Four new compounds from the bulbs of Lycoris aurea with neuroprotective effects against CoCl2 and H2O2-induced SH-SY5Y cell injuries

An Jin,Xuelian Xiang,Yun-Yun Zhu,Heng-Yi Yu,Hui-Fang Pi,Peng Zhang,Han-Li Ruan 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.3

Three new alkaloids, 2a-hydroxy-6-O-n-butyloduline,O-n-butyllycorenine, (-)-N-(chloromethyl)lycoramine(1–3), and a new phenolic compound, ((7S)-7-(4-hydroxyphenyl)-7-hydroxypropyl)-20-methylbenzene-30,60-diol (14), along with ten known alkaloids (4–13), wereisolated from the bulbs of Lycoris aurea collected fromHuaihua County of Hunan Province, China. Their structureswere elucidated by spectroscopic methods includingHRESIMS, UV, IR, and NMR. All the isolated compoundswere tested for their neuroprotective effects against CoCl2and H2O2-induced SH-SY5Y cell death. Compounds 1–7and 10 exhibited significant neuroprotective effects againstCoCl2-induced SH-SY5Y cell injury, while compounds1–5, 7, 10 and 12 showed obvious neuroprotective effectsagainst H2O2-induced SH-SY5Y cell death.

관상동맥 스텐트 삽입술을 시행한 환자에서 안지오텐신 전환효소 억제제와 안지오텐신 수용체 차단제가 재협착에 미치는 영향

김연경,정진원,윤경호,박은미,송미진,최준호,이은미,유남진,김남호,오석규 圓光大學校 醫科學硏究所 2006 圓光醫科學 Vol.21 No.1

Tryophagus putrescentiae induces inflammatory cytokine secretions from the human cell lines THP-1 and EoL-1 cells

Jeon Sang‐Jin,Kim Eun Joo,Oh Jihyun,Yun Chi‐Young 한국곤충학회 2020 Entomological Research Vol.50 No.7

The present study aimed to identify the roles of the storage mite Tyrophagus putrescentiae (Tp) in relation to human skin diseases, such as atopic dermatitis. We examined the effects of T. putrescentiae extracts (TpE) on the secretion of inflammatory cytokines and their mRNA expression in human immune cells. Human monocytic THP-1 and eosinophilic EoL-1 cells were challenged with TpE and the inflammatory cytokines, interleukin-6 (IL-6), interleukin-8 (IL-8), and monocyte chemotactic protein-1 (MCP-1) secreted in culture supernatant were analyzed using an enzyme-linked immunosorbent assay (ELISA). The mRNA levels in the cell cultures were also measured via reverse transcriptase-polymerase chain reaction (RT-PCR). In the THP-1 cells, the TpE significantly induced the secretion of IL-6, IL-8, and MCP-1 in a time- and dose-dependent manner. It also stimulated increases in the expression levels of the IL-6, IL-8, and MCP-1 mRNA. However, while the TpE induced IL-8 and MCP-1 mRNA levels in the EoL-1 cells, it did not induce IL-6 expression. Using Western blot analysis, we confirmed the activation of extracellular signal-regulated kinase (ERK), a member of the mitogen-activated protein kinases (MAPKs), in response to TpE challenge of the THP-1 cells. Collectively, our results show that TpE challenge elicits inflammatory response in the human monocytic THP-1 and eosinophilic EoL-1 cells, and it induces increased production of the inflammatory cytokines IL-6, IL-8, and MCP-1.

CPTED 관점에서 안전한 대학교캠퍼스를 위한 적용요소 연구

윤소진(Yun, So-Jin),이승재(Lee, Seung-Jae),강석진(Kang, Seok-Jin) 대한건축학회 2012 대한건축학회논문집 Vol.28 No.3

The purpose of this study was to suggest the applicable factors for making safe campus focused on the CPTED. In order to do that, the questionnaire survey and the observation survey were conducted in the 3 universities in Jin-Ju. This study was processed as follows : first, the analyses of the relations among the variables such as satisfactory and important rate about the physical factors for crime prevention, fear of crime, and crime experienced rate. ; second, comparing analyses the questionnaire survey and the observation survey results among the universities. Followings are the results. : 1) the crime experienced rate was 25%, and the theft and breakage were happened frequently. The hotspots were lecture rooms, dormitories and parking lots. 2) as the fear of crime was higher, the satisfaction of crime prevention was lower. The unsafe places were promoted the fear of crime were basement floors, toilets, green zones, sidewalks and parking lots, etc. 3) the factors caused the fear of crime were insufficient lightings and CCTV, and blind spots among the buildings. 4) the important things for the making crime-free campus were the natural surveillance and access control focused on the CPTED. Especially, it was founded that the access control methods were more effective at indoor spaces and individual buildings, and the natural surveillance methods were more important outdoor spaces.

텔레비전 역사드라마 〈이산〉의 정치적 성향 고찰

윤석진(Yun, Suk-Jin) 한국비평문학회 2013 批評文學 Vol.- No.50

2000년대 중반 이후 텔레비전 역사드라마는 군왕의 영웅적 면모가 아니라 인간적인 고뇌에 초점을 맞추면서 현대 사회가 필요로 하는 지도자의 덕목을 환기시키는 경향이 강해졌다. 그 결과 역사드라마에 내재될 수밖에 없는 역사 인식이 퇴조하는 대신에 방영 당시의 정치 상황에 따라 역사적 사실을 자의적으로 재구성하는 부작용이 나타나기 시작하였다. 개혁 담론이 풍성했던 2000년대 중반에 방영된, 조선왕조 제22대 임금 정조를 호출한 일련의 역사드라마들이 대표적인 경우였다. 특히 개혁군주 정조대왕의 일대기를 형상화한 〈이산〉은 노무현 정부에서 이명박 정부로 정권이 교체되던 시기에 방영되면서 정치 상황에 의해 극적 상황과 캐릭터가 변하는 문제를 드러냈다. 본고는 아버지 사도세자의 비극적인 죽음을 가슴에 묻은 세손 ‘이산’이 권력 투쟁에서 살아남아 임금의 자리에 올라 펼치는 개혁 정치를 다룬 〈이산〉을 중심으로 텔레비전 역사드라마의 정치적 성향을 고찰하였다. 그 결과 텔레비전 역사드라마의 정치적 성향은 방영 당시의 정치 상황과 밀접한 상관관계가 있음을 알 수 있었다. 정조대왕의 죽음과 함께 개혁의 동력이 멈추면서 그의 정책과 정신이 훼손되었던 것처럼, 역사드라마 <이산>이 환기시켰던 2000년대 중반 대한민국의 정치 개혁도 2008년 2월 정권 교체와 함께 동력을 상실한 채 좌초되고 말았음을 확인할 수 있었던 것이다. 이는 곧 〈이산〉의 극적 현실이 실제 현실로 전이되지 못한 것은 물론, 정조대왕의 정치 개혁 담론이 현실 정치의 영향을 받으면서 왜곡되었음을 의미한다. While focusing on human agonies, not a ruler‘s heroic aspects, since the 2000s when a historical TV drama arousing virtues of a leader needed in the modern society started gaining attention, the political traits of a historical TV drama have gotten closely engaged in the political environment at the time of being aired. A series of historical dramas which dealt with Jung Jo, the 22nd king of the Joseon Dynasty aired in the mid 2000s when there were plentiful discussions for renovation represented the political situation. In particular, the TV drama <Yi San> which dramatized the life of King Jung Jo spaning from his early years to death has been politically blamed for glorifying the President equipped with renovation traits by the conservative force and been engaged in the political debate concerning the issue of representing the dominating ideology of the ruling force since the change of government. The study was designed to find out political traits of a historical TV drama centering on 〈Yi San〉 dealing with the story of ‘Yi San’ who beared resentment about the tragic death of his father ‘Crown Prince Sado’ survived the battles for power to sworn in as king and unfolded the renovation of politics. As a result, it was found that the political traits of a historical TV drama were closely related to political environment at the time of being aired. In addition, it was confirmed that when the driving force for renovation stoped along with the death of the great king Jung Jo, his policies and spirits were also damaged, and the political renovation of Korea in the mid 2000s presented by the historical TV drama 〈Yi San〉 lost its driving force to be in trouble along with the change of government in February 2008. It meant that the dramatic reality of 〈Yi San〉 couldn’t spread to reality because discussions for Jung Jo’s political renovation were distorted while being affected by real politics.

심근 허혈-재관류 백서 모델에서 mitogen-activated protein kinase 활성화에 대한 α-lipoic acid의 효과

김연경,박은미,최준호,윤경호,유남진,이은미,김남호,정진원,김민선,박병림,오석규 圓光大學校 醫科學硏究所 2006 圓光醫科學 Vol.21 No.1

김만중(金萬重)의 여성시(女性詩)에 드러난 군신(君臣)의 형상(形象)

윤호진 ( Ho Jin Yun ) 연민학회 2010 연민학지 Vol.14 No.-

The theory above is that Kim Man-jung`s feminine poems are apparently seem like the poems about the love between men and women, but actually are the poems about sovereigns and subjects. In this point of view we looked through Kim Man-jung`s feminine poems. Former researches about Kim Man-jung`s feminine poems considered that only parts of the poems, which are about abandoned court ladies, represent the relationship between sovereigns and subjects. However, this thesis considered that the songs about an enduring wife, a refrained women and a spring dream like beauty are also about the relationship between sovereigns and subjects. In this thesis, through the through analyse we discoursed in three ways to explain the relationship between sovereign and subject. Firstly, Kim Man-jung`s feminine poems are about subjects` destinies changed by the level of kings` love. Kim Man-jung wrote that when men and women first met each other, they didn`t care about whether they are ugly, or whether they are wise. Like this, when sovereigns first met subjects, sovereigns hired subjects as their abilities, but soon after time had passed sovereigns loved subjects by their feelings. This kind of thinking is found well at Kim Man-jung`s poem he wrote when Ban Cheb-yo expelled to Zhang Sin Palace after losing king`s love. Secondly, Kim Man-jung`s feminine poems are about subjects` loyalties that would never change. Kim Man-jung wrote a poem called Yi Sha Su Si and in this poem four paragraphs are about a woman missing her husband far away. Kim Man-jung`s nephew Kim Jin-kyu commented that this song was written because Kim Man-jung worried about the political situation at that time. It means that Kim Man-jung compared subjects` loyalties as the integrities of women. Thirdly Kim Man-jung`s feminine poems are about the subjects that have to refrain their attitudes and keep their integrities. He expressed his opinion that subjects never lost their honors through the stories about Tack Mun Gun who followed a man blindly and a ordinally faithful woman became a Dae Urn Eu and Soe Si`s kisaeng life. Finally, Kim Man-jung`s feminine poems are about the loneliness of abandoned subjects. Generally, we think that Musan female believer is a dream of all men, but in his poem Musan female believer yearned for the King Hui. And he also wrote a poem called Sang Yang which is about a court woman who could not help writing a letter on a leaf to the king because of the loneliness. Therefore, as we looked through above the reason that Kim Man-jung wrote lots of feminine poem is not that Kim Man-jung was a lascivious man or he was interested in ancient poems. It`s because he cared about those days` political situation and compared the relationship between sovereigns and subjects to the love of men and women.

급성 관동맥증후군 환자의 신기능 이상과 주요 심장사건과의 관계

이상재,윤경호,최준호,송미진,김연경,박은미,김현정,이은미,유남진,김남호,오석규,정진원 圓光大學校 醫科學硏究所 2006 圓光醫科學 Vol.21 No.1

죽상경화 혈관 합병증의 예측 인자로서의 경동맥 내중막 두께 및 대동막 판막 두께

박은미,김연경,송미진,최준호,윤경호,오석규,정진원,김남호 圓光大學校 醫科學硏究所 2006 圓光醫科學 Vol.21 No.1

서울 시내 4년제 남자 대학생의 우울과 흡연량, 흡연기간, 니코틴 의존도와의 관계

박지영,박소영,이미숙,백수진,신의경,예혜련,오승진,장윤정,조혜진,김수지 이화여자대학교 간호과학대학 2003 이화간호학회지 Vol.- No.37

Background: With reports on the relation between smoking and depression appearing since 1980, it has become clear that depression is one of the psychodynamics of smoking, though there has been little or no progress made in the study of whether or not there is indeed a relation between depression and nicotine dependence. Purpose: The purpose of the study was to investigate the effects of depression on the amount and period of smoking and nicotine dependence among university man student smokers. Method: In periodical examination between 14 and 21, May, 2003, using 170 university male. The CES-D(Center for Epidemiologic Studies Depression) Scale and the FTQ(Fagerstrom Tolerance Qustionnaire) were utilized to measure the level of depression and nicotine dependency. The amount of smoking was calculated based on the number of cigarette used. Result: Results indicated that depression had something to do with amount of smoking. Nicotine dependence also was related to depression but total value was relatively low. finally the period of smoking had nothing to do with depression. Conclusion: The results of this study revealed that the amount of smoking of university man student smokers was very high. Both the amount of smoking and nicotine dependence were affected by levels of depression. Accordingly psychiatric nursing access such as emotional support is needed to manage depression and decrease smoking.