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장성동,이은희,홍명엽,문성진,김주혁,이윤관,김영준 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1
This study is purposed to analyse the effects of long-term & one-time 10km running exercise from bone metabolic marker change on bone metabolism. 7 male members(18.6±1.08) from a marathon club were subjected to the study. They were allowed to do long-term 10 km running training once a week for 6 months. And bone metabolism mark was determined according to the respective times : before/after 6 months training, before/after 10 km race, one day after the race, 3 days after the race. The examination items of bone metabolism mark were serum calcium, phosphorus, paratyroid hormone, osteocalcin, calcitonin, alkaline phosphatase in blood and calcium, phosphorus, deoxypyridinolin in urine. The results of study were as follows; 1) There was no change in deoxypyridinolin and alkaline phosphatase but there was significant change in calcitonin, paratyroid hormone and osteocalcin(p<.01). 2) There was no change of Calcium in serum and urine but there was significant change of phosphorus in blood(p<.01). To make a conclusion, it is determined that long-term 10 km running at low intensity and low frequency tends to restrict bone metabolism circulation, but exercise at a little high level activates bone metabolism into building up bones and absorbing bones and finally shows up high bone metabolism circulation, which is inferred to have an effective influence on bone health. It is considered there is a possibility that different exercise intensity, even same kind of exercise, influences on bone metabolism sdifferently.
Thermocycling이 상아질과 복합레진의 결합강도에 미치는 영향
이지연,배태성,백병주,이승영 大韓齒科器材學會 1993 대한치과재료학회지 Vol.20 No.2
The purpose of this study was to evaluate the effect of thermocycling on the tensile bond strength and marginal leakage of composite bond to dentin surface. Four kinds of dentin conditioner and adhesives including Superbond D-Liner, All-Bond 2, Prisma Universal Bond 3, and Clearfil Photobond were used for this study. Thermocycling consisted of 500 cycles, 15 seconds dwell time each in 5℃ and 55℃ bath. Tensile bond strength was measured using an Instron testing machine with a crosshead speed of 1mm/min, marginal leakage was evaluated using an image analyzer, and applicated dentin surface was observed by SEM. The results obtained were summerized as follows; 1. Tensile bond strength was 6.64 ±2.32 MPa at Superbond D-Liner group, 6.35 ±1.56 MPa at All-Bond 2 group, 4.75 ±0.95 MPa at Prisma Universal Bond 3 group and 4.66 ±1.89 MPa at Clearfil Photobond group. Superbond D-Liner group and All-Bond 2 group were larger than Clearfil Photobond group(P<0.05). 2. After thermocycling, tensile bond strength showed significant difference between All-Bond 2 group and the others, Superbond D-Liner group and clearfil Photobond group(P<0.05). 3. Marginal leakage after thermocycling of Superbond D-Liner group and All-Bond 2 group were less than Prisma Universal Bond 3 group and Clearfil Photobond group(P<0.05).
Flavobacterium meningosepticum에 의한 균혈증 1예
장성원,유진홍,진승원,김선우,김연식,박순민,이대훈,최민호,최주연,신완식,강문원,강지민 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.1
1996년 6월 카톨릭대학교 부천성가병원에 뇌경색으로 입원했던 61세 남자 환자의 혈액에서 Flavobacterium meningosepticum을 분리하였다. 환자는 폐렴을 동반한 패혈증의 예로 ceftriaxone과 metronidazole을 투여하였으나 입원 48시간만에 사망하였다. Flabovacterium meningosepticum is a rae cause of nosocomial infection which shows multi-drug resistance. It mainly invades patients with impaired immunity. Recently, we experienced a case of F. meningosepticum bacteremia in a patient with chronic debilitated state owing to stroke. The clinical progress was so rapid that he died within 48 hours. Blood culture revealed F. meningosepticum which showed characteristic yellow colony in blood agar plate.
[P479] Photosensitivity to multiple drugs: a case report
( Seung Ju Yun ),( Ji Young Lee ),( Gwang Hoon Kim ),( Tae Han Kim ),( Jong Su Hong ),( Seung Ho Lee ),( Ai-young Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Photodermatoses are group of skin disease that caused or exacerbated by light radiation. Typically, skin lesions represent a characteristic photodistribution. As a subgroup, drug induced photosensitivity were explained by photoallergy and phototoxicity. Most cases are caused by single drug, and cases with multiple drugs are rare. We report a case of photosensitivity to more than one drug. A 67-year-old man was first seen for pruritic rash on face, V-shaped area of neck, dorsum of hands from a month ago. He had been taking nebivolol, trimetazidine, isosorbide mononitrate, aspirin, rosuvastatin-ezetimibe combination for 4 years and metformin for 3 months. On phototest, minimal erythema dose (MED) to UVA and UVB were decreased as 15J/㎠ and 150mJ/㎠ respectively. Laboratory studies showed GGT 166IU/L, anti-nuclear antibody titer 1:1280, positive anti-mitochondrial antibody and negative urine porphyrin. We suspected drug induced photosensitivity and performed phototest to identify culprit drug. Despite the absence of common chemical structure, metformin and aspirin were judged to culprit drugs by discontinuing each drug for 2 weeks and performing phototest. While continuing sun protection, culprit drugs were stopped. 3 weeks later, symptoms were notably improved. 6 weeks later, trimetazidine was discontinued, and nebivolol, isosorbide mononitrate, rosuvastatin-ezetimibe combination were changed. Lesions were improving steadily thereafter.
( Ju Seung Kim ),( Young Kul Jung ),( Soo Yong Park ),( Min Young Rim ),( In Ku Yo ),( Min Su Ha ),( Ju Won Lee ),( Oh Sang Kwon ),( Yun Soo Kim ),( Duck Joo Choi ),( Ju Hyun Kim ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Back ground/Aims: In a genome wide association study, two variants in inosine triphosphatase (ITPA: rs1127354, rs7270101) gene showed to protect against ribavirin induced anemia during early stages of treatment. ITPA gene on chromosome 20, rs1127354 and rs7270101, cause ITPase deficiency and protect from hemolytic toxicity of RBV. In this present study, we aimed to evaluate the clinical significance of ITPA variants who were treated with peg-interferon and ribavirin in Korea. Methods: A total 133 patients who treated with Peg-interferon and ribavirin from January 2008 to December 2011 in Gil Hospital were genotyped at polymorphic site rs1127354 and rs7270101 on chromosome 20. Then we tested for association with Hgb reduction at week 4, 8, 12 and SVR. We investigated the impact of ITPA variants on hemoglobin level and sustained virologic response (SVR). Results: Total of 82 (61%) were genotype 1, and 51 (39%) were non-genotype 1. There was no significant difference in the age, gender, BMI, initial Hgb, ALT, HCV RNA, liver cirrhosis or not between each group. Among 133, 108 patients were CC at rs1127354 (group A) and 25 patients were non-CC at rs1127354 (group B). On the other hands, all of 133 were AA at rs7270101. The mean value of Hgb for group A and B at week 4, 8, and 12 were 12.2 vs. 14.0, 11.8 vs. 13.2, and 11.5 vs. 12.9, respectively (p < 0.05). Overall SVR was achieved in 67.8% (40/59) at genotype 1 and 75% (27/36) at non-genotype 1. As aspects ITPA variants, SVR was achieve in 55% and 50% at genotype 1 (p=0.441), 71% and 66% (p=0.861) at non-genotype 1. SVR was no significant statistical difference between group A and group B. Conclusions: Non-CC at rs1127354 without involvement of those at rs7270101 is strongly associated with protection from RBV-induced anemia. However, ITPA genotype was not associated with SVR.
P187 Study for usefulness of ultrasonography in the evaluation of skin tumor
( Seung Ju Yun ),( Gwanghoon Kim ),( Tae Han Kim ),( Nam Hee Sung ),( Seung Ho Lee ),( Ai Young Lee ),( Hyoseung Shin ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: Ultrasonography is an important modality for diagnosis of skin tumor. It is non-invasive, safe, and provides high-resolution real time images. Objectives: To evaluate the diagnostic accuracy of ultrasonography for skin tumors. Methods: We retrospectively examined data for 125 patients with skin tumors who underwent ultrasonography and biopsy at Dongguk University Ilsan Hospital between March 2013 and February 2016 Results: Ultrasonography significantly increased the diagnostic yield of skin tumors. Rates of sensitivity and specificity for the diagnosis of epidermal cyst were signficantly increased after ultrasonography than after physical exam. Additionally, rates of sensitivity and specificity for the diagnosis of pilomatricoma and lipoma were signficantly increased after ultrasonography than after physical exam. Conclusion: This study suggested that ultrasonography is a convenient and reliable tool that can be useful in the diagnosis of skin tumors.