RANGIFER 屬 雌馴鹿의 角發生에 關한 文獻的 硏究

金敬彬,李尙仁 대한본초학회 1986 大韓本草學會誌 Vol.1 No.1

주요 정신질환의 진단과 치료기능을 가진 감성통신 시스템

김경빈,조면균 한국특허학회 2011 특허학연구 : 한국특허학회지 Vol.13 No.4

최근 우울증 등의 주요 정신질환에 의한 폐해들이 위험수위에 도달해 있으며 이로 인한 사회·경제적 손실 또한 막대한 것이 사실이다. 본 연구는 널리 보급된 이동통신 단말기를 이용하여 주요 정신질환을 진단하고 그 치료 기능을 탑재하여, 사용자로 하여금 정신질환의 위험을 미리 알려 대비하게하며 지인과 전문기관의 도움으로 피해를 최소화하는 방안을 제공하고자 한다. 먼저 이동 통신 단말기에 주요 정신질환인 우울증을 검출할 수 있는 어플리케이션 프로그램과 센서를 장착하고, 검출된 질환의 심각성 정도에 따라 적절한 감성반응 서비스를 제공함으로써 인간적인 유대감을 느끼게 하여 극단적인 선택을 방지할 수 있다. 본 논문에서는 우울증의 정도를 정량적으로 계산하여 임계치에 따라 분류하고, 그 위험정도에 따라 적절한 감성반응을 제공함으로써 우울증을 극복할 수 있는 방안에 대해서 제안하고 미래 감성통신서비스에 대한 실현가능성을 전망해 보고자 한다.

알콜리즘의 임상적 연구(2) : 최근 5년간 국립서울정신병원에 입원한 알콜중독환자의 신체적·정신적 합병증에 대한 비교연구

김경빈,김창현 국립서울정신병원 1987 臨床硏究論文集 Vol.1987 No.-

미세유체소자 기반 혈액점도 및 적혈구응집성 측정

변정경(J. G. Byeon),함희영(H. Y. Ham),김소미(S. M. Kim),강양준(Y. J. Kang) 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.12

In this study, a simple method for measurement of blood viscosity and RBC aggregation in a microfluidic device is suggested. Using a disposable air-compression pump, shear rates of blood flow are varied continuously over time. By monitoring image intensity, blood velocity, and cell-to-liquid interface, RBC aggregation and blood viscosity are simultaneously measured with respect to shear rate. From the experimental demonstrations, it is found that the suggested method is capable of measuring blood viscosity and RBC aggregation over varying shear rate, with reliability.

디자인씽킹 및 CPTED적용을 통한 안양천 공공디자인 개선

김경빈,엄소현,임영재 대한인간공학회 2020 대한인간공학회 학술대회논문집 Vol.2020 No.10

1인가구를 위한 AR 가구배치 서비스

김경빈,주현수,엄소현,이재인,임영재 대한인간공학회 2021 대한인간공학회 학술대회논문집 Vol.2021 No.6

精神分裂症 患者의 指紋 硏究

김경빈 대한신경정신의학회 1980 신경정신의학 Vol.19 No.3

In the research on the heredity in schizophrenia, it is impossible to eliminate all the envirom ental factors. Fingerprints, form ed in the 3rd and 4th months of fetal development, remain unchanged throughout life: hence, a comparative exam ination of fing erprints can lead to the identification and the elimination of some enviromental factors. Fingerprints differ by race, sex, and right-or left-handedness, especially in the chromosomal aberrations (Down’s syndrome, Kleinefelter’s Syndrome and Turner’s Syndrome), mental retardation and congenital heart disease. Therefore they have been the subject of researches in various medical fields. There have been lots of researches on male schizophrenic fingerprints from 1930 to the present. However, the auther attempted in this study to know how are fingerprints in female schizophrenics and also to know th e differences between Korean schizophrenics and schizophrenics in western countries. The auther compared 140 male schizophrenics with 130 female schizophrenics and also with 100 male and 117 female normal subjects in their fingerprints. The results are as follows: 1) The frequency distribution of fingerprints, pattern intensity and pattern combinations of fingerprints, when compared with those of the control group, generally showed no significant correlations. 2) Comparison of Arch-shaped F ingerprints: In the male control group, arch-shaped fingerprints were evident in 11.1% of the cases as compared to a 22.6% rate in the male schizophrenic without family history of schizophrenia, hence a significant correlation. (p < 0 .05) Comparing with the female control group, the controls showed a 13.7% frequency, whereas the female schizophrenics without family history of schizophrenia showed significant correlations at 27.7%. (p < 0 .05) 3) Total Finger-Ridge Count: Comparing with the total finger ridge count in the male control group, there was an average of 149 as comparad to an average total finger ridge count of 129 in the fingerprints of male schizophrenics without family history of schizophrenia: hence a highly significant correlation. (p < 0 .001) The fingerprints of male schizophrenic patient with family history of schizophrenia averaged 131, which is a moderately significant correlation. (p < 0 .005) Comparing the total finger ridge count of the female control group (an average of 132) with those of the female patients without family history of schizophrenia (an average of 111), a highly significant correlation is apparent. (p < 0 .001) Female patients with family history of schizophrenia averaged 113, a moderately significant correlation. (p < 0 .005) 4) Ridge Dissociation: Ridge Dissociation in the male control group was 10%, as compared to a ridge dissociation rate of 23.6% in the male schizophrenic group, a moderately significant correlation. (p < 0 .005) The female schizophrenic group rate of 10%, which is apparently not a significant correlation rate.

알콜리즘에 대한 임상적연구(Ⅳ)

김경빈,김종원 국립서울정신병원 1988 臨床硏究論文集 Vol.1988 No.-

The Role of TWIST in Ovarian Epithelial Cancers

김경빈,최경운,박은영,윤만수,서동수,김기형,이정희,신동훈,김지연,설미영 대한병리학회 2014 Journal of Pathology and Translational Medicine Vol.48 No.4

Background: Epithelial-mesenchymal transition (EMT) is associated with tumor hypoxia. EMT is regulated, in part, by the action of TWIST, which inhibits of E-cadherin expression and may interfere with the p53 tumor-suppressor pathway. Methods: We examined the expression of TWIST, E-cadherin, hypoxia-inducible factor 1α (HIF1α), and p53 by immunohistochemistry in 123 cases of ovarian epithelial cancers (OEC) to evaluate the role of TWIST in OEC. We assessed the association between protein expression and clinicopathologic parameters. Results: The expression of TWIST, E-cadherin, HIF1α, and p53 proteins was found in 28.5%, 51.2%, 35.0%, and 29.3% of cases, respectively. TWIST expression was associated with higher histologic grade and unfavorable survival. TWIST expression was correlated with HIF1α expression and reduced E-cadherin expression. The altered HIF1α/TWIST/E-cadherin pathway was associated with lower overall survival(OS), while the co-expression of TWIST and p53 was correlated with lower progression-free survival. In the multivariate analyses, TWIST expression was an independent prognostic factor for OS. Conclusions: Our data imply that TWIST expression could be a useful predictor of unfavorable prognosis for OEC. TWIST may affect the p53 tumor-suppressor pathway. Moreover, hypoxia-mediated EMT, which involves the HIF1α/TWIST/E-cadherin pathway may play an important role in the progression of OEC.

Prognostic Relevance of the Expression of CA IX, GLUT-1, and VEGF in Ovarian Epithelial Cancers

김경빈,최경운,박원용,김지연,설미영,신동훈,박도윤,이창훈,이정희 대한병리학회 2012 Journal of Pathology and Translational Medicine Vol.46 No.6

Background: Tumor hypoxia is associated with malignant progression and treatment resistance. Hypoxia-related factors, such as carbonic anhydrase IX (CA IX), glucose transporter-1 (GLUT-1), and vascular endothelial growth factor (VEGF) permit tumor cell adaptation to hypoxia. We attempted to elucidate the correlation of these markers with variable clinicopathological factors and overall prognosis. Methods: Immunohistochemistry for CA IX, GLUT-1, and VEGF was performed on formalin-fixed, paraffin-embedded tissues from 125 cases of ovarian epithelial cancer (OEC). Results: CA IX expression was significantly associated with an endometrioid and mucinous histology,nuclear grade, tumor necrosis, and mitosis. GLUT-1 expression was associated with tumor necrosis and mitosis. VEGF expression was correlated only with disease recurrence. Expression of each marker was not significant in terms of overall survival in OECs; however, there was a significant correlation between poor overall survival rate and high coexpression of these markers. Conclusions: The present study suggests that it is questionable whether CA IX, GLUT-1, or VEGF can be used alone as independent prognostic factors in OECs. Using at least two markers helps to predict patient outcomes in total OECs. Moreover, the inhibition of two target gene combinations might prove to be a novel anticancer therapy.