스파르가눔증의 세침흡인 세포학적 소견

팽성숙,김윤주,양성은,장희진,서정일,문영천,Paeng, Sung-Suk,Kim, Yoon-Ju,Yang, Seong-Eun,Chang, Hee-Jin,Suh, Jung-Il,Moon, Young-Chun 대한세포병리학회 1996 대한세포병리학회지 Vol.7 No.1

Human sparganosis is a rare parasitic disease in which the larval cestode proliferates in the various organs in the body. It usually presents as a subcutaneous or soft tissue mass. By fine needle aspiration this lesion can be diagnosed with its characteristic cytologic findings. We experienced 3 cases of sparganosis diagnosed by the fine needle aspiration. Aspirates were taken from subcutaneous mass in the abdomen and both thighs respect ively. The aspirates showed a portion of body of sparganum with numerous calcospherules, smooth muscles and tegmental cells. They also revealed granulomas with various inflammatory infiltration of eosinophils, neutrophils, lymphocytes and plasma cells.

타액선 선방 세포암종의 악성도와 연관된 세포학적 및 조직학적 소견 - 2예 보고 -

팽성숙,장희진,서정일,박효숙,Paeng, Sung-Suk,Chang, Hee-Jin,Suh, Jung-Il,Park, Hyo-Sook 대한세포병리학회 1997 대한세포병리학회지 Vol.8 No.1

Acinic cell carcinoma is a slow-growing solid neoplasm of salivary gland. Although their cytological and histological finding is bland-looking, their biological behavior is unpredictable. We experienced two cases of acinic cell carcinoma of the salivary gland diagnosed by fine needle aspiration biopsy and confirmed by tissue examination. They showed different clinical courses. We compared their cytologic and histologic findings. The first case was a right preauricular mass in a 58 year-old female of 3 years duration. The cytologic smear revealed sheets or small clusters of monotonous cells mimicking normal serous acinar cells with little cellular pleomorphism. She underwent superficial parotid lobectomy. The tumor was a well demarcated 1.5cm sized nodular mass without infiltration into surrounding parenchyme. The second case was a left submandibular mass in a 23 year-old male of 4 years duration. The smear showed more severe pleomorphism of the tumor cells than those of previous case. Excisional biopsy was done. The excised tumor was $5.5{\times}3.5{\times}3cm$ sized multilobulated solid mass with invasion into surrounding parenchyme. The tumor recurred after 20months, thus total excision of the mass and modified radical neck dissection was carried out. From the above findings, cytologic atypism, infiltrative growth pattern and type of initial therapy may be correlated with biologic behavior.

결직장선암종에서의 p53, E-cadherin, nm23, CD44의 발현양상과 종양의 맥관형성의 의의

팽성숙,장희진,서정일 대한병리학회 1997 Journal of Pathology and Translational Medicine Vol.31 No.4

유선의 침윤성 관암종에서 스테로이드 수용체와 p53 및 bcl-2 종양단백질의 발현양상

팽성숙 中央大學校 醫科大學 1997 中央醫大雜誌 Vol.22 No.3

Interdigitating Reticulum Cell Sarcoma of Lymph Node -1 증례 보고-

팽성숙,김윤주,양성은,김덕환,장희진,서정일,김철우 대한병리학회 1996 Journal of Pathology and Translational Medicine Vol.30 No.7

유선의 침윤성 곤암종에서 스테로이드 수용체와 p53 및 bcl-2 단백질의 발현양상

팽성숙,박언섭,강응택,유재형 중앙대학교 의과대학 의과학연구소 1997 中央醫大誌 Vol.22 No.3

This study was conducted to evaluate the expression of p53 and bcl-2, known as important prognostic factors of breast carcinoma, using immunohistochemical method in 64 invasive duct carcinoma, and the correlation with steroid receptors including estrogen (ER) and progesteron receptors (PR). The results were as follow; 1. The frequency of steroid receptor positivity in invasive duct carcinoma by four prognosic group was 18 cases(28.1%) in ER(+) and PR(+) group, 18 cases(28.1%) in ER(+), PR(-) group, 6 cases (9.4%) in ER(-) and PR(+) group, and cases (34.4%) in ER(-) and PR(-) group. 2. The immunohistochemical association between p53 and steroid receptor showed 28.6% & p53 expression in steroid receptor positive group and 54.3% & p53 expression in steroid receptor negative group. However, the statistical significance was not present. 3. A positive relationship was seen between bcl-2 and steroid receptor was statistically significant, presenting 76.2% bcl-2 expression in steroid receptor positive group and 45.5% bcl-2 expression in steroid receptor negative group. 4. The frequency of p53 and bcl-2 expression in invasive duct carcinoma was 14 cases(21.9%) in p53(+), bcl-2(+) group, 8 cases(12.5%) in p53(+) and bcl-2(-) group, 26 cases(40.6%) in p53(-) and bcl-2(+) group, and 16 cases(25%) in p53(-), bcl-2(-) group.

모배아종(Trichogerminoma) l예

팽성숙,김덕환,장희진,서정일,손진희,송계용 대한병리학회 1996 Journal of Pathology and Translational Medicine Vol.30 No.4

외상성 신경종의 예방에 관한 연구

팽성숙,장효죽,홍인표,김남호,서정일,김종환 大韓成形外科學會 1997 Archives of Plastic Surgery Vol.24 No.6

A painful neuroma in the hand can be psychologically and physically disabling. The difficulty in alleviating the problems is attested by the numerous methods of treatment espoused in the literature. Traumatic neuroma was first described by Odier in 1881. He described the enlargement or swelling which develops at the distal ends of the proximal segments of peripheral nerves after partial or complete division and spoke of these as nerve tumors. In 1920 Huber and Lewis published reports of their experimental work in the prevention and causes of traumatic neuromas. Little of practical significance has been done since the work of Huber & Lewis, and most surgical techniques of today are still based on their experiments. There is no procedure that is completely and consistently successful in preventing neuroma formation. Altyough some different technique have been described, successful method of treatment hasn't been found as ever. These treatments include crushing the neuroma, ligating it, burying it in soft tissue or bone, injecting it with alchohol, or gentian violet, capping it with a silicone cuff, or pulling a perineurial sleeve over the axial ends. In spite of its advocates, these methods was insufficient as well. So the authors carried out animal study to find out the better operative procedure to prevent the traumatic neuroma. In the result of study, epineural closure combined with the use of chemical coagulent (5-flurouracil) in the severed end was satisfactory method compared with the others.

기관지-연관 림프조직에서 발생한 악성 림프종 - 1예 보고 -

김윤주,팽성숙,장희진,서정일 대한병리학회 1998 Journal of Pathology and Translational Medicine Vol.32 No.11

소아 결절성 십이지장염의 임상적 및 조직병리학적 소견

차한,팽성숙,Tchah, Hann,Paeng, Sung-Suk 대한소아소화기영양학회 2000 Pediatric gastroenterology, hepatology & nutrition Vol.3 No.2

목 적: 결절성 십이지장염은 내시경 검사상 십이지장에 두 개 이상의 홍반성 결절들이 보이며 주변에 염증 소견이 관찰되는 질환이다. 최근 위내시경 검사의 발달로 인해 결절성 십이지장염은 소아에서도 발생빈도가 증가하는데 아직 국내외적으로 전반적인 연구가 미미한 실정이다. 이에 저자들은 소아에서 결절성 십이지장염의 임상적 및 조직병리학적 소견을 조사하여 이 질환에 대한 전반적인 이해를 도모하고자 본 연구를 시행하였다. 방 법: 1995년 1월부터 1999년 12월까지 서울적십자병원 소아내시경실에서 시행된 상부위장관 내시경 검사상 결절성 십이지장염으로 진단된 39례를 대상으로 유병률, 성별 및 연령별 분포, 주증상, 내시경 소견과 조직병리학적 소견 및 이의 상관관계 등에 대해 후향적으로 연구를 실시하였다. 내시경 검사상 병변의 정도는 십이지장 결절의 크기와 분포에 따라 제 1, 2, 3 도로 분류하였고 십이지장의 조직병리학적 검사는 십이지장 고유층의 염증세포 침윤 정도, 상피세포 및 융모의 소실 정도에 따라 정상, 제 1, 2, 3 도로 분류하였다. 위의 조직학적 소견은 위점막의 고유판과 상피내에 염증세포의 침윤 정도 및 상피의 손상 정도에 따라 0에서 6까지 구분하였다. H. pylori의 감염 정도는 Prieto 등의 분류법에 따라 제 0, 1, 2, 3 도로 구분하였다. 십이지장에서 내시경적 소견의 정도와 조직병리학적 소견의 정도 및 H. pylori 감염 정도 간에 상관관계가 있는지 알아보기 위해 통계 프로그램으로 Graph PAD InStat의 linear regression module을 사용하여 correlation coefficient와 p-value를 구하였다. 결 과: 1) 결절성 십이지장염은 17.1%의 유병률을 나타내었고 남녀비는 1 대 2이었다. 7세부터 12세까지에서 가장 빈도(61.5%)가 높았고 주증상은 복통이 69.2%로 가장 많았다. 2) 본 질환의 내시경 등급은 제 1 도 45.7%, 제 2도 34.3%, 제 3 도 20.0%이었으며 동반된 내시경적 소견상 결절성 위염은 28.3%이었다. 3) 십이지장의 조직병리학적 검사상 제 1 도는 22.9%, 제 2 도는 54.3%, 제 3 도는 22.9%이었으며 위의 조직검사상 제 1 도는 22.9%, 제 2 도는 42.9%, 제 3 도는 25.7%, 제 4 도는 8.6%이었다. 4) 십이지장의 조직병리학적 검사상 H. pylori의 감염 정도는 제 1 도 5.7%, 제 2 도 8.6%, 제 3 도 22.9%로 37.1%의 십이지장 조직에서 H. pylori가 발견되었다. 위의 조직병리학적 검사상 H. pylori의 감염정도는 제 1 도 11.4%, 제 2 도 11.4%, 제 3 도 8.6%로 31.4%의 위 조직에서 H. pylori가 발견되었다. 5) 본 질환의 내시경적 등급과 조직병리학적 등급 간의 상관계수는 0.3983 (p=0.0178)이었고, 조직병리학적 등급과 십이지장 조직에서의 H. pylori 감염 등급간의 상관계수는 0.5154 (p=0.0018)이었다. 결 론: 결절성 십이지장염의 내시경적 등급과 조직병리학적 등급 사이에 통계적으로 의미있는 상관관계가 나타났으며(r=0.3983, p=0.0178), 또한 조직병리학적 등급과 십이지장 조직에서의 H. pylori 감염 등급간에도 통계적으로 의미있는 상관관계를보였다(r=0.5154, p=0.0018). 따라서 H. pylori 감염이 본 질환의 발생에 주요한 역할을 할 것으로 여겨지며 이외의 유발 원인에 대해서는 추후 지속적인 추적 관찰 및 보다 많은 연구가 시행되어야 하겠다. Purpose: Recently, a wide application of gastrofiberscopy in the pediatric group have revealed that nodular duodenitis is not an uncommon disease in children and is suspected to be associated with H. pylori infection. The aim of this retrospective study was to investigate the clinical and histopathologic features in children with nodular duodenitis, and to assess the correlations beween both. Methods: During a period of 5 years (Jan. 1995~Dec. 1999), we investigated clinical, endoscopic and histopathologic features of 39 consecutive patients diagnosed as having nodular duodenitis at Pediatric department of Seoul Red Cross Hospital. In 35 children with nodular duodenitis endoscopic biopsy specimens were stained with Hematoxylin & Eosin and Giemsa's stain, and were graded according to the criteria outlined by Triadafilopoulos, Whitehead et al., and Prieto et al.. Statistical analyses were performed with Graph PAD InStat. Results: The prevalence rate of nodular duodenitis was 17.1% and the most frequent chief complaint was abdominal pain (69.2%). Endoscopically grade 1 was the most common (45.7%) and nodular gastritis was coexistent in 28.3%. The most common histology of the duodenum was grade 2 (54.3%), and the most common histologic score of the stomach was 2 (42.9%). H. pylori was found in the duodenum in 37.1%, and in the stomach in 31.4%. The correlation coefficient between the endoscopic grade and the histologic grade of nodular duodenitis was 0.3983 (p=0.0178). And the correlation coefficient between the histologic grade and the grade of H. pylori colonization in the duodenum was 0.5154 (p=0.0018). Conclusion: There was significant correlation between the endoscopic grade and the histologic grade of nodular duodenitis, and was also significant correlation between the histologic grade and the grade of H. pylori colonization in the duodenum. Therfore H. pylori infection should be regarded as an etiologic factor of nodular duodenitis.