관상동맥 질환에서 SDF-1α의 농도

김보영,박용규,박형서,노상필,정승현,이유선,이정우,이재환,최시완,정진옥,성인환 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

Atherosclerosis is now viewed as an inflammatory disease of the vascular system. Expression of several chemokines, including monocyte chemoattractant protein(MCP)-1, MCP-4, RANTES(regulated on activation normal T-cell expressed and secreted), and interleukin-8(IL-8) are increased in human atherosclerotic plaques compared with normal vessels. They are involved in the pathogenesis of atherosclerosis and plaque rupture by activating and directing leukocytes into the atherosclerotic lesions. However, some are involved in homeostatic functions such as normal leukocyte traffic and growth regulation. SDF-la is a multi-functional cytokine that is involved in myelogenesis, hematopoiesis, angiogenesis and injured gastric mucosal regeneration in the gastric ulcer patient. SDF-la is recently shown to be highly expressed in atherosclerotic plaques and a potent platelet agonist. At least in high concentrations, SDF-la may mediate antiinflammatory and matrix stabilizing effects in unstable angina. Many studies are going on to know the function of SDF-la in coronary artery diseases. I investigated the difference of the plasma level of SDF-la between control group and coronary artery disease group. Total 75 subjects were enrolled. The diagnosis of coronary artery disease was confirmed in all patients by coronary angiography. Control subjects in this study were confirmed normal by coronary angiography. Clinical profile and risk factors were also reviewed. Control subjects in this study were 27 (M=10, F=17). Plasma for the study was collected before the angiography and centrifuged. SDF-la analysis was performed by ELISA. Plasma level of SDF-la is significantly increased in patients with stable angina(n=20) and unstable angina group(n=28) compared with healthy control group(n=27). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases. In this study, plasma level of SDF-la is increased in patients with stable angina and unstable angina groups compared with healthy control group(P<0.05). the risk factors do not influence the plasma level of SDF-la in coronary artery diseases.

흡연에 의한 급성 호산구성 폐렴 2예

박종빈,김학렬,주현준,유태양,신성남,신정현,송정섭,황기은,김소영,양세훈,정은택 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.2

최근 흡연을 시작한 젊은 성언에서 급성 호산구성 폐렴의 발생에 대한 증례가 보고되고 있다. 급성 호산구성 폐렴은 대개 발열을 동반하기 때문에 초기에는 감염성 폐렴으로 잘못 진단, 치료되는 경우가 많다. 아직 정확한 병태 생리 및 조직학적 소견은 밝혀져 있지 않지만 병력 청취 및 임상 양상, 방사선 소견의 관찰을 통해 급성 호산구성 폐렴을 의심하고, 진단을 위해 기관지 폐포 세척액 검사를 시행한다면 좀 더 쉽게 진단 내릴 수 있을 것이다. 본 저자들은 최근 처음 시작한 흡연에 의해 발생한 급성 호산구성 폐렴을 진단하고, 스테로이드를 투여하여 성공적으로 치료한 환자 2예를 경험하였기에 이를 문헌 고찰과 함께 보고하는 바이다. Acute eosinophilic pneumonia(AEP) is characterized by acute febrile respiratory illness associated with diffuse pulmonary infiltration and pulmonary eosinophilia. The specific etiology for acute eosinophilic pneumonia is elusive. By some investigators, cigarette smoking is suggested as a causative substance which can cause AEP. In recent, the authors experienced two cases of AEP following cigarette smoking. Both cases had characteristic features including age around 20 years, new onset smoking before occurance of AEP, diffuse infiltration on chest radiography, pulmonary eosinophilia based on bronchoalveolar lavage and acute improvement after steroid therapy. These clinical features are resemble with previous smoking induced AEP case reports. Base on these clinical features, cigarette smoking associated AEP could be diagnosed more easily.

시각장애인의 유산소성 운동이 체력에 미치는 영향

박재성,김주혁,황영성,김도호,이수판,한성유,허정석 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.4

This research fulfilled the program of aerobic exercise for living during 6 months with seven men and women who are disabled people with visual impairment, The program consists or gym, swimming, aerobic and running, During 6 months, all exercises were executed 1 hours, twice a week for 6 weeks. Each exercise had self-servant and was carried out 60 minutes with teaching method of special directors in every weep Physique by height, weight, condition of exercise ability by the capacity of the lungs of the heart and lung endurance and intake of the maximum oxygen, muscular strength of stomach, grasping power, pliability by forward bending with the upper part of the body, instantaneous force of muscle in a sudden jump, muscular endurance by put-up and sit-up, agility by side-step and response of the whole body, and balance by one leg standing while closing eyes as using Helmas (sewoo systems korea) were measured. The Results, 1.There is a significant difference for both men and women in the capacity of the lungs and the heart and lung endurance, However only women have a significant difference in intake of the maximum oxygen. 2. Both men and women have a significant difference in muscular strength of stomach and grasping power to measure muscular strength. 3. Both men and women have a significant difference in forward bending with the upper part or the body to measure flexibility. 4. Sudden jump to measure instantaneous force of muscle, sit-up, and push-up to measure muscular endurance show that both men and women have a significant difference.(p<.01) 5. Side-step and response of the whole body to measure agility show that both men and women have a significant difference. 6. One leg standing with closing eyes to measure balance show that both men and women have a significant difference.

닭의 成體 및 胚에 있어서 各 臟器의 Alkaline Phosphatase

朴大圭,兪貞雅 경북대학교 1985 論文集 Vol.40 No.-

Alkaline phosphatases were partially purified from several tissues of chick embryos and adults, and compared their isoenzyme patterns on polyacrylamide gel electrophoresis with the following results. It was found that embryo liver enzyme showed the slowest B- and S-type bands, while adult enzyme has S- and F-type bands. In serum enzymes, embryo alkaline phosphatase was appeared as a single S-band and adult alkaline phosphatase was exhibited S- and F-bands. Kidney enzyme preparations were comprised of B- and S-bands both in embryo and adult. Yolk alkaline phosphatase appeared as a S-band, and yolk sac enzyme showed S- and F-tpye bands. From the above results it can be concluded that the isoenzymes obtained from embryo and adult tissues might have heterogeneities.

X-선 회절법에 의한 소결광내의 칼슘페라이트 생성에 미치는 Al_2O_3, SiO_2 및 MgO의 영향

朴埈賢,趙兪貞,尹晟燮,許完旭,金亨順 대한금속재료학회 2002 대한금속·재료학회지 Vol.40 No.7

In order to elucidate the fundamental aspects of the minerals formation processes during sintering, the Fe_2O_3-CaO-Al_2O_3-SiO_2 system and the effect of MgO on synthesized iron ore sinter were studied by image analysis and X-ray diffraction method. Most existed calcium ferrite was identified to be a solid solution of CaO·2Fe_2O_3 with a small amount of solubility of Al_2O_3 and SiO_2. With an increase of the content of Al_2O_3 in the system, the amount of calcium ferrite was increased. On the other hand, the amount of calcium ferrite was decreased, and the amount of hematite was increased with increasing the content of SiO_2. Crystal structure of calcium ferrite with Al_2O_3 and SiO_2 was changed from monoclinic to triclinic as well as the unit cell volume shrank with fixing Al_2O_3 and increasing SiO_2. With increasing the content of MgO(1∼3 wt%), the amount of magnetite was increased and hematite was decreased but calcium ferrite was not changed.

저분자량 폴리에틸렌이민을 이용한 유전자 송달 및 발현 유효성 연구

정길재,박귀례,신지영,최한곤,오유경 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.4

Branched and linear polyethylenimines (PEIs) have been studied as efficient and versatile agents for gene delivery in vitro and in vivo. PEIs exist in a linear or branched topology and are available in a wide range of molecular weight (Mw). Most studies have been done using PEIs with Mw higher than 10Kd. This study was aimed to test the transfection efficiency and the cell viability following gene delivery using PEI of Mw 2Kd, a relatively lower Mw cationic polymer. We used murine interleukin-2(mIL-2) plasmid DNA complexed with branched PEI 2Kd or 25Kd, and transfected them into a myoblast muscle cell line, C2C12. The cellular uptake of mIL-2 plasmid DNA was determined using quantitative polymerase chain reaction. RNA transcript levels were studied in the myoblast cells. Our results show that PEI 2Kd was as effective as PEI 25Kd in celluar gene delivery and transfection efficiency in C2C12 cells. Moreover, MTT assay indicated that PEI 2Kd/DNA complexes did not significantly reduce the cell viability regardless of N/P ratios. These results suggest that PEI of Mw 2Kd might play a role as effective and low toxic nonviral vector systems for muscular cell lines.

漢文 敎科書 內의 漢詩 分析 硏究 : 第7次 高等學校 漢文 敎科書를 중심으로

박완식,김창용,김상곤,김유태,정인덕 전주대학교 교육문제연구소 2001 敎育論叢 Vol.16 No.-

원격 체육수업 콘텐츠 개발 방향 연구

유창완,양종현,박정준 이화여자대학교 교과교육연구소 2021 교과교육학연구 Vol.25 No.3

The purpose of this study is to provide a direction for developing content to be utilized in online physical education( PE) class situations. Four faculty members and four school sports content production experts produced examples of content development after identifying the forms and difficulties of PE curriculum analysis, online PE class content analysis, and online PE classes. The principles and methods for restructuring the areas of PE curriculum and achievement criteria were adjusted from five to four, and achievement criteria were restructured in the categories of ‘maintenance’, ‘integration’, ‘modification’ and ‘movement’. Examples of physical activities were selected to develop content for online PE classes, and details of content development examples were defined, including topics for each unit, major learning activities, teaching and learning strategies, and evaluation methods. The direction of future development of contents for online PE classes is as follows. First, the PE curriculum should be restructured following the proportion of online PE classes. Second, while utilizing ‘modified physical activity’ to be carried out in online PE classes, it should be aligned to existing physical activities. Third, it should be developed as ‘real-time interactive’ content rather than one-way video content. It is required to establish an online evaluation system in the future and adopt diversified ways to reflect performance evaluations. 본 연구의 목적은 원격 체육수업 상황에서 활용할 콘텐츠 개발 방향을 제시하는 데 있다. 4명의 교수진과 4명의 학교체육 콘텐츠 제작 전문가가 체육과 교육과정 분석, 원격 체육수업 콘텐츠 분석, 원격 체육수업의 형태 및 어려움 등을 파악하고 콘텐츠 개발 예시를 제작하였다. 체육과 교육과정의 영역과 성취기준의 재구성 원칙과 방법을 구안하여, 영역은 5개에서 4개로 조정하고, 성취기준은 ‘유지’, ‘통합’, ‘수정’, ‘이동’ 의 방식으로 재구성하였다. 원격 체육수업 콘텐츠 개발을 위해 신체활동 예시를 선정하고, 단원별 주제, 주요 학습 활동, 교수·학습 전략, 평가 방법이 포함된 콘텐츠 개발 예시를 상세화하였다. 향후 원격 체육수업 콘텐츠 개발 방향은 첫째, 체육과 교육과정은 원격 체육수업 비중에 따라 재구성해야 한다. 둘째, 원격 체육수업에서 수행할 ‘변형 신체활동’을 활용하되, 기존 신체활동과 연계성이 있어야 한다. 셋째, 일방향의 동영상 콘텐츠 활용형보다는 ‘실시간 쌍방향형’ 콘텐츠로 개발해야 한다. 향후 온라인 평가 시스템을 구축하고, 수행평가를 반영할 수 있는 방법을 현재보다 다양화해야 한다.

사회적지지 프로그램을 이용한 노인 건강증진센터의 운영효과

박오장,김유정 노인간호학회 2009 노인간호학회지 Vol.11 No.2

Purpose: The purpose of this study was to identify the effect of applying a social support program in the operation of an health promotion center for elders. Methods: The participants were 50 elderly women over 65 years dwelling in a rural area and 25 each were assigned to an experimental and a control group. A social support program was implemented for 6 hours a day, 3 times a week, for 4 months for the experimental group. It included health assessment, health education, counseling, consultation, exercise, physical & occupational therapy, primary care, recreation, lunch & transfer service for the elders. Data were collected from May 1 to August 31, 2006 using questionnaires about the dependant variables, and were analyzed by χ2 test, t-test, Pearson correlation coefficients and stepwise multiple regression with the SPSS program. Results: The social support program for elders was effective for all dependent variables of health promotion behaviors (t=4.03, p=.001), life satisfaction (t=3.27, p=.002), health knowledge (t=-2.94, p=.005), perceived health state (t=-1.69, p=.020) and lowering the amount of depression (t=-.1.43, p=.040). Conclusion: By applying a social support program, the health promotion center was able to effectively improve the health promotion behaviors in elderly woman.

한국형 노인주거개발을 위한 이론적 고찰

박유복,최영선,김현정,오이진,박정희 목포대학교 생활과학연구소 2000 생활과학논집 Vol.3 No.-

According to the increase of the number and portion of the elderly people, the elderly housing is an important social welfare factor as the solution of the elderly problem. When we consider the elderly housing of Korea, it should be appropriate to Korean culture and emotion. This study aims to suggest two ways of Korean elderly housing: three-generation housing and the renovation of housing which one elderly person have lived in. Considering that family centrism is remained a lot in Korean consciousness, those two ways should be developed well so as to build a unique Korean housing culture for the elderly.