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슬관절 전치환술에서 후방 안정 임플란트의 오정렬이 경골 기둥에 미치는 영향
김상훈,안옥균,배대경,김윤혁,김경수,이순걸,Kim, Sang-Hoon,Ahn, Ok-Kyun,Bae, Dae-Kyung,Kim, Yoon-Hyuk,Kim, Kyung-Soo,Lee, Soon-Gul 대한의용생체공학회 2007 의공학회지 Vol.28 No.1
Recently, it has been reported that the posterior stabilized implant, which is clinically used for the total knee replacement (TKR), may have failure risk such as wear or fracture by the contact pressure and stress on the tibial post. The purpose of this study is to investigate the influence of the mal alignment of the posterior stabilized implant on the tibial post by estimating the distributions of contact pressure and von-Mises stress on a tibial post and to analyze the failure risk of the tibial post. Finite element models of a knee joint and an implant were developed from 1mm slices of CT images and 3D CAD software, respectively. The contact pressure and the von-Mises stress applying on the implant were analyzed by the finite element analysis in the neutral alignment as well as the 8 malalignment cases (3 and 5 degrees of valgus and varus angulations, and 2 and 4 degrees of anterior and posterior tilts). Loading condition at the 40% of one whole gait cycle such as 2000N of compressive load, 25N of anterior-posterior load, and 6.5Nm of torque was applied to the TKR models. Both the maximum contact pressure and the maximum von-Mises stress were concentrated on the anterior-medial region of the tibial post regardless of the malalignment, and their magnitudes increased as the degree of the malalignment increased. From present result, it is shown that the malalignment of the implant can influence on the failure risk of the tibial post.
김상훈,김세계,정경화,윤성녀,김윤기,김민철,류삼곤,이해완,채영규,Kim, Sang Hoon,Kim, Se Kye,Jung, Kyoung Hwa,Yoon, Sung Nyo,Kim, Yun Ki,Kim, Min Cheol,Ryu, Sam Gon,Lee, Hae Wan,Chai, Young Gyu 한국군사과학기술학회 2015 한국군사과학기술학회지 Vol.18 No.4
Decontamination of biological agents utilizes hydrogen peroxide($H_2O_2$) for its effectiveness and safeness. Bacillus anthracis is a major target for $H_2O_2$ decontamination. To assess the effect of $H_2O_2$ on B. anthracis and identify biomarkers for decontamination, whole transcriptomic profiling of $H_2O_2$-treated B. anthracis was performed. Here we identified deregulation in stress response genes, transcription factors and cellular homeostasis genes. We also found that expression of antisense RNAs increased in B. anthracis during decontamination. We postulate that B. anthracis prioritizes survival and adaptation in response to $H_2O_2$ treatment by changing its gene expression pattern.
과산화수소 증기를 이용한 다양한 쿠폰 표면의 Geobacillus Stearothermophilus 아포 제독조건
김상훈,정경화,김세계,채영규,김윤기,황현철,김민철,박명규,류삼곤,Kim, Sang Hoon,Jung, Kyoung Hwa,Kim, Se Kye,Chai, Young Gyu,Kim, Yun Ki,Hwang, Hyun Chul,Kim, Min Cheol,Park, Myung Kyu,Ryu, Sam Gon 한국군사과학기술학회 2013 한국군사과학기술학회지 Vol.16 No.4
Biological decontamination means the removal of microorganisms from the inanimate object such as building or equipment. In this study, hydrogen peroxide vapor efficacy test using VHP 1000ED system(Steris LifeSciences) were conducted for G. stearothermophilus spore with agent materials(aluminum, stainless steel, poly-carbonate, viton, silicone, kapton and glass). Total recovered spores exposed to hydrogen peroxide vapor(1.0 g/min) during 7, 15, 30, 60 min were calculated. As a result, all agent materials were totally decontaminated within 60 min at 1.0 g/min concentration with 35% hydrogen peroxide vapor. Finally, we could confirmed that hydrogen peroxide vapor possess sporicidal capacity of G. stearothermophilus and found the optimum decontamination conditions with VHP1000ED system.
김상훈,Yong Beom Shin,Myung Hun Jang,Soo-Yeon Kim,Jung Hoon Ro 대한재활의학회 2016 Annals of Rehabilitation Medicine Vol.40 No.5
In this case report, we want to introduce a successful way of applying non-invasive ventilation (NIV) with a full face mask in patients with high cervical spinal cord injury through a novel alarm system for communication. A 57-year-old man was diagnosed with C3 American Spinal Injury Association impairment scale (AIS) B. We applied NIV for treatment of hypercapnia. Because of mouth opening during sleep, a full face mask was the only way to use NIV. However, he could not take off the mask by himself, and this situation caused great fear. To solve this problem, we designed a novel alarm system. The best intended motion of the patient was neck rotation. Sensing was performed by a balloon sensor placed under the head of the patient. A beep sound was generated whenever the pressure was above the threshold, and more than three consecutive beeps within 3,000 ms created a loud alarm for caregivers.
김상훈,Doh-Hyung Kim,Paul Lavender,Ji-Hee Seo,Yun-Seop Kim,Jae-Suk Park,Sahng-June Kwak,Young-Koo Jee 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.5
Increased expression of a number of proinflammatory genes, including IL-8, is associated with inflammatory conditions such as asthma. Glucocorticoid receptor (GR)β, one of the GR isoforms, has been suggested to be upregulated in asthma associated with glucocorticoid insensitivity and to work as a dominant negative inhibitor of wild type GRα. However, recent data suggest that GRβ is not a dominant negative inhibitor of GRα in the transrepressive process and has its own functional role. We investigated the functional role of GRβ expression in the suppressive effect of glucocorticoids on tumor necrosis factor (TNF)-α-induced IL-8 release in an airway epithelial cell line. GRβ expression was induced by treatment of epithelial cells with either dexamethasone or TNF-α. GRβ was able to inhibit glucocorticoid-induced transcriptional activation mediated by binding to glucocorticoid response elements (GREs). The suppressive effect of dexamethasone on TNF-α-induced IL-8 transcription was not affected by GRβ overexpression, rather GRβ had its own weak suppressive activity on TNF-α-induced IL-8 expression. Overall histone deacetylase activity and histone acetyltransferase activity were not changed by GRβ overexpression, but TNF-α-induced histone H4 acetylation at the IL-8 promoter was decreased with GRβ overexpression. This study suggests that GRβ overexpression does not affect glucocorticoid- induced suppression of IL-8 expression in airway epithelial cells and GRβ induces its own histone deacetylase activity around IL-8 promoter site. Increased expression of a number of proinflammatory genes, including IL-8, is associated with inflammatory conditions such as asthma. Glucocorticoid receptor (GR)β, one of the GR isoforms, has been suggested to be upregulated in asthma associated with glucocorticoid insensitivity and to work as a dominant negative inhibitor of wild type GRα. However, recent data suggest that GRβ is not a dominant negative inhibitor of GRα in the transrepressive process and has its own functional role. We investigated the functional role of GRβ expression in the suppressive effect of glucocorticoids on tumor necrosis factor (TNF)-α-induced IL-8 release in an airway epithelial cell line. GRβ expression was induced by treatment of epithelial cells with either dexamethasone or TNF-α. GRβ was able to inhibit glucocorticoid-induced transcriptional activation mediated by binding to glucocorticoid response elements (GREs). The suppressive effect of dexamethasone on TNF-α-induced IL-8 transcription was not affected by GRβ overexpression, rather GRβ had its own weak suppressive activity on TNF-α-induced IL-8 expression. Overall histone deacetylase activity and histone acetyltransferase activity were not changed by GRβ overexpression, but TNF-α-induced histone H4 acetylation at the IL-8 promoter was decreased with GRβ overexpression. This study suggests that GRβ overexpression does not affect glucocorticoid- induced suppression of IL-8 expression in airway epithelial cells and GRβ induces its own histone deacetylase activity around IL-8 promoter site.
비정상강우를 적용한 자연사면에서의 포화깊이 산정 및 사면안정성 평가
김상훈,김성필,손영환,허준,장병욱,Kim, Sang-Hoon,Kim, Seong-Pil,Son, Young-Hwan,Heo, Joon,Chang, Pyoung-Wuck 한국농공학회 2007 한국농공학회논문집 Vol.49 No.1
In Korea, most landslides occurr during the rainy season and have shallow failure planes parallel to the slope. For these types of rainfall-induced failures, the most important factor triggering slope unstability is decrease in the matric suction of unsaturated soils with increasing saturation depth by rainfall infiltration. For this reason, estimation of cumulative infiltration has a significance. In this study, infiltration rate and cumulative infiltration are estimated by using both Mein & Larson model based on Green-Ampt infiltration model and using modified Mein & Larson model to which unsteady rainfall is applied. According to the results, the modified model is more reasonable than Mein & Larson method itself in estimation of infiltration rate and saturation depth because of considering real pending condition.
Seismic Performance of Transportation Networks
김상훈,김종인,Kim, Sang-Hoon,Massanobu, Shinozuka,Kim, Jong-In Earthquake Engineering Society of Korea 2004 한국지진공학회논문집 Vol.8 No.3
본 연구는 캘리포니아 내 고속도로망을 대상으로 지진발생 후 교통흐름의 변화를 평가하는 기법에 대하여 이루어졌으며, 고속도로망 상에 위치한 교량의 손상정도가 평가기법의 가장 기본적인 요소로 사용되었다. 본 연구에 사용된 교량의 지진취약도는 PGA 또는 PGV의 함수로 나타내어졌고, 1994년 Northridge 지진과 일련의 시나리오 지진에 대하여 교통망 손상 평가를 수행하였다. 또한 교량 보수 및 보강 후 교통망에 대한 피해정도를 정량화하기 위해 확률모델을 개발하였으며, 그 피해정도는 시간(Drivers Delay)으로 나타내었다. 본 연구가 캘리포니아를 대상으로 이루어져 국내적용 및 활용가능성에 대해서는 후속 연구가 뒤따라야 할 것으로 사료된다. This paper describes a method of evaluating seismic system performance of highway transportation network in California. The basic element that plays a crucial role in this study is the fragility information of highway bridges in Caltrans' (California Department of Transportation) freeway network. The bridge fragility information is expressed as a function of the ground motion intensity, such as peak ground acceleration (PGA) or peak ground velocity (PGV). Network damage was evaluated under the 1994 Northridge earthquake and scenario earthquakes. A probabilistic model was developed to determine the effect of repair of bridge damage on the improvement of the network performance as days passed after the event. As an example, the system performance degradation measured in terms of an index, “Drivers Delay”, is calculated for the Los Angeles area transportation system, and losses due to Drivers Delay with and without retrofit were estimated.
고등학교(高等學校) 재학생(在學生)들의 비합리적(非合理的) 신념(信念)과 정신병리(精神病理)
김상훈,최훈동,김학렬,Kim, Sang-Hoon,Choi, Hoon-Dong,Kim, Hack-Ryul 한국정신신체의학회 1995 정신신체의학 Vol.3 No.1
The purpose of this study is to investigate the relationship between irrational belief and psychopathology. The Korean version of Symptom Check List-90-R and Irrational Belief Test were administered to 621 high school students in group. The author used Pearson correlation coefficiency and multiple regression analysis to seek the regression patterns of the irrational belief. The results were as follows. 1) Most of the subscales of the SCL-90-R and Irrational Belief Test were correlated significantly. 2) In multiple regression analysis, the irrational belief associated with anxious overconcern was the most predictable variable for psychopathology.