흉선종 제거후에 발생한 재생 불량성 빈혈 : 증례보고

전원선,이상철,김현정,배상병,김찬규,이남수,박노진,이규택,박성규,홍대식,박희숙,원종호 순천향의학연구소 2007 Journal of Soonchunhyang Medical Science Vol.13 No.2

Thymoma is associated with myasthenia gravis, Pure red cell aplasia, and autoimmune diseases such as autoimmune hemolytic anemia, aplastic anemia, and hypogammaglobulinemia. It's association with aplastic anemia is rare and aplastic anemia appearing after surgical removal of thymoma is especially rare. The authors hereby report a case of aplastic anemia occuring in a patient who was diagnosed with thymoma and myasthenia gravis and had the tumor surgically removed. The patient was treated with anti-thymocyte globulin, cyclosporin, and prednisolone, and showed partial remission with hematologic improvements after 12 months.

재발 또는 불응성 비호즈킨 림프종 환자에서 CDME 구제항암화학요법 후 고용량 항암화학요법 및 자가말초혈액 조혈모세포이식의 효과

김세형,한강원,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background and objectives : The long-term survival in patients with non-Hodgkin's lymphoma (NHL) after conventional dose chemotherapy is about 35% and the rest of the patients tend to have relapse. So, in relapsed or refractory NHL, we compared the outcome of patients undergoing high-dose chemotherapy with autologous peripheral blood stem cell transplantation(APBSCT) with only salvage chemotherapy of cisplatin, dexamethasone, mitoxantrone, and etoposide(CDME). Materials and methods : From June 1993 to December 1999, 25 patients with relapsed or resistant NHL were treated with CDME regimen as salvage chemotherapy. Twelve patients were received four cycles of CDME chemotherapy, and 13 patients were received high-dose chemotherapy with APBSCT following two cycles of CDME chemotherapy. Results : The median follow-up duration was 12.8 months(range:4-68). The overall response rate was 41.7% (complete response rate 25%, partial response rate 16.7%) in 12 patients with CDME only. Thirteen patients who were treated with high-dose chemotherapy with APBSCT achieved 61.5% complete response rate and 15.4% partial response rate, with an overall response rate of 76.9%. The estimated 3-year progression-free survival rate was significantly higher among patients who received high-dose therapy than patients who received CDME only(41.5% vs 20.0%, p<0.05). And, 3-year overall survival rate was significantly higher among patients who received high-dose therapy(51.3% vs 25.0%, p <0.05). Conclusions : In relapsed or refractory NHL, CDME chemotherapy is an effective salvage chemotherapy and allow peripheral blood stem cell collection. Also, high-dose chemotherapy with APBSCT following CDME is superior to CDME salvage chemotherapy only.

퍼지제어를 이용한 루프검지식 교통 신호등의 최적주기연구

김원규,박종국,홍유식 慶熙大學校 1994 論文集 Vol.23 No.-

This is a study of the electro sensitive traffic system which uses sensors to both extend the cycle if there are many vehicles waiting at a stop light, and reduces it, if there are only a few. It was determined that each vehicle which passes through the loop detector neither is the same length, nor weighs the same, nor is going the same speed. Therefore, the conventional traffic control method is an inadequate measure of traffic volume and can cause delays and increaes waiting time. This paper proposes the optimal traffic cycle using fuzzy control as a system which will reduce vehicle waiting time and will improve the average speed a vehicle travels.

악성림프종 환자에서 복합화학요법으로 유발된 백혈구 감소증에 대한 인형 재조합 과립구 집락형성-촉진인자(rhG-CSF: Neutrogin)의 효과

박성규,전진우,기신영,유병우,김홍수,백승호,원종호,홍대식,박희숙 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.1

Clinical effects of rhG-CSF were investigated in 17 patients receiving chemotherapy for non-Hodgkin's lymphoma. Patients were given G-CSF 2㎍/㎏/day after 2nd cycle chemotherapy for least 14 consecutive days, and clinical and laboratory results were compared to results of the first cycle. Treatment with G-CSF resulted in increase of mean WBC count(952.9±152.2㎜³vs 1882.4±350.4/㎜³) and neutrophil count(212.9±53.0/㎜³vs 841.5±238.0/㎜³), reduced the duration of leukocytopenic days(12.4±1.3 days vs 5.5±1.0 days, WBC count less than 4000/㎜³) and neutropenic days(4.5±0.9 days vs 2.3±0.7 days, neutrophil count less than 500/㎜³), and reduced the duration of neutropenic fever(5.8±1.1 days vs 0.9±0.5 days). The side effects of G-CSF were not so significant. These results demonstrated that G-CSF is safe and useful for the treatment of neutropenia induced by anticancer chemotherapy of non-Hodgkin's lymphoma and reducing the incidence of febrile periods and duration of antibiotic administration.

다품종 소량생산 기업을 위한 체계적인 조립계획 시스템

박홍석,이원규 울산대학교 1995 공학연구논문집 Vol.26 No.1

오늘날 생산 내외적 요소의 영향으로 생산성 향상이 중심과제가 되고 있지만 다품종 소량생산 기업에서는 적극성을 보이지 못하고 있다. 그 이유는 제품의 다양성 및 복잡성으로 인한 조립 계획수립의 어려움과 경험 부족등을 들수 있다. 본 연구에서는 이들 기업이 어떻게 계획을 수립해야하는가를 각각의 계획기능에서 보여주고자 한다. Improvement of productivity becomes an more and more important issue in today's industries due to the domestic and exterior requirements, but most of small to medium size companies can not positively be coped with such situation. Main reasons are considered to be the difficulties of assembly planning arising from the variety and sophistication of products and the lack of planning experiences. In this study it was intended to show how to establish assembly plans with individual planning functions required in a manufacturing company.

Aspergillus awamori와 Zymomonas mobilis로 구성된 고정화혼합 배양계의 에탄올 생산에 미치는 Triton, PVA 및 PEG의 영향

이상원,서권일,박석규,손봉수,김홍출,성찬기 순천대학교 기초과학연구소 1995 基礎科學硏究誌 Vol.6 No.-

The effects of triton-X 100, PVA and PEG on the ethanol production and raw starch hydrolysis by co-immobilized A. awamori and Z. mobilis (A-Z system) were investigated. When gel beads containing A. awamori(1.25 × 10 exp (9) spores/ℓ - gel) and Z. mobilis(0.5g cell/ℓ - gel) were cultured in 2% raw starch solution at 30℃ for 120 hours, ethanol concentration, ethanol yield (Y_p/s) and pH of culture broth were 2.8g/ℓ, 0.16 and 3.8~4.0, respectively. Ethanol production and starch hydrolysis by addition of PVA was efficient, compared to that of PEG and ethanol concentration in culture broth with 0.2% PVA was 3.56g/ℓ. At A-Z 36 culture system with changing silicon check valve for cotton plug at 36 hours in A-Z culture system, ethanol yield on glucose, Y_p/s = 0.36, showed 2 times higher than that of control culture system(cotton plug culture). Ethanol production and productivity by cultivating 85g gel beads at 30℃ in a 1ℓ jar fermentor(220rpm) of medium 500㎖ were 32g/ℓ and 1.8g/ℓ/day, respectively. After 12 hours of cultivation, gel beads were distinguished oxygen-rich surface for A. awamori from oxygen-deficient central part for Z. mobilis.

웹 기반 가상현실 프로그램이 초등학생의 공간시각화 능력 향상에 미치는 효과

곽원규,김홍래 춘천교육대학교 초등교육연구소 2004 敎育硏究 Vol.22 No.-

공간 능력 및 공간 시각화 능력의 향상은 우리가 살고 있는 세계를 표현하고 설명하는데 도움을 주고 실생활과 작업에 관련된 문제해결 능력을 기를 수 있게 한다. 제 7차 수학과 교육과정에서 공간 능력 및 공간 시각화 능력을 향상시키기 위한 학습으로 구체적 조작물과 학습지 사용을 병행하고 있다. 하지만 초등 기하는 공간적인 경험을 현실 상황이나 구체물 조작을 통하여 형성된 공간직관을 수학화하도록 하여야 하나, 실제 현장에서는 학교여건 등의 여러 실정으로 조작 자료들이 제대로 마련되어 있지 않거나 잘 사용하지 않고 있다. 이에 본 연구에서는 이런 요구에 의해 아동과의 상호 작용성과 접근성을 향상시킨 웹 기반 가상현실 프로그램을 개발하고 그 효과를 분석하였다. Spatial assembly skills and spatial visualization skills help us to express the world we are living in and to develop problem-solving abilities related to real life and professions. The 7th Mathematics Curriculum use specific tools and learning materials to improve spatial skills and spatial visualization skills. However, though elementary geometry is supposed to archive spatial experiences or spatial intuitions formed by manipulating real situations and specific tools, actual classrooms do not have or do not often use sufficient manipulative materials due to school's conditions etc. To meet such demands, this study aims to develop a web-based virtual reality program with improved internationality with children and accessibility, and to diagnose the possibility of a web-based virtual reality study program through the analysis of the effect.

지방 국립대학의 우수학생 유치방안에 관한 연구 : 부산대학교를 중심으로

이원호,안창규,정영홍,황해익,주철안 釜山大學校 敎育硏究所 1992 敎育硏究 Vol.2 No.1

Korean universities have developed rapidly since its liberation from hapanese rule in 1945. Korean higher education system has contributed to the socio-economic development of the country. However, Korean higher educational system has some problems. One of the problems is its unbalanced development of higher educational institutions between the capital city and other cities. Koreans traditionally regarded highly colleges and universities in the capital city. The government including private foundations have invested large resources in building colleges and universities in cities and providences had been neglected. However, colleges and universities play crucial role in the local, regional development of the country. It is important to raise academic quality of the colleges and universities in non-capital cities. The quality of colleges and universities depended primarily on faculty, finance, etc. Therefore, it is an imperative condition to recruit academically excellent students for the development of colleges and universities in non-capital cities. Three research questions have guided the research. 1) How the college entrants' academic performance has changed. 2) What colleges and universities have utilized admission policy to recruit excellent students. The research has found out the following results. 1) The academic performances of college entrants in non-capital city were lowered in the 1980s. 2) Colleges and universities have emphasized the academic excellence, which is primarily related to research and academic activities of the faculty. 3) High school students and teachers in Pusan city give local university lower rate than what it is The findings suggest that local college and university make sustained, ststematic efforts in order to develop its status among the institutions. The efforts should include short-term and long-term policies : 1) Marketing activities about scholarship programs, graduates' career prospects, facilities, and the faculty etc. 2) Hiring excellent faculty members 3) Strengthening graduates' gaining job 4) furnishing required facilities and making attractive campus 5) Upgrading the quality of academic and research activities

압력변화에 대한 2성분계 기액평형치의 추산

심홍섭,박원규 영남대학교 공업기술연구소 1984 연구보고 Vol.12 No.1

The relation between logarithmic value of the relative volatilities and liquid phase compositions in the binary methanol-methylethylketone systems with the variable pressure could be expressed as linear function. And the pressure variation does not change the slope of the linear relations. This study proposed the empirical equation which can be used to predict the vaporliquid equilibrium relationship of the methanol-methylethylketone system with the variable pressure. The calculated values are compared with the experimental data, and the calculated results agree well the experimental results.

Xanthomonas sp. EPS-1의 Exopolysaccharide생산을 위한 무기염류의 영향

박석규,손봉수,이상원,서권일,김홍출 순천대학교 기초과학연구소 1995 基礎科學硏究誌 Vol.6 No.-

For the production of high viscosity exopolysaccharide from Xanthomonas sp. EPS-1 which isolated and identified from soils, optimum concentration of inorganic salts were investigated : 0.2% KH_2PO_4, 0.05% MgSO_4·7H_2O, 0.3% NaCl, 0.005% CaCO_3, 0.007% FeSO_4·7H_2O, 0.005% MnSO_4·7H_2O. When EPS-1 strain was cultivated at 30℃ for 72 hours in a jar fermentor (impeller speed 300 rpm, aeration rate 3 vvm, 2 liter), polymer content, product rate and yield(Y_p/s) was 18.4g/ℓ, 0.26g/ℓ/h and 37%, respectively.