위장관 간질종양의 임상 및 병리학적 고찰

김영호,장우영,이순진,손희정,최규완,도재혁,백승운,이준행,이풍렬,이종철,박철근,임윤정,김갑철,김재준,임효근 대한소화기학회 2001 대한소화기학회지 Vol.37 No.3

Background & Aims: Gastrointestinal stromal tumor (GIST) constitutes primary nonepithelial neoplasms of the gastrointestinal tract and includes most tumors previously designated as leiomyomas/leiomyosarcomas. GIST is pathologically divided into benign, borderline and malignanct tumor. This study was carried out to delineate the clinical and pathologic features of GIST and to establish the features predicting malignancy. Methods: Clinicopathologic data of 84 patients who had GIST from 1995 to 1999 were reviewed. Results: The subjects were 42 men and 42 women, and their mean age was 59.3±13.2 years. We located fifty-two tumors in the stomach, 28 tumors in the small intestine and 4 tumors in the colorectum years. Histopathology revealed benign tumors in 23 of the 84 patients, borderline tumors in 22, malignant tumors in 39. The average size of tumors was 6.23 cm in diameter (range, 0.6-26 cm). Metastasis was noted in 15.5% of the patients at diagnosis. On endoscopy, ulceration was more common in malignancy. Endsonographic findings except size were not significant statistically. On contrast enhanced computed tomography, malignancy showed more irregular shape and variable attenuation than benign lesions, which seemed to be valuable factor. Conclusions: The variables predicting malignancy were large tumor size (≥5 cm), location of the colorectum, palpable abdominal mass, ulceration on endoscopy, and less uniformity in shape and variable attenuation on computed tomography.

대장 선종과 Apolipoprotein E 유전형과의 관계

김영호,최윤호,손희정,강태욱,최규완,최봉준,이종철,박상종,이지민,배문희,김재준,이풍렬 대한소화기내시경학회 2001 Clinical Endoscopy Vol.23 No.1

Background/Aims: Apolipoprotein B polymorphism plays an important role in the metabolism of cholesterol. And bile acids, which may be related to the development of colorectal adenomas, An association between apolipoprotein B genotype and colonic adenomas bas been reparted in a western country. This study was designed to determine whether the apolipopratein S was genotype would be associated with proximal or distal colonic adenomas in Koreans. Methods: On the colonoscopy, colonic adenomas were found in 132 patients. Proxima1 colonic adenoma was found in 35 patients and distal colonic adenoma was found in 97 patients. Serum leveis of total cholesterol, LDL-cholesterol, HDL-cholesterol and trlglyceride were measured. Apolipoprotein E genotype was determined by PCR and allele specific oligonucleotide hybridization. 279 contro1 subjects without an adenoma on the screening sigmoidoscopy were se1ecfed randomly. Results: The serum levels of total choles0'rol, LDL-cholesterol, HDL-cholesterol and triglyceride did not significantiy differ between each adenoma group and control group. The individual frequencies of ε2, ε3 and ε4 alleles in patients with colonic adenomas did not differ from those in control subjects. The frequency of either heterozygote or homozygote for g 4 allele in patients with proximal adenoma was lower than that in control subjects (0.029 vs O.I68, p $lt; 0.05). Conclnsions: The data suggest that g 4 allele may be associated with a lower risk for the development of proximal colonic adenoma in Korean men.

Glutaraldehyde 와 자동 세척기를 이용한 내시경 소독방법의 임상에서의 유용성

김영호,손희정,윤성원,최규완,이남용,백승운,이준행,고광철,이풍렬,이종철,송재훈,안병훈,김재준,최원혁,홍일철 대한소화기내시경학회 2001 Clinical Endoscopy Vol.22 No.6

Background/Aims: Safety of endoscopic procedures has been a major issue over the last 10 years. Most endoscopy units use 2% glutaraldehyde and automated endoscope reprocessors (AERs) for disinfecting gastrointestinal endoscopes. We attempted an in-use evaluation of the current reprocessing procedures. Methods: Thirty flexible endoscopes were randomly collected just after upper endoscopic examinations and were disinfected using 2% glutaraldehyde in an AER. Cultures were taken from biopsy channels (S-l), tip of the insertion tubes (S-2), umbilical cords (S-3), and angulation knobs (S-4). Results: In 63,3% (19/30) of endoscopes, there was no microbial contamination after disinfection procedures. The culture positive rates of S-l, S-2, S-3, and S-4 samples were 20,0%, 0.0%, 3.3%, and 20.0%, respectively. Microorganisms of 13 species were identified, but there was no pathogen related with reported infectious complications after endoscopic procedures. Conclusions: Current disinfection procedure using 2% glutaraldehyde and an AER appears to be very effective in decontaminating patient-used endoscopes. Low level microbial contamination of endoscopes after conventional reprocessing methods may not impose great risk on patients.

활동성 크론병에서 초기 스테로이드 치료 반응에 따른 임상적, 생화학적, 병리학적 인자들에 관한 연구

김영호,장재권,김지은,최규완,박동일,도재혁,백승운,고광철,이풍렬,이종철,현재근,안병훈,김재준,류민규 대한소화기내시경학회 2001 Clinical Endoscopy Vol.22 No.6

Background/Aims: The predictory factors of the response to initial steroid therapy in active Crohn's disease has been controversial in numerous literature reviews. We evaluated any predictory faetor of the response to initial steroid therapy in active Crohn`s disease patients, Methods: The medical records of 32 patients with active Crohn`s disease who clinically responded to oral steroid therapy were retrospectively reviewed. The steroid responsive group was defined as the one showing maintenance of response for more than one month from steroid withdrawal and the steroid dependent group as the one showing relapse or exacerbation during steroid tapering or within 30 days from steroid withdrawal. The clinical, biochemical, and pathologic factors were evaluated. Results: There were 22 male and 10 female patients. The mean age was 28.9 years. The number of steroid responsive and dependent group was 22 (68.8%) and 10 (31.2%), respectively. There were no significant differences between these two groups in age, sex, time to diagnosis, perianal lesion, extent of disease, extraintestinal manifestations, presence of granuloma, presenting features, hemoglobin, ESR, and CRP, except serum albumin level. Conclusions: Serum albumin level was significantly lower in steroid dependent group than steroid responsive group, reflecting severe inflammation in steroid dependent group.

역류성 식도염 환자에서 Helicobacter pylori 치료 1 년 후 증상과 내시경적 변화

김영호,손희정,최규완,박동일,백승운,이준행,고광철,이풍렬,이종철,임윤정,김재준 대한소화기내시경학회 2001 Clinical Endoscopy Vol.24 No.1

성인에서 반복적인 위장관출혈로 발현한 공장 거대 중복성 낭종

김영호,이경수,이상수,문원,강태욱,최규완,박동일,도재혁,백승운,이풍렬,이종철,김재준,류민규 대한내과학회 2001 대한내과학회지 Vol.61 No.3

Duplication of the alimentary tract is an unusual congenital anomaly which may occur at any level, from the oral cavity to the rectum. Jejunal duplication cyst is quite rare and most of them are presented in infancy with the symptoms of abdominal mass, obstruction, hemorrhage and perforation. But some cases has not been diagnosed till adult if duplication cyst was too small enough to cause symptoms. We report a case of a 28-year-old woman who presented with recurrent gastrointestinal hemorrhage as a result of an ulceration without ectopic mucosa in jejunal duplication cyst and was successfully treated with surgery.(Korean J Med 61:264-269, 2001)

위암의 연령에 따른 차이

김영재(Young Jae Kim),이영철(Young Chul Rhee),이만길(man Kill Lee),차호(Ho Cha),정영채(Young Chae Jung) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.1

N/A Comparative analytic review on clinical, endoscopic and histopathological findings was done in 13 cases of young age (under 29), 446 cases of mid age (30~69) and 39 cases of old age (above 70) stomach cancer who were visited Department of Internal Medicine of Masan Koryo General Hospital from March 1981 to July 1985. The following results were obtained: The peak of age incidence was the 5th decade amounting to 36.8%. The ratio between male and female was 2.6:1. The main chief complaint of each group was epigastric pain and it was followed by epigastric fullness. The most patient had the duration of symptom from 3 months to 6 months. For old-age group, mid-age group, major site of lesion in the antrum, meanwhile body for young-age group. The most frequent type of gastric cancer was type III in each group by Borrmanns classification. For each group, adenocarcinoma was major cases in the view of histopathological findings, and incidence of well differentiated type adenocarcinoma were lower in young-age group than others.

Invention Rules:A Look into the Creative Process of Yeats's "Sailing to Byzantium"

Rhee,Young-Suck 漢陽大學校 人文科學大學 1989 人文論叢 Vol.17 No.-

좋은 글을 쓰는 일은 쉽지 않다. 더욱이, 다른 사람들에게 훌륭한 글을 쓰도록 가르치는 일은 더욱 힘들다. 지금까지 작문하면, 학생들에게 글을 쓰게하고 완성된 글을 문법적으로나 주재상으로 범한 오류를 지적하고 수정하는 것으로 만족했었다. 그러나 Richard E. Young등의 학자들은 학생들에게 보다 적극적인 방법으로서 글의 창안(invention)에서 부터, 독자와 필자 사이의 관계 정립을 거쳐, 문장, 수정, 문체, 등에 이르기까지 작문의 전과정을 해부함으로써 글쓰는 일이 기계적인 것이 아니라, 어떤 창조적 과정을 거치는 작업임을 강조한다. 따라서 이들이 가장 중요시하는 부분이 창안(invention), 즉 글쓰기 직전의 모든 영역이며, 이를 분석 정리하여 법칙(maxim)으로 제시하고 있다. 본고에서는 이 법칙을 통해서, Yeats의 시를 분석함으로써 좋은 글이란 스스로 생성하는 것이 아니라, 작자의 창조적 사고 과정을 거친다는 점을 두드러지게 보여주고 있다.

Yeats in Albright : Poetics of the Modernist and Post-Modernist (for the late Professor Daniel Albright)

Young Suck Rhee 한국예이츠학회 2015 한국예이츠 저널 Vol.46 No.-

이논문은예이츠의시에비추어올브라이트가최근에발표한새롭게(포스 트)모던하게창작한 시의시학에 초점을 맞추어우리의 당대의시인 대니얼 올브라이트의 시를읽으려는시도이다. 올브라이트는자신이예이츠의영향에있다고생각하지는못했을 지 모른다. 그러나 그는, 예이츠가 젊은 시절 블레이크의 시를 편집했던 것처럼 예이츠의 모든시를편집한바있다. 예이츠학자로서저자는올브라이트의시에서예이츠의반향을 들을수있다. 이논문은예이츠의시를새롭게조명할수있을것이며앞으로포스트모던한 시들이 올브라이트 시가 보여주는 방법을 취할 수도 있을 것이다. My paper makes an attempt to read Yeats’s poetry in the light of new poetry our contemporary poet, Daniel Albright, has written by focusing on the Yeatsian poetics renewed and (Post-)Modernized in Albright’s recent poetry in comparison with Yeats’s. Albright may never have thought he was under the influence of Yeats, but he has edited all of Yeats’s poetry, just as Yeats has edited Blake’s poetry when young. As Yeats scholar, I hear the Yeatsian echoes in Albright’s poetry. This reading is to help throw new light on Yeats’s poetry and give some direction Post-Modern poetry may take as exemplified in Albright’s poetry.

항암항생제 Daunorubicin의 Aglycone, 7,9-Dideoxydaunomycinone의 합성 (제1보)

조인호,이풍래,노영쇠,In Ho Cho,Richard P. Rhee,Young Soy Rho,F. M. Hauser 대한화학회 1986 대한화학회지 Vol.30 No.1

항암항생제 Daunorubicin(2a)합성단계의 최종물질인 7,9-Dideoxydaunomycinone (32)를 3-methoxybenzoic acid(5)로 부터 합성하였다. 3-methoxybenzoic acid를 4-methoxy-3-(phenylsulfonyl)-1(3H)-isobenzofuranone(11)으로 변형시킨 뒤 Hauser와 Rhee가 개발한 고리접합법을 이용하여 trimethoxynaphthoate 16을 얻은 후에 phenylsulfonylnaphthofuranone 22로 변화시킨 뒤 이 물질을 7-(ethylenedioxy)-2-octenoate(23)과 Michael형태의 반응을 전개시켜 anthracenoate 24를 얻었다. Anthracenoate을 tetracyclic 화합물 28로 바꾼뒤 ring B와 C에 붙은 methyl기들을 제거하여 7,9-Dideoxydaunomycinone(32)를 만들었다. 7,9-Dideoxydaunomycinone (32), a late-stage precursor of the aglycone of antitumor antibiotic daunorubicin(2a) was prepared from 3-methoxybenzoic acid(5). Thus, 3-methoxybenzoic acid was converted to 4-methoxy-3-(phenylsulfonyl)-1(3H)-isobenzofuranone(11), which furnished trimethoxynaphthoate 16 upon ring annelation developed by Hauser and Rhee. The trimethoxynaphthoate 16 upon ring annelation developed by Hauser and Rbee. The trimethoxynaphtboate 16 was then transformed into phenylsulfonylnaphthofuranone 22, which was used to make anthracenoate 24 via Michael type reaction with 7-(ethylenedioxy)-2-octenoate(23). Conversion of anthracenoate 24 to tetracyclic product 28, followed by subsequent deprotection of the methyl groups in ring-B and C furnished 7, 9-Dideoxydaunomycinone(32).