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Overexpression of PRAT1 protein is closely related to triple-negative breast cancer
Sang Eun Nam,Young-Sin Ko,Kyoung Sik Park,TongYi Jin,Young-Bum Yoo,Jung-Hyun Yang,Wook-Youn Kim,Hye-Seung Han,So-Dug Lim,Seung Eun Lee,Wan-Seop Kim 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.103 No.2
Purpose: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with a poor prognosis and a lack of targeted therapy. Overexpression of PRAT1 is thought to be associated with this aggressive subtype of cancer. Here, we performed a comprehensive analysis and assessed the association between overexpression of PRAT1 and TNBC. Methods: First, using different web-based bioinformatics platforms (TIMER 2.0, UALCAN, and GEPIA 2), the expression of was assessed. Then, the expression of the PRAT1 protein and hormone receptors and HER2 status were assessed by immunohistochemical analysis. For samples of tumors with equivocal immunoreactivity, we performed silver in situ hybridization of the HER2 gene to determine an accurate HER2 status. Next, we used the R package and bc-GenExMiner 4.8 to analyze the relationship between PRAT1 expression and clinicopathological parameters in breast cancer patients. Finally, we determined the relationship between PRAT1 overexpression and prognosis in patients. Results: The expression of PRAT1 in breast cancer tissues is significantly higher than in normal tissue. PRAT1 expression was significantly related to worse overall survival (P < 0.05) and was correlated with these clinicopathological features: T stage, N stage, age, high histologic grade, estrogen receptor status, progesterone receptor status, Her-2 status, TNBC status, basal-like status, CK5/6 status, and Ki67 status. Conclusion: PRAT1 was overexpressed in breast cancer compared to normal tissue, and it may be involved in the progression of breast cancer malignancy. This study provides suggestive evidence of the prognostic role of PRAT1 in breast cancer and the therapeutic target for TNBC.
우영민(Youngmin Woo),장진영(Jinyoung Jang),표영덕(Young Dug Pyo),정용진(Yongjin Jung),고아현(Ahyun Ko),조종표(Chongpyo Cho),김강출(Gangchul Kim),신영진(Youngjin Shin) 한국자동차공학회 2022 한국자동차공학회 지부 학술대회 논문집 Vol.2022 No.5
After the IMO (International maritime organization) announced GHG (green-house-gas) reduction plans, marine engine makers were confronted with a serious challenges on their fixture businesses. According to the Plan, every ships in operation in the sea must reduce its GHG emissions by 70%. Thus, a radical transition is inevitable from the residual oils into the gas fuels, which is eventually hydrogen or ammonia rather than LNG fuel. Between the zero carbon fuels, ammonia is on the spotlights to abate GHG emission from ships. Ammonia emits only water and nitrogen theoretically but both unburned ammonia and nitric oxides are also found in reality. This can raise another emission issue. In this study, many low flash point fuels such as LPG, CNG, and hydrogen in addition to ammonia were investigated to draw a feasible option for the low GHG emissions from the internal combustion engine. As a result, ammonia can be easily supplied into the diesel engine and it substituted some diesel so that the same amount of carbon dioxide emission is reduced from the test engine without any significant increase of NOx emission. Not only ammonia but also different low flash fuel mix showed better combustion characteristics to reduce engine emissions than ammonia-diesel case.
Clevudine myopathy in patients with chronic hepatitis B
Kim, Byung Kook,Oh, Jeeyoung,Kwon, So Young,Choe, Won Hyeok,Ko, Soon Young,Rhee, Kyoung Hoon,Seo, Tae Ho,Lim, So Dug,Lee, Chang Hong Elsevier 2009 Journal of hepatology Vol.51 No.4
<P>Clevudine (<SMALL>L</SMALL>-FMAU) is a thymidine <SMALL>L</SMALL>-nucleoside analogue that was recently introduced for the treatment of chronic hepatitis B virus infection. Previous studies showed that clevudine has potent and sustained antiviral activity without causing viral resistance. No severe adverse event occurred during clinical trials. We describe two cases of drug-induced myopathy during long-term treatment of chronic hepatitis B with clevudine.</P>
Kim, Ok-Sun,Jeong, Seung-Min,Ro, Ji-Young,Kim, Duck-Kyoung,Koh, Young-Cho,Ko, Young-Sin,Lim, So-Dug,Shin, Hwa-Yong,Kim, Hae-Kyoung The Korean Pain Society 2010 The Korean Journal of Pain Vol.23 No.1
Occipital neuralgia is a form of headache that involves the posterior occiput in the greater or lesser occipital nerve distribution. Pain can be severe and persistent with conservative treatment. We present a case of intractable occipital neuralgia that conventional therapeutic modalities failed to ameliorate. We speculate that, in this case, the cause of headache could be the greater occipital nerve entrapment by the obliquus capitis inferior muscle. After steroid and local anesthetic injection into obliquus capitis inferior muscles under fluoroscopic and sonographic guidance, the visual analogue scale was decreased from 9-10/10 to 1-2/10 for 2-3 weeks. The patient eventually got both greater occipital neurectomy and partial resection of obliquus capitis inferior muscles due to the short term effect of the injection. The successful steroid and local anesthetic injection for this occipital neuralgia shows that the refractory headache was caused by entrapment of greater occipital nerves by obliquus capitis inferior muscles.
간세포암종으로 오인된 면역글로불린 G4-연관 염증 가성종양
강승헌 ( Seung Heon Kang ),박상훈 ( Sang Hoon Park ),박호현 ( Ho Hyun Park ),이정록 ( Jeong Rok Lee ),최원혁 ( Won Hyeok Choe ),임소덕 ( So Dug Lim ),고순영 ( Soon Young Ko ) 대한간암학회 2016 대한간암학회지 Vol.16 No.2
Immunoglobulin G4-related disease is a recently recognized entity characterized by a massforming or regional lesion that contains an extensive infiltration of IgG4-producing plasma cells with dense fibrosis. Immunoglobulin G4-related disease can affect any organ system, but solitary hepatic lesion of Immunoglobulin G4-related disease is very rare. This entity mimics primary malignant hepatic tumor, such as hepatocellular carcinoma or intrahepatic cholangiocarcinoma. We experienced a case of hepatic IgG4-related inflammatory pseudotumor in a 50-year-old woman, mimicking hepatocellular carcinoma. (J Liver Cancer 2016;16:151-154)
관절염 대상자의 건강상태 조사 : 일개 도ㆍ농 복합시를 중심으로
이은희,최선하,서길희,소애영,이경숙,최정숙,고경덕,김명천,박현자,백승리,유보비,윤현숙,이애란,이명희,이은숙,임영옥,정복녀,이영숙 대한류마티스 건강전문학회 2001 근관절건강학회지 Vol.8 No.2
The Purpose of this study was to investigate the health status and to examine the relationship between health related variables of the clients with arthritis. This descriptive-correlational study was measured physical health status(pain, fatigue, physical disability, joint flexibility) and psycho-social health status(social function disability, self-efficacy, depression) . The clients were consisted of 127 arthritis clients who were randomly selected from health center, 2 sub health center and 6 primary health care center in Wonju City. The data was collected from November 2000 to January 2001. The results of the study analyzed using a SPSS win were as follows : 1) The subjects' average age was 64.81 years old(female : 86.6%, male : 13.4%). 2) In physical health status, the average score of fatigue was 63 scores and pain was 69.77 Physical disability score was higher than total disability score. In psycho-social disability, housekeeping management disability score was higher than social function disability score. In psycho-social health status, the average score of self-efficacy was 70.86 and the subjects have higher level of depression, more than 20 scores. 3) On Pain sites, almost of subjects complained of a knee joint pain. The waist, wrist, and shoulder joint Pain were followed. The numbers of Pain site were 8.3 Per individuals 4) The flexibility of knee and shoulder joint were lower than another joints. 5) Correlation with fatigue, pain, physical disability, social disability, self-efficacy and depression was revealed highly significant. We suggest that health Promotion program considering our research results should be provided for arthritis clients in community level .