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제주도 해안선주변 1개정점(용두암 근처)에서 부유성갑각류 현존량의 일주변화
고유봉,신희섭,정용진 제주대학교 해양연구소 1989 해양자원연구소연구보고 Vol.13 No.-
Planktonic crustacean samples and hydrographic data were obtained seasonally at intervals of two hours for one day at one station(near the Dragon Head Rock) around the coast line of northern part in Cheju Island from 1987 to 1988. Seasonal average individuals were low in February (307 indv./㎥) and October (282 indv./㎥), and highest in August (3.459 indv./㎥). Most of individuals were small animals retained on fine mesh(90μm mesh) net, composing over 91% of the total crustaceans. Range of seasonal average biomass was 3.0~20.5㎎/㎥. Generally, individuals and biomass of small planktonic crustaceans were higher during the daytime than those at night. whereas those on medium or large organisms were remarkably higher during the nighttime, Daily mean production, and ratio of daily production to biomass(P/B ratio) were highest in August and lowest in February, showing the larger the number of individuals and water temperature. the greater daily production and P/B ratio.
심재주,신동호,최윤석,김정구,유승재 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.12
The corrosion behavior of copper in neutral aerated synthetic tap water was investigated using electrochemical methods, SEM and XPS. All potentiodynamic polarization curves showed active corrosion behavior, and the corrosion rate was more sensitive to flow velocity than Cl^(-) ion concentration and temperature. The result of potentiostatic test indicated that the current density decreased with increasing time regardless of Cl^(-) ion concentration and temperature in stagnant condition because copper compounds were formed uniformly on the surface. The EIS plot was changed from two time constants to three time constants with the formation of Cu₂O, and the charge transfer resistance (R_(ct)) was very large and increased with increasing immersion time. From all results, copper had good corrosion resistance in this potable water system.
저체중 또는 과체중 청소년에서 캠프 프로그램을 이용한 영양 교육효과에 관한 연구
성미경,승정자,류화춘,박재년,박동연,최미경,조경옥,최선혜,이윤신,김유경,이은주 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.4
This study was performed to evaluate the effectiveness of a nutrition education program developed for nutritionally imbalanced adolescents. A summer nutrition camp was held for 23 overweight and 16 underweight subjects. Its effectiveness with regard to was evaluated at the end of the camp and 6 months later. Nutrition knowledge, nutritional attitude, food behavior, nutrient intake, exercise habit and ideal body figures desired by the subjects. The results showed significantly higher nutrition knowledge scores at the end of the camp as compared to those obtained prior to the camp program, and these scores were maintained for at least six months. Nutrition attitude scores also improved after the education program, and these improved scores also lasted for 6 months. However, the food behavior scores measured 6 months after the education program were not significantly different from those obtained prior to the camp. Also, the exercise habit, the ideal body figures and the body figures desired by the subjects remained unchanged. When nutrient intakes of subjects were assessed before the program and 6 months later, the mean daily vitamin C intake was significantly increased after the education program. Also, the intake of iron from plant food sources increased in the overweight subjects, while less iron from animal source were consumed by the underweight subjects. Both groups tended to consume more vegetables and fruits 6 months after the education program which may have contribute to the higher vitamin C and plant-based iron intakes. These results indicate that a 4-day nutrition education camp program sustained changes in nutrition knowledge and nutrition attitude for 6 months. The increased intake of vegetables and fruits was also achieved through this education program. However, changes in dietary behavior in adolescents may require repeated education.
李龍均,朴유미,鄭大一,金寅植,朴鍾勳,盧信愛,鄭逸守,朴敏洙 東亞大學校附設基礎科學硏究所 1998 基礎科學硏究論文集 Vol.15 No.1
Tropinone 화합물들은 색다른 고리계의 존재로 아주 오래전부터 약리학적으로 매우 흥미로운 연구과제로 주목되어 최근에 그들의 합성법,?? 입체적 구조분석?? 그리고 약리학적인 연구??가 활발히 진행되고 있다. Tropinone 1은 흔히 마약으로 알려져 있는 cocaine 2, 소염작용과 항경련성 작용 및 심장박동수를 조절 등 다양한 약리작용을 하는 tropane spirohy-dantoin ?? 그리고 안과질환을 검사 할 때 눈의 동공을 확장시키는 데 사용하는 atropine ??등을 합성하는 데 중요한 중간체이다. ??????????? Trigo, G, G등 ??은 aliphatic amine과 succinic aldehyde를 acetonedicarboxylic acid와 반응하여 nortropane 유도체를 합성하였으며, 그 후 [3+2] nitrone cycloaddition? 과 [3+4] cyclocoupling? 을 거치는 tropane alkaloid의 새로운 합성법이 개발되었다. 최근 lzquier M. L. 등¹은 acetonedicarboxylic acid를 사용하여 1차 지방족 amine과 succinic aldehyde대신 2,5-dimethoxytetrahydrofuran을 반응시켜 N-alkyl nortropinone 유도체를 합성하였다. 그러나 일반적으로 빙초산 속에서 amine과 2,5-dimethoxytetrahydrofuran을 반응시키면 pyrrole 유도체가 합성되어진다.?? 이러한 사실은 분명히 반응조건(예, 산, 온도)에 따른 다양한 화학이 존재한다고 볼 수 있다. 따라서 우리는 반응조건, 즉 산의 변화 및 온도 변화에 의한 amine과 2,5-dimethoxytetrahydrofuran의 반응을 자세하게 검토하면서 새로운 N-arylnortropinone 유도체를 합성하고자 한다.
비만 여성을 대상으로 한 해조류 추출물의 국부처치와 운동 병행을 통한 지방분해 효과의 임상적 검정
서태수,이인숙,변재철,김규호,박승한,김유영,김상국,김현정,김상기,신동철,성미영,박종석,김종기,박언휘 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.3
This study was carried out to test the body fat breakdown during topical seaweed extract treatment and in combination with the aerobic exercise. Of 20 female obesity subjects, ten treated a cream types of seaweed extract(control group) and ten treated a placebo cream(placebo group). Topical treatment of each sample was designed for 4 weeks, and treated with 2 times a day about 10ml on the abdomen and the thigh, respectively. All subjects were participated aerobic dance half hour a day and four times a week. After 4 weeks of topical treatment and exercise, they were measured body fat, skinfold thickness, body circumference. Then venous blood samples were taken and analyzed blood cells, serum enzymes, and serum lipids. There were reduction of body weight, % of body fat, antebrachium, brachium, chest, waist, thigh circumference and abdomen thickness between pre and post treatment in both group. Especially, body weight and % of body fat significantly reduced in the subjects treating the seaweed extract than those treating the placebo. There were significant decrement in total cholesterol and LDL whereas increment in HDL and TBIL in the control group, but no significant difference in the placebo group. In conclusion, there were 7.6% of body fat reduction during 4 weeks of aerobic exercise and 21% of body fat reducement in combination of topical seaweed treatment and exercise, respectively. These results suggest that the topical treatment of seaweed extract should be very effective for fat breakdown. Especially, the body fat breakdown maximized in the combination with the topical seaweed extracts treatment and the aerobic exercise.
OB-26 : Genome-wide microRNA expression profiling in fetal trisomy 21 placenta
( You Jung Shin ),( Ji Hyae Lim ),( So Yeon Park ),( Da Eun Lee ),( Hyun Kyong Ahn ),( Si Won Lee ),( June Seek Choi ),( Dong Wook Kwak ),( Jin Hoon Chung ),( Hyun Mee Ryu ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: Differential expression of microRNAs (miRNAs) has been identified in many diseases, including trisomy 21 (T21). However, the changes of the genome-wide miRNAs expression in the T21 placenta have yet to be determined. Moreover, the biological functions of the differentially expressed miRNAs in the T21 placenta are still unclear. Thus, we investigated the genome-wide miRNAs expression profiling of the T21 placenta using microarray and analyzed their biological functions using bioinformatics tools. 방법: Total RNA extracted from placenta samples of T21 and euploid fetus was hybridized onto human miRNA microarray and expression data were analyzed on R statistical environment. To investigate the functions of the differentially expressed miRNAs (fold change>2.0 and p<0.05), the miRWalk database was used to predict their potential targets, which were afterwards submitted to the functional annotation tool provided by the WebGestalt database. 결과: In total, 34 miRNAs were significantly differentially expressed in the T21 placenta (16 up-regulated and 18 down-regulated). However, chromosome 21-derived miRNAs were not detected. In analysis of genes predicted to be targeted by the differentially expressed miRNAs, target genes of up-regulated and down-regulated miRNAs were identified 7,434 and 6,071, respectively. Out of total target genes, 76 genes were identified within chromosome 21 and were potentially regulated by the differentially expressed miRNAs in the T21 placenta (10 and 34 genes being controlled by the down- and up-regulated miRNAs, respectively, and 32 by both). Functional annotation analyses revealed that target genes of abnormally expressed miRNAs were significantly associated with in T21 as well as T21-related disorder such as mental retardation, neurobehavioral manifestations, congenital abnormalities, and so on. 결론: Our results provide a new insight into understanding the expression characteristic of miRNAs in the T21 fetal placenta. Additionally, findings of our study indicate that the differentially expressed miRNAs in the T21 placenta may potentially affect various pathways related with pathogenesis of the T21.
( Shin Ok Jeong ),( You Jung Shin ),( Sue Yeon Park ),( Dong Wook Kwak ),( You Jung Han ),( Si Won Lee ),( Min Hyoung Kim ),( Jin Hoon Chung ),( June Seek Choi ),( Hyun Kyeong Ahn ),( Hyun Mee Ryu ),( 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-
목적: Urinary concentrations of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) could be used as a reliable biomarker of exposure to tobacco smoke. We therefore developed a relatively simple high-throughput analytical method using ultra-performance liquid chromatography coupled with tandem mass spectrometry (UPLC-MS/MS) to quantify total urinary NNAL concentrations in the general population. 방법: We developed and validated the UPLC-MS/MS method to quantify total NNAL concentrations in urine. And we studied quantified this biomarker of exposure in n=232 first-trimester pregnant women, of which n=17 were smokers, n=34 non-smokers, and n=181 with second-hand smoke exposure. 결과: Standard curves for total NNAL concentrations in urine were linear between 20-1500 pg/mL, with coefficients of determination >0.95, with precision ranging from 2.2 to 8.6% (CV), and accuracy from -5.6 to 10.9% (percent error). The lowest limit of quantitation was 6.7 pg/mL, and 2.0 pg/mL the lowest limit of detection (LLOD). Total urinary NNAL concentrations in non-smoker subjects (phase 1) non-smoker pregnant women (phase 2) were <LLOD, whereas in smokers total NNAL concentrations were between 0-35.2 pg/mL. Second-hand smoke exposure in pregnancy resulted in total urinary concentrations varying between 0-7.7 pg/mL. NNAL and cotinine in non-smoker samples were not detected. Measurement of urinary cotinine could be up to 14 days after last smoking. Measurement of urinary total NNAL could be up to 35 days after last smoking. 결론: We successfully developed an UPLC-MS/MS analytical method to quantify total urinary NNAL concentrations in the pregnant women. NNAL is better biomarker than cotinine to detect smoker in early pregnancy.