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김혜린,김혜은,조혜중,SUN QIOACHU,안규현,김옥준,최홍란 대한구강악안면병리학회 2017 대한구강악안면병리학회지 Vol.41 No.6
Acinic cell carcinoma is a well-differentiated, low-grade tumor that accounts for 1-3% of salivary gland tumors. Among the variant of acinic cell carcinoma, papillary cystic variant of acinic cell carcinoma is much more rare and it is known to be difficult to diagnose and has a poor prognosis. In this paper, we report a case of 58 - year - old man diagnosed as papillary cystic variant of acinic cell carcinoma and the characteristics of the lesion by integrating the recent cases of papillary cystic variant of acinic cell carcinoma. This study emphasizes the need for long-term studies and further investigation of papillary cystic variants of acinic cell carcinoma.
장은덕,이은정,이아원,김정수,강창석 한국유방암학회 2011 Journal of breast cancer Vol.14 No.2
Acinic cell carcinoma (ACC) of the breast is extremely rare and is characterized by widespread acinar cell-like differentiation. We report of a 39-year-old woman presented with a palpable breast mass with significant morphological, immunohistochemical and ultrastructural findings. Histologically, ACC showed a diffuse glandular infiltrative pattern, with small acinar or glandular structures mixed with solid nests. Neoplastic cells were monotonous proliferation of cells with a granular or clear cytoplasm, resembling acinar cells of the salivary glands or Paneth cells. Both glandular and solid tumor cell populations were strongly positive for lysozyme and α-1-antitrypsin.
타액선 유두상-낭성 선방세포암종의 세침흡인 세포학적 소견 - 1예 보고 -
이아원,유진영,김병기,강석진,Lee, Ah-Won,Yoo, Jin-Young,Kim, Byung-Kee,Kang, Seok-Jin 대한세포병리학회 2001 대한세포병리학회지 Vol.12 No.1
Acinic cell carcinoma(ACC) is the third common malignancy in major salivary gland. Fine needle aspiration cytology is a useful tool for the diagnosis of salivary gland lesions. However, some low grade malignancies, such as ACC and mucoepidermoid carcinoma show relatively high false negative rate, mainly due to deceptively benign cytomorphologic appearance. We experienced a papillary-cystic variant of ACC, having different cytopathologic features compared with those of classic ACC. Our case showed monolayered sheets and papillary clusters without any acinic structures or naked nuclei of the tumor cells. Foamy proteinaceous material was seen in the background. The tumor cells had a large amount of granular cytoplasm and eccentric nuclei. Many vacuolated or clear cells were also noted.
선양치성종양으로 오진하여 수 차례 재발한 상악동의 선방세포암종
윤정훈,조세인,김수관 大韓顎顔面成形再建外科學會 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.6
A 46-year-old male appealed severe palatal and buccal swelling in the Lt. maxilla in 1990. In 1986, the patient was already carried out the clinical and radiological examination in our hospital. Multiple radiolucency was seen from #21 to #25 periapical area and Lt. maxillary sinus in the panoramic view at this time. But, the patient came home without special examination or inspection for itself. January 1990, the mass took an impression to grow bigger and the patient had visited again. Partial maxillectomy was carried out at this time and pathologic diagnosis was an adenomatoid odontogenic tumor. After 3 years, lesion was recurred and carried out hemimaxillectomy with Weber-Furgusson incision. September 2001, facial swelling was recurred again and patient was suffered from nasal breathing, lacrimal obstruction and exopthalmus. In this case, the tumor cells composed of nodular and papaillary cystic pattern with microcyst formation, highly suggestive of an adenomatoid odontogenic tumor. Histopathologically, the recurrent tumor was proved to be the same pattern of the primary tumor, which is compatible with acinic cell carcinoma. However, adenomatoid odontogenic tumor did not appear destructive multilocular radiolucency. In addition, this tumor had frequently observed amyloid-like or calcified materials in biopsy specimen. Therefore, oral pathologists had kept in mind into the correlative analysis of histopathologic and oral radiographic features, which is essential for definitive diagnosis.
민경인,이주현,서경숙,김철환,Min, Kyong-In,Lee, Ju-Hyun,Seo, Kyung-Suk,Kim, Chul-Hwan 대한구강악안면외과학회 2001 대한구강악안면외과학회지 Vol.27 No.6
Acinic cell carcinoma is a rare salivary gland carcinoma, usually being found in the parotid gland and is uncommon in the other major and minor salivary glands. The tumor cells consist of either serous or mucous acinar cells with few ductal or myoepithelial cell elements. The tumor is a low-grade malignancy with slow growth potential. Surgical therapy depends on tumor size and the extent of infiltration into neighboring tissues. Superficial parotidectomy or total parotidectomy is the initial method of therapy in case of acinic cell carcinoma on parotid gland. When regional neck lymph nodes are involved, the operation is combined with a neck dissection, or with radiation therapy. In the short follow up period, acinic cell carcinoma has good prognosis with 5 year survival rate after surgery is over 80%. In the long-term follow-up, however, there is a tendency to increase in recurrence or metastasis. We experienced a case of acinic cell carcinoma of parotid gland in a 57-year-old female, so we report it with literatures review.
타액선 선방 세포암종의 악성도와 연관된 세포학적 및 조직학적 소견 - 2예 보고 -
팽성숙,장희진,서정일,박효숙,Paeng, Sung-Suk,Chang, Hee-Jin,Suh, Jung-Il,Park, Hyo-Sook 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.1
Acinic cell carcinoma is a slow-growing solid neoplasm of salivary gland. Although their cytological and histological finding is bland-looking, their biological behavior is unpredictable. We experienced two cases of acinic cell carcinoma of the salivary gland diagnosed by fine needle aspiration biopsy and confirmed by tissue examination. They showed different clinical courses. We compared their cytologic and histologic findings. The first case was a right preauricular mass in a 58 year-old female of 3 years duration. The cytologic smear revealed sheets or small clusters of monotonous cells mimicking normal serous acinar cells with little cellular pleomorphism. She underwent superficial parotid lobectomy. The tumor was a well demarcated 1.5cm sized nodular mass without infiltration into surrounding parenchyme. The second case was a left submandibular mass in a 23 year-old male of 4 years duration. The smear showed more severe pleomorphism of the tumor cells than those of previous case. Excisional biopsy was done. The excised tumor was $5.5{\times}3.5{\times}3cm$ sized multilobulated solid mass with invasion into surrounding parenchyme. The tumor recurred after 20months, thus total excision of the mass and modified radical neck dissection was carried out. From the above findings, cytologic atypism, infiltrative growth pattern and type of initial therapy may be correlated with biologic behavior.
Imaging Findings of Primary Acinic Cell Carcinoma of the Breast: A Case Report
Eui Hyun Yu,Kyounglan Ko,Joon Yeun Park,Yoon Yang Jung,Hyuk Jai Shin,Hyun Jung Choi 대한영상의학회 2024 대한영상의학회지 Vol.85 No.3
Acinic cell carcinoma is a rare malignant tumor that accounts for 2%–3% of salivary gland tumors. Acinic cell carcinoma arising from the breast is extremely rare, with only approximately 70 cases reported to date. Owing to its rarity, previous studies have primarily focused on pathological findings. Herein, we present the clinical and radiological features of acinic cell carcinoma of the breast in a 33-year-old woman.
이하선의 선방세포암종의 세침흡인 세포학적 소견 - 1예 보고 -
이원애,전이경,오미혜,강신광,Lee, Won-Ae,Chun, Yi-Kyeong,Oh, Mee-Hye,Khang, Shin-Kwang 대한세포병리학회 1992 대한세포병리학회지 Vol.3 No.2
Acinic cell carcinoma is a rare salivary gland tumor of low-grade malignancy. It comprises only about 2.5% of all salivary gland tumors. We recently experienced a case of fine needle aspiration cytology of acinic cell carcinoma of the parotid gland. The characteristic cytopathologic features were 1) cellular aspirate consisting of monomorphic cells in large sheets or singly, 2) formation of acini and/or microcysts, 3) abundant granular cytoplasm with sharp cytoplasmic borders, 4) bland nuclei with micronucleoli, and 5) clear background.
Clinical Analysis of Acinic Cell Carcinoma in Parotid Gland
차원재,김민수,안재철,조성우,선우웅상,송창면,권택균,성명훈,김광현 대한이비인후과학회 2011 Clinical and Experimental Otorhinolaryngology Vol.4 No.4
Objectives. Acinic cell carcinoma (AciCC) is a rarely encountered malignancy in parotid gland. Because AciCC is rare and was recently recognized as the entity of malignancy, AciCC has been difficult to study. We aimed to analyze the diagnosis and treatment experience for this malignancy in our hospital. Methods. We retrospectively reviewed medical records of the 20 patients with AciCC of parotid gland diagnosed from 1990to 2009. The preoperative computed tomography scan, preoperative fine needle aspiration cytology (FNAC) and intraoperative frozen section results were compared with the final diagnosis. The survival and recurrence were analyzed with the cancer stages and treatment modalities. Results. There were 10 males and 10 females, with a mean age of 44.4 years, ranging 8-77 years. The AJCC tumor stage distributions of the patients were 70%, 15%, and 15% for stages I, II, and IV, respectively. The sensitivity of FNAC and intraoperative frozen section was 26.7% and 50.0% respectively. The 10-year survival rate was 90.9% with a mean follow-up of 111 months, ranging 17-251 months. The 10-year disease free survival rate was 74.2% and the mean duration of recurrence from initial surgery was 92.3 months. Conclusion. AciCC of the parotid gland is a rare malignancy that has features of less aggressive behavior, and good prognosis. Intraoperative frozen section examination may be helpful in the diagnosis of AciCC of the parotid gland because of the low sensitivity of preoperative computed tomography scan and FNAC. Surgery with adjuvant postoperative radiotherapy is satisfactory for disease control.