우심방을 침범한 거대 비호지킨씨 림프종 1예

강상범,진승원,이은경,박용현,최용호,김용주,박준철,김재형,홍순조,최규보,권종범,원용순,박건,이은희 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.4

급속여과법의 여층구성과 유기오염물 제거특성

姜龍太,金相玖 동아대학교 환경문제연구소 1993 硏究報告 Vol.16 No.2

The purpose of this study was to present optimum filter configuration and removal charecteristics of TOC, THMFP and UV-254 in conventional water treatment processes furthermore the removal efficiency of algae to compare with turbidity treatment. The results of this investigation were as follow. 1. The headloss of 0.6㎜ filter media increased drastically to 180㎝ within 8hours, on the other hand the filtration time of dual layer filter was two or three times longer than that of singer layer filter. 2. Sedimentation process was effective for removing turbidity materials and organic pollutants in conventional treatment system, however the removal of those organic pollutants did not distinctively removed in filter process. 3. Algaes was removed 90~96% by settlement process and 91~98% by filter process which used the water treated by Settlement process. Scenedesmus, Cyclotella, Merosira and Fragilaria are main appearing algaes in downstream of Nak-Dong River during this experiment period. 4. It is difficult to treat soluble materials in conventional water treatment system, accordingly davanced water treatment systems are required to treat these soluble materials.

桑白皮가 皮膚癌 및 骨髓癌細胞의 細胞毒性 , NO 및 Apoptosis 에 미치는 影響

康城溶 대한본초학회 1997 大韓本草學會誌 Vol.12 No.2

The effect of Mori Cortex Radicis on the human cancer cell-lines(A431 and KHOS-NP), the regulation of immune cells and the apoptosis, nitric oxide(NO) from macrophage in mice were studied. Mori Cortex Radicis decreased human cell lines, and inhibited proliferation of splenocytes in mice. Mori Cortex Radicis decreased production of NO from macrophages in vitro and vivo. Apoptosis was increased by Mori Cortex Radicis in a dose dependent manner. Mori Cortex Radicis increased CD4+ T_H cell however did not change CD8 Tc/Ts cell sub-population in the thymocytes of mice.

오존을 이용한 하수2차 처리수의 처리 및 슬러지 감량화에 관한 연구

강용태,조용현,장성부,최선영 東亞大學校建設技術硏究所 2004 硏究論文集 Vol.28 No.1

Nowadays, most of water source is deteriorating due to depending on surface water more than 90%. New disinfection facilities are urgent because a provision of total coliforms was made newly and have gone into effect since in January 2003 for securing of water source. And waste sludge treatments is an outstanding environment question because of several reasons such as increases of waste sludge, high cost of waste sludge treatment and prohibition of sludge treatment method having been utilized. In this study, specific characteristics of ozone treatment for wastewater effluent and volume reduction of waste sludge were studied with pilot-plant. The results of the study are followed: A removal efficiencies of total-coliforms with ozone dose change of 1.6, 2.6, 3.5, 4.5gO3/m3Water were 73.7, 88.1, 95.6, 97.2% .respectively. And MLSS reduction rate of waste sludge with ozone dose change of 0.2, 0.4, 0.6, 0.8gO3/gSS were 38.0, 50.0, 57.9, 62.0%.respectively. CODMn removal efficiency of that was 50.5, 65.0, 76.6, 82.1% respectively and SV30 reduced 92.6% even if ozone dose was 0.2gO3/gSS. Therefore, it is found that ozone treatment is very effective for sludge volume reduction and solidㆍliquid separation.

해양으로 유입되는 도심 하천의 비점오염물질 특성에 관한 연구

강용태,장성부 東亞大學校 海洋資源硏究所 2005 硏究論文集 Vol.17 No.-

It is now recognized that controlling the pollution entering the rivers and coasts from non-point sources, including agricultural and urban runoffs, is of great urgency. In this paper, Quantity and quality of basins streaming down ocean were surveyed and concentration of biological oxygen demand(BOD), Chemical oxygen demand(COD), Suspended solids(SS), heavy metal, etc. were measured. The results showed that: 1. On dry weather, a quantity of Gamjeon basin is 0.18CMS in the summer but 0.11CMS in the winter. 2. Gamjeon basin's quality was represented that BOD, COD, T-N and T-P was 115mg/L(max), 163mg.L(max), 12.9~27.0mg/L, and 0.40~1.43mg/L. on the other hand the heavy metal was appeared serious pollution. Hakjang was represented that BOD and COD was 15.7~43.0mg/L, 12.0~52.9mg/L respectively. 3. During the wet weather, quantities of Gamjeon and Hakjang were peaked in one hour and pollutant loading was similar. Peak quantity of Gamjeon and Hakjang basin was 18CMS and 25.25CMS. 4. Gamjeon basin's quality was represented that maximum BOD concentration was 250mg/L and DO concentration of Hakjang basin was 0.64~13.2mg/L. Heavy metal concentrations of Eomgung area was over the guide line;Cd and Cr^(+6) were estimated to be 0.1mg/L and 0.197mg/L. 5. It is clear that runoff load by urban non-point source pollutants plays important role in the control and management of non-point sources for the watershed.

數種 漢藥材가 肝癌細胞(Hep G2)와 마우스 腹腔 大食細胞에 미치는 影響

康城溶,韓宗鉉,趙南根 대한본초학회 1997 大韓本草學會誌 Vol.12 No.1

The action mechanism of herb drugs on the cytotoxicity and apoptosis in tumors undoubtedly are diverse. Apoptosis often is particularly prominent near foci of confluent necrosis, where mild ischemia is likely to be involved in its initiation. Apoptosis in tumors found in living body is occured by cytokines released from macrophage or cytotoxic T-lymphocyte, but the mechanism is not known accurately. A variety of cancer chemotherapeutic agents have been shown to induce extensive apoptosis in rapidely proliferating normal cell population, lymphoid tissues and tumors. The way in which anti-cancer drugs induce apoptosis is unknown. However, there is an additional important consequence of the realization that anti-cancer drugs mediate their therapeutic affects by triggering apoptosis. The activated macrophage can selectively destroy tumor cells Therefore, macrophage-mediated tumor cytotoxicity can have a important significance. Recently, it has been reported that some crude drugs stimulates IFN-v production in T-lymphocyte, and IFN-v stimulate nitric oxide production in peritoneal macrophage. The nitric oxide can affect the cytotoxicity and apoptosis in tumor cells. In this study, antineoplastic activity against human hepatocellular carcinoma cell line(Hep G2) was tested in four species of herb drugs. The plant materials were extracted with water, and the cytotoxic activity was tested using a calorimetric tetrazolium assay(MTT assay), the apoptosis was tested using a DNA electrophoresis and flow cytometry. The nitric oxide production from mouse peritoneal macrophage was tested using a Griess method. The four species of herb drugs were Arisaemitis Tuber, Bupleuri Radix and Coptidis Rhizoma extracts against the proliferation of Hep G2 cells showed cytotoxicity at the concentration of less than 100ug/㎖, and Bupleuri Radix and Coptidis Rhizoma extracts increased the cytotoxicity of mitomycin C and Coptidis Rhizoma extracts increased the cytotoxicity of cisplatin on Hep G2 cells. Bupleuri Radix and Coptidis Rhizoma extracts against the proliperation of BALB/c 3T3 cells showed cytotoxicity, and Coptidis Rhizoma extracts aginist the proliperation of mouse thymocytes showed cytotoxicity at the concentration of less than 100ug/㎖. Arisaemitis Tuber extracts increased nitric oxide production from macrophage.

최초 침전지를 대체하기 위한 고속생물막 침전지의 특성에 관한 연구

강용태,장성부,조용현 동아대학교 건설기술연구소 2003 硏究報告 Vol.27 No.1

It is not easy to find reasonable area for construction of wastewater treatment facility. and biological treatment such as a conventional activated sludge process can't remove non-point source pollutant in initial rainfall, sufficiently. So if we use physical treatment and disinfection process, combined sewer overflows don't cause significant pollution. In this study, to reduce area of wastewater treatment facility, the rapid biofilm clarifier was configurated and its characteristics were analyzed according to the velocity of filtration and cycles of backwash. Specific characteristics of the rapid biofilm clarifier with 50 ㎥/d of volume were represented that Turbidity and SS removal rate was 30.2%, 30.9% respectively, and that of BOD and COD was 22.0%, 21.0% without regard to change of quality of raw water. By comparing the rapid biofilm clarifier and clarifier of conventional activated sludge process with having 50 ㎥/㎡·d, of surface-loading rate and 2.0 m of depth, we could know the rapid biofilm clarifier could reduce area of clarifier 11 times as much than that of conventional activated sludge process. Cycle of backwash was represented as 24, 18, and 24 hours when velocity of filtration was 222 ㎥/㎡·d, 333 ㎥/㎡·d, and 555 ㎥/㎡·d, and BOD. SS biologically removed in the rapid biofilm clarifier was 342.80, 346.82 g/d, 258.08, 222.72 g/d, and 143.36, 136.52 g/d respectively.

혈청 neuron specific enolase를 이용한 심정지후 신경학적 예후의 예측

강용선,정성필,박기일,김승환,김태승,이한식 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: The purpose of this study was to determine that the assessment of serum neuron specific enolase(NSE) could provide a reliable early predictor of neurologic outcome after cardiac arrest. Methods: Prospective, observational study was performed from April 1996 to March 1998 at a university teaching hospital ED. Serum NSE concentrations were analysed twice at 24 and 48 hours after return of spontaneous circulation(ROSC). Neurologic outcome was categorized using cerebral performance category(CPC). Results: Twenty-nine patients(16 were men) were enrolled during the study period. The mean age was 50.8 years. Nine(31%) of them showed good outcome defined as CPC 1-3, and 20(69%) patients showed bad outcome defined as CPC 4-5. In the good outcome group, the serum NSE was revealed 33.8±9.3 ng/ml at 24 hours, 34.0±4.73 ng/ml at 48 hours. While in the bad outcome group, it was 99.5±11.7 ng/ml and 114.6±15.8 ng/ml. The NSE at 48hr after ROSC was more prescise than that of 24hr. When the cutoff value of 50 ng/ml at 48hr, the sensitivity was 82%, and specificity was 93%. Conclusion: This study suggest that the serum NSE may represent a valuable, noninvasive, and useful clinical tool for prediction of neurologic outcome after cardiac arrest.

Paraquat lung에서 Fibronectin 분포에 관한 연구

강상균,양승하,김대중,김의한,김성용 순천향의학연구소 1996 Journal of Soonchunhyang Medical Science Vol.2 No.1

To investigate the process of the Paraquat induced pulmonary fibrosis, 10 mg/Kg and 20mg/kg of paraquat was administered intraperitoneally each of 10 rats respectively. Three, five, seven, ten and fifteen days after this injection, the rats were sacrificed. Immunohistochemical studies for fibronectin and histologic studies were carried out. Results were as follows. 1. Toxic effect of the paraquat seems to be depend on the dose of administered paraquat since the groups of the rate treated with 10 mg/kg revaled no significant tissue damage after 7 days. 2. The pulmonary changes seen in 20 mg/Kg treated group could be classified into two stages: the early changes such as hemorrhage, edema and hyaline membrane formation which are similar to the findings observed in adult respiratory distress syndrome and the late change characterized by fibrosis which observed in mild degree even after 2 weeks, so the fibrosis seen to need more time for full blown. 3. The positivity of fibronectin were observed in macrophage and exudate in the early stage of tissue destruction that the fibronectin productin is preceded fibrosis and plays an important role for the collection of inflammatory cells such as macrophaques and fiboblasts. The more tissue desturction is severe, the more strong positivity of fibronectin was observed in the early stage of tissue destruciton.

액체-고체 순환유동층에서 액상의 반경 방향 혼합 및 액체-고체 Chaotic 흐름 거동

강석환,이찬기,송평섭,강용,김상돈,김승재 한국화학공학회 2004 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.42 No.2

직경이 0.102m이고 높이가 3.5m인 액체-고체 순환유동층의 상승관에서 압력요동 및 액체의 반경 방향 혼합 특성을 고찰하였다. 상승관에서 얻은 압력요동을 해석하기 위하여 chaos 이론을 도입하였다. 액체 유속, 유동입자의 크기 그리고 고체 유동입자의 순환속도가 연속액상의 반경방향 분산계수 및 압력요동의 위상공간투영과 상관차원에 미치는 영향을 결정하였다. 본 연구의 결과 액상의 반경방향 분산계수는 유동입자의 크기와 순환속도가 증가함에 따라 증가하였으며 액상의 유속이 증가함에 따라 감소하였다. 상승관에서 압력요동의 위상공간투영은 유동입자의 크기가 고체 유동입자의 순환속도가 증가함에 따라 점점 분산되고 복잡하게 되었으나, 액체유속이 증가함에 따라서는 위상공간에서 궤적의 분산이 다소 감소하는 경향을 나타내었다. 압력요동의 상관차원은 유동입자의 크기와 고체 순환속도가 증가함에 따라 증가하였으나, 액체의 유속이 증가함에 따라서는 큰 변화가 없었다. 본 연구의 결과는, 상승관에서 액상의 반경 방향 혼합 특성 압력요동 측정함으로써 실시간으로 예측하는 것을 가능하게 하여 실제공정에 응용함으로써 그 실용적 측면이 크다고 하겠다. Characteristics of pressure fluctuations and liquid dispersion in the radial direction were investigated in the riser of a liquid-solid circulating fluidized bed whose diameter was 0.102m and 3.5m in height. The concept of chaos theory was employed to analyze the pressure fluctuations obtained in the riser. Effects of liquid velocity, particle size, and solid circulation rate on the liquid radial dispersion coefficient and phase space portraits and correlation dimension of pressure fluctuations were determined. It was found that the radial dispersion coefficient of liquid phase increased with increasing particle size or solid circulation rate, but decreased with increasing liquid velocity. The attractor in the phase space portraits became more scattered and complicated with increasing particle size or solid circulation rate, but it became somewhat less scattered with increasing liquid velocity. The correlation dimension of pressure fluctuations increased with increasing particle size or solid circulation rate, but it did not change considerably with increasing liquid velocity. The results of this study enable us to predict the characteristics of liquid radial dispersion by means of the pressure fluctuations for the practical applications.