Taxol합성에 관한 연구. Ⅱ : 3-(2-Hydroxyethyl)-2, 2, 4-trimethyl-3-cyclohexenone SEM ether의 합성

임남수,신동수,정윤성,김정주,박두천,주우홍 昌原大學校 基礎科學硏究所 1995 基礎科學硏究所論文集 Vol.7 No.-

3-(2-Hydroxyethyl)-2,2,4-trimethyl-3-cyclohexenone SEM ether ??, an intermediate in the synthesis of taxol was provided in eight steps. The keto ketal ?? was obtained in three steps from 1,3-cyclohexanedione. Reaction of the potassium enolate of ?? with N-phenyltrifluoromethanesulfonimide provided triflate ?? in 84% yield. Thus palladium-mediated cross-coupling reaction of enol triflate ?? with vinyltributylstannane afforded diene ?? in a 89% yield. 3-(2-Hydroxyethyl)-2,2,4-trimethyl-3-Cyclohexenone SEM ether was prepared from diene ?? by sequential hydroboration [9-BBN, THF, 89%], deprotection[pTsOH ·H₂O, THF-H₂O,~100%], and silyation [SEMC], iPr₂NEt, nBu₄NI, CH₂Cl₂, 94%]

치아우식증 수복용 북합레진의 개발과 치아 적합성에 관한 연구 제1편 : 치과용 복합레진의 개발과 기계적 성질의 평가에 관한 연구

임호남,박상진,김형찬 大韓齒科器材學會 1992 대한치과재료학회지 Vol.19 No.2

An esthetic and permanent restorative materials that could be placed directly into the cavities prepared in anterior teeth would be an important contribution to dental practice and public well-being. This studies were planned to produce some experimental composite resins with the evaluation of literatures related to manufacture processes of it. It was assumed that through this studies we wish to get some fundamental data using for the domestic production of commercial dental composite resins with the confirmation of manufacturing process repoted by forein researchs, and to evaluate the physical properties of it. Summarized manufacturing process used in this studies include the synthesis of BIS-GMA inlaboratory, the silanization of fillers, and the its incorporation into prepared BIS-GMA resin to make two paste system. As a first research project, its usefulness as a composite resin and characteristics under the some experimental conditions were evaluated by the measurements of hardening time, compressive strength, diametral tensile strength, and elastic modulus, and the observation of surface using SEM. Following conclusions were drawn: 1. Concentration control of initiator and accelerator from 2% to 4% resulted the working time ranged from 0.33 minutes to 1.00 minute and the setting time from 1.66 minute to 5 minutes. 2. Compressive strength of unfilled resins was highest on KM-33 specimens, diametral tensile strength were decreased by rise of accelerator contents, but it was increased by the rised content of initiator. 3. Higher storage temperature made all of experimental resins became excellent ones. 4. By the incorporation of filler, resins become harder and stronger with the higher values of measurement, but it was decreased by the long term immersion in water. 5. Both of filled and unfilled resins showed the higher dimetral tensile strength over each allowable values of American Dental Specification.

메탄으로부터 합성가스 생산을 위한 압축점화 개질기 연구

임문섭,홍성인,홍명석,전영남 조선대학교 환경공해연구소 2007 環境公害硏究 Vol.20 No.1

Recently, various technologies have been devised to convert methane, a main ingredient of natural gas and biogas, into hydrogen as part of efforts to develop new low pollution energies and reduce greenhouse gases. This study, different from existing methods of reformation, suggests a new form of a partial oxidation compression ignition reformer, to which the concept of super-adiabatic combustion is applied. In addition, the study also conducts experiments by variables about the oxygen/methane ratio, the total flow rate. the intake preheating temperature and the oxygen enrichment ratio, all of which affect the production of hydrogen, in order to understand the optimal feature of the reformer's movement. Results showed that the concentration of hydrogen was 20.84%, under the optimal standard condition of oxygen/methane ratio 0.26, total flow rate 106.5 L/min and intake preheating temperature 355℃. Under the same condition, the concentration of hydrogen became 20.31% when the oxygen enrichment ratio was 55.6%.

태양광 에너지 학습에 대한 초등학생들의 흥미 특성 분석

남일균, 권성기, 임성민 大邱敎育大學 科學敎育硏究所 2016 과학·수학교육연구 Vol.39 No.-

교육적 패러다임의 변화와 지속발전이라는 새로운 시대적 담론의 등장은 태양광 에너지 학습에 대한 과학적 소양교육 강화의 필요성을 제시하였다. 특히 태양광 에너지는 중등과학의 다른 에너지 주제들과 연결되어 있고 태양광 에너지와 관련된 개념들은 초등학생들의 일상생활 속에서 구성되고 있기 때문에 태양광 에너지에 대한 더욱 효과적이고 실제적인 과학교육의 모델이 제시되어야 할 것이다. 본 연구에서는 이러한 맥락에서 초등학생들의 태양광 에너지학습에 대한 흥미의 특성을 분석하였다. 3개 초등학교와 G시의 교육지원청 영재교육원에서 수학중인 초등학생과 초등 영재학생 299명에 대한 요인분석 결과 태양광에너지 학습에 대한 초등학생들의 흥미는 주제, 동기, 활동차원으로 분리 되었다. 주제 차원은 어떤 의미 있는 하위차원을 가지지 않았고 반면 동기차원은 도구적 동기와 과정적 동기로 구분되었다. 활동차원은 역시 정보 수용, 지식 생산 그리고 체험 활동으로 분리 되었다. 초등학생들은 성별, 태양광 에너지에 대한 선행학습의 정도와 유형, 장래희망과 연구대상 학생들의 집단별 특징에 따라 태양광에너지 학습에 대한 다양한 다차원적 특징들을 보여주었고 이러한 연구의 결과는 효과적인 태양광에너지 교육 프로그램 개발을 위해 초등학생들의 이러한 흥미의 특징을 반영해야 함을 시사한다.

好氣性 固定床 生物膜 反應槽의 메디아로 폐칫솔의 利用可能性 檢討에 관한 基礎硏究 : 처리효율을 중심으로

임채영,김정권,성낙창,신남철,김형석,전기일 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.1

This study was conducted to evaluate the possibility to apply the waste toothbrush to aerobic fixed biofilm reactor for media. The media used for this research was waste toothbrush (WTB) and Pall-Ring. The feed used for this research was synthetic wastewater which was made at the laboratory. The COD, NH₄^(+)- N and PO₄^(-3)-P removal efficiency variations with the organic loading rate was examined at this research. The conclusions drawn from these experiments are listed below : 1. When the influent COD concentration was respectively 300mg/ℓ, 600mg/ℓ, the COD removal efficiency was decreased with the increase of the organic loading rate and the COD removal efficiency for Pall-Ring was higher than the COD removal efficiency was 0.4~1.9%. 2. When the influent NH₄^(+)-N concentration was respectively 13mg/ℓ (COD 300mg/ℓ), 25mg/ℓ (COD 600mg/ℓ ), the NH₄^(+)-N removal efficiency for Pall-Ring was slightly higher than the NH₄^(+)-N removal efficiency for Wastetooth brush. The difference of NH₄^(+)-N removal efficiency was about 0.5~1.5%. 3. When the influent PO₄^(-3)-P concentration was respectively 7mg/ℓ (COD 300mg/ℓ), 14mg/ℓ (COD 600mg/ℓ ), the PO₄^(-3)-P removal efficiency for Pall-Ring was higher than the PO₄^(-3)-P removal efficiency for Wastetooth brush. The difference of PO₄^(-3)-P removal efficiency was about 1.1~2%. 4. COD, NH₄^(+)-N and PO₄^(-3)-P removal efficiencies show very small difference between Pall-Ring and Wastetooth brush as media. So it was showed that wastetooth brush can be used as media very successfully.

齒科用 貴金屬 合金과 陶材사이의 化學的 結合에 關한 實驗的 硏究

林時德,남상용 대구산업정보대학 1992 논문집 Vol.6 No.-

Real bonding between metal and porcelain is influenced by various bonding Mecanisms which also influence each other, and is caused by aseries of complicated thermochemical reaction. For this reason, clear determination of the degree and distribution. Fators influencing the bonding strength consist of chemical bonding(including primary bond)52%, Mechanical bonding 22%, compression bonding 26%. Effects of the Base Metal Elements Added to Allots. The elements Sn, In, and Fe were added originally in accordanc with the concept that they might strengthen the Alloy though a dispersion effect. We heated the Degudent G. U Dental porcelain and analysis the surface elemental chang by Energy Dyspersive X-ray analysis and obtained the result that mainly the In element was concentrated to the alloy surface.

인체 유방암종에서 Cyclic-Dependent Kinase Inhibitor, p27^Kip1 발현의 의의

송상용,김덕환,서연림,고영혜,김대식,남석진,양정현 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.12

조선대학교 의과대학 의학과 학사편입학제도의 전향적 검토

임성철,박상기,도남용,박상학,이승일,송창훈,박종 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

소아 크기의 인간형 로봇 MHR-1의 개발

임승철,김갑일,손영익,강환일,오성남 明知大學校 産業技術硏究所 2009 産業技術硏究所論文集 Vol.28 No.-

As the related researches progress successfully, humanoid robots are attracting huge attention from various sectors worldwide. However, the levεI of domestic technology still cannot compare to that of leading countries where the support is much more stronger and diverse. To improve such a present situation, authors have worked on a 3-year project and come to announce the development of a new humanoid robot named MHR-l that is 135cm tall and 45kg heavy. It possesses a total of 22 DOFs, adding up 12 for lower limbs, 8 for arms, and one for each of the neck and waist. Dynamic locomotions are enabled by two kinds of micro-conterllers which are hierarchically connected via a high-speed serial communication protocol. Various walking experiments have proved MHR-l to be stable and fairly fast Especially. incorporated rate gyro sensors are expected to greatly enhance stability.

제약업종 부산물 및 화장품 제조업 폐수처리오니 처리토양에 대한 유기화합물 및 Bioassay 분석 평가

임동규,이상범,이승환,남재작,나영은,권장식,권순익,소규호 한국환경농학회 2004 한국환경농학회지 Vol.23 No.4

본 연구는 퇴비원료로 지정된 제약업종 부산물(공정오니) 및 화장품 제조업 폐수처리오니를 퇴비로서 활용 가능성을 판단하기 위하여 기존의 일반성분이나 중금속 성분 분석 이외 유기성 화합물과 기타 여러 생물검정법 등을 활용하여 시용한 오니에 의한 토양 내 비료의 피해를 밝혀내고 이들의 평가방법을 확립하고자 포장시험을 수행하였다. 오니의 처리에 따른 HEM의 함량은 제약업종 오니2(PS2)와 화장품 오니(CS)처리가 각각 0.51, 1.10 mg/kg로 가장 높았고, PAHs의 함량은 제약업종 오니2(PS2) 처리에서 3,406.8 μg/kg로 가장 높았다. 토양에 서식하는 미소동물의 밀도변화는 생육 중기(7월 23일) 및 수확기(10월 1일) 모두 제약오니2 및 돈분 처리구에서 가장 높았으며, 기타 처리구는 차이가 없이 아주 낮았다. 오니의 처리에 따른 세균 및 사상균의 균수는 제약업종 오니2처리에서 각각 736, 909 cfu/g로 가장 많았고, 화장품 오니도 각각 440, 236 cfu/g으로 다른 처리에 비해 많은 경향을 보였다. 제약오니 및 화장품오니 처리시 우점세균은 무비, 돈분처리에 비해 일정한 경향이 없었으나 3요소 처리보다 다양한 세균이 검출되었다. 오니의 처리에 따른 우점사상균은 무처리에 비해 제약업종 오니3와 화장품 오니처리에서 형태적 특징이 다른 콜로니가 검출되었으나 다른 처리는 비슷한 경향으로 종류 간에 큰 차이는 보이지 않았다. Microcosm test를 통하여 오니 처리 후 3개월이 경과한 토양의 오염정도를 평가한 결과는 제약업종 오니3과 화장품 오니처리는 약간 영향을 받아서 80~90% 생존하였으나, 제약업종 오니1처리는 처리 2주(14일) 이후에는 급격히 생존율이 떨어져서 4주 이후에는 10%만 생존하였다. 그러나 6개월이 경과한 토양에서는 지렁이의 생존율은 제약업종 오니1처리만 약간 영향을 받은 것으로 보였으며 다른 처리들은 전혀 영향을 받지 않았던 것으로 조사되었다. 유기성 오니의 퇴비원료로 활용은 비료관리법의 비료공정 규격 중 퇴비의 비고란에 "퇴비의 원료로 사용 가능한 물질과 사용 불가능한 물질'(별표1)에서 "희비의 원료 중 사전 분석검토 후 사용 가능한 원료에 대한 지정요령'에는 유기물과 중금속(8성분) 함량(건물증)과 제조공정 등을 검토하여 지정하고 있으나, 지정된 원료가 과연 회비원료로 적합한지 잘 알 수 없으며 또한 앞으로 현재의 퇴비원료 규정을 변경할 필요가 있을 경우를 대비하여 희비원료의 적합성 여부를 판별할 수 있는 방법의 개발이 필요하다. 따라서 퇴비원료로 이미 지정('02. 12. 31)된 제약오니 및 화장품 오니를 과량으로 토양에 시용한 후 유해 유기화합물, 미소동물, 미생물 및 생물학적(지렁이) 유해성 검정방법의 도입 가능성을 평가하기 위하여 고추를 재배한 포장에서 비료의 피해시험을 실시한 결과 유해 유기화합물과 생물학적(지렁이) 유해성 검정방법은 앞으로 연구를 통해서 보완할 경우 상당히 활용 가능성이 있는 좋은 평가방법인 것으로 생각된다. This study was conducted to assessment organic compound and bioassay (density of inhabited animal, fluctuation of predominant fungi, and survival ratio of earthworm) for finding damage on red pepper by heavily amount application of sludges in soil, which was treated with 3 pharmaceutical byproducts and a cosmetic industry wastewater sludge as raw materials of compost, and for establishing estimation method. HEM contents in the soil treated with pharmaceutical byproducts sludge2 (PS2) and cosmetic sludge (CS) were 0.51, 1.10 mg/kg respectively. PAHs content of PS2 treatment in the soil was 3406.8 ug/kg on July 8. In abundance of soil faunas, the pharmaceutical byproducts sludge2 treatment was the most highest. The next was decreased in the order of pig manure (PM) and the cosmetic sludge treatment. However the other pharmaceutical sludge treatments were remarkably reduced populations of soil inhabited animals. In upland soil treated with organic sludges, the numbers of bacteria and fungi of the pharmaceutical sludge treatment were 736, 909 cfu/g and those of the cosmetic sludge treatment were 440, 236 cfu/g, respectively. The pharmaceutical sludge treatments and the cosmetic sludge treatment in identification of predominant bacteria were not any tendency to compare with non fertilizer and pig manure treatments, but they had diverse bacteria than NPK treatment. In microcosm tests, the survival of the tiger earthworm in five soil samples was hardly affected against the soil of PSI (20%) after three months treated in the upland. But after six months, survival of PSI was 80%. At present, raw material of compost was authorized by contents of organic matter, heavy metal (8 elements), and product processing according to "The specified gist on possible materials of using after analysis and investigation among raw materials of compost", however, for preparing to change regulation of raw material of compost and for considering to possibility of application, this study was conducted to investigate toxic organic compound and bioassay methods using inhabited animal, fungi, and earthworm without current regulation.