갑상선 결절의 감별진단에 있어 탄성 초음파검사

김정훈,최재영,최영식<SUP>1<,SUP>,정미희<SUP>2<,SUP>,정경순<SUP>2<,SUP>,Jung Hoon Kim,M,D,Jae Young Choi,M,D,Young Sik Choi,M,D,<SUP>1<,SUP>,Mi Hee Jung,M,D,<SUP>2<,SUP> and Kyung Soon Jung,M,D,<SUP>2<,SUP> 대한갑상선-내분비외과학회 2011 The Koreran journal of Endocrine Surgery Vol.11 No.1

Purpose: Ultrasound (US) elastography is a newly developed imaging technique for assessing tissue stiffness by measuring the degree of the tissue's deformation in response to the application of an external force. This technique has recently been applied for making the diagnosis of nodular thyroid disease. The purpose of this study was to evaluate the diagnostic utility of US elastography for differentiating benign thyroid nodules from malignant thyroid nodules. Methods: A total of 63 consecutive patients with thyroid nodules and who were referred for surgical treatment were examined in this study. Seventy-five nodules in these patients were examined by US B-mode, color Doppler US and US elastography. The final diagnosis was obtained from the histologic findings. The tissue stiffness on ultrasound elastography was scored from 1 (elasticity in the whole nodule) to 5 (no elasticity in the nodule and in the posterior shadowing). Results: On US elastography, 18 of 32 benign nodules (56.3%) had a score of 1 to 3, whereas 23 of 43 malignant nodules (62.8%) had a score of 4 to 5. With applying a US elastography score of 4-5 as an indicator for malignancy, the sensitivity, specificity, positive predictive value and negative predictive value of US elastography were 65.9%, 52.9%, 62.8% and 56.3%, respectively. Of the 14 follicular tumors, 12 were follicular adenoma and four were follicular carcinoma. The sensitivity and specificity of US elastography for diagnosing follicular carcinoma were 50.0% and 81% (56=69), respectively. The positive and negative predictive values were 55.2% (16=29) and 60.0%, respectively. The accuracy of the technique was 57.1%. The findings of US elastography were not significantly correlated with the histopathologic findings. Conclusion: This study has shown that US elastography may be not useful for differentiating between benign and malignant thyroid nodules. Further studies are needed to confirm the usefulness of US elastography for making the differential diagnosis of thyroid nodules. (Korean J Endocrine Surg 2011;11:12-17)

Recurrence and Extraneural Metastasis in 31 Meningeal Hemangiopericytomas

김정훈,김준수,김창진,황승균,정희원,권병덕,Kim, Jeong Hoon,Kim, Joon Soo,Kim, Chang Jin,Hwang, Sung Kyun,Jung, Hee Won,Kwun, Byung Duk The Korean Neurosurgical Society 2001 Journal of Korean neurosurgical society Vol.30 No.3

목 적 : 높은 재발율과 전이 가능성의 특징을 갖고 있는 수막 혈관외세포종은 perivascular pericytes에서 기원하는 드문 종양으로, 저자들이 경험한 수막 혈관외세포종에 있어서 종양의 재발 및 신경계외 전이에 대하여 알아 보고자 한다. 연구 대상 및 방법 : 1982년부터 1999년까지 수술을 시행하여 수막 혈관외세포종으로 진단받은 31명의 환자를 대상으로 후향적 연구를 시행하였다. 진단 후 재발까지의 기간, 재발에 영향을 미칠 수 있는 여러 가지 인자들, 그리고 신경계외 전이의 기간 및 부위 등을 분석하였다. 결 과 : 총 31명의 환자들 중 12명의 환자들에서 원발성 부위에 종양이 재발하였다(38.7%). 전체의 환자들에서 재발이 발생하지 않았던 평균 기간(recurrence-free period : RFP)은 104개월이었으며 처음 수술 후 5년, 그리고 10년의 재발이 발생하지 않았던 율(recurrence free period : RFP)은 각각 59.2%, 33.6% 이었다. 원발성 부위에 종양의 재발을 보였던 12명의 환자들 중 4명의 환자들에서 첫 수술 후 5년 이후에 재발을 관찰 할 수 있었다. 처음 수술시의 절제 정도가 재발에 가장 큰 영향을 미쳤다. 처음 수술시에 완전 절제한 군의 RFP는 111 개월이었으며, 추적 관찰 5년째 RFR는 완전 절제한 경우 72.7%, 불완전 절제한 경우 20.8%로 그 차이는 통계 적으로 유의하였다(p=0.0060). 통계적으로 유의성은 없었지만 완전 절제 후 부가적인 방사선 치료를 시행하였을 경우가 완전 절제만을 시행한 경우보다 RFR가 높아 추적 관찰 5년째의 RFR는 각각 100%, 그리고 70.3% 이었다(p=0.3359). 4명의 환자들(12.9%)에서 수막 혈관외세포종의 신경계외 전이가 발생하였으며, 이 경우 신경계 외 전이의 평균 기간은 107개월, 그리고 추적 관찰 5년, 10년째의 신경계외 전이율은 각각 4.4%, 24.9% 이었다. 결 론 : 수막 혈관외세포종은 수술적 제거 후 원발성 부위에 또는 원발성 부위에서 멀리 떨어진 부위에 재발의 가능성이 무척 높은 종양이다. 이러한 재발의 가능성을 줄이는 가장 중요한 인자는 수술적 제거 정도로 처음 수술시에 가능한 완전 절제를 시도하여야 한다. 그리고 처음 수술시에 완전 절제가 가능하였다고 하여도 완전 절제 후 부가적인 방사선 치료를 시행하는 것이 재발의 위험성을 낮출 수 있을 것으로 생각한다. 원발성 부위의 재발 또는 신경계외 전이는 오랜 시간이 지난 후에도 가능할 수 있으므로 장기간의 추적 관찰이 필요하다고 생각한다. Purpose : Meningeal hemangiopericytoma(M-HPC), characterized by a high local recurrency and metastatic potential, is a rare neoplasm arising from perivascular pericytes. A retrospective study was performed to identify the recurrence and extraneural metastasis in M-HPC. Materials and Methods : We reviewed the records of 31 M-HPC patients treated from 1982 through 1999 at our institution. The time to recurrence and the various parameters affecting recurrence were determined. Extreneural metastasis was also analyzed. Results : The rate of local recurrency was 38.7%(12/31). The overall average recurrence-free period(RFP) before the first recurrence was 104 months, with overall recurrence-free rates(RFRs) at 5 and 10 years after first surgery of 59.2% and 33.6%, respectively. Of the 12 patients who experienced local recurrence, 4 had recurrences 5 years later after the first surgery. Complete excision at the first operation significantly extended the average time before first recurrence from 43 to 111 months. The 5-year RFRs for the groups of complete excision and incomplete excision were 72.7% and 20.8%, respectively(p=0.0060). Although there was no statistical significance, complete excision followed by adjuvant radiotherapy of more than 50Gy extended the RFP. The 5-year RFRs for the groups of complete excision and complete excision with adjuvant radiotherapy were 70.3% and 100%, respectively(p=0.3359). Four patients(12.9%) presented one or more extraneural metastases that were developed at an average of 107 months after the first operation with the 5- and 10-year metastasis rates of 4.4% and 24.9%, respectively. Conclusions : M-HPC has a propensity to recur either locally or at distant sites after surgical resection. Complete excision is the most important factor to reduce recurrence. However, even with complete excision, adjuvant radiotherapy of more than 50Gy significantly reduces the risk of recurrence. Local and distant recurrences may occur after a prolonged disease-free interval, emphasizing the need for long-term follow-up.

유료 콘텐츠의 N-스크린 서비스를 위한 일시적 시청권한 위임 기법

김정훈,이훈정,김상진,오희국,Kim, Jung-Hoon,Lee, Hoon-Jung,Kim, Sang-Jin,Oh, Hee-Kuck 한국정보처리학회 2011 정보처리학회논문지 C : 정보통신,정보보안 Vol.18 No.3

최근, 통신기술의 급속한 발전으로 인해 때와 장소에 구애받지 않고 콘텐츠를 소비하고자 하는 사용자의 욕구와 새로운 비즈니스 모델을 찾고자 하는 사업자의 바람이 맞물려 N-스크린 서비스 전략이 주목 받고 있다. N-스크린은 TV, 컴퓨터, 휴대용 단말 등 다양한 기기에서 끊김 없이 콘텐츠를 공유, 소비할 수 있도록 지원하는 스크린 확장 개념의 서비스로서 미국의 통신회사인 AT&T에서 처음 제안했던 3-스크린 서비스 전략이 발전된 형태이다. 유료 콘텐츠에 대한 N-스크린 서비스에서 유료 콘텐츠에 대한 끊김없는 스크린 전환을 지원하기 위해서는 스크린을 전환하고자 하는 기기로 일시적인 시청권한을 부여해야 한다. 하지만 접근제어 시스템을 사용하고 있는 현재의 방송환경에서는 일시적으로 권한을 부여하는 것이 불가능하다. 본 논문에서는 현재 방송환경에서 유료콘텐츠에 사용하고 있는 접근제어 기법에 대해 살펴보고 일시적인 권한 부여를 할 수 없는 이유에 대해서 살펴본 뒤 현재 사용 중인 접근제어 기법을 기반으로 추가적인 키를 사용해 시청권한 문제를 해결하는 방법을 제안한다. Recently, the strategy for N-screen service is in the spotlight along with the consumer's need to use contents regardless of time and place due to the rapid development of communication technology, which is meshing with the desire of service providers seeking a new business model. N-screen, as a screen-extension-concept service which enables consumers to continuously share and use contents in various equipments such as TV, computer and portable terminals, is an advanced type of 3-screen service strategy initially proposed by AT&T, an American telecommunication company. In the N-screen service for pay-contents, in order to support continuous screen changes to and from various equipments, temporary watching right should be given to the equipment intended for screen change. However, it is impossible to give the temporary watching right in the present broadcasting environment, adopting an access-control system. In this paper, the access-control technology being used for pay-contents in the present broadcasting environment and the reason for not being able to give temporary watching right, will be examined. After the examination, the solution for delegation of watching right by using an additional key on the basis of currently used access-control technology, will be proposed.

취업 주부의 취업선호 인식이 개인 , 가족 직업생활에 미치는 영향

김정훈,박성옥,어은주 ( Jung Hoon Kim,Sung Ok Park,Eun Joo Eo ) 대한가정학회 1996 Human Ecology Research(HER) Vol.34 No.3

전탕 조건에 따른 쌍화탕 전탕액 비교 연구

김정훈,서창섭,신현규,Kim, Jung-Hoon,Seo, Chang-Seob,Shin, Hyeun-Kyoo 대한한의학방제학회 2010 大韓韓醫學方劑學會誌 Vol.18 No.2

Objectives : This study was performed to compare the differences between decoctions extracted by different extraction conditions. Methods : Two different decoctions were prepared with pressured or non-pressured extraction conditions for 60, 120 and 180min. The yields of extracts, sugar contents, hydrogen ion concentrations(pH), the contents of reference compounds and individual preferences on Ssanghwa-tang(Shuanghe-tang) were investigated. Results : As extraction time increased, individual preferences for decoctions by pressured extraction tended to increase more than those by non-pressured extraction, and the yields and sugar contents of both decoctions showed the tendency of increase. The pH values of decoctions in pressured conditions were lower than those in non-pressured conditions in all extraction times and both extraction conditions showed decreasing pH values according to increase of extraction times. Of the reference compounds, paeoniflorin showed higher contents in non-pressured conditions than in pressured conditions and the contents of cinnamaldehyde were always lower in non-pressured conditions than in pressured conditions at all time. Conclusions : The decoctions of Ssanghwa-tang(Shuanghe-tang) extracted by pressured or non-pressured extraction for 60, 120, 180min exhibited different individual preferences, yields of extracts, sugar contents, pH, reference compounds contents.

초등학생 대상의 인공지능교육을 위한 스마트팜 활용 융합교육 프로그램

김정훈,문성환,Kim, Jung-Hoon,Moon, Seong-Hwan 한국융합학회 2021 한국융합학회논문지 Vol.12 No.10

이 연구는 초등학생들이 인공지능 학습원리에 대해 직관적으로 쉽게 이해할 수 있도록 입력 데이터(온도, 습도 등)와 출력 데이터(채소, 과일 등) 모두 생활 속에서 쉽게 접할 수 있는 형태의 스마트팜을 이용한 융합교육 프로그램을 개발하기 위해 수행하였다. 이를 위해 초등학교의 2015 교육과정에 따른 실과교과의 원예·sw·로봇 단원에 대한 내용 분석과 인공지능교육 내용 체계에 관한 선행연구 분석을 통해 스마트팜 적용이 쉬우며 인공지능 학습원리를 쉽게 설명해 줄 수 있는 구성 요소 13개와 성취 기준 16개를 선정하여 4회기(8차시) 분량의 인공지능교육 프로그램과 스마트팜 기능이 들어있는 비닐하우스 교구를 개발하였다. 이 연구에서 개발한 융합교육 프로그램은 추후 초등학생을 대상으로 하는 인공지능교육에 대한 다양한 교수학습자료 개발 시 참고자료로 활용할 수 있다. This study was conducted to develop a convergence education program using smart farms with both input data(temperature, humidity, etc.) and output data(vegetables, fruits, etc.) that are easily accessible in everyday life so that elementary school students can intuitively and easily understand the principles of artificial intelligence(AI) learning. In order to develop this program, we conducted a prior study analysis of a horticulture, software, robot units in the 2015 Practical Arts curriculum and artificial intelligence education. Based on this, 13 components and 16 achievement criteria were selected, and AI programs of 4 sessions(a total of 8 hours). This program can be used as a reference when developing various teaching materials for artificial intelligence education in the future.

코눈물관폐쇄 환자의 눈물주머니조영술과 임상적 의의

김정훈,김준모,우경인,Jung Hoon Kim,Joon Mo Kim,Kyung In Woo 대한안과학회 2006 대한안과학회지 Vol.47 No.11

Purpose: To investigate the configuration of the lacrimal sac and its clinical significance in patients who underwent dacryocystorhinostomy. Methods: The subject of this study were 132 eyes of 109 patients who were diagnosed as having nasolacrimal duct obstruction and who underwent surgical therapy from 2001 to 2005. According to the size of the lacrimal sac, eyes were divided into a common canalicular obstruction group, a small sac group, and a large sac group. The relationship between the sac size and clinical characteristics of the patients was evaluated. Results: There were 27 male and 82 female patients with a mean age of 53.6 years. The common canalicular obstruction group included 17 eyes, the small sac group 79 eyes, and the large sac group 36 eyes. The proportion of female patients (p=0.042) and mean age (p=0.029) were higher in the small sac group, compared with the large sac group. Patients in the large sac group had favorable surgical outcomes (p=0.001). Conclusions: Dacryocystography is a useful method to assess the lacrimal drainage system. We found a relationship between the sac size and clinical characteristics of nasolacrimal duct obstruction patients. Further pathophysiologic studies on the mechanism of contraction of the lacrimal sac are needed.

오령산 효능에 관한 기초 실험 연구 문헌 분석

김정훈,신현규,Kim, Jung-Hoon,Shin, Hyeun-Kyoo 대한한방내과학회 2012 大韓韓方內科學會誌 Vol.33 No.1

Objectives : To establish objective and scientific evidence of Korean medicine (KM), the papers on Oryeong-san (Wuling-san) frequently used in medical institutions of Korean Medicine were analyzed. Methods : The papers were classified by the registration of domestic or international journals, the year of publication, experimental fields and the kinds of studies on biological activities. The therapeutic mechanism was investigated in accordance with therapeutic effect of Oryeong-san (Wuling-san). Results : Out of 57 articles selected, 16 were published in domestic journals, 17 were in Chinese journals and 24 were in Japanese journals. Most papers reported as biological activities were on improvement of renal function. Oryeong-san (Wuling-san) increased urine factor such as urine excretion and electrolyte balance while decreasing proteinuria, serum factors including creatinine, cholesterol and triglyceride. In addition, injured renal tissue was recovered normally and gene expression controlling urine excretion was down-regulated. Conclusions : Improvement of renal function could be interpreted as objective and scientific evidence for Oryeong-san (Wuling-san).

S-value of Radioiodine($^{131}I$) in Korean Reference Adult Male

김정훈,임창선,황주호,Kim, Jung-Hoon,Lim, Chang-Seon,Whang, Joo-Ho Korean Society of Radiological Science 2008 방사선기술과학 Vol.31 No.1

한국 성인 남성 표준인(Korean Reference Adult Male)의 기초 자료를 이용하여 수학적 모의 피폭체(Mathematical Phantom)를 제작하였다. 또한 이를 이용하여 방사성옥소($^{131}I$)의 각 장기별 S-value를 산출 하였다. 산출된 S-value는 기존 ICRP-23표준인에 근거하여 산출한 MIRD 5, 및 ORNL-TM 8381자료와 비교해 보았다. 그 결과 S-value는 한국 성인 남성 표준인에 기초한 모의 피폭체가 높은 값을 나타냈다. 이는 몸통이라는 특수한 공간에 위치하게 되는 선원장기(source organ) 및 표적장기(target organ)가 함유하고 있는 구성물질도 중요하지만 그에 못지않게 이들이 차지하고 있는 위치 및 방사성핵종의 특성 또한 중요하게 작용한다는 것을 알 수 있었다. In order to better understand the effects of absorbed radioiodine upon Korean reference adult male, a mathematical phantom representation was contrived based on composite data of the physiology of Korean reference adult male. Using this, S-values of radioiodine($^{131}I$) per each organ were calculated. The calculated S-values were compared to the existing data described in the TM-8381 report of ORNLcalculated on the basis of an ICRP-23 reference male. The results indicated that S-values were higher for the phantom based on Korean reference adult male. The results of this study illustrate that, while the bio-chemical constitution of each source and target organ of the torso are important, the relative location of the organs and characteristics of the radionuclides also exert important influences.

광 PCB 접속용 플러거블 렌즈의 설계 및 제작 연구

김정훈,이태호,김동민,정명영,Kim, Jung Hoon,Lee, Tae Ho,Kim, Dong Min,Jeong, Myung Yung 한국마이크로전자및패키징학회 2014 마이크로전자 및 패키징학회지 Vol.21 No.1

본 연구에서는 기존의 PCB의 한계를 극복할 수 있는 광 PCB에 대한 연구를 수행하였으며, 고효율 수동정렬을 위한 플러거블 렌즈구조를 제안하였다. 제안된 구조는 광 도파로 수동 정렬시 발생할 수 있는 렌즈와 도파로 간의 정렬 오차를 개선하고자 도파로와 렌즈를 합한 형태이다. 또한 탈착에 의해 손상되는 렌즈표면을 보호하기 위한 보호벽 형태를 지님으로써, 고효율의 수동정렬이 가능하게 하였다. 최적화 시뮬레이션을 통하여 구조를 설계하였고, 반복적 포토 리소그래피와 열적 리플로우 공정을 통하여 플러거블 렌즈 구조 제작을 위한 공정 연구를 수행하였다. 렌즈일체형 플러거블 접속구조의 광도파로를 PDMS복제공정으로 제작된 mold를 이용하여 임프린트 공정을 통해 제작하였다. 따라서 본 논문에서는 수동정렬이 가능한 광PCB접속용 플러거블 렌즈 구조의 제작이 가능함을 확인하였다. In this study, an optical PCB was proposed which can overcome the limitations of the conventional PCB, and a new structure with pluggable lens was considered for a high-efficient passive alignment. The structure was a lens-added optical waveguide for the improvement of misalignment between the lens and the waveguide in the alignment. Also, as it had a barrier-type structure to prevent the surface damage of the lens by desorption, the high-efficient passive alignment can be realized. The structure was designed by optimizing the simulation and the fabrication process of the pluggable lens structure was conducted using the repetitive photolithography and the thermal reflow. The optical waveguide with the lens-integrated pluggable interconnection was fabricated by the imprint process using the polydimethylsiloxane(PDMS) replica mold. Therefore, we confirmed the possibility of pluggable lens-added optical waveguide structure fabrication for high-efficient passive alignment.