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김배영(Bai Young Kim),김효종(Hyo Jong Kim),정형근(Hyung Keun Chung),김영관(Young Kwan Kim),동석호(Seok Ho Dong),김병호(Byung Ho Kim),이정일(Jung Il Lee),장영운(Young Woon Chang),장린(Rin Chang) 대한내과학회 1993 대한내과학회지 Vol.45 No.5
N/A Background: According to the rapid changes in social environment such as increasing alcohol consumption and the marked improvement in diagnostic technique, we expect that there have been major changes in various aspects of acute pancreatitis during the recent 12 years in Korea. Methods: The medical records of 317 patients with acute pancreatitis diagnosed from 1980 through 1992 were reviewed about clinical, laboratory and radiological findings in the three different time period. Results: 1) There has been an increasing incidence in male sex about three folds. 2) There has been an increasing trends in the duration of hospitalization. 3) A significant increase was observed in the proportion of patients with alcoholic pancreatitis in the three different time period; 26.9%, 45.7%, 50.7% respectively. 4) The complication rates have been slightly increased in the three different time period; 46.3%, 47.1%, 59.1% respectively. But, the type of complications has not been changed. 5) There is increasing severity in non-gallstone group, but no significant differences in gallstone group. There is a declining trends in the number of patients with muld severity index, but increasing trend in the number of patients with moderate severity index in non-gallstone group. 6) There was no significant differences in mortality rate. Conclusions: There has been major changes in the etiology ans severity of acute pancreatitis from 1980 through 1992. Especially, significant increase in the proportion of patients with alcoholic pancreatitis was observed in the three differnt time period. These results might be due to socioeconomic changes.
장린(Rin Chang),김병호(Byung Ho Kim),장영운(Young Woon Chang),이정일(Jung Il Lee),김효종(Hyo Jong Kim),김영관(Young Kwan Kim),동석호(Seok Ho Dong),정형근(Hyung Keun Chung),김배영(Bai Young Kim) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.1
N/A In most young adults with colorectal cancer, tumors are already in advanced stage at the initiation of the treatment and the prognosis has been considered unfavorable. However, some recent articles have shown that it is not necessarily dismal. Therefore, we evaluated retrospectively the incidence, the clinical characteristics and the prognosis in 50 patients with colorectal cancer less than 40 years of age who admitted to the Kyung Hee University Hoapital from Jan. 1981 to Jan 1991. The incidence of colorectal cancer in patients less than 40 years af age was 6.8% (50/739) and the male versus female ratio revealed 1:1. The patients whose clinical, symptom had been for over 6 months before visiting the hospital was 74%, but the duration of clinical symptom had no significant relation to overall survival. The most common pathologic type was moderately differentiated adenocarcinoma. The 5 year cumulative survival rate was 39%. In conclusion, the clinical characteristics of colorectal cancer in patients less than 40 years of age were not different from those of overall colorectal cancer patients, and the prognosis was not unfavorable.
B형 만성 간염 환자에서 인터페론 단독 요법과 인터페론과 라미부딘 병합 요법의 비교
정은미,홍창권,오성욱,박재완,이준성,김경철,김배영,홍성표,박필원,임규성,김세현,황성규,Jeong, Eun-Mi,Hong, Chang-Kwon,Oh, Seong-Wook,Park, Jae-Wan,Lee, June-Sung,Kim, Kyung-Chul,Kim, Bai-Young,Hong, Sung-Pyo,Park, Pil-Won,Rim, Kyu-Sung,Kim 대한임상약리학회 2000 臨床藥理學會誌 Vol.8 No.1
Background/Aims: Hepatitis B virus (HBV) is associated with clinically significant chronic infection that may lead to the development of cirrhosis or even hepatocellular carcinoma. However, interferon alpha is effective in only 25-40% of chronic hepatitis B patients. The purpose of this study was to evaluate the effectiveness of interferon and lamivudine combination treatment comparing with interferon alone. Methods : Twenty patients with chronic hepatitis B(moderate to severe activity) were randomized to with interferon alone (11 patients) or combination (9 patients) therapy for 24 weeks. The patients were monthly evaluated, biochemically and serologically. Results : There was no statistical difference between both groups in HBeAg seroconversion rate and ALT normalizaion rate at the end of treatment. But, HBV DNA suppression rate was significantly higher in combination group (100%) than the interferon alone group (54%). No serious side effects were noted in both groups. Conclusion : Combinaton therapy with alpha interferon plus lamivudine given for 24 weeks appears safe and is well tolerated. But, combination therapy was no more efficient than interferon alone in HBeAg seroconversion except HBV DNA suppression rate during the treatment period.
내시경으로 확진된 위선암의 VATER 팽대부 림프선 전이 1 예
김영호,김경호,김남훈,김규식,김진범,김배영,이영록,추무엽,황교승,곽재영,이명기,조연회,이주택 대한내과학회 1997 대한내과학회지 Vol.53 No.4
Cancer of the stomach is responsible for approximately 650,000 deaths globally each year and is probably second only to lung cancer worldwide as an overall cause of cancer-related mortality. Similar to the situation with most adenocarcinomas of the gastointestinal tract, carcinomas of the stomach can spread by local extension to adjacent normal structures and can develop lymphatic, peritoneal, and distant metastases. The tumor cells, can also permeate diffusely into the lymphatic plexus of the bowel, more often at the level of the upper duodenum hut sometimes down into the distal ileum and the large bowel. We report a case of lymphatic metastasis of gastric adenocarcinoma to the ampulla of Vater with review of the literature.
내시경적 용종절제술로 치유한 십이지장의 Brunner`s Gland 선종 1예
김남훈,한지영,권영철,김배영,추무엽,황교승,김진범,윤환곤,이주택 대한소화기내시경학회 1995 Clinical Endoscopy Vol.15 No.4
The Brunner's gland adenoma is characterized by a nodular proliferation of histologically normal Brunner's gland, accompanied by ducts and scattered stromal elements. First descrived by Salvioli in 1876, the tumor is relatively rare, with 119 cases reported by 1977, The most common benign tumor of the small bowel is the adenoma, 25% of which occur in the duodenum. They make up 30% to 50% of all hyperplastic polyps of the duodenum. Most frequently these tumors are discovered in patients in the fourth to sixed decades of life, though the age in reported caes ranges from l 1 days to 80 years. The benign tumors of the duodenum 30% to 50% contain elements of Brunner's gland and 10.6% of them are adenomas of Brunner's gland. We report a case of Brunner's gland adenoma treated by endoscopic polypectomy in 63 year-old woman, and reviewed the literatues of adenoma of the Brunne'r gland.
김병호,이정일,김효종,김영관,장린,동석호,김배영,장영운 대한소화기내시경학회 1992 Clinical Endoscopy Vol.12 No.1
Since the introduction of Percutaneous Endascopic Gastrostom(P!EG) into clinical practice by Painsky in 1980, the endoscopic procedure for the placement of a gastrostomy feeding tube 18 been, markedly develapel in the-world. In 1989,. PEG was first diescrihed in Korea, thereafter it i.s widely used in many Korean institutons. Butuntil raertly the clinical stwdies of the long ierm efficacy of PEG has almost not been reporexd. So, to evaluate the long term efficacy of PEG for nutritional support we have performed the retrpectixe study of 140 cases of 'PEG done from 1987 through 1991. The results wrere as fellows: l) Technfcal success rates were 100%. 2) Averiage pracedsare time was 2U minutes(l0 to 50 minutes). 3) Averae tube exchange interval was 8 manths(1 to 24 manths). 4) Major Complicaton rates were l.4%(2/140). 5) Minor cornpiication rates were 23.696(33/14U), but easily treated by conservative mnagement. 6) Of total 140 patients, follow-up was possible in 118 patients. In those 118 patients, feing tube was removed in 23 patients, and feeding tube was exchanged in 29 patients because bf worn-out, and i 3 paints because of malfunction. These results suggests that PEG is a simple, safe and rapid method for the placement of a gastrostomy tube and makes possible that the patients have comfortable and ambulatory life styles. Also in terms of the long term efficacy of PEG, we could have a conclusion that PEG is a very effective method.
김경철,안희정,김배영,임규성,차영수,국진환,홍성표,박필원,오성욱 대한내과학회 1998 대한내과학회지 Vol.54 No.5
Idiopathic hemochromatosis is hereditary hemochromatosis without secondary cause. Hereditary hemoduomatosis is a common disorder of iron metabolism with a prevalence of 1 case per 250-300 persons. Affected individuals absorb excessive amounts of dietary iron for a long time and tissue iron deposition results in skin discoloration, arthropathy, hepatic cirrhosis, heart cirrhosis, heart failure, diabetes mellitus and impotence. Fly diagnosis and institution of phlebotomy tneatment will prevent these manifestations and normalize life expectancy. We report a of hemochromatosis in 65-year-old male of no transfusion and iron ingestion history who was anti-HCV(+), chronic alcoholic, hepatic iron index$gt;2.24.
전격성 간부전증을 동반한 조직구성 세포탐식성 지방충염 1 예
김병호,김선희,김효종,장린,이정일,김배영,장영운,박용구 대한내과학회 1991 대한내과학회지 Vol.41 No.1
Histiocytic cytophagic panniculitis was first described in 1980 by Winkelmann, et al. It is characterized by the presence of fever, serositis, inflammatory panniculitis, pancytopenia, coagulation defects, hepatosplenomegaly, and subcutaneous nodules resulting from the infiltration of lympho-histiocytes in the dermis and subcutaneous adipose tissue. A characteristic finding is the presence of bean-bag histiocytes containing phagocytized red blood cells, lymphocytes, and platelets. We experienced a case of histiocytic cytophagic panniculitis in a 30-year-old woman with a clinical picture of jaundice, recurrent chronic panniculitis, pancytopenia, hepatosplenomegaly, and a terminal, febrile illness with bleeding diathesis. In the skin biopsy and bone marrow study, characteristic histiocytes with prominent phagocytic activity and so-called bean-bag appearance were identified in subcutaneous fat as well as in the bone marrow. The patient died with DIC due to fulminant hepatic failure.
김병호,김효종,이기형,장린,이정일,김배영,장영운,전정열 대한내과학회 1991 대한내과학회지 Vol.40 No.2
Growth retardation and delayed sexual maturation occur in 15-30% of adolescents afflicted with Crohn`s disease and social complication of these immaturity are often more debilitating than the gastrointestinal manifestation. The etiology of this abnormal growth had been unknown, and various forms of therapy including surgery had yielded disappointing results. Recently, however, chronic caloric insufficiency has been documented in several reports and nutritional restitution using enteral and parenteral routes reverses growth retardation in these patients, and these nutritional effects on growth may be mediated by somatomedin-C. We recently experienced a case of Crohn`s colitis with growth retardation and delayed sexual maturation in adolescent who underwent surgical resection, so we couldn't confirm the nutritional effect on growth but the patient had no endocrine dysfunction and no history of corticosteroid therapy which had been incriminated as possible causes of growth retardation. We report a case of Crohn`s colitis with growth retardation.