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Lee, Beom-Il,You, Seung-Gyu,You, Seung-Min,Kang, Seen-Young,Kim, Ji-Hwan The Korean Academy of Prosthodonitics 2021 The Journal of Advanced Prosthodontics Vol.13 No.1
PURPOSE. This study was to evaluate the effect of rinsing time on the accuracy of interim crowns fabricated by digital light processing. MATERIALS AND METHODS. The maxillary right first molar master die was duplicated using a silicone material, while a study die was produced using epoxy resin. Scans of the epoxy resin die were used in combination with CAD software to design a maxillary right first molar interim crown. Based on this design, 24 interim crowns were fabricated with digital light processing. This study examined the trueness and precision of products that were processed with one of the three different postprocessing rinsing times (1 min, 5 min, and 10 min). Trueness was measured by superimposing reference data with scanned data from external, intaglio, and marginal surfaces. Precision was measured by superimposing the scan data within the group. The trueness and precision data were analyzed using Kruskal-Wallis, nonparametric, and post-hoc tests, and were compared using a Mann-Whitney U test with Bonferroni correction (α=.05). RESULTS. The trueness of the external and intaglio surfaces of crowns varied significantly among the different rinsing times (P=.004, P=.003), but there was no statistically significant difference in terms of trueness measurements of the marginal surfaces (P=.605). In terms of precision, statistically significant differences were found among the external, intaglio, and marginal surfaces (P=.001). CONCLUSION. Interim crowns rinsed for 10 minutes showed high accuracy.
A Study on Performance Evaluation of Magnetic Dental Attachments
Seen-Young Kang,Ji-Min Yu,Hyoung-Sik Kim,Ki-Sook Park,Seung-Youl Lee 한국자기학회 2019 Journal of Magnetics Vol.24 No.4
This study measures retentive force as function of the diameter, the cross-head speed, and the number of detachments of dental magnetic attachments in a clinical environment, and analyzes the validity of the international standard method for testing them. In this study, tests 1, 2, and 3 were used to measure the retentive force as a function of the contact area of the magnetic attachment, and tests 2 and 4 as a function of the cross-head speed. Test 2 and 5 compared function of the retentive force as a function of repeated detachments Results showed that the retentive force increases as the sample surface increases, and decreases as the cross head speed increases. Additionally, after 1500 detachment cycles, the retentive force increased. Finally, the international standard test method was validated, because an objective method for testing magnetic attachments in clinical environment could not be found.
Production of Porcine Parvovirus Virus-like Particles Using the Baculovirus Expression System
Seung Hee Lee,Sung Min Bae,Tae Young Sin,Won Seok Kwak,Young Oh Ahn,In Hui Kim,See Nae Lee,Dong Jun Kim,Min Joo Kim,Ra Mi Woo,Soo Dong Woo 한국응용곤충학회 2014 한국응용곤충학회 학술대회논문집 Vol.2014 No.10
Porcine parvovirus (PPV), a member of the genus Parvovirus, family Parvoviridae, is a significant causative agent in porcine reproductive failure, causing serious economic losses in the swine industry. PPV is a non-enveloped virus and its capsid is assembled from three viral proteins (VP1, VP2, and VP3). The major capsid protein, VP2 is the main target for neutralizing antibodies in PPV. When VP2 was expressed in large amounts, it assembled into virus-like particles (VLPs) similar in size and morphology to the original virions. In this study, we generated the recombinant Bombyx mori nucleopolyhedrovirus (BmNPV) to express the VP2 protein. Expression of the VP2 protein was analyzed by SDS-PAGE and Western blot. The recombinant VP2 protein of approximately 64 kDa was detected by both analyses. The formation of VLP by recombinant VP2 was confirmed through transmission electron microscopy examination. The purified VP2 protein assembled into spherical particles with diameters ranging from 20 to 22 nm.
Accuracy Analysis of Digital Dental Model Data acquired by Dental Cone Beam Computed Tomography
Seen-Young Kang,Ji-Min Yu,Jun-Seok Lee,Ki-Sook Park,Seung-Youl Lee 한국자기학회 2020 Journal of Magnetics Vol.25 No.4
The purpose of this study is to analyze the accuracy of digital dental models acquired using cone beam computed tomography (CBCT), an electromagnetic wave method. While there are many reports comparing CBCT and intra oral scanners, there are few comparative studies on the accuracy of different digital dental models acquired using CBCT. Targeting this problem, in this study, we tried to analyze the accuracy of dental prosthesis data generated by different CBCT models with 3D computer programs. To this end, a single preparation dental model, 3-unit bridge dental model, and full dental model were selected and photographed using CBCT to obtain a DICOM file, which was later converted into an STL file. The converted STL file was analyzed qualitatively and quantitatively for trueness and precision using a 3D superimposition program. Although there were statistically significant differences in the trueness values of the three digital dental models (P < 0.05), no significant differences could be observed in the precision values (P > 0.05). In conclusion, using CBCT-based dental models, it may be difficult to fabricate dental prosthesis due to a distortion between the rounded part of the tooth, the prepared tooth, and adjacent teeth. However, if the accuracy of sharpness in CBCT images can be increased, in the future, this method may be employed to manufacture dental prosthesis for clinical applications.
Aspergillus sp. F184가 생산하는 Xanthine Oxidase 저해제에 관한 연구
박시형,윤상웅,박정민,옥승호,유주현,배동훈 한국산업미생물학회 2000 한국미생물·생명공학회지 Vol.28 No.2
통풍과 oxygen free radical의 독성에 관여하는 xanthine oxidase에 대한 새로운 저해물질의 탐색 및 개발을 목적으로 본 연구에서 선택분리한 Aspergillus sp. F184가 생산하는 저해물질을 분리·정제하고 구조를 결정하였으며 효소저해활성을 조사하였다. 본 균주를 배양 후 배양액을 여과하여 균체와 배양액을 분리하고 균체를 acetone으로 추출하고 감압농축하고 남은 수용액층을 배양액과 합쳐 HP-20 adsorption column chromatography, ethyl acetate추출, silica gel column chromatography, 결정화 등을 실시하여 xanthine oxidase에 대한 저해물질을 분리, 정제하였다. 본 저해물질의 구조를 NMR 및 MS 스펙트럼을 측정하여 분석한 결과 5,6-epoxy-2-hydroxy-3-methyl-2-cyclohexene-1,4-dione으로서 terreic acid로 동정되었다. Terreic acid의 xanthine oxidase에 대한 저해활성을 조사한 결과 IC_50가 1.1×10 exp (-7) M로서 기존의 저해제인 allopurinol과 유사하였다. 이에 terreic acid에 의한 xanthine oxidase 저해활성은 보고된 바가 없기에 새로운 통풍치료제로서의 가능성이 있음을 보고한다. Aspergillus sp. F184 was isolated from soil for the development of new xanthine oxidase inhibitor. This xanthine oxidase inhibitor was sequentially purified by filtration, HP-20 adsorption column chromatography, ethyl acetate extraction, silica gel column chromatography and crystallization, and was named as YUX 104. YUX 104 was identified to be 5,6-epoxy-2-hydroxy-3-methyl-2-cyclohexene-1,4-dione(terreic acid) by NMR and mass spectroscopic sudies.
α-Viniferin : A Prostaglandin H₂ Synthase Inhibitor from Root of Carex humilis
Lee, Seung-Ho,Shin, Nam-Ho,Kang, Seh-Hoon,Park, Ji Soo,Chung, See Ryun,Min, Kyung Rak,Kim, Youngsoo 영남대학교 약품개발연구소 1998 영남대학교 약품개발연구소 연구업적집 Vol.8 No.-
An inhibitor on cyclooxygenase activity of prostaglandin H₂ synthase was purified from the root of Carex humilis Leyss (Cyperaceae) by a variety of column chromatographic methods. As a result of the structure analysis by FAB-mass, ¹H-NMR, and ^(13)C-NMR spectral data, the active compound was identified as (+)-α-viniferin, an oligomeric stilbene characterized originally from Corogono chomlogu Lamaeck (Leguminosae). (+)-α-Viniferin exhibited a dose-dependent inhibition on cyclooxygenase activity, where 50% of inhibition (IC_(50)) was shown at a final concentration of about 7 μM. Resveratrol, a putative building block of oligomeric stilbenes, also inhibited the cyclooxygenase activity. The inhibitory potency of (+)-α-viniferin was about 3-to 4-fold stronger than that of resveratrol on cyclooxygenase activity of prostaglandin H₂ synthase partially purified from sheep seminal vesicles.