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오적산(五積散)을 투여한 흰쥐의 간장, 신장, 골중 금속농도 비교에 관한 연구
박철수,이선동,박해모,박영철,Park Chul-Soo,Lee Sun-Dong,Park Hae-Mo,Park Yeong-Chul 대한예방한의학회 2002 대한예방한의학회지 Vol.6 No.2
Traditional herbal medicine is used extensively among the Korean populations, and other Asian countries employ similar therapies as well In recent years, extensive focus was laid on adulteration of the herbal medicine with heavy metals. This may be mainly due to a soil contamination by an environmental pollution. The objective of this study is to identify the contents of various heavy metals in the blood from OhJeokSan-Decoction (OD) treated-rats. For this study, 13 kinds of metals including essential and heavy metals, i.e. Al, As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Se and Zn were analyzed by a slight modification of EPA methods and the following results are obtained. ; 1. There is no significant difference between the OD-treated groups and control group in liver, kidney, bone, brain, weight, food intake. 2. The amount of each metal analyzed in the liver are as follows; Al ; $0.235{\sim}4.215mg/kg$, As ; $0.103{\sim}0.461mg/kg$, Cd ; $0.005{\sim}0.010mg/kg$, Co ; $0.017{\sim}0.046mg/kg$, Cr ; $0.137{\sim}0.403mg/kg$, Cu ; $1.736{\sim}4.827mg/kg$, Fe ; $54.472{\sim}381.447mg/kg$, Hg ; not detected, Mn ; $1.159{\sim}2.803mg/kg$, Ni ; $0.007{\sim}0.095mg/kg$, Pb ; not detected, Se ; $0.682{\sim}1.887mg/kg$, Zn ; $10.213{\sim}26.119mg/kg$, by groups, respectively. In control and other experimental group, several metal (Co, Cu, Mn, Zn, As, Cr) has a significant difference, but in experimental I and other experimental II, III, IV, V groups, there are no significant difference. 3. The amount of each metal analyzed in the kidney are as follows; Al ; $1.712{\sim}31.230mg/kg$, As ; $0.062{\sim}0.439mg/kg$, Cd ; $0.010{\sim}0.062mg/kg$, Co ; $0.000{\sim}0.101mg/kg$, Cr ; $0.125{\sim}0.636mg/kg$, Cu ; $3.385{\sim}12.502mg/kg$, Fe ; $41.148{\sim}99.709mg/kg$, Hg ; $0.000{\sim}0.270mg/kg$, Mn ; $0.433{\sim}2.301mg/kg$, Ni ; $0.000{\sim}0.221mg/kg$, Pb ; $0.000{\sim}0.584mg/kg$, Se ; $0.540{\sim}1.600mg/kg$, Zn ; $8.775{\sim}17.060mg/kg$, by groups, respectively. The concentration of Cu, Se, Cr, and Hg are variated significantly in control and other experimental group, and Cu, Se, Cd, Cr are variated significantly in experimental I and other experimental II, III, IV, V groups. 4. The amount of each metal analyzed in the bone(tibia and fibula) are as follows; Al ; $9.557{\sim}119.464mg/kg$, As ; $0.139{\sim}12.250mg/kg$, Cd ; $0.000{\sim}0.295mg/kg$, Co ; $0.022{\sim}0.243mg/kg$, Cr ; $0.239{\sim}1.999mg/kg$, Cu ; $0.000{\sim}2.291mg/kg$, Fe ; $240.249{\sim}841.956mg/kg$, Hg ; $0.000{\sim}0.983mg/kg$, Mn ; $0.214{\sim}7.353mg/kg$, Ni ; $5.473{\sim}11.453mg/kg$, Pb ; $0.000{\sim}8.502mg/kg$, Se ; $0.000{\sim}3.005mg/kg$, Zn ; $61.158{\sim}195.038mg/kg$, by groups, respectively. The concentration of Se, Cd are variated significantly in control and other experimental groups, and Se is variated significantly in experimental I and other experimental II, III, IV, V groups. 5. Exceptionally several metal concentration is increased or decreased. but there is no significant harmful difference of metal concentration in the liver, kidney and bone, from the OD-treated-rats compared to those of the control group even if higher dosage($1{\sim}8$ times dosage of person) of OD was administered. Thus, it is expected that the herbal decoction in the traditional herbal medicine would not lay any burden on the body and the heavy metal toxins would not affect our physiological system. However, other kinds of herbal treatment, such as i.v. and i.p. should be considered in terms of
1930년대 여성잡지의 ‘가정탐방기’에 나타난 이상적 주거공간 연구
박철수 대한건축학회 2006 대한건축학회논문집 Vol.22 No.7
This study focused on analysis of ‘Family Visit Report’ in three main Women's magazines in 1930s. Women's literacy rate grew dramatically at the time and numerous women's magazines were published for them. These magazines played important role of disciplinary guides for Modernization not only to ordinary women but also to men. This study observed the influence of these magazines on modern dwelling styles and summarized several aspects of ideal dwelling space of the day as follow: First, magazines, another form of public discourses, brought out people's private experiences to the public realm and offered references to modern life to ordinary readers who were unfamiliar with then. However most of them were intentionally tailored by male perspective and encouraged changes of dwelling space to women in compulsive manner. Secondly, Subjects of discourses through 'Family Visit Reports' regarding ideal dwelling space were analysed into four categories, which were recommendation of scientific life style based on technology, distribution of sanitary discourses and stresses on hygienics, improvement of kitchen wares and space and utilities changes, and indirect discipline of westernized residing culture and cultural residences. Thirdly, routine space of everyday life of leading group people in ‘Family Visit Report' still maintained mostly traditional form. However, individual rooms inside house were divided into diningroom, livingroom, study room, bedroom, children's room and etc. Furniture supporting routine life were also transformed from traditional style such as Meoryt-Jang(bed side chest), Boryo(Korean bedding), Mungap(stationery chest) and Yeageyry(dresser) toward western-style furniture like fire place, bed, table, gramophone, piano and carpet.
박철수,정욱성,윤호중,신용주,김지훈,오용석,승기배,김재형,최규보,홍순조 대한심장학회 2006 Korean Circulation Journal Vol.36 No.5
Background and Objectives:Osteoprotegerin (OPG) is a decoy receptor for receptor nuclear factor-kB ligand(RANKL). We sought to evaluate the association between the serum OPG level and the target lesion calcium(TLC) in those patients suffering with coronary artery disease (CAD). Subjects and Methods:We assayed theserum OPG levels in 65 CAD patients (mean age: 62±10 yrs, M:F=46:19) with using enzyme immunoassay,and these patient underwent intravascular ultrasound (IVUS) examinations of their target lesions. The degree ofTLC was estimated by the maximum arc of calcium and also the calcified plaque surface area that was calculatedfrom the serial cross-section IVUS images. Results:The median serum OPG levels were greater in the subjects withTLC than in the subjects without TLC (1.36 vs 0.95 ng/mL, respectively, p<0.05). Significant correlation was notedbetween the serum OPG levels and the maximum arc of calcium (r=0.274, p=0.027). The median serum OPGlevels were significantly increased more in the subjects who had a maximum arc of calcium ranging from 90 to 180degrees than in those subjects who had a maximum arc of calcium less than 90 degrees (1.63 vs 1.14 ng/mL, respectively,p<0.05) and the median serum OPG levels were also increased more in the subjects who fell within thesecond tertile of the calcified plaque surface area than that in those subjects who fell within the first and thirdtertile (0.96, 1.53, 1.40 ng/mL for the first, second, third tertile, respectively, p<0.05). On the stepwise multivariatelogistic regression analysis, the serum OPG level remained a risk factor for TLC after adjustment was made forthe other risk factors such as age, diabetes mellitus, HbA1C and a smoking history (p=0.019, odds ratio 5.208[95% confidence interval: 1.308-20.744]). Conclusion:In patients with CAD, an increased serum OPG levelis associated with target lesion calcification. (Korean Circulation J 2006;36:337-342)