일개 삼차대학병원에서 최근 6년간 임상검체에서 분리된 Salmonella의 혈청군과 항균제 내성률

서소연,이미애 대한임상미샐물학회 2004 Annals of clinical microbiology Vol.7 No.1

전립선암 진단에 있어서 Architect 총 PSA 화학발광면역검사법의 유용성 평가

서소연,조성은,홍기숙 대한진단검사의학회 2005 Annals of Laboratory Medicine Vol.25 No.6

Background : Serum prostate specific antigen (PSA) is used as a marker for early diagnosis, monitoring of therapy, and detection of recurrence of the prostatic tumor or benign prostatic hyperplasia (BPH). In Korea, over 15 instruments have been used for measuring PSA. In this study, chemiluminescence microparticle immunoassay Architect total PSA (Abbott Lab., Abbott Park, IL, USA) was evaluated for analytical performance and diagnostic usefulness as a marker for prostate cancer. Methods : The within-run and between-run precision, lower detection limits, correlation with AxSYM total PSA (Abbott Lab., Abbott Park, IL, USA) and clinical investigation were evaluated. Three level control serums (0.5, 4.0, and 23.0 ng/mL) were used for a precision test. The linearity was evaluated using a patient serum sample with a PSA concentration of 100 ng/mL. Functional and analytical sensitivities were tested using a patient serum sample with a PSA concentration of less than 0.1 ng/ mL and saline. A correlation study with AxSYM total PSA was done with 42 serum samples. Clinical evaluation was done with 230 patients of whom 17 had prostate cancer. Results : The total PSA showed a good precision result with less than 5 % of CV and showed linearity to 100 ng/mL. The functional sensitivity was 0.025 ng/mL and analytical sensitivity 0.001 ng/mL. The correlation evaluation showed Y (Architect)=1.0575X(AxSYM)+0.1895, r=0.9960. A Cut-off value of 8.35 ng/mL showed 88.2% sensitivity, 80.3% specificity as a diagnostic marker for prostate cancer. Conclusions : Architect total PSA showed an acceptable analytical performance with its high sensitivity and could be a useful marker for early detection and recurrence of prostate cancer. 배경 : 혈청 prostate specific antigen (PSA) 검사는 전립선암 조기 진단, 치료 추적 및 재발의 판정에 절대적으로 중요하다.한국에서는 15종 이상의 PSA 측정기가 사용되고 있다. 이에최근에 많이 사용하고 있는 화학발광면역분석법인 Architect totalPSA (Abbott Lab., Abbott Park, IL., USA)의 분석력 및 전립선암 진단의 유용성을 평가하고자 한다. 재료 및 방법 : 검사내 및 검사간 정밀도 평가, 최저검출한계는세 단계(0,5, 4.0, 23.0 ng/mL)의정도관리 물질을 사용하였다.직선성검토는 PSA 100 ng/mL의 환자 검체로, 기 상관성 검토는 환자검체 42개로 시행하였다. 임상적 검토는 2003년 10월부터 2004년 3월까지 이대동대문병원 진단검사의학과에 PSA 검사를 의뢰한 230명으로 전립선암 17명, 양성 질환 213명 환자를 대상으로 하였다. 전립선암 여부는 의무기록지의 경직장전립선 초음파소견 및 전립선 조직검사 보고서로 확인하였다.결과 : PSA의 정밀도는 5% 정도를 보였고, 100 ng/mL까지직선성을 유지하였다. 최저검출한계는 기능적 예민도는 0.025 ng/mL, 분석예민도는 0.001 g/mL이었다. 기간 비교는 Y (Archi-tect)=1.0575X (AxSYM)+0.1895, r=0.9960이었다. 전립선암진단에 있어서 PSA 결정치는 8.35 ng/mL으로 예민도 88.2%,특이도 80.3%이었다. 결론 : Architect 총 PSA를 이용한 검사는 전립선암의 조기진단과 치료 후 최저치 및 재발 판정 추적검사에 적절한 검사로 판단된다.

류마티스 관절염환자의 진단에서 항Cyclic Citrullinated Peptide항체와 IgM 류마티스 인자의 임상적 유용성

서소연,이지수,강은숙 이화여자대학교 의과학연구소 2005 EMJ (Ewha medical journal) Vol.28 No.2

방광암 진단 및 추적 시 NMP22 BladderChek 검사의 유용성

서소연,조성은,홍기숙,심봉석,권성원 대한진단검사의학회 2007 Annals of Laboratory Medicine Vol.27 No.1

배경 : 방광암은 재발률이 높은 표재성 암으로 조기 진단 및재발의 확인이 중요하다. 이에 저자들은 방광암 진단 및 추적에있어서 NMP22 BladderChek (NMP22BC) 검사의 효용성을 확인하고자 하였다.재 료 및 방 법 : 2004년 7월부터 12월까지 혈뇨, 배뇨통으로 이대 동대문병원 비뇨기과에 방문하여 NMP22BC 검사를 실시한670명을 대상으로 하였다. BTA stat와 NMP22BC를 21명에서동시에 검사하여 일치도를 구하였고, NMP22BC의 위양성 분석을 위해 10명에서 간섭 실험을 하였다. 결과 : 방광암이 치료된 환자의 97%에서 NMP22BC 검사 음성을 보였고, 재발된 20명에서는 95%에서 양성 소견을 보여서 재발된 방광암의 진단에 있어서 NMP22BC의 진단적 민감도, 특이도, 양성 예측치, 음성 예측치, 검사 효율도는 각각 95.0%, 91.5%,25.7%, 99.8%, 91.6%였다. 또한 위양성 률 및 위음성률은 8.5%와5%이었다. 위양성으로 구분된 환자는 5명이었고, 위양성 결과의원인으로 요 백혈구 증가가 가장 많았다. BTA stat과 NMP22BC검사간의 일치율은 높았다(kappa 일치도: 0.5, P=0.008). 간섭실험 결과, 전체 10명 대상 중 백혈구 esterase가 3+ 이상 보이는두 명의 환자에서만 NMP22BC가 위양성을 보였다.

Serologic Screening of Pregnant Korean Women for Primary Human Cytomegalovirus Infection Using IgG Avidity Test

서소연,조영숙,박준석 대한진단검사의학회 2009 Annals of Laboratory Medicine Vol.29 No.6

Background : Primary human cytomegalovirus (CMV) infection during pregnancy is a major cause of congenital malformation. We detected primary CMV infection in pregnant Korean women by using an algorithm that comprises CMV IgG, IgM, and IgG avidity tests. Methods : During a 2-month period, 744 pregnant women who were at 10-19 weeks of gestation were consecutively enrolled in this study. Human anti-CMV IgG and IgM levels in their sera were determined by chemiluminescence immunoassays. Serum samples from the women who were positive for CMV IgG and IgM were assayed by the ARCHITECT CMV IgG avidity test in order to distinguish primary from non-primary CMV infection. Gross examination of the neonates of the women who were positive for CMV IgM was conducted. Results : The seroprevalence of CMV IgG and IgM was estimated to be 98.1% and 1.7%, respectively. The samples from all the women who were positive for CMV IgM or with grey zone results contained high avidity CMV IgG. Seven women with positive CMV IgG and IgM results who completed follow-up up to delivery showed no gross evidence of in utero CMV transmission. Conclusions : Maternal primary CMV infection was not detected in any of the pregnant women included in this study cohort. CMV IgG avidity test enabled the identification of women who were at a low risk of transmitting CMV infection and provided informative for subsequent pregnancy outcomes. Compared to previous studies, the seroprevalence of CMV IgG antibody across pregnant Korean women remained unchanged. Background : Primary human cytomegalovirus (CMV) infection during pregnancy is a major cause of congenital malformation. We detected primary CMV infection in pregnant Korean women by using an algorithm that comprises CMV IgG, IgM, and IgG avidity tests. Methods : During a 2-month period, 744 pregnant women who were at 10-19 weeks of gestation were consecutively enrolled in this study. Human anti-CMV IgG and IgM levels in their sera were determined by chemiluminescence immunoassays. Serum samples from the women who were positive for CMV IgG and IgM were assayed by the ARCHITECT CMV IgG avidity test in order to distinguish primary from non-primary CMV infection. Gross examination of the neonates of the women who were positive for CMV IgM was conducted. Results : The seroprevalence of CMV IgG and IgM was estimated to be 98.1% and 1.7%, respectively. The samples from all the women who were positive for CMV IgM or with grey zone results contained high avidity CMV IgG. Seven women with positive CMV IgG and IgM results who completed follow-up up to delivery showed no gross evidence of in utero CMV transmission. Conclusions : Maternal primary CMV infection was not detected in any of the pregnant women included in this study cohort. CMV IgG avidity test enabled the identification of women who were at a low risk of transmitting CMV infection and provided informative for subsequent pregnancy outcomes. Compared to previous studies, the seroprevalence of CMV IgG antibody across pregnant Korean women remained unchanged.

현성굴절검사로 추적관찰한 조절내사시에서의 안경중단 예측인자

서소연,오민진,임기환,Soh-Youn Suh,Min Jin Oh,Key Hwan Lim 대한안과학회 2011 대한안과학회지 Vol.52 No.2

Purpose: To investigate the predictive factors of successfully weaning children from glasses with accommodative esotropia who were monitored with manifest refraction on follow-up visits. Methods: A retrospective review of 48 patients with accommodative esotropia was performed. Weaning was accomplished by monitoring patients with manifest refraction on follow-up visits. The patients were divided into 2 groups: patients who were weaned successfully from glasses and patients who still needed glasses at their final visit. A comparative analysis of the multiple clinical features between the 2 groups was performed. Results: Among the 48 patients, 15 patients were weaned successfully from glasses. The age of onset was significantly different between the 2 groups, 39.6 ± 14.9 months in patients who were weaned successfully from glasses and 30.7 ± 16.9 months in patients who still needed glasses. In particular, the patients with onset of accommodative esotropia after 3 years of age were more likely to be weaned from glasses at their final visit. Conclusions: Monitoring with manifest refraction could be another method of weaning children from glasses with accommodative esotropia and the age of onset appears to be the useful predictor of successful weaning in children who can finally be weaned from glasses. J Korean Ophthalmol Soc 2011;52(2):227-232

60 GHz 대역 28 dBm 출력전력을 갖는 GaAs 증가형 pHEMT 전력증폭기 MMIC 설계

서소연,이용호,신현철 한국전자파학회 2023 한국전자파학회논문지 Vol.34 No.2

A 60 GHz power amplifier (PA) monolithic microwave integrated circuit (MMIC) with +28 dBm output power is designed in an enhancement-mode 0.15 μm GaAs pseudomorphic high-electron-mobility transistor (pHEMT) technology. A two-stage topology and a four-way power combining technique are adopted to achieve a high power gain, high output power, and high linearity. Transistor-level circuit and layout designs are developed, and the circuit performances are verified through three-dimensional electromagnetic simulations. The designed PA MMIC exhibits a saturated output power of +28.4 dBm, output-referred 1-dB gain compression point of +28 dBm, power gain of +8.1 dB, and power added efficiency of 29.3 %. S-parameter simulations show that the small-signal gain is +8.1 dB, and the operating bandwidth is between 55.7 and 63.1 GHz, with a fractional bandwidth of 12.3 %. The supply voltages are 4 V for the drain and 0.6 V for the gate. The positive-only supply voltages resulting from the enhancement-mode pHEMT simplify the supply voltage network compared with the conventional depletion-mode pHEMT design. The layout die size of the PA MMIC is 1.99×1.62 mm2 , and the power density performance of 214 mW/mm2 is satisfactory.

유리체강 내 베바시주맙이 각막내피세포에 미치는 영향

서소연,이정희,전루민.Soh-youn Suh. MD. Jeong-hee Lee. MD. PhD. Roo Min Jun. MD. PhD 대한안과학회 2010 대한안과학회지 Vol.51 No.12

Purpose: To evaluate the in vivo corneal endothelial changes after intravitreal bevacizumab (Avastin®; Genentech Inc., San Francisco, California, USA) injection. Methods: A total of 30 eyes of 28 patients who received intravitreal bevacizumab injections were included in the present study. Before injection and one and three months after injection, specular microscopy was performed to analyze the corneal endothelial cell changes. In order to compare the differences in the changes of corneal endothelial cells, the eyes were divided into two groups, a single injection group and a multiple injection group. Results: The mean endothelial cell count decreased from 2,497.4 ± 427.8 at baseline to 2,421.2 ± 430.5 at one month and to 2,362.7 ± 366.2 at three months after the injection in all patients. However, the change in endothelial cell count was not statistically significant. In addition, the postoperative change in endothelial cell count was more prominent in the multiple injection group than in the single injection group, although the difference was again not significant. No significant changes in preoperative or postoperative coefficients of variation for cell area or hexagonalities were observed in either patient group or within each group. Conclusions: There was no significant change in corneal endothelial cells after intravitreal bevacizumab injection. In addition, there was no significant difference in the changes in corneal endothelial cells according to the number of bevacizumab injections. J Korean Ophthalmol Soc 2010;51(12):1549-1553

Properties of Silicone Nanocomposite : Effects of Sizes and Contents of Silver Nanoparticles

서소연,신동현,김남희,이영희,원석재,김주영,인교진 한국공업화학회 2005 한국공업화학회 연구논문 초록집 Vol.2005 No.1

Effect of Sizes on the Melting Temperature of Ag Nanoparticles

김남희,서소연,김주영,인교진 한국공업화학회 2006 한국공업화학회 연구논문 초록집 Vol.2006 No.-