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Xue, Lu-Chen,Xu, Zhi-Wen,Wang, Kun-Hao,Wang, Ning,Zhang, Xiao-Xu,Wang, Shang Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.2
Genes and microRNAs (miRNAs) have important roles in human oncology. However, most of the biological factors are reported in disperse form which makes it hard to discover the pathology. In this study, genes and miRNAs involved in human endometrial cancer(EC) were collected and formed into regulatory networks following their interactive relations, including miRNAs targeting genes, transcription factors (TFs) regulating miRNAs and miRNAs included in their host genes. Networks are constructed hierarchically at three levels: differentially expressed, related and global. Among the three, the differentially expressed network is the most important and fundamental network that contains the key genes and miRNAs in EC. The target genes, TFs and miRNAs are differentially expressed in EC so that any mutation in them may impact on EC development. Some key pathways in networks were highlighted to analyze how they interactively influence other factors and carcinogenesis. Upstream and downstream pathways of the differentially expressed genes and miRNAs were compared and analyzed. The purpose of this study was to partially reveal the deep regulatory mechanisms in EC using a new method that combines comprehensive genes and miRNAs together with their relationships. It may contribute to cancer prevention and gene therapy of EC.
Chen, Nai-Zhi,Zhang, Xiu-Qing,Wei, Peng-Cheng,Chen, Qi-Jun,Ren, Fei,Chen, Jia,Wang, Xue-Chen Korean Society for Biochemistry and Molecular Biol 2007 Journal of biochemistry and molecular biology Vol.40 No.6
The HAP complex has been found in many eukaryotic organisms. HAP recognizes the CCAAT box present in the promoters of 30% of all eukaryotic genes. The HAP complex consists of three subunits - HAP2, HAP3 and HAP5. In this paper, we report the biological function of the AtHAP3b gene that encodes one of the HAP3 subunits in Arabidopsis. Compared with wild-type plants, hap3b-1 and hap3b-2 mutants exhibited a delayed flowering time under long-day photoperiod conditions. Moreover, the transcription levels of FT were substantially lower in the mutants than in the wild-type plants. These results imply that AtHAP3b may function in the control of flowering time by regulating the expression of FT in Arabidopsis. In a subsequent study, AtHAP3b was found to be induced by osmotic stress. Under osmotic stress conditions, the hap3b- 1 and hap3b-2 mutants flowered considerably later than the wild-type plants. These results suggest that the AtHAP3b gene plays more important roles in the control of flowering under osmotic stress in Arabidopsis.
Xue-Lin Wang,Feng Chen,Lei Wang,Ke-Ming Wang 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.-
Planar waveguides have been fabricated in z-cut lanthanum gallium silicate (LGS) crystal by 6.0 MeV oxygen-ionsimplantation with a dose of 6×10^15 ions/cm². The waveguides were characterized by the prism-coupling method. The dark modes are measured before and after annealing at 600, 700, 750 and 800℃ for different times in air. The refractive index profiles are reconstructed by using a reflectivity calculation method. TRIM'98 code is used to simulate the process of the oxygen-ion implantation into LGS. It is found that the refractive-index change may be partly due to the damage induced by nuclear collision, and the waveguide has thermal stability below 600℃. Planar waveguides have been fabricated in z-cut lanthanum gallium silicate (LGS) crystal by 6.0 MeV oxygen-ionsimplantation with a dose of 6×10^15 ions/cm². The waveguides were characterized by the prism-coupling method. The dark modes are measured before and after annealing at 600, 700, 750 and 800℃ for different times in air. The refractive index profiles are reconstructed by using a reflectivity calculation method. TRIM'98 code is used to simulate the process of the oxygen-ion implantation into LGS. It is found that the refractive-index change may be partly due to the damage induced by nuclear collision, and the waveguide has thermal stability below 600℃.
Feng Chen,Xue-Lin Wang,Ke-Ming Wang,Zhen-Xiang Cheng,Huan-Chu Chen,Ding-Yu Shen 한국진공학회(ASCT) 2002 Journal of Korean Vacuum Science & Technology Vol.6 No.2
NaEr(WO₄)₂ is a new laser material. The planar optical waveguide was formed in NaEr(WO₄)₂ crystal by 2.6 MeV He^+ ion implantation at doses of 1.0-1.5×10^(16) ions/㎤ at room temperature. The effective refractive indices of the dark modes were measured using the prism coupling method. Four TE modes and five TM modes were observed in the waveguide. The refractive index profiles were analyzed using the reflectivity calculation method (RCM). The influence of heat treatment at moderate temperature on the refractive index profiles of the waveguide was also investigated. We used the TRIM’98 (Transport of Ions in Matter) code to simulate the damage profile in the NaEr(WO₄)₂ crystal by 2.6 MeV He^+ ion implantation which is helpful for a better understanding of the waveguide formation.
Tri-metal-based hollow nanorods-on-microrod arrays as efficient water splitting electrocatalysts
Jianzhi Wang,Hongliang Yu,Xianming Wang,Chen Chen,Shuaijie Li,Ning Cai,Weimin Chen,Yanan Xue,Hui Li,Faquan Yu 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.105 No.-
Constructing ordered hierarchical porous electrocatalysts while maintaining their high efficiency and stabilityfor oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) is highly desirable butstill remains challenging. Herein, hierarchical tri-metal-based hollow nano/micro rod-on-rod array structures,including hydroxides and phosphates, are vertically grown on Cu foam by the cation-exchangingand anion exchanging approaches. Such ordered porous architecture, providing multi metal center, regularinterconnection of macropore channel, large electrochemical surface area, small charge-transferresistance, efficient mass transport and electron transfer for overall water splitting in alkaline media. These obtained hydroxide OER catalysts (CoMn LDH@Cu(OH)2/CF) and phosphide HER catalysts(CoMnP@Cu3P/CF) exhibited low onset potential, low Tafel slope, and prominent durability. Such excellentperformance, ordered porous structure and simple preparation methods indicate that this study providesa new strategy for assembling promising catalysts for water splitting and other applications.
Preparation of Silver Nanocap Arrays and Their Surface-enhanced Raman Scattering Activity
Chunxu Wang,Duo Xu,Yuhai Wang,Li Wang,Lei Chen,Xiangxin Xue,Zhengkun Qin 대한화학회 2017 Bulletin of the Korean Chemical Society Vol.38 No.10
In this article, a surface-enhanced Raman scattering (SERS) substrate of silver nanocap arrays was reported. With increasing the size of nanocaps, the localized surface plasmon resonance (LSPR) of the arrays exhibited tunable ability in the visible spectral region. The optical response of the nanocap arrays stimulated their use in SERS experiments. The assessment of SERS activity of the nanocap arrays was performed by using the 514.5 nm excitation line, and different average enhancement factor (EF) values were obtained. The good tunability of LSPR, relatively high average EF values and long-range order of these substrates suggest that the silver nanocap arrays have promising applications as functional components in spectroscopy, immunoassay, biosensors, and biochips.
NEW FORM OF INDUSTRIAL FREQUENCY WATTMETER BASED ON DOUBLE THREE SLOPE PRINCIPLE
Wei, Wang Xue,Sheng, Fei Zheng,Chen, Liu Bei,Lin, Wang 대한전자공학회 1992 HICEC:Harbin International Conference on Electroni Vol.1 No.1
This paper proposes a double three slope multiplying A/D converter and introduces the new A/D converter application with sample/hold technique and microprocessor in the field of industrial power measurement. The new A/D converter has low price. The wattmeter based on the new A/D converter and microprocessor now is used, its precision is better than 0.1%.
RBPJ contributes to acquired docetaxel resistance in prostate cancer cells
Li Xue,Zhenlong Wang,Hecheng Li,Zhaolun Li,Qi Chen,Peng Zhang,Haiwen Chen,Ziming Wang,Tie Chong,T. Chong 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.3
Our previous work has shown that depletion of recombination signal-binding protein J (RBPJ) results in reduced cell growth in prostate cancer cells. In this study, we aimed to investigate the function of RBPJ in the chemoresistance of prostate cancer. The expression of RBPJ was quantified in docetaxel-resistant and parental prostate cancer cells. Loss- and gainof- function experiments were conducted to explore the regulatory role of RBPJ in prostate cancer sensitivity to docetaxel. The pro-apoptotic effect of RBPJ silencing was checked in docetaxel-resistant prostate cancer cells. We found that docetaxel-resistant PC3-DR and DU145- DR cells expressed 3-5-fold high levels of RBPJ than parental PC3 and DU145 cells. Short hairpin RNAmediated knockdown of RBPJ inhibited cell proliferation and colony formation and reversed docetaxel resistance in docetaxel-resistant prostate cancer cells. In contrast, overexpression of RBPJ promoted cell growth, colony formation, and docetaxel resistance in parental prostate cancer cells. Downregulation of RBPJ induced apoptosis in docetaxel-resistant cells, which was accompanied by enhanced cleavage of caspase-3. In addition, RBPJ silencing or overexpression markedly modulated the expression of the Bcl-2 family members including Bcl-2, Bcl-xL, Mcl-1, Bax, and Bak. Altogether, RBPJ contributes to acquisition of docetaxel resistance in prostate cancer cells and may thus represent a potential target for overcoming chemotherapeutic resistance in this malignancy.
Liu, Xue-Ou,Huang, Yu-Bei,Gao, Ying,Chen, Chuan,Yan, Ye,Dai, Hong-Ji,Song, Feng-Ju,Wang, Yao-Gang,Wang, Pei-Shan,Chen, Ke-Xin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
Background: Evidence for associations between dietary factors and breast cancer risk is inconclusive among Chinese females. To evaluate this question, we conducted a systematic review of relevant case-control and cohort studies. Methods: Studies were systematically searched among 5 English databases (PudMed, ScienceDirect, Wiley, Clinicaltrials.gov, and Cochrane) and 3 Chinese databases (CNKI, WanFang, and VIP) until November 2012. Random effects models were used to estimate summary odds ratios (ORs) and the corresponding 95% confidence intervals (CIs). Results: Thirty one case-control studies and two cohort studies involving 9,299 cases and 11,413 controls were included. Consumption of both soy and fruit was significantly associated with decreased risk of breast cancer, with summary ORs of 0.65 (95% CIs: 0.43-0.99; I2=88.9%, P<0.001; N=13) and 0.66 (95% CIs: 0.47-0.91; $I^2$=76.7%, P<0.001; N=7), respectively. Consumption of fat was significantly associated with increased risk of breast cancer (OR=1.36; 95% CIs: 1.13-1.63; $I^2$=47.9%, P=0.088; N=6). There was nonsignificant association between consumption of vegetables and breast cancer risk (OR=0.72; 95% CIs: 0.51-1.02; $I^2$= 74.4%, P<0.001; N=9). However, sensitivity analysis based on adjusted ORs showed decreased risk of breast cancer was also associated with consumption of vegetables (OR=0.49; 95% CIs: 0.30-0.67). Conclusion: Both soy food and fruit are significantly associated with decreased risk of breast cancer among Chinese females, and vegetables also seems to be protective while dietary fatexerts a promoting influence.