소아에서 편도 및 아데노이드 절제술이 주의력 결핍과과잉행동에 미치는 영향

구본조,박경훈,박정준,최선명,권순욱,윤상원,구영진 대한이비인후과학회 2006 대한이비인후과학회지 두경부외과학 Vol.49 No.2

Background and Objectives:Sleep disordered breathing (SDB) is a common problem in the otolaryngology clinic and adenotonsillar hypertrophy is thought to be one of the most common etiologic factors. SDB possibly exhibits problems of behavioral regulation, such as inattention, hyperactivity and impulsive behavior. The goal of this study was to assess the effect of adenotonsillectomy on inattention and hyperactivity in children. Subjects and Method:We selected 54 pediatric patients with sleep disordered breathing. Adenotonsillectomy was performed for all patients. Adenotonsillar hypertrophy and the degree of SDB were evaluated preoperatively. The degree of inattention and hyperactivity was evaluated by attention deficit hyperactivity disorder rating scale-IV (ADHD RS-IV) before and after surgery. Results:ADHD RS-IV score showed significant improvement after the operation in most children with SDB. But the improvement of ADHD RS-IV was not associated with the degree of adenotonsillar hypertrophy. However, much improvement in postoperative ADHD RS-IV was observed with children having higher preoperative ADHD RS-IV and/or SDB scale. Conclusion:Adenotonsillectomy seems to improve inattention and hyperactivity in most children with SDB. Improvement is more apparent in children with severe sleep disturbance and severe attention deficit and hyperactivity. (Korean J Otolaryngol 2006;49:187-93)

비내시경 절제술을 이용한 거대 비석 치험 1예

구본조,최선명,윤상원,주종은 대한이비인후과학회 2006 대한이비인후과학회지 두경부외과학 Vol.49 No.9

A Lithiasis within the nasal cavity (rhinolith) can be formed by either endogenous or exogenous material. It occurs as a result ofthe solidification of mucus and nasal debris by mineral salts, calcium, magnesium phosphate and carbonate. Rhinolithiasis leadsto unilateral obstruction of the nasal airway followed by inflammation of the nasal mucus membrane and the paranasal cavities.It can be seen by the endoscopic examination as a hard intranasal mass, but diagnosis of rhinolithiasis can be difficult due to thevarying clinical presentations. Surgery is obligatory for the removal of rhinoliths and in most cases it can be done by nasal endoscopicremoval. Giant rhinolith, which is penetrated into the surrounding anatomical structures, needs more extended surgicalapproaches such as Caldwell-Luc operation or lateral rhinotomy. Here, we report one case of rhinolithiasis, which was removedsurgically for the purpose of diagnosis and treatment, and present a literature review of this condition. (Korean J Otolaryngol2006;49:936-8)

폐쇄성 수면무호흡·저호흡 환자의 수면다원검사에서 각 지수들간의 상관관계에 대한 연구

심현준,구본조,박경훈,권순욱,윤상원,김의중 대한이비인후과학회 2004 대한이비인후과학회지 두경부외과학 Vol.47 No.9

Background and Objectives:The polysomnography is essential for diagnosis of obstructive sleep apnea-hypopnea (OSAH) and provides important objective information. But, in fact, there are some difficulties for comprehensive interpretation of multiple indices from the polysomnogram. This study was designed to find out which polysomnogram indices were significant to respiratory distress indices (RDI) and apnea index (AI) on statistical correlation and which other indices should be considered together for proper management plan apart from RDI and AI (respiratory index). Subjects and Method:We evaluated 40 patients whose RDI were over 5 as the result of overnight polysomnography before any management from February 2003 to September 2003 at Eulji medical center. By multiple linear regression analysis, we studied the relationship of RDI and AI as dependent variables to ST, O2 desaturation events (O2DE), lowest O2 saturation (LoO2), slow wave sleep portion (S3&S4), arousal index (ArI), body-mass index (BMI) and age. We also studied the relationship of ST as an dependent variable to O2DE, LoO2, S3&S4, ArI, BMI, and age. Results:1) There were significant correlations between RDI and O2DE, ArI as was true between AI and O2DE, ArI (p<0.05). And there was no significant difference in the degree of the correlation between RDI and AI. 2) Other variables such as ST, LoO2, S3&S4, BMI and age were not significant. 3) ST had no significant correlation with respiratory index and any other variables (p<0.05). Conclusion:Because the respiratory index may not the entire physical status during sleep for OSAH patients, multiple indices (such as LoO2, BMI, ST, S3&S4, age) should be considered together apart from the respiratory index for proper management plan.

Effects of Acupuncture Stimulation on the Radial artery’s Pressure Pulse Wave in Healthy Young Participants: Protocol for a prospective, single-Arm, Exploratory, Clinical Study

신재영,구본조,김태훈,배장한,전민호,이준환,김재욱 대한약침학회 2016 Journal of pharmacopuncture Vol.19 No.3

Introduction: This study aims to investigate the effects of acupuncture stimulation on the radial artery’s pressure pulse wave, along with various hemodynamic parameters, and to explore the possible underlying mechanism of pulse diagnosis in healthy participants in their twenties. Methods and analysis: This study is a prospective, single- arm, exploratory clinical study. A total of 25 healthy participants, without regard to gender, in their twenties will be recruited by physicians. Written informed consent will be obtained from all participants. The participants will receive acupuncture once at ST36 on both sides. The radial arterial pulse waves will be measured on the left arm of the subjects by using an applicable pulse tonometric device (KIOM-PAS). On the right arm (appearing twice), electrocardiogram (ECG), photoplethysmogram (PPG), respiration and cardiac output (CO) signals, will be measured using a physiological data acquisition system (Biopac module), while the velocity of blood flow, and the diameter and the depth of the blood vessel will be measured using an ultrasonogram machine on the right arm (appearing twice). All measurements will be conducted before, during, and after acupuncture. The primary outcome will be the spectral energy at high frequencies above 10 Hz (SE10-30 Hz) calculated from the KIOM-PAS device signal. Secondary outcomes will be various variables obtained from the KIOM-PAS device, ECG, PPG, impedance cardiography modules, and an ultrasonogram machine. Discussion: The results of this trial will provide information regarding the physiological and the hemodynamic mechanisms underlying acupuncture stimulation and clinical evidence for the influence of acupuncture on the pressure pulse wave in the radial artery. Ethics and dissemination: This study was approved by the Institutional Review Board (IRB) of Kyung Hee University’s Oriental Medical Center, Seoul, Korea (KOMCIRB-150818-HR-030). The study findings will be published in peer-reviewed journals and presented at national and international conferences. Trial registration number: This trial was registered with the Clinical Research Information Service (CRIS) at the Korea National Institute of Health (NIH), Republic of Korea (KCT0001663), which is a registry in the World Health Organization’s (WHO’s) Registry Network.

Benzodiazepine이 인후두 역류증에 미치는 영향

박경훈,구본조,박정준,김선기,최선명,권순욱,윤상원 대한이비인후과학회 2005 대한이비인후과학회지 두경부외과학 Vol.48 No.10

Background and Objectives:Anti-anxiety drugs such as benzodiazepines are often given to globus patients in practice, based on the notion that globus is a kind of somatization disorder. However, many of globus are caused by laryngopharyngeal reflux (LPR) and the effects of anti-anxiety drugs to LPR are unknown. The study goal was to assess the efficacy of benzodiazepines to LPR. Subjects and Method:We selected 51 LPR patients, who were confirmed by 24-hour double-probe ambulatory pH monitoring. Patients were allocated into case and control groups at random and entered into a double-blind trial. Patients in the control group received proton pump inhibitors and prokinetics. Diazepam was added to patients in the case group. Assessments were made after 4 weeks of treatment using reflux symptom index (RSI) and reflux finding score (RFS). Results:In both groups, RSI and RFS were improved significantly at the end of the study. However, there was no significant difference between the two groups. Conclusion:Diazepam seems to have little efficacy in the treatment of LPR.

SFF/SFP 장 송수신기용 TO-can 패키지 주파수 응답 향상 연구

이상훈,정현도,구본조,한상국,Lee Sang-Hoon,Jung Hyun-Do,Koo Bon-Jo,Han Sang-Kook 한국통신학회 2004 韓國通信學會論文誌 Vol.29 No.1A

본 논문은 SFF/SFP 광 송수신기에 사용되는 TO-38 패키지의 대역폭 향상을 위해 여러 구조적 변수를 변화시켜 최적화하여 3dB대역폭의 성능향상을 제안하였다. 먼저 실험을 통해 PIN PD 칩에 인가된 바이어스에 따른 캐패시턴스 값을 구하였으며 TO-can 패키지의 주파수 응답을 측정하여 3.5GHz의 3dB 대역폭을 얻었다. 또한 3차원 시뮬레이션으로 측정치와의 주파수 응답 특성의 일치를 재확인하였다. 더 나은 주파수 응답을 얻기 위해 TO-can 패키지 여러 물리적 구조 변수를 변화시켜 최적화시킨 TO-38 패키지는 3dB대역폭 15GHz의 아주 우수한 성능향상을 보였으며 이는 10Gbps대의 bit rate 성능을 만족할 수 있는 SFF/SFP 광 송수신기 모듈에 적용이 가능하다. We propose the optimum TO-can package design in SFF/SFP optical transceiver modules to improve 3dB-bandwidth. The frequency response of TO-38 package is measured and compared to simulation where the 3dB-bandwidth was 3.5GHz. For a higher operating bandwidth (>15GHz), the new optimized physical geometries of TO-can package such as bonding-wire, lead and material was suggested. The optimal result of simulation shows that TO-can package can be used at a higher bit rate optical module of 10Gbps.

G-PON용 높은 전광변환효율을 갖는 1.31 um 비냉각 DFB-LD

김정호,피중호,김덕현,박칠성,류한권,구본조,Kim, Jeong-Ho,Pi, Joong-Ho,Kim, Deok-Hyun,Park, Chil-Sung,Ryu, Han-Gwon,Koo, Bon-Jo 한국광학회 2007 한국광학회지 Vol.18 No.5

[ $-40^{\circ}C$ ]에서 $85^{\circ}C$의 온도에서 냉각장치 없이 동작하는 1.31 um 비냉각 DFB-LD가 유기 금속 화학 증착법에 의해 성장되었다. 높은 전광변환효율을 갖는 레이저의 제작은 스트레인이 인가된 다중양자우물 구조의 최적화를 통해 가능하며, 특히 스트레인의 양, 양자 우물의 두께, 전위장벽의 두께, 양자 우물의 수, 활성층의 폭에 주로 영향을 받는다. 본 연구에서 제작된 DFB-LD는 $25^{\circ}C$와 $85^{\circ}C$에서 전광변환효율은 0.38[mW/mA]와 0.26[mW/mA], 발진개시전류는 각각 7.1[mA]와 19.8[mA]의 값을 가졌다. A Strained Layer Multiquantum-Well (SL-MQW) distributed feedback laser at a wavelength of 1.31 um operating from $-40^{\circ}C$ to $85^{\circ}C$ without any cooling is grown by metal-organic chemical vapor deposition (MOCVD). Lasers with high slope efficiency are achieved through careful optimization of a SL-MQW active layer, especiallyoptimizing the amount of strain, the well thickness, the barrier thickness, the number of wells, and the active layer width. In this paper, we obtain the slope efficiencies of 0.38[mW/mA] and 0.26 [mW/mA] at $25^{\circ}C$ and $85^{\circ}C$, respectively. Threshold currents are 7.1[mA] and 19.8[mA] at $25^{\circ}C$ and $85^{\circ}C$, respectively.

0 이 아닌 Decision Threshold에 의한 수신 감도의 감소

이재일,김진철,류한권,이창미,김재동,길홍민,강지훈,구본조,윤현재 한국통신학회 2001 한국통신학회 기타 간행물 Vol.2001 No.10

2.5 Gbps용 Avalanche 광다이오드의 제작 및 특성 분석

이창미,김진철,류한권,이재일,심효진,길홍민,구본조,윤현재,박찬용 한국통신학회 2001 한국통신학회 기타 간행물 Vol.2001 No.10

2.5Gb/s 급 PIN 광 검출기 제작과 특성 측정

김진철,이재일,류한권,길홍민,이현상,강지훈,한재호,이창미,구본조,윤현재 한국통신학회 2001 한국통신학회 기타 간행물 Vol.2001 No.10