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Chen, Nai-Zhi,Zhang, Xiu-Qing,Wei, Peng-Cheng,Chen, Qi-Jun,Ren, Fei,Chen, Jia,Wang, Xue-Chen Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.6
The HAP complex has been found in many eukaryotic organisms. HAP recognizes the CCAAT box present in the promoters of 30% of all eukaryotic genes. The HAP complex consists of three subunits - HAP2, HAP3 and HAP5. In this paper, we report the biological function of the AtHAP3b gene that encodes one of the HAP3 subunits in Arabidopsis. Compared with wild-type plants, hap3b-1 and hap3b-2 mutants exhibited a delayed flowering time under long-day photoperiod conditions. Moreover, the transcription levels of FT were substantially lower in the mutants than in the wild-type plants. These results imply that AtHAP3b may function in the control of flowering time by regulating the expression of FT in Arabidopsis. In a subsequent study, AtHAP3b was found to be induced by osmotic stress. Under osmotic stress conditions, the hap3b- 1 and hap3b-2 mutants flowered considerably later than the wild-type plants. These results suggest that the AtHAP3b gene plays more important roles in the control of flowering under osmotic stress in Arabidopsis.
Dexmedetomidine (DEX) is an anesthetic that is widely used in the clinic, and it has been reported to exhibit paradoxical effects in the progression of multiple solid tumors. In this study, we sought to explore the mechanism by which DEX regulates hepatocellular carcinoma (HCC) progression underlying liver ﬁbrosis. We determined the effects of DEX on tumor progression in an orthotopic HCC mouse model of ﬁbrotic liver. A coculture system and a subcutaneous xenograft model involving coimplantation of mouse hepatoma cells (H22) and primary activated hepatic stellate cells (aHSCs) were used to study the effects of DEX on HCC progression. We found that in the preclinical mouse model of liver ﬁbrosis, DEX treatment signiﬁcantly shortened median survival time and promoted tumor growth, intrahepatic metastasis and pulmonary metastasis. The DEX receptor (ADRA2A) was mainly expressed in aHSCs but was barely detected in HCC cells. DEX dramatically reinforced HCC malignant behaviors in the presence of aHSCs in both the coculture system and the coimplantation mouse model, but DEX alone exerted no signiﬁcant effects on the malignancy of HCC. Mechanistically, DEX induced IL-6 secretion from aHSCs and promoted HCC progression via STAT3 activation. Our ﬁndings provide evidence that the clinical application of DEX may cause undesirable side effects in HCC patients with liver ﬁbrosis.
This paper presents a method for assessing the risk of wave run-up and overtopping of existing coastal defences and for analysing the probability of failure of the structures under future hydraulic conditions. The recent UK climate projections are employed in the investigations of the influence of changing environments on the long-term performance of sea defences. In order to reduce the risk of wave run-up and overtopping caused by rising sea level and to maintain the present-day allowances for wave run-up height and overtopping discharge, the future necessary increase in crest level of existing structures is investigated. Various critical failure mechanisms are considered for reliability analysis, i.e., erosion of crest by wave overtopping, failure of seaside revetment, and internal erosions within earth sea dykes. The time-dependent reliability of sea dykes is analysed to give probability of failure with time. The results for an example earth dyke section show that the necessary increase in crest level is approximately double of sea level rise to maintain the current allowances. The probability of failure for various failure modes of the earth dyke has a significant increase with time under future hydraulic conditions.
This paper studies the tracking control problem of hypersonic vehicle in the process of external disturbance, parameters uncertainties and actuator faults. Firstly, a non-triangular velocity and altitude nonlinear subsystem with mismatched disturbances and actuator faults are established based on the feedback linearization model. Secondly, adaptive dynamic surface fault-tolerant controllers are designed for velocity and altitude subsystems by combining nonlinear filter, adaptive control and back-stepping method. Finally, the Lyapunov stability theory and numercial simulation are carried out to verify the availability of the proposed control strategy.
Bacterial cellulose (BC), which is produced by bacteria, has unique and desirable structural, physical and chemical properties. The production process and intrinsic properties of BC have been widely investigated. Recently, these studies have focused on functionalized BC materials and BC-based composites, where BC is used as a substrate. Following this trend, this paper provides general information about cellulose as well as BC cultivation and its properties. The recent advances in BC modification methods and the properties of current BC-based composites are also emphatically reviewed. The potential for further BC work is also examined.
Colorectal cancer has become a major disease threatening human health. To establish animal models that exhibit the characteristics of human colorectal cancer will not only help to study the mechanisms underlying the genesis and development effectively, but also provide ideal carriers for the screening of medicines and examining their therapeutic effects. In this study, we established a stable, colon cancer nude mouse model highly expressing green fluorescent protein (GFP) for spontaneous metastasis after surgical orthotopic implantation (SOI). GFP-labeled colon cancer models for metastasis after SOI were successfully established in all of 15 nude mice and there were no surgery-related complications or deaths. In week 3, primary tumors expressing GFP were observed in all model animals under fluoroscopy and two metastatic tumors were monitored by fluorescent imaging at the same time. The tumor volumes progressively increased with time. Seven out of 15 tumor transplanted mice died and the major causes of death were intestinal obstruction and cachexia resulting from malignant tumor growth. Eight model animals survived at the end of the experiment, 6 of which had metastases (6 cases to mesenteric lymph nodes, 4 hepatic, 2 pancreatic and 1 mediastinal lymph node). Our results indicate that our GFP-labeled colon cancer orthotopic transplantation model is useful with a high success rate; the transplanted tumors exhibit similar biological properties to human colorectal cancer, and can be used for real-time, in vivo, non-invasive and dynamic observation and analysis of the growth and metastasis of tumor cells.
This article focuses on the relationship among culture identity, power to influence tourism, institution trust, tourism support and tried to build a model to examine the connections between them. Based the collecting data from Chinese local community, using a structural equation modeling (SEM) and this paper found that: First, community residents? culture identity has a negative effect on their trust on tourism institutions but a positive effect on tourism support. And community residents? power to influence tourism has a positive effect on their institution trust and tourism support. Specially, residents’ institution trust exhibited a significantly positive effect on their tourism support. This finding recommends increased attention to the tourism support of Chinese local residents and also suggest that institution should become more trustworthy and professional.
Fractured horizontal wells have been widely used in tight reservoirs. The distribution of the formation pressure is related to the fracturing design, well pattern optimization and development effect. In addition, there is generally a stress sensitivity effect in tight reservoirs, which makes the pressure distribution more complex. Therefore, it is necessary to analyze the formation pressure distribution in the development process of tight reservoirs by fractured horizontal wells. In this paper, using the Pedrosa transform, perturbation transform, Green formula and boundary element method, a pressure calculation model is first built and solved for a stress-sensitive reservoir with a multistage fractured horizontal well. Second, comparing the bottom hole pressure of this method with those of existing tight reservoir models illustrates the accuracy of this model. Finally, pressure contours with different permeability moduli and boundaries are obtained by solving the seepage model. The results indicate that this model can conveniently calculate the pressure at any position in stress-sensitive reservoirs with arbitrary boundaries. The pressure contours show that the stress-sensitive effect occurs mainly near the wellbore and affects the pressure distribution of this region. The results have a certain significance for fracturing design and well pattern optimization, which is beneficial for improving the development efficiency of tight oil reservoirs.
Background: The high recurrence rate after hepatic resection in hepatocellular carcinoma (HCC) is a major obstacle to improving prognosis. The objective of the present study was to explore the function of genistein, a soy-derived isoflavone, in enhancing the inhibitory effect of cisplatin on HCC cell proliferation and on tumor recurrence and metastasis in nude mice after curative hepatectomy. Methods: Proliferation of human HCC cells (HCCLM3) was detected by 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) assay. Synergistic effects of genistein and cisplatin were evaluated with the median-effect formula. Nude mice bearing human HCC xenografts underwent tumour resection (hepatectomy) 10 days post implantation, then received intraperitoneal administration of genistein or cisplatin alone or the combination of the two drugs. 33 days after surgery, recurrent tumours and pulmonary metastasis were evaluated individually. MMP-2 level in recurrent tumours was detected by immunohistochemistry and real-time PCR; MMP-2 expression in HCCLM3 was detected by immunocytochemistry. Results: Genistein and cisplatin both suppressed the growth and proliferation of HCCLM3 cells. The two drugs exhibited synergistic effects even at relatively low concentrations. In vivo, mice in the combined genistein and cisplatin group had a smaller volume of liver recurrent tumors and fewer pulmonary metastatic foci compared with single drug treated groups. Cisplatin upregulated the expression of MMP-2 in both recurrent tumours and HCCLM3, while genistein abolished cisplatin-induced MMP-2 expression. Conclusions: Genistein reinforced the inhibitory effect of cisplatin on HCC cell proliferation and tumour recurrence and metastasis after curative hepatectomy in nude mice, possibly through mitigation of cisplatin-induced MMP-2 upregulation.