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배양 흰쥐 인슐린종세포에서 싸이클로스포린에 의한 세포독성에 미치는 글루타치온의 영향
최동헌,이병래,장대용,김종오,김병수,정기영,임태영,신병철,배학연 대한당뇨병학회 2002 Diabetes and Metabolism Journal Vol.26 No.1
연구배경:Cycloporine A는 장기이식 환자에게 면역거부 반응을 억제할 목적으로 사용되고 있는데 이는 당뇨병, 고혈압, 신장세포 손상 등 여러 가지 부작용을 초래한다. Cyclosporine A의 이런 부작용에 대한 독성 기전은 아직 명확치 않으나 산화적 세포손상이 한 요인으로 생각되고 있다. 본 실험에서는 Cyclosprine A에 의한 췌장 베타세포의 독성이 미치는 GSH의 영향을 알아 보았다. 방법:흰쥐 인슐린종(RIN5mF)세포를 배양한 후 배양액에 글루타치온 합성효소 억제제인 buthione sulfoximine(BSO)과 cyclosporine A(CsA)및 GSH을 첨가하여 배양한 후 생존한 세포를 MTT법으로 측정하였다. 결과:CsA 용량이 증가함에 따라서 흰쥐 인슐린종 세포의 생존율은 감소되었다. BSO+CsA 투여군의 MTT 환원율은 CsA 단독 투여군보다 감소되었다. GSH+CsA 투여군의 MTT 환원율은 CsA 단독 투여군보다 증가되고, GSH+CsA+BSO 투여군의 MTT 환원율은 CsA+BSO 투여군보다 증가되었다. 결론:CsA는 췌장 베타세포에 직접적인 손상을 유발할 수 있으며, GSH은 CsA에 의한 베타손상방지 기능이 있는 것으로 추측된다. Background : Cyclosporin A (CsA) is a immunosuppressive agent that is most widely used in organ transplanted patients to prevent immunorejection, However, it has some side effects, including diabetes mellitus, nephrotoxicity and hypertension. The mechanism of CsA cytotoxicity is unclear but it has been suggested that reactive oxygen species are involved in the cytotoxic reactions. The purpose of this study was to determine the effects of glutathione, as a physiological antioxidant on CsA induced β-cell toxicity. Methods : Rat insulinoma (RINm5F) cells were incubated with culture media (RPMI1640) in the presence of CsA and/or buthionine sulfoximine (BSO), which is an inhibitor of r-glutamyl cysteine synthetase, and reduced glutathione. The viable cells were examined using 3-〔4,5-dimethylthiazol-2-yl〕-2,5-diphenyl tetrazolium bromide (MTT) and was determined by a spectrophotometer at a wavelength of 570 nm. Results : Incubating the RINm5F cells with CsA resulted in a decrease in cell viability with increasing dose. This deceased cells viability, induced by CsA was potentiated by BSO treatment. The CsA and BSO induced cells toxicity was reduced significantly by the reduced glutathione. Conclusion : The results suggest that pancreatic β-cell may be injured by CsA and glutathione may have some role in cytotoxicity (J Kor Diabetes Asso 26:57~63, 2002).
디이젤 機關에서 排出되는 微粒子의 測定方法에 관한 硏究
卓泳祚,崔東憲,河鍾律 東亞大學校 大學院 1987 大學院論文集 Vol.12 No.-
The Mini-dilution tunnel has been designed and constructed for the diesel particulate emission measurement and in order to reduce the pariculate emission from diesel engines. In this system, raw exhaust is split off and then diluted in the tunnel with air to control the mixture temperature and the CO₂ tracer method is used to determine the dilution ratio for the calculation of particulate mass fraction For designing this system, experimental data relative to tunnel diameter, length, volume flow, mixture temperature degree of mixing and sampling flow rate were reviewed. Concequently, this mini-dilution tunnel system was found to have a good correlation with a larger dilution tunnel.
MRI와 3D 스캔 데이터를 이용한 3D 프린팅 유방 인공보형물의 제작 알고리즘
정영진,최동헌,김구진 한국멀티미디어학회 2019 멀티미디어학회논문지 Vol.22 No.12
In this paper, we propose a method to fabricate a patient-specific breast implant using MRI images and 3D scan data. Existing breast implants for breast reconstruction surgery are primarily fabricated products for shaping, and among the limited types of implants, products similar to the patient's breast have been used. In fact, the larger the difference between the shape of the breast and the implant, the more frequent the postoperative side effects and the lower the satisfaction. Previous researches on the fabrication of patient-specific breast implants have used limited information based on only MRI images or on only 3D scan data. In this paper, we propose an algorithm for the fabrication of patient-specific breast implants that combines MRI images with 3D scan data, considering anatomical suitability for external shape, volume, and pectoral muscle. Experimental results show that we can produce precise breast implants using the proposed algorithm.
주유철,이동민,양종태,신병철,임태영,서정균,정기영,최동헌,김원,조영신,고희관 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2
Background and Objectives : Palindromic rheumatism (PR) is known to be triggered without any obviously inciting events in most patients, although, in a few cases, attacks have been noted to relate to another events such as weather change, childbirth, ingestion of certain foods, or over-exercise. The aim of this study was to characterize the triggering factors on palindromic attacks. Materials and Methods : We evaluated sixty-four patients with PR for the presence of triggering factors and the relationship between attacks and triggering factors by interview of patients. We considered that there was an probable association between episodes and PR, if episodes within 24 hours prior to PR had triggered at least 50% of all attacks and a definite association between episodes and PR, if episodes within 24 hours prior to PR had triggered 100% of all attacks. Results : In 15 patients (35.9%), there was a possible association between episodes of PR and initiating events. In 8 patients (12.5%), there was a definite association between episodes of PR and initiating events. The triggering factors were physical over-activity including exercise (19/64: 29.7%), foods, such as rawfish, crab, and chicken, including alcohol (19/96: 19.8%). However, there were no difference between the groups with and without the triggering factor in sex ratio, duration and onset of PR, the positive rate of rheumatoid factor and involved sites. Conclusion : Our observations showed that PR was triggered by physical over-activity more than in previous reports and hypersensitivity to foods was a causative factor in some patients with PR. However, patients with triggering factors had a similiar clinical profile to patients without triggering factors.