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      • KCI등재후보

        Major clinical research advances in gynecologic cancer in 2010

        서동훈,김재원,김기동,강순범 대한부인종양학회 2010 Journal of Gynecologic Oncology Vol.21 No.4

        This review summarizes 11 major clinical research advances in gynecologic oncology in 2010. For ovarian cancer,bevacizumab as a leading molecular targeted agent, pegylated liposomal doxorubicin in recurrent disease, the role of neoadjuvant chemotherapy in an advanced setting, an effective screening method, and ARID1A mutations as a clue to the origin of clear cell carcinoma are mentioned. For cervical cancer, confirmation of the efficacy and the introduction of a self collection method of the human papillomavirus (HPV) test, and the association between the HPV vaccine and miscarriage are examined. For endometrial cancer, the superiority of laparoscopy in staging operation, the role of vaginal brachytherapy in an adjuvant setting, and the effect of para-aortic lymph node dissection are reviewed. In addition, the trend of geriatric oncology and chemotherapy in carcinosarcomas is also assessed.

      • KCI등재

        쇄골밑정맥 카테터삽입 시 천자 횟수를 증가시키는 요인

        서동훈,강희철,윤방부,오동희,서희선,조경희,김경곤 대한가정의학회 2006 Korean Journal of Family Medicine Vol.27 No.4

        연구배경: 중심 정맥 카테터삽입은 중심 정맥압의 측정, 수액과 혈액의 빠른 주입, 고단위 영양수액의 투여뿐만 아니라 패혈증상, 심장성 및 혈액량 감소 쇼크의 치료, 혈관 작용성 약제의 투여 등에 널리 이용되어 왔다. 중심 정맥 카테터삽입 시 흔히 발생하는 기계적 합병증은 동맥천자, 혈종, 기흉, 혈흉이 있으며, 이러한 합병증을 줄일 수 있는 관련 요소들을 알아내고자 본 연구를 시행하였다. 방법: 2003년 9월 1일부터 11월 30일까지 일산병원에서 쇄골밑정맥 카테터삽입을 시술한 가정의학과 전공의를 대상으로 시술 직후 시행한 설문을 통해 40예의 쇄골밑정맥 카테터삽입에 대한 정보를 수집하여 1, 2회만 시도한 경우와 3회 이상 시도한 경우, 각각 두 군으로 분류하여 연관된 요인을 분석하였다. 결과: 천자 횟수가 3회 미만인 경우가 23건이었고, 3회 이상인 경우가 17건이었다. 천자 횟수가 3회 미만인 경우와 3회 이상인 군을 비교했을 때 통계학적으로 유의한 차이를 보였던 요소는 환자의 혈색소 수치, 환자의 해부학적 이상 유무, 과거 술기 경험 횟수(20회), 시술 전 천자부위 표시하기(puncture site marking), 삽입위치(쇄골 정중앙선)이다. (P<0.05). 결론: 쇄골밑정맥 삽관 시 합병증을 줄이기 위해선 천자 횟수를 3회 미만으로 줄이는 것이 바람직한데, 이에 영향을 미치는 시술자 요소는 풍부한 술기 경험과 시술 전 천자부위 표시하기, 쇄골정중앙선에서의 삽입이다. Factors Attributing to Increasing Attempts at Central Venous CatheterizationDong Hoon Suh, M.D., Dong Hee Oh, M.D., Hee Sun Seo, M.D.*, Kyung Hee Cho, M.D., Ph.D.*, Kyoung Kon Kim, M.D.†, Hee Cheol Kang, M.D., Ph.D., Bang Bu Youn, M.D., Ph.D.

      • KCI등재후보

        Fifteen-year Results of Precoated Femoral Stem in Primary Hybrid Total Hip Arthroplasty

        서동훈,Ho Hyun Yun,Sung Kwang Chun,손원용 대한정형외과학회 2013 Clinics in Orthopedic Surgery Vol.5 No.2

        Background: There has been controversy whether methylmethacrylate precoating of the cemented femoral stem is a solution for aseptic loosening or rather contributes to increased failure rates in cemented total hip arthroplasties. Methods: On a retrospective basis, we analyzed 76 primary hybrid total hip arthroplasties from 63 patients with precoated, cemented femoral stems between October 1990 and December 1995. The mean age of the patients was 46.8 years (range, 22 to 77 years) with a minimum follow-up of 14 years (mean, 15.5 years; range, 14 to 19.5 years). Third generation cementing techniques were employed in all cases. Results: Twenty-four out of 76 cases (31.6%) showed aseptic loosening of the femoral stems, of which 23 stems were revised at an average revision time of 8 years (range, 3 to 14.8 years). The main mode of loosening was cement-stem interface failure in 22 hips (91.7%). Twenty-one out of 24 failed hips (87.5%) demonstrated C2 cementing grades (p < 0.001). Kaplan-Meier survivorship analysis using radiographic aseptic loosening of the femoral stem as the endpoint for failure showed survival rates of 76.5% at 10 years (95% confidence interval [CI], 71.4 to 81.6) and 63.2% at 19 years (95% CI, 57.3 to 69.1). Conclusions: An early failure of the precoated femoral stem in this study was mainly due to an insufficient cementing technique. Achievement of good cement mantle may improve the survival rates.

      • KCI등재

        샌드위치패널 벽면보호용 스프링클러설비 적용 실험

        서동훈,김운형,김종훈,이영재 한국화재소방학회 2017 한국화재소방학회논문지 Vol.31 No.5

        국내 샌드위치패널 건축물은 공장·창고시설의 벽·지붕에 널리 사용된다. 공장·창고시설은 용도특성상 화재하중이높고 화재확산이 신속히 진행되어 대형화재로 이어지며 재료특성 상 벽 · 지붕이 무너져 인명피해 및 재산피해가 증가하고 있는 추세이다. 이를 위하여 본 연구에서는 샌드위치패널 스프링클러설비의 국내·외 관련기준을 검토하였다. 현장조사결과 가연물이 벽면에 밀착되어있는 경우가 있어 벽면으로부터 10 cm, 60 cm, 120 cm 이격하여 벽면보호여부를 확인하는 실험을 수행하였다. 화재실험결과, 방수압력 0.1 MPa, 방수량 K-80의 헤드 설치 시, 샌드위치패널착화방지를 확인하였다. 또한 가연물이 벽면으로부터 60 cm일 때 샌드위치패널벽면의 최고온도가 525 ℃, 120 cm에서는 최고온도가 276 ℃로 측정되었다. 한편, 국외소방연구기관의 EPS 샌드위치패널연구에 따르면 발화점이 4 Domestic sandwich panel buildings are widely used on walls and roofs of factories and warehouse facilities. Factory andwarehouse facilities have high fire load and rapid spread of fire due to their use characteristics, leading to large fires. Dueto the characteristics of materials, walls and roofs are collapsed, resulting in life damage and property damage. In this regard,this study examined domestic and international standards of sprinkler facilities to prevent ignition of sandwich panel walls. Also, in order to check whether the fire was prevented by installing the head on the wall of the sandwich panel, the fire testwas carried out with 10 cm, 60 cm, and 120 cm from the wall along the sprinkler head installation standard of domestic firesafety standards. As a result of the fire test, it was confirmed that the sandwich panel was prevented from igniting when thehead of water pressure 0.1 MPa and water quantity K-80 was installed. According to the separation distance, it was impossibleto measure the temperature at 10 cm, but at 60 cm, At the maximum temperature of 525 ℃ and 120 cm, the maximumtemperature of the wall of the sandwich panel was measured as 276 ℃. As a result of the fire test, considering the fire pointof 450 degrees Celsius in the fire test of the sandwich panel, the distance from the sandwich panel wall to the combustibleis more than 120 cm.

      • KCI등재

        Major clinical research advances in gynecologic cancer in 2016: 10-year special edition

        서동훈,김미선,김기동,김학재,이경훈,김재원 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.3

        In 2016, 13 topics were selected as major research advances in gynecologic oncology. For ovarian cancer, study results supporting previous ones regarding surgical preventive strategies were reported. There were several targeted agents that showed comparable responses in phase III trials, including niraparib, cediranib, and nintedanib. On the contrary to our expectations, dose-dense weekly chemotherapy regimen failed to prove superior survival outcomes compared with conventional triweekly regimen. Single-agent non-platinum treatment to prolong platinum-free-interval in patients with recurrent, partially platinum-sensitive ovarian cancer did not improve and even worsened overall survival (OS). For cervical cancer, we reviewed robust evidences of larger-scaled population-based study and cost-effectiveness of nonavalent vaccine for expanding human papillomavirus (HPV) vaccine coverage. Standard of care treatment of locally advanced cervical cancer (LACC) was briefly reviewed. For uterine corpus cancer, new findings about appropriate surgical wait time from diagnosis to surgery were reported. Advantages of minimally invasive surgery over conventional laparotomy were reconfirmed. There were 5 new gene regions that increase the risk of developing endometrial cancer. Regarding radiation therapy, Post-Operative Radiation Therapy in Endometrial Cancer (PORTEC)-3 quality of life (QOL) data were released and higher local control rate of image-guided adaptive brachytherapy was reported in LACC. In addition, 4 general oncology topics followed: chemotherapy at the end-of-life, immunotherapy with reengineering T-cells, actualization of precision medicine, and artificial intelligence (AI) to make personalized cancer therapy real. For breast cancer, adaptively randomized trials, extending aromatase inhibitor therapy, and ribociclib and palbociclib were introduced.

      • KCI등재후보

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