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      • KCI등재

        FFS 모드에서 Reverse Twist가 구동전압에 미치는 영향에 관한 연구

        김미숙,정연학,신승민,김향율,김서윤,임영진,이승희,Kim, Mi-Sook,Jung, Yeon-Hak,Seen, Seung-Min,Kim, Hyang-Yul,Kim, Seo-Yoon,Lim, Young-Jin,Lee, Seung-Hee 한국전기전자재료학회 2005 전기전자재료학회논문지 Vol.18 No.11

        We have studied on the effect of the operation voltage according to the reverse twist for the different fringe field switching (FFS) structure. The FFS structure with a vertically patterned edge of the pixel electrode (VPP) has lower operation voltage comparing to the one with a horizontally patterned edge of the pixel electrode (HPP). The reason is like that the number of the pattern of the pixel edge for the VPP structure is one third comparing with the HPP structure and thus, there is small reverse twist area for the VPP structure. Actually, the reverse twist disturbs the twist of LC near adjacent active area, result that LCs near there have the unstable dynamics. That is, the operation voltage increases as the reverse twist area increases. Therefore, it is very important to design pixel electrode with a small reverse twist region for the FFS mode.

      • KCI등재

        압력에 안정한 3분할 FFS 모드의 화소 설계에 관한 연구

        김미숙,신승민,정연학,김향율,김서윤,임영진,이승희,Kim, Mi-Sook,Seen, Seung-Min,Jung, Yeon-Hak,Kim, Hayng-Yuil,Kim, Seo-Yoon,Lim, Young-Jin,Lee, Seung-Hee 한국전기전자재료학회 2005 전기전자재료학회논문지 Vol.18 No.7

        We studied the external pressure-stable advanced frnge field switching (FFS) pixel design with 3 slit sructue. In this mode, a patterned pixel slit is partitioned into 3 areas, namely, two edges and a center, where the edge slit angle is larger than the center slit angle. Thus the reverse twist region in the pixel edge is reduced comparing to the conventional FFS mode so that the LC dynamics in this region becomes very stable. And also, when the external pressure is applied to the panel at the high voltage, the disclination lines (DLs) were barely intruded into active area. Therefore, the structure is use for the pen based system such as the tablet personal computer (PC), personal digital asistant (PDA).

      • KCI등재

        TN 모드와 FFS 모드에서 Pretilt Angle이 전기 광학 특성 및 동력학 안정성에 미치는 영향에 관한 연구

        김미숙,정연학,김향율,김서윤,이승희,Kim, M.S.,Jung, Y.H.,Kim, H.Y.,Kim, S.Y.,Lee, S.H. 한국전기전자재료학회 2004 전기전자재료학회논문지 Vol.17 No.11

        We studied on the electro-optic characteristics and dynamic stability according to an undesirably defined pretilt angle induced in high step coverage of pixel area for the Twisted Nematic (TN) / Fringe-Field Switching (FFS) mode. In case of the TN mode, LC directors twist reversely near the edges of thin-film-transistor and black matrix where the pretilt angle of the LC is not well defined. Therefore, the voltage-dependent dynamics of the LC in TN mode is unstable and shows the bad electro-optic characteristics. On the other hand, in case of the FFS mode, the LCs are twisted parallel to the bottom substrate by fringe electric field and the electro-optic characteristic is not influenced by the pretilt angle of the LC which is not well defined.

      • KCI등재

        FFS 모드에서 러빙 방향에 따른 Reverse Twist 변화에 대한 연구

        김미숙,신승민,정연학,김향율,김서윤,이승희,Kim Mi Sook,Seen Seung Min,Jung Yeon Hak,Kim Hyang Yul,Kim Seo Yoon,Lee Seung Hee 한국전기전자재료학회 2006 전기전자재료학회논문지 Vol.19 No.2

        We studied on the reverse twist near the pixel edge depending on the rubbing direction for the fringe field switching (FFS) mode. Liquid crystal (LC) dynamic and the transmittance near the pixel edge, where the various field directions are generated, depend on the initial rubbing direction because the position of reverse twist is decided by the angle between the electric direction and the LC director at a bias voltage. For example, when the rubbing angle is $7^{\circ}$, the reverse twist appears on the bottom position of the right sharp comer of the pixel edge so that the reverse region exists far away from main active region. But, when the rubbing angle is $-7^{\circ}$, the reverse twist appears on the top position of the right sharp comer of the pixel edge, resulting that the region becomes more close to the main active area and the unstable disclination lines (DLs) easily intrude into the active region. Therefore, it is necessary to keep the reverse twist region far from the active region and it is possible by controlling the rubbing direction in the design of a pixel electrode.

      • KCI등재

        한국 여성노동력의 성격변화와 노동정책: 1960-2000

        김미숙(MiSook Kim) 한국인구학회 2006 한국인구학 Vol.29 No.1

        본 연구의 일차적 목적은 지난 40년간 일어난 초고속 경제성장의 경험에 유념하면서 한국 여성노동력의 성격변화와 그 대응양식으로서 노동(관련)정책을 해당 정권별(박정희-전두환-노태우-김영삼-김대중)로 구분하여 살펴보는 것에 있다. 60년대 초반 산업화 도입기부터 역대 정권은 각기 다른 모습으로 여성노동력을 저임금-단순-미숙련-산업인력으로 주변화시켜 왔음을 관련자료를 통해서 확인할 수 있었다. 구체적으로 60년대 산업화 초기에는 노동집약적 산업에 저임금 산업인력으로, 70년대 중화학공업 육성기에는 저임금을 특징으로 하는 전통적 여성직종에 집중배치되었다. 80년대 들어서는 의류 전자 신발 등의 업종으로부터 집단해고 또는 대량감원의 대상으로 전락하였다. IMF 경제위기 전후 90년대는 비정규직 노동의 확산과 고용불안정 혹은 실업이 한국 여성노동의 현실에 충격을 주어 여전히 그 영향력에서 벗어나지 못한 상태에 놓여있다고 하겠다. 한편 정부 측의 다양한 대응양식으로서 노동(관련) 정책이 제안되고 있으나, 불합리한 노동 현실의 근본적인 대안으로 평가되기에는 역부족이라고 말할 수 있을 것이다. This paper tries to explore the overall profile of Korean female labor force over the period of 1960-2000. A particular emphasis is put on portraying major over-time characteristics of female labor force, following five different political regimes--that of Park, J.H .(1960 and 1970s), of Chon D.H. (early and late 1980s), of Roh T.W. (late 1980-early 1990s), of Kim,Y.S. (early 1990-late 1990s), and of Kim. D. J. (late 1990-early 2000s), respectively. Discussions have centered around: 1) utilization of young single girls from rural areas during the early industrialization process of 1960-1985; 2) the beginning of married women's entry into labor market and issues of the so-called "M-curve" thesis in Korean experiences since 1990s; 3) the emergence and enlargement of non-regular workers; and 4) the launching of labor related legal measures such as the Equal Employment Act of 1988 and its successive revisions, the Maternity Leave Acts, the On-the-Job Childcare Centers, and the prohibition of sexual harassments on the job setting, and so on. All in all, although it is undeniable that the Korean female labor force has experienced much progress over the period of time in terms of "equality and protection" issues, overall industrial reality we are facing with has not been so prosperous in the sense that most women workers have become the victims of industrial polarization, as time goes by.

      • SCOPUSSCIEKCI등재

        사람의 신경교종 세포주에서 아데노바이러스 벡터를 이용한 p16/INK4a 유전자 전달에 의한 종양성장 억제

        김미숙,권희충,강희석,박인철,이창훈,김창민,이춘택,홍석일,이승훈,Kim, Mi-Suk,Kwon, Hee-Chung,Kang, Hee-Seog,Park, In-Chul,Rhee, Chang-Hun,Kim, Chang-Min,Lee, Choon-Taek,Hong, Seok-Il,Lee, Seung-Hoon 대한신경외과학회 2000 Journal of Korean neurosurgical society Vol.29 No.4

        Objective : p16/INK4a, a kind of tumor suppressor genes, encodes a specific inhibitor of the cyclin D-dependent kinases CDK4 and CDK6. This prevents the association of CDK4 with cyclin D1, and subsequently inhibits phosphorylation of retinoblastoma tumor suppressor protein(pRb), thus preventing exit from the G1 phase. According to previous reports, over 50% of glioma tissue and 80% of glioma cell lines have been demonstrated inactivation of p16/INK4a gene. The purpose of this study was to determine whether recombinant adenovirus-p16 virus is a suitable candidate for gene replacement therapy in cases of glioma. Methods : Three human glioma cell lines(U251MG, U87MG and U373MG) that express mutant p16 protein were used. Replication-deficient adenovirus was utilized as an expression vector to transfer exogenous p16 cDNA into the cells ; control cells were infected with the Ad-${\beta}$-gal expressing ${\beta}$-galactosidase. To monitor gene transfer and the expression of exogenous genes, we used Western Blotting analysis. Flow cytometry studies of cellular DNA content were performed to determine the cell cycle phenotype of the glioma cells before and after treatment. Results : We showed here that restoration of p16/INK4a expression in p16 negative U87MG, U251MG and partially deleted U373MG by Ad-CMV-p16 induced growth suppression in vitro. Flow cytometric study revealed that Ad-CMV-p16 infected U87MG cells were arrested during the G0-G1 phase of the cell cycle. Expression of p16 transferred by Ad-CMV-p16 in glioma cells was highly efficient and maintained for more than seven days. Conclusions : Our results suggest that Ad-CMV-p16 gene therapy strategy is potentially useful and warrants further clinical investigation for the treatment of gliomas.

      • SCOPUSKCI등재

        HCMV에 감염된 TBP-1 세포에서 세포간 부착분자-1 발현 촉진물질의 방출

        김미숙,이현아,이찬희,Kim, Mi-Suk,Yi, Hyun-Ah,Lee, Chan-Hee 한국미생물학회 2008 미생물학회지 Vol.44 No.2

        다양한 염증 질환을 유발하는 사람세포거대바이러스(Human cytomegalovirus: HCMV)는 단핵구 세포주인 THP-1 세포에서 염증반응의 중요한 매개체인 세포간부착분자-1(intercellular adhesion molecule: ICAM-1) 발현을 촉진한다. ICAM-1 발현은 자외선으로 불활화시킨 HCMV (UV-HCMV)에 의해서도 촉진되므로 이 과정에 HCMV 유전자발현은 꼭 필요하지는 않은 것 같다. HCMV에 감염된 THP-1 세포 배양액을 감염되지 않은 THP-1 세포에 처리하거나 공유하게 하였을 시 감염되지 않은 세포에서도 ICAM-1 발현이 증가하였다. 감염된 세포 배양액에 의한 ICAM-1 발현 증가는 $NF-{\kappa}B$ 경로를 거친다. UV-HCMV에 감염된 세포의 배양액은 ICAM-1 발현을 촉진시키지 못하였다. 따라서 HCMV에 의한 THP-1 세포에서 ICAM-1 발현 증가는 바이러스 유전자 발현을 필요로 하지 않지만, 감염된 세포에서 ICAM-1 발현을 촉진하는 물질을 분비하는 과정에는 바이러스 유전자 발현이 필요한 것으로 생각된다. Human cytomegalovirus (HCMV) stimulates the expression of intercellular adhesion molecule (ICAM-l) on the surface of monocytic THP-1 cells. Stimulation of ICAM-l did not require HCMV gene expression since UV-inactivated HCMV (UV-HCMV) was able to induce ICAM-l expression. ICAM-l expression was also stimulated in uninfected THP-l cells which were fed with culture supernatant of HCMV-infected THP-l cells. Co-culture experiment using trans-well insert supported that HCMV-infected THP-l cells secreted some cytokine(s) stimulating ICAM-l expression. The stimulation of ICAM-l by HCMV-infected cell culture supernatant appears to involve $NF-{\kappa}B$ pathway. Culture supernatant from THP-l cells infected with UV-HCMV, whose gene expression was abrogated, failed to stimulate ICAM-l expression on naive THP-l cells. Thus, HCMV gene expression seems to be required in secretion of cytokine(s) stimulating ICAM-l expression.

      • KCI등재

        의료기관 QI 담당자의 목표추구몰입에 관한 연구

        김미숙,박재성,Kim, Mi-Sook,Park, Jae-Sung 보건의료산업학회 2008 보건의료산업학회지 Vol.2 No.1

        The purpose of this research is to provide the data base for the activation of Quality Improvement operation through investigating the status of Quality Improvement operation, and finding out factors influencing on the goal-orientation of QI performers in the medical centers of more than one hundred beds where are practicing Quality Improvement operation. In order to reach the purpose, document study was carried out grounded on the proceeding researches and formulated statistical data in relation with the status of Quality Improvement performers, and proof study was carried out through questionnaire survey. The subjects of the survey were the Quality Improvement performers working in seventy three medical centers in Pusan-Gyeongnam, Daegu-Gyeongbuk, and Ulsan. Among eighty three Quality Improvement performers, fifty, five were questionnaire surveyed, on the result of which Reliability Analysis, Factor Analysis, and Multiple Regression Analysis were made, using statistical program. The the results of the proof analysis on this research are as follows. First, in the factors influencing the devoting to goal pursuit of QI performers, organization-goal contribution(0.44) had significant positive effects, while organization conflict(-0.25) had significant negative effects. In other words, the higher the organization-goal contribution was, the higher the devoting to goal pursuit was, while the less the organization conflict was, the higher the devoting to goal pursuit was, which was statistically significant.(p<0.05). Second, in the aspect of goal performance types of QI performers, the process-centered type showed high level of the devoting to goal pursuit, which was statistically significant.(p<0.05). Third, in the aspect of QI performance degree, the higher the devoting to goal pursuit was, the higher the QI performance degree was, which was statistically significant.(p<0.05). In addition, the performers who perceived their workplaces organic structure showed much higher QI performance degree, which statistically significant.(p<0.05). Generalizing the results of this research, it is possible to offer a few suggestions as follows. First, as the competition among the medical centers is more severe recently owing to medical center evaluation system, medical centers are practicing various Quality Improvement operation in all of medical services such as clinical performance and management performance, to reach the purpose of both cost-cutting and medical quality improvement. Thus in order to practice Quality Improvement operation more efficiently in medical centers, it is essential to nuke use of problem-solving methods and statistical members. This as the willingness of chief executives and positive attitude and recognition of organization members. This requires the installation of divisions in charge and disposition of persons in charge, not to speak of persistent training of Quality Improvement. Second, the divisions in charge of QI carry out Quality Improvement operation at the medical center level, and take the role of generalizing and adjusting QI performances of various departments. Owing to this role, the division in charge of QI is considered indispensable organization in the QI operation of medical centers along with medical QI committee, while it contributes to the government's goal of reducing quality level gaps among medical centers. Therefore it is necessary for government and QI organizations to give institutional support and resources for the sake of QI operation of medical centers, besides to supply systematic trainning and informations to the divisions and persons in charge of QI. Third, it is certain that disposition of persons in charge should be determined in view of the scale and the scope of QI operation in medical centers.

      • KCI등재

        119 구급대원들의 업무에 관한 연구 -2개 광역시 소방구급대를 중심으로-

        김미숙,여진동,Kim, Mi Sook,Yeo, Jin Dong 보건의료산업학회 2007 보건의료산업학회지 Vol.1 No.1

        This Study aims to examine the relative importants of various tasks of EMT and to examine knowledge level and problems associated with AED. It is based on the survey of paramedics and rescurers. The instrument by Hoe Sum Lim(1999) was used. as the questionaire for this research. The collected data were analyzed by means of $x^2$ test, t-test, and measured by percents. The results for this study were follows: 1) Among the tasks of EMI, "Basic Life Support" were rated as the most important, followed by "O2 supply" and foreign-body removal from mouth. 2) Some of the lower level of importance in task were Intubation, IV, dextrose infusion of Hypoglycemia, NTG S/L for chest pain, hydration for fluid therapy, brochodilator IV for Bronchial Asthma. 3) Some of the lower level of importance in task were apply of MAST, Vital Sign check and administration of traction & spine immobilization & air splint. 4) The most important reason that the used of AED is delayed is "unclear boundary of treatment directed by medical control".

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