용에 미치는 영향

장응찬(Jang Eung Chan),이수천 한국운동영양학회 1997 한국운동영양학회 학술발표논문집 Vol.- No.2

운동과 카페인 투여가 에너지 기질 및 글리코겐 함량에 미치는 영향

류승필,장응찬,김형렬,이수천 한국운동영양학회 1998 Physical Activity and Nutrition (Phys Act Nutr) Vol.2 No.1

Caffeine has been used as an ergogenic aid to most of endurance athletes. As this point of view, we hypothesized that caffeine and training exercise could affect the glycogen contents in skeletal muscle and serum energy substrates in rats. Forty-eight male sprague-dawley rats had taken treadmill exercise at 28m/min/30min for 5days of week during 4wks. At the experimental day, all rats, except sedentary group(sed, n=12), were ingested 50㎎/㎏ of caffeine using round-ended needle directly into the mouth. They were killed at pre(pre-exercise group), 1hr(1hour exercise group), and 2hr(2hours exercise group) exercise and were followed by sed rats. Serum glucose, TG, FFA, and glycerol concentrations were analyzed and liver, soleus, gastrocnemius white muscle glycogen contents were determined. Serum FFA and glycerol were increased but glucose was decreased following exercise. Liver and muscle glycogen were not changed. In conclusion, even though serum FFA and glycerol increased, glycogen-sparing effect was not occurred. And, we thought that further research and discuss will be needed.

고지방식이가 운동시 흰쥐의 글리코겐 이용에 미치는 영향

민경선,장응찬,김형렬,민진아,신덕수 慶山大學校 2000 論文集 Vol.18 No.1

Carbohydrate and fat ingestion during exercise are essential nutrient, but a number of opinion is different from their contents of food. In this point of view, to study how high-fat dietary contents affects glycogen utilization, 48 female Sprague-Dawley rats were trained on the treadmill trained for 4wk with consuming two high-fat diet and one high-carbohydrate diet. All animals were fed 79%high-fat diet(n=16, 79F), 40% high-fat diet(n=16, 40F), 70% high-carbohydrate diet(n=16, 70C). After the final day of training, one-half of rats in each the three groups were run to exhaustion (E), whereas the remaining rats served as rested controls (R). All animals were trained on a motorized rodent treadmill. The animals ran for 30min/d at 28m/min(0% grade), analysis items were glycogen, body weight and %Fat were measured. All data were examined by means of one-way ANOVA and significance was set at the p<0.05. The Duncan method was used for a post hoc test. Body weight were similar among the 79F, 40F and 70C groups. %Fat was significantly greater in animals that consumed the 79F group than in those on the 70C group (P<0.05), even though similar body weight each other. Generally liver and muscle glycogen concentration had more in 79FR, on the other hand, had less in 79FE compared with the others. The mean overall glycogen utilization rate was depressed in muscle and liver after animals were on the 79% F diet. In summary, the present study has suggested that consumption of 79% F diet during endurance training can lead to an increase in exercise performance in female rats. Some of the consequences training on F diet are an increase in body fat deposition and slower utilization of glycogen during exercise. These data indicate that rats exposed to a high-fat diet are capable of prolonging exercise in spite of limited glycogen stores. This improved capacity for exercise appears to be partially the result of muscular adaptations to the diet, which apparently increase the ability to oxidize fat and concomitantly spare glycogen.

12주간의 유산소 운동에 의한 비만아동의 신체구성 및 혈액성분 변화

김영범,장응찬,류승필,이수천 한국운동영양학회 1997 Physical Activity and Nutrition (Phys Act Nutr) Vol.1 No.2

We concerned about child and adolescent obesity which is now the big problem of the world including our country. In order to investigate the effects of 12-week aerobic exercise on body composition and blood profiles, twenty obese students in elementary school(male=10, female=10) were selected as subject. They performed aerobic exercise at 60%VO2max for 30minutes a day during 12-week following four times a week respectively. Height, Weight, %body fat, lean body mass(LBM), and skinfolds thickness(triceps, subscapular, and abdominal) were measured as body composition, glucose, total cholesterol(TC), triglyceride(TG), high density lipoprotein cholesterol(HDL-C), and low density lipoprotein cholesterol(LDL-C) were analyzed as blood profile. Body composition and blood profile were beneficially changed by the performence of 12-week aerobic exercise. We carefully suggest that if they exercised more continuously, they could get better health and could prevent the adult obesity.

지구성 운동수행시 수분공급의 중요성

류승필,장응찬,김형렬,이수천 한국운동영양학회 1998 Physical Activity and Nutrition (Phys Act Nutr) Vol.2 No.1

Body fluid and electrolyte loss increase during prolonged endurance exercise and the sweating rate largely depends on environmental temperature, humidity and physical activity. For every liter of fluid lost, core temperature rises 0.3℃, cardiac output declines 1L/min, and heart rate rises 8bpm. Since it has been known that dehydration state by severe sweating cause heat stroke, fluid supplement is emphasized. The optimal amount of fluid depends on exercise intensity, time, environmental condition, and individual physical condition. The increase of sodium intake facilitate glucose uptake on small intestine. The large amount of hypotonic fluid intake or none intake of water during prolonged endurance exercise could lead hyponatremia. But, it has been known that sodium depletion is happned only triathlon or ultra marathon which has longer distance and time than marathon. The types of carbohydrate fluid are used as energy source. As under 20g of carbohydrate is oxidized in the first hour of exercise, thus 3∼5g/100mL of carbohydrate intake every 10minute could maintained 1g/min of carbohydrate oxidation rate. Sports drink such as carbohydrate-electrolyte combined drink is known to prevent hyperthermia and to increase endurance exercise performance. As discribed above, we thought that fluid supplement and nutrient during prolonged exercise is essential and, further research will be need to enhance exercise performance.

카페인 섭취가 훈련자 및 비훈련자의 최대근력에 미치는 영향

류승필,서일호,장응찬,이수천 한국운동영양학회 2002 Physical Activity and Nutrition (Phys Act Nutr) Vol.6 No.1

Caffeine is known to stimulate lipolysis during endurance exercise that enhances free fatty acid utilization in skeletal muscle. However, caffeine also stimulates calcium secretion in sarcoplasmic reticulum that increases muscle power out during high intensity ∼ 15 min of exercise. Therefore, this study investigated the effect of caffeine ingestion on muscle power out in trained and untrained adolescents. Subjects were administered caffeine (5㎎/㎏ bw) or water as a placebo 1 h before the Cybex test then rest in sits position. Leg and arm muscle peak torque were measured at 60, 180, and 240 degree. Blood were collected at rest, before the test, and just after the test. The same protocol was performed 1 week after the test to the same subject with different supplement as used before. Arm and leg muscle peak torque was significantly increased both extension and flexion in trained subjects. Blood calcium concentration was significantly increased by caffeine ingestion just after exercise in trained subjects, and was significantly increased 1 h after caffeine ingestion in untrained subjects. These results suggested that caffeine also increased muscle power in specific types of exercise performance as an anaerobic exercise. However, its effects were not shown in untrained adolescents.

글루코스 투여가 운동 중 에너지 기질 이용에 미치는 영향

류승필(Sung Pil Ryu),장응찬(Eung Chan Jang),이상직(Sang Jik Lee),권태동(Tae Dong Kwon),정관우(Kwan Woo Jung),이수천(Soo Chun Lee) 한국운동영양학회 2000 Physical Activity and Nutrition (Phys Act Nutr) Vol.4 No.1

N/A Maintaining blood glucose concentration during exercise is important in the athletic field. Therefore, the purpose of this study was the effects of glucose administration on energy substrates utilization during exercise in the untrained (Utr) and trained (Tr) rats. Rats were administered glucose (1.4g/㎏) into the mouth 1h prior to exercise then exercised on the treadmill speed at 20m/min. They were decapitated at pre, 30min, 60min of exercise, and exhausted. Glucose, lactate, FFA, glycerol, glycogen, and liver triglycerides were measured. Glucose concentration was not significantly changed to the groups. Lactate production, however, was significantly increased during the exercise in the Utr. In addition, FFA was significantly increased during the exercise in the Tr. Glycogen utilization ratio during the exercise in the groups were not significantly different, however, the concentration of before the exercise was significantly higher in the Tr. Moreover, exercise time to exhaustion was shorter in the Utr compared with the Tr. These results suggested that glucose administration 1h prior to exercise was possibly maintained blood glucose concentration, however, training-effect was higher compared with glucose-effect during exercise in the groups.