Dimethylnitrosamine 유발 백서 간섬유화에 있어서 TGF-β1 유전자 산물의 세포성 분포

박도윤,이선경,이숙녀 대한병리학회 1997 Journal of Pathology and Translational Medicine Vol.31 No.11

실험적 흰쥐 간 질환 모델의 이해 -형태학적 특징을 중심으로-

박도윤,서강석 대한병리학회 2003 Journal of Pathology and Translational Medicine Vol.37 No.3

Experimental liver disease models of rats have many similarities with those of humans, especially in morphological characteristics. Rat liver disease models can be categorized as models of hepatic fibrosis, hepatic stem cell and hepatocarcinogenesis. The purpose of this article is to review experimental liver disease models, with a major emphasis on morphologic features, including routine morphological, immunohistochemical, and electron microscopic features.

교통유발부담금 경감을 위한 주차유도시스템 활용도 제고 방안에 관한 연구

박도윤,최양원 대한교통학회 2012 대한교통학회 학술대회지 Vol.67 No.-

위축성 위염과 장상피화생의 조직학적 진단

박도윤 대한상부위장관ㆍ헬리코박터학회 2020 Korean Journal of Helicobacter Upper Gastrointesti Vol.20 No.2

Atrophic gastritis and intestinal metaplasia are well-known to be reliable indicators of gastric cancer risk. They are clinically important in deciding whether to recommend endoscopic surveillance. Herein I review the histopathologic diagnosis of atrophic gastritis and IM. Gastric atrophy is divided into metaplastic atrophy and non-metaplastic atrophy. IM is categorized as complete (type I) and incomplete (type II, III). Systematic interpretation of gastric atrophy and IM using the updated Sydney system or operative link on gastritis assessment is recommended. Furthermore, I suggest using the consensus definition of gastric atrophy and incomplete IM in the gastric biopsy pathology report to support the surveillance of high-risk gastric cancer group.

위점막조직에서 Ghrelin 양성세포의 발현

박도윤,전태용 부산대학교 병원 암연구소 2009 부산대병원학술지 Vol.- No.25

화학적으로 유도한 백서 간암에서 TGF-β1 및 TGF-β type II receptor의 발현

박도윤,박강우,서강석 대한병리학회 2003 Journal of Pathology and Translational Medicine Vol.37 No.2

Background : Transforming growth factor (TGF)-β1 inhibits hepatocyte proliferation by inducing apoptosis. Expression of TGF-β1 is tightly associated with the TGF-β type II receptor (TGR2) expression level, and has been regarded as an important change of TGF-β1 and TGR2 during hepatocarcinogenesis. We investigated the gene expressions and protein localizations of TGF-β1 and TGR2 in chemical hepatocarcinogenesis. Methods : Solt and Farber’s method was used as the chemical hepatocarcinogenesis model of the rat. Northern blot analyses and immunohistochemistry for TGF-β1 and TGR2 were performed to investigate the gene expressions and protein localizations, respectively. Results : The Northern blot analyses showed a slight increase of TGF-β1 transcripts one month after partial hepatectomy, which is more than in sham operated control liver, and a decrease of transcripts for TGR2 two months after partial hepatectomy. The number of TGF-β1-positive preneoplastic hepatocytes was increased and correlated with the increase of the number of TGR2 negative hepatocytes or reduction of expressions of TGR2 in preneoplastic lesions. HCC tissues showed an increase of TGF-β1 protein expressions and a decrease of TGR2 compared to the adjacent liver parenchyme. Conclusion : Our data suggest that down regulation of TGR2 in preneoplastic lesions and HCC might contribute to the resistance to the growth inhibitory effects of TGF-β1.

글루텐프리 통곡물 배터믹스의 물리화학적 특성과 육가공품의 적용

박도윤,조민지,김재원,박수원,김현석 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

본 연구는 육가공품에 증량제와 결착제인 밀 전분을 대체하는 통곡물 배터믹스의 물리화학적 특성을 조사하였다. 실험에 사용된 통곡물 배터믹스의 혼합비율(BCA, BCOA, BAOA)은 이전의 현미, 옥수수, 알파콘, 귀리, 율무의 통곡물 배터믹스 혼합비율 최적화 실험결과이다. 이를 통해 육가공품에서 밀 전분의 물성을 대체하며 높은 호화도와 낮은 이수율을 가지는 통곡물 배터믹스 조성을 제시하고자 하였다. 알파콘이 포함되어있는 BCOA에서 최고점도와 최종점도의 온도 프로파일 범위에서 상대적으로 낮은 페이스팅 점도를 가졌고, 모든 시료가 거의 비슷한 팽윤력값을 가졌다. 하지만 팽윤인자, 총당 용해도, 아밀로오즈 용해도는 알파콘을 함유한 BAOA에서 높은 값을 가졌고 나머지 시료는 비슷한 상승세를 보였다. 이것은 입자내 기공 속 수분의 양이 BAOA가 가장 높은 것으로 알 수 있었다. 통곡물 배터믹스의 호화 특성으로는 To, Tp, Tc의 측정값은 비슷했으나 △H는 옥수수와 율무를 포함한 BCOA에서 높은 값을 가졌다. 냉장과 해동시의 안정성을 측정한 이수율은 BCA, BCOA, BAOA 순으로 높았다. 이것을 적용한 호화된 배터믹스를 육가공품인 떡갈비에 적용했을 때, 경도는 BCA는 28724.24N/m²이고 BCOA는 23325.71 N/m²이므로 BCA에 비해 BCOA가 더 부드러운 것으로 확인되었다. 이 수치는 고령친화식품 1단계(치아섭취)경도에 해당하므로 추후 발전가능성이 크다고 보인다.

1980년대 국내 신사복 광고를 통해 본 남성성 연구 -TV CF와 잡지 광고를 중심으로-

박도윤,조혜영 한국기초조형학회 2023 기초조형학연구 Vol.24 No.5

This study examines the changing trends in men’s suits during the 1980s in the context of a transitional period marked by political and social changes, aiming to analyze the influx and expansion of men’s suits by a design history perspective, connected with the masculinity. The scope of the study involved selecting about 100 advertisements from the 1980s, which were aired on TV and a featured in magazines, focusing on ‘men’s suits’ and ‘tailored suits’. In addition, the 1980s was divided into three periods-early, mid and late to study the values of consumers that changed dramatically through economic growth, and during this period, men have been observed to have a desire for success, an influx of Western values, the formation of a liberated lifestyle, and the expression of individual tastes and sensibilities through fashion to shape their social identity, as analyzed through men’s suit advertisements. As a result, it can be understood that in the early 1980s, with the rapid industrialization of society, socially successful men were in the spotlight with an Western-style appearance based on traditional masculinity. In the mid 1980s, “openness” and “globalization” were set as national goals and goals through exports, and Western values were pursued through the influx of foreign cultures. After the Seoul Olympics in 1988, as the nation embraced a fully open and liberal society, it was confirmed that men’s image and masculinity was shifting from one of seriousness and authoritarianism to one that was more cheerful, soft and family-oriented. Consequently, through the men’s suit advertisements in 1980s, we can analyze the ‘change in perception of masculinity according to the political and cultural situation to see how Korean men have changed through consumption and mediating fashion, a symbolic expression culture that represents individual tastes and individuality.

메타버스 플랫폼과 크리에이터의 ‘윈-윈’ 전략에 대한 비판적 분석: 제페토 아이템 크리에이터를 중심으로​

박도윤 서울대학교 비교문화연구소 2024 비교문화연구 Vol.30 No.1

이 연구는 가상공간에서 경제활동을 하는 메타버스 크리에이터의 경험을 살피면서 비판적 플랫폼 노동의 개념으로 분석한다. 메타버스 크리에이터는 쉽게 돈을 버는 일로 그려지지만 실제로는 플랫폼의 정책에 많이 의존하며 저임금의 불안정한 노동을 하고 있다. 창작한 아이템의 활용이나 판매 금액, 현금화 방식은 거의 플랫폼에 결정권이 있고 그 체제가 자주 변동하고 있다. 크리에이터가 가져가는 수입은 판매 금액의 30%가 채 되지 않기에 긴 시간을 노동에 쓴다. 반면 크리에이터는 이를 현실의 직업과는 다르게 편하고 쉬운 일로 여겼으며, 노동함에 있어 주체성과 자율성을 발휘하고 있다. 이러한 점은 크리에이터의 불안정함과 플랫폼의 통제를 용인하도록 하는 요인이었으며 어플리케이션 스토어가 가져가는 수수료는 메타버스 플랫폼과 크리에이터를 같은 편으로 묶어 동질감을 느끼게 만든다. 그렇지만 비표준적인 노동환경을 경험하면서 이들이 우선시하는 삶의 가치가 유연하고 다양해지는 모습을 보았다. 이들은 재미, 열정, 자유로움, 주체성과 같은 요소에 만족하며 제페토와 자신을 ‘윈-윈’의 관계로 생각했다. 이 연구에서 다룬 제페토 크리에이터의 사례는 다양한 분야에서의 플랫폼 노동에 대한 비판적 논의의 범위를 넓히는 데 기여한다. This study identifies metaverse creator as a norm of critical platform labour by exploring the experiences of ZEPETO creators who make Avatar Items in virtual space. Metaverse creators are known as autonomous and easy job to earn money, but in reality, they rely heavily on the platform’s policies and receive low wages, engaging in precarious and unstable work. The platform has almost all authority over the use of created items, sales amounts, and methods of monetization, and the system changes frequently. Since creators’ income is less than 30% of the sales amount, they spend a lot of time to increase sales as much as possible. Nevertheless, creator considered this as an easy task compared to traditional work, allowing them to exercise greater autonomy and subjectivity over their labor. These factors allowed creators to accept their unstable work conditions and tolerate the platform’s control over them. Additionally, the fees taken by the app store put the metaverse platform and creators on the same side and create a sense of homogeneity. However, as the creators experience a non-standard work conditions, their prioritized values in life become more flexible and diverse. They found satisfaction in elements such as fun, passion, freedom and autonomy, perceiving their relationship with ZEPETO as a ‘win-win’ situation. The case of ZEPETO creators examined in this study contributes to broadening the scope of critical discussions on platform labor in various fields.

Synthesis of Platinum-Reduced Graphene Oxide (Pt-rGO) Nanocomposite for Selective Detection of Hydrogen Peroxide as a Peroxidase-Mimic Catalyst

박도윤,조민영,신권수 대한화학회 2023 대한화학회지 Vol.67 No.6

In this study, we report the one-pot synthesis of reduced graphene oxide (rGO) containing platinum nanoparticles with catalytic activity to break down hydrogen peroxide as a peroxidase-mimicking catalyst. A single reducing agent was used to reduce graphene oxide and a platinum precursor at a moderately low temperature of 70 ℃. The rGO was homogeneously decorated with platinum nanoparticles. The catalytic activity of Pt-rGO was investigated for the oxidation of 3,3’,5,5’- tetramethylbenzidine (TMB), a peroxidase substrate, in the presence of hydrogen peroxide. The Pt-rGO coupled with glucose oxidase was also able to detect glucose at millimolar concentrations (up to 1 mM). Our results show that the Pt-rGO composite is a promising catalyst for the detection of hydrogen peroxide. This method was also applied for the detection of glucose.