파종시기가 다른 일미찰의 등숙 중 호화 특성 비교

김미정, 박효진, 이유영, 김선림, 김정태, 우관식, 권영업, 정일민 忠北大學校 農業科學硏究所 2014 農業科學硏究 Vol.30 No.2

This study was conducted to investigate the pasting properties of waxy corn ‘Ilmichal’ during ripening with different sowing date. Starch content of Ilmichal was increased as matured (p<0.05). Analysis of pasting properties with waxy corn starch using a rapid visco analyser (RVA) showed linear changes in peak viscosity, trough viscosity, final viscosity, breakdown and consistency according to ripening. There were significantly positive correlation between starch content of Ilmichal and peak viscosity (0.39*), trough viscosity (0.58***), final viscosity (0.58***), and consistency (0.57**). Differential scanning calorimerty (DSC). The enthalpy of gelatinization was increased as ripening. But onset and peak temperature were decreased. There were significantly positive correlation between starch content of Ilmichal and onset temperature (0.44*), peak temperature (0.38*), and completion temperature (0.59***), on the other hand, crude protein content presented significantly negative correlation between completion temperature (-0.41*).

소아과 입원 환자에 대한 통계적 고찰

정용현,서우식,유재홍,변상현 충남대학교 의과대학 지역사회의학연구소 1995 충남의대잡지 Vol.22 No.2

For the purpose of assessing the disease patterns by the body organ system in patients of the pediatric age, we performed a statistical analysis of diseases of patients admitted to the department of pediatrics at Chungnam National University Hospital from January 1990 to December 1994. The results obtained were as follows : 1. Total numbers of in-patients were 8,007, of which 4,923 were male and 3,084 were female. The ratio male to female was 1.60 : 1. 2. Prevalence of the diseases classified by body organ system was in the following order : neonatal diseases (34.6%), respiratory diseases (17.4%), infectious diseases (11.5%), congenital anomalies (5.5%), digestive diseases (5.1%), genitourinary diseases (4.9%), neoplasm (4.7%), blood diseases (3.3%), nervous system diseases (2.8%), metabolic and endocrine diseases (2.4%), circulatory system diseases (2.3%), skin and subcutaneous diseases (1.3%), musculoskeletal and connective tissue diseases (1.2%), mental and behavior disorders (0.4%). 3. Major diseases in each body organ system were as follows : 1) infectious diseases : unspecified acute gastroenteritis (35.9%), viral meningitis (10.4%), Rotaviral enteritis (6.8%), sepsis (6.7%), measles (5.8%). 2) neoplasm ; ALL (34.1%), AML (15.8%), Wilms tumor (12.8%), NHL (8.2%), neuroblastoma (5.6%) 3) blood diseases : allergic purpura (24.2%), aplastic anemia (17.1%), ITP (16.4%), iron deficiency anemia (15.8%). 4) metabolic and endocrine diseases : short stature (22.0%), hypocalcemia (13.8%), metabolic acidosis (9.6%), IDDM (6.4%). 5) mental and behavior diseases : neurosis (47.7%), mental retardation (18.2%). 6) Nervous and sensory system diseases : epilepsy (43.2%), cerebral palsy (12.1%), otitis media (9.3%), encephalopathy (6.2%). 7) circulatory system diseases: congestive heart failure (29.2%), dilated cardiomyopathy (8.0%), rheumatic fever (8.0%), mitral insufficiency (6.8%), hypertension (6.4%). 8) respiratory diseases : pneumonia (40.1%), URI (9.6%), acute tonsillitis (9.4%), asthma (8.5%), acute bronchiolitis (8.3%), croup (7.1%), acute bronchitis (4.1%). 9) digestive system diseases : unspecified hepatitis (22.8%), acute gastritis (13.8%). CAH (12.6%), intussusception (7.8%), constipation (7.1%). 10) skin and subcutaneous diseases : cellulitis (23.1%), lymphadenitis (19.7%), urticaria (15.6%), atopic dermatitis (8.8%), furuncle (8.2%). 11) musculoskeletal and connective tissue diseases : Kawasaki disease (76.8%), JRA (8.5%), SLE (7.0%). 12) genitourinary system diseases : UTI (29.0%), minimal change nephrotic syndrome (27.3%), APSGN (7.6%), APN (4.9%). 13) congenital or chromosomal abnormalities : VSD (38.7%), ASD (10.5%), TOF (8.4%), PDA (5.2%), CHPS (4.5%), Down syndrome (4.1%). 14) neonatal diseases : jaundice (32.0%), prematurity (12.7%), RDS (5.7%), sepsis (4.5%), birth asphyxia (3.0%), SGA (3.0%). 15) Others : febrile convulsion (45.6%), failure to thrive (9.2%), FUO (8.9%), drug intoxication (8.2%). 4. Common diseases for admission in pediatrics were in the following order : jaundice, pneumonia, unspecified acute gastroenteritis, VSD, RDS, URI, acute tonsillitis, acute lymphadenitis, ALL, sepsis, asthma, acute bronchiolitis, UTI.

Eisenmenger씨 증후군 산모의 긴박 제왕절개술시 전신마취 경험

김준,고우석,정종달,유병식,임경준,소금영,안태훈,한승룡 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.1

Eisenmenger's syndrome describes a situation in which the left-to-right intracardiac shunt is reversed as a result of increased pulmonary vascular resistance. The patients with Eisenmenger's syndrome are poorly tolerated and markedly increased maternal mortality to 30 - 50% during pregnancy, Physiological change of pregnancy decreases systemic vascular resistance that further aggravates the bi-directional or left shunt associated with Eisemnenger's syndrome. We report a case of 37 weeks a pregnant woman with an urgent cesarean section under general anesthesia for preterm labor. She was a pregnant patient with Eisenmenger's syndrome and did not receive antenatal care during pregnancy. Anesthesia was induced with ketamine-midazolam-fentanyl and maintained with ketamine-midazolam. The patient was ventilated with 100% O₂. Blood pressure was maintained with intravenous phenylephrine, crystalloid solution, and blood. Phenylephhne was used to maintain systemic vascular resistance (SVR). Even though the patient was carried rapid and adequate medical management, the patient was transferred to the ICU in an intubated state and died 2 days after surgery. We conclude that the parturients with Eisenmenger's syndrome require more regular, careful antenatal care, monitoring, and adequate management.

동종 조혈모세포이식 후 발생한 치명적 홍역 폐렴 1예

백창렬,이동건,최정현,정현화,조유경,박훈준,이승훈,박윤희,이교영,민우성,김춘추,신완식 대한감염학회 2001 감염 Vol.33 No.4

As a result of the enlarging pool of unvaccinated children and young adults, there has been an increase in measles in our countries. In these situation, it has been reported that measles associated pneumoinia is easily complicated with fatal respiratory failure, espycially in immunocompromised patients. Herein we report the case of lethal measles pneumonia after allogenic hematopoietic stem cell transplantation in adults proven by autopsy. Recently, one case of measles was encountered in 39-year-old female patients after allogenic bone marrow transplanted case (chronic myelogenous leukemia), who progressed into interstitial pneumonia pattern, despite treatment including antibiotics, immunoglobulin. The patient died of giant cell pneumonia compatible with that of measles which was comfirmed in the section of necropsy lung specimen. (Korean J Infect Dis 33:301∼309, 2001)

The Genome-Wide Expression Profile of 1,2,3,4,6-Penta-O-Galloyl-β-D-Glucose-Treated MDA-MB-231 Breast Cancer Cells: Molecular Target on Cancer Metabolism

Woo Sik Yu,정수진,김지현,Hyo-Jung Lee,Hyo Sook Song,Min-Seok Kim,Eunjung Ko,이효정,Jae-Ho Khil,Hyeung-Jin Jang,김영철,배현수,Chang Yan Chen,김성훈 한국분자세포생물학회 2011 Molecules and cells Vol.32 No.2

1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG), a polyphe-nolic compound isolated from Rhus chinensis Mill. PGG has been known to have anti-tumor, anti-angiogenic and anti-diabetic activities. The present study revealed another underlying molecular target of PGG in MDA-MB-231 breast cancer cells by using Illumina Human Ref-8 expression BeadChip assay. Through the Beadstudio v3 micro assay program to compare the identified genes expressed in PGG-treated MDA-MB-231 cells with untreated control, we found several unique genes that are closely associated with pyruvate metabolism, glycolysis/gluconeogenesis and tyrosine metabolism, including PC, ACSS2, ACACA, ACYP2, ALDH3B1, FBP1, PRMT2 and COMT. Consistent with microarray data, real-time RT-PCR confirmed the sig-nificant down-regulation of these genes at mRNA level in PGG-treated MDA-MB-231 cells. Our findings suggest the potential of PGG as anticancer agent for breast cancer cells by targeting cancer metabolism genes.

The genome-wide expression profile of 1,2,3,4,6-penta-O-galloyl-β-D-glucose-treated MDA-MB-231 breast cancer cells: Molecular target on cancer metabolism

Yu, Woo Sik,Jeong, Soo-Jin,Kim, Ji-Hyun,Lee, Hyo-Jung,Song, Hyo Sook,Kim, Min-Seok,Ko, Eunjung,Lee, Hyo-Jeong,Khil, Jae-Ho,Jang, Hyeung-Jin,Kim, Young Chul,Bae, Hyunsu,Chen, Chang Yan,Kim, Sung-Hoon Springer-Verlag 2011 Molecules and cells Vol.32 No.2

근력 운동과 균형 운동이 발목 불안정성이 있는 성인의 발목 불안정성 지표, 근력 및 균형 능력에 미치는 효과 비교

김태우 ( Tae-woo Kim ),홍유진 ( Yu-jin Hong ),김민서 ( Min-seo Kim ),강재원 ( Jae-won Kang ),김가람 ( Ga-ram Kim ),김영우 ( Young-woo Kim ),최우식 ( Woo-sik Choi ),차용준 ( Yong-jun Cha ) 대전대학교 기초과학연구소 2023 혜화보건의료학회지 Vol.2 No.1

Objectives: The purpose of this study was to suggest a more effective exercise method for chronic ankle instability by comparing an effect of strengthening exercise and the balance exercise. Methods: After recruiting 24 people in their 20s with chronic ankle instability(CAI) and dividing them into two groups. The control group performed strengthening exercises(calf raise, heel walks and theraband exercise) three times a week for four weeks for 30 minutes. In the experimental group, they conducted a combination of ankle strengthening exercises and balance exercises(dumbbell cross exercise, BOSU Exercise) three times a week for four week s for 40 minutes. We measured ankle instability index, muscle strength, and balancing abilities before and after the training. Results: In both the experimental group and the control group, there was a significant difference in the Cumberland ankle instability tool(CAIT), static balance before and after the intervention(p< .05). But there was no significant difference between the two groups(p >.05). In the dynamic balance, the experimental group had significant differences (p< .05). However, the control group had no significant difference(p >.05). There was no statistically significant difference in the outcomes both the experimental group and control group(p>.05). Conclusions: We propose that ankle strengthening exercises and balance exercises can be an effective clinical exercise method to improve the ankle instability and balance ability of people with ankle chronic ankle instability.

덖음 시간에 따른 감국(Chrysanthemum indicum L.) 차의 이화학적 특성

유정식(Jung Sik Yu),황인국(In Guk Hwang),우관식(Koan Sik Woo),장영득(Young Deug Chang),이철희(Chul Hee Lee),정정학(Jeong Hag Jeong),정헌상(Heon Sang Jeong) 한국식품과학회 2008 한국식품과학회지 Vol.40 No.3

덖음 처리가 감국차의 품질 특성에 미치는 영향을 살펴보고자 감국 꽃을 230℃에서 5, 7.5, 10, 12.5 및 15분간 덖음 처리 후 감국 꽃 침출액을 제조하여 품질특성을 조사하였다. 덖음 시간이 길어질수록 L 및 a 값은 감소하고 b 값은 증가하여 차의 색은 점차 황색을 나타내었으며, 총 질소함량은 3.15-3.33%의 범위를 보였고 구성 아미노산은 감칠맛의 주성분인 glutamic acid를 비롯하여 18종이 분석되었으며, 이들 중 glutamic acid와 aspartic acid가 가장 많은 비율을 차지하였다. Chlorophyll 함량은 덖음 시간이 길어질수록 감소하는 경향을 나타내었다. Tannin, 총 폴리페놀 및 플라보노이드 함량은 덖음 시간에 따라 대체적으로 증가하는 경향을 보였으며, 15분 덖음 시 각각 0.63 ㎎ gallic acid equiv./g, 13.85 ㎎ tannic acid equiv./g 및 9.77 ㎎ catechin equiv./g이었다. 전자공여능은 15분 덖음 시 9.93%, 총 항산화력은 10분 덖음 시 19.33 ㎎ ascorbic acid equiv./100 g으로 대조구보다 높은 항산화 활성을 나타내었다. 덖음 감국 꽃차의 관능검사 결과 색은 12.5분, 맛과 향 및 종합적 기호도는 10분 덖음 처리된 차가 가장 우수한 것으로 나타났다. In this study, Chrysanthemum indicum L. flower tea was prepared according to different pan-firing times (5, 7.5, 10, 12.5, and 15 min) and its quality characteristics were investigated. Total nitrogen and tannin contents increased with increasing pan-firing time, whereas chlorophyll and total amino acid (AA) contents decreased. The total AA contents of the samples ranged from 6,399 to 7,068 ㎎%, and the highest content (7,068 ㎎%) was found with the 10 min panfiring treatment. The AAs occurring in the C. indicum L. flower tea included glutamic acid and aspartic acid, which are desirable flavor components. As the pan-firing time increased, antioxidant activity as well as total polyphenol and flavonoid contents increased. The highest total polyphenol and flavonoid contents were found in the 15 min treatment at levels of 13.85 ㎎ tannic acid equiv./g and 9.77 ㎎ catechin equiv./g, respectively. The 15 min pan-firing treatment also had the highest total antioxidant activity at 19.33 ㎎ ascorbic acid equiv. eg/100 g. Finally, based on sensory evaluations, the 10 min pan-fired C. indicum L. flower tea had the best overall quality.

감국, 국화 및 구절초 꽃 휘발성 성분의 항산화활성

우관식(Koan Sik Woo),유정식(Jung Sik Yu),황인국(In Guk Hwang),이연리(Youn Ri Lee),이철희(Chul Hee Lee),윤향식(Hyang-Sik Yoon),이준수(Junsoo Lee),정헌상(Heon Sang Jeong) 한국식품영양과학회 2008 한국식품영양과학회지 Vol.37 No.6

감국, 국화 및 구절초 등 3종의 국화과 식물에 대해 향기성분을 분석하고 향기성분 추출물의 항산화활성을 측정하고자 3종의 국화과 식물에 대한 향기특성을 SDE법으로 추출하여 GC/MS로 분석한 결과 camphene, 1,8-cineole, benzene, pinocarvone, bicyclo-2,2,1-heptan-2-ol, trans-caryophyllene, 3-cyclohexen-1-ol, γ-curcumene, zingiberene, β-bisabolene 등이 검출되어 주요 향기성분임을 확인할 수 있었다. 또한 감국, 국화 및 구절초의 향기추출물에 대한 전자공여능을 DPPH법으로 측정한 결과 1 g/mL의 농도에서 각각 30.57, 46.36 및 51.72%로 나타내어 구절초 추출물이 항산화활성이 가장 높은 것으로 나타났다. 또한 총항산화력을 ABTS법으로 측정한 결과 각각 34.99, 35.31 및 38.48 ㎎ AEAC/g으로 나타내어 전자공여능과 마찬가지로 구절초가 항산화활성이 가장 높은 것으로 나타났다. 이러한 이유는 구절초가 camphene, 1,8-cineole, camphor, germacrene D, myrtenol 등의 성분이 감국이나 국화보다 다량 함유되어 있어 항산화활성이 높게 나타난 것으로 생각된다. The objective of this study was to compare the aroma characteristics and antioxidant activity of Chrysanthemum indicum Linne (CIL), C. morifolium Ramat (CMR) and C. zawadskii var Latilobum (CZL). The volatile compounds were extracted by simultaneous steam distillation extraction and identified with gas chromatography/mass spectrometer. The major volatile compounds of Chrysanthemum sp. were camphene, 1,8-cineole, benzene, pinocarvone, bicyclo-2,2,1-heptan-2-ol, β-caryophyllene, 3-cyclohexen-1-ol, γ-curcumene, zingiberene and β-bisabolene. The DPPH radical scavenging activity (EDA, %) of volatile compounds in CIL, CMR and CZL were 30.57, 46.36, and 51.72%/g sample, respectively. The ascorbic acid equivalent antioxidant capacity (AEAC) of volatile compounds were 34.99, 35.31, and 38.48 mg AEAC/g, respectively.

DWP305 ( Ursodeoxycholic acid Silymarin Fursulthiamine Riboflavin tetrabutyrate ) 의 경구 투여에 의한 랫드에서의 급성 및 아급성 독성 연구

남석우(Suk Woo Nam),박승희(Seung Hee Park),유세근(Se Geun Yu),서동완(Dong Wan Seo),김형식(Hyung Sik Kim),이병무(Byung Mu Lee),심점순(Jeon Soon Shim),유영효(Young Hyo Yu),박명환(Myung Hwan Park),이향우(Hyang Woo Lee) 한국응용약물학회 1994 Biomolecules & Therapeutics(구 응용약물학회지) Vol.2 No.3

The acute toxicity of DWP305 (Ursodeoxycholic acid : Silymarin : Fursulthiamine : Riboflavin tetrabutyrate=1 : 1 : 0.1 : 0.05) was evaluated in both sexes of Sprague-Dawley rats, 6 weeks old by the oral route of administration. DWP305 was not considered to induce any toxic effect on the rats in mortalities, clinical findings, body weights and gross findings. It is suggested that LD_(50) value in rats would be above 5 g/㎏ in the oral administration. Subacute toxicity of DWP305 was examined in Sprague-Dawley rats. Four groups of rats were administered orally at doses of 0, 0.32, 0.8, and 2.0 g/㎏/day of DWP305 for one month. Any significant toxic clinical symptom was not observed in the treated rats during the experimental period. Macroscopic examination on the organs of tested animals showed no abnormal findings. On autopsy, no significant changes were found in organs examined. Maximum tolerated dose of DWP305 for the rat was estimated to be above 2 g/㎏ in this study.