Insulation Coating of Fe–Si–Cr Soft Magnetic Powder by Selective Oxidation

Jae‑Young Park,Kwangsuk Park,Bosung Seo,Julien O. Fadonougbo,Tae‑Wook Na,Ki Beom Park,Hyeon‑Tae Im,Nong‑Moon Hwang,Hyung‑Ki Park 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.7

This study examines the insulation coating technology of Fe–Si–Cr powder via selective oxidation annealing, which oxidizeselements selectively by controlling the oxidation potential. The study calculated the oxidation driving force of Fe, Si, andCr, and conducted a thermodynamic analysis of oxidation and reduction conditions according to temperature and oxidationpotential. Based on the results, a selective oxidation annealing was performed in an atmosphere in which Fe is reduced andonly Si and Cr are selectively oxidized. The oxidation potential was controlled through the partial pressure ratio of hydrogenand water vapor. The XPS analysis results confirmed that a Si and Cr complex oxide layer formed on the powder surfaceafter the selective oxidation annealing. Afterward, withstanding voltages were analyzed to evaluate the insulation property. Then, the withstanding voltage of the powder applying the selective oxidation annealing increased significantly comparedto that of the initial powder. Further analysis showed that the powder annealed in an air atmosphere had a significantly lowersaturation magnetic flux density than the initial powder, while the powder applying the selective oxidation annealing hadonly a slightly reduced saturation magnetic flux density.

공복 시 Caffeine 투여 후 일회성 운동이 흰쥐의 인슐린 및 골격근의 GLUT-4 발현에 미치는 영향

정일규,오명진,김영표,김종오,윤재석,서태범,윤진환 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

This study was done to investigate the effects of caffeine ingestion on the expression of GLUT-4 in rats' skeletal muscle(soleus m) and blood insulin level after 12 hr fasting condition and one hour treadmill running. Total 19 rats(Sprague-Dawley) who were 7week Did were used for experimental subjects and raised for 1week in the room controled the air temperature and relative humudity(22℃ and 50%). They were divided three groups ; 12hr fasting group(F group, n=5), fasting+exercise group(FE, n= 7) and fasting+caffeine+exercise group(FCE group, n=7). FG and FCE group performed treadmill running for one hour and the treadmill speed was 18m/min that was supposed to be moderate exercise to rats. Each Dr rats in FCE group was forced to he given the caffeine solution(5mg/kg, Sigma Chemical co.) through stainless steel tube directly to their stomachs one hour before treadmill exercise. Immediately after treadmill running, we anesthetized them with the mixed solution(Ketamin 80g/kg and Rompun 5ml/kg) to draw 3ml blood from heart four insulin analysis and then obtained the rats' soleus muscle for GLUT-4 expression. We found that FCE group showed significantly higher GLUT - expression then the other groups and FE group showed the lowest GLUT-4 expression. This rusults suggest that the endurance type of exercise in fasting condition inhibit the GLUT-4 expression in working muscle and the caffeine helped to facilitate the GLUT-4 expression during endurance type of exercise. The future studies needed to confirm the action of caffeine to increase the GLUT- 4 and the mechanism.

독성물질의 세포사 기전 및 세포사 유발물질의 검색법 개발에 관한 연구(Ⅱ) : 망간 신경독성을 이용한 파킨슨증 모델의 세포사 Studies on the Mechanism of Parkinsonism induced by Manganese

김종민,박창원,오정자,이보경,서경원,서수경,김규봉,김종원,김광진,김영옥,전범석,박찬웅,이선희 식품의약품안전청 2001 식품의약품안전청 연보 Vol.5 No.-

1960년대 이후 파킨슨병의 유발물질 중 한 후보로서 망간이 주목받으면서 많은 역학적, 병러학적 연구가 수행죄브다. 그러나 망간이 파킨슨병을 직접 일으키는지, 혹은 파킨슨병과 관련된 부위의 신경세포를 파괴시쿡 파킨슨증만을 초래하는 것인지가 아직 정립되지 않은 실정이다 본 연구에서는 실험동물모델에서 행등학적 변화 측정 및 병리학적, 샐화학적 연구를 통하여 망간의 과다노출글 따른 파킨슨병 유발 여부를 확인하고자 하였다. Sprague-Datylet· 렛드에 망간을 1, 2, 5, 10 mgAg/day의 응량으로 30일 등안 복강 투여하였을 때 모든 망간투여군에서 운동성 감소가 관찰되었다. 뇌조직의 망간 함량을 ion chromatograph?로 측정한 결과 중뇌 흑질과 기저핵 선조체에서 망간 함량의 뚜렷한 증가 소견이 관찰되었으며, 니슬염색체서 선조체의 신경세포수의 유의성 있는 감소가 관찰되었다. 그러나, 흑질의 TH효소 면역염색, GFAP 면역염색, 흑질과 선조체의 T릿효소 western blot 결과는 대조군과 차이가 없었다. 이상의 결과에서, 망간-파킨슨증 모델에서 파킨슨증어 유발되는 기전은 흑질 도파민성 신경 세포의 신호를 받는 선조체 씬경세포의 사멸에 의한 것으로 생각된다. 결론적으로, 망간 독성에 의한 파킨스증 모델에서는 파킨슨 병과는 달리 흑질 도파민성 신경세포의 세포사는 관여하지 않는 것으로 관찰되었다. Manganese(Mn) intoxication causes a parkinsonian syndrome. It may be difficult to distinguish Mn-induced parkinsonism from idiopathic Parkinson disease(IPD). Neuropathological descriptions on the brains with Mn intoxication showed the perferential damage in the globus pallidus and substantia nigra pars reticularis. Pathological reports on the substantia nigra pars compacta(SNpc), a mafor focus of pathologic changes in IPD, are discordant and controversial. The SNpc involvement is of critical importance for the elucidation of pathogenesis of IPD. Therefore, the neurodegeneration in SNpc was investigated in the experimental model of Mn neurotoxicity. Sprague-Dawley rats were administered with manganese chloride(1, 2, 5, 10 mg/kg/day, i.p.) for 30 days. Treated animals showed low levels of distance-traveled from locomotor activity tests. Ion chromatography revealed that Mn accumulation was significant in SN and basal ganglia in Mn-treated animals. Nissl staining showed neuronal loss of the striatum in all treated animals. The degree of neurodegeneration in SN was determined by immunohistochemical staining of tyrosine hydroxylase(TH). The numbers of TH-positive cells on nigral sections were not different from each groups(P>0.05). The densities of glial fibrillary acidic protein immunoreactivity from SN were similar between groups. TH-westen blotting showed no differences between treated animals and controls. In conclusion, the SNpc remains intact in Mn intoxication, and Mn-induced parkinsonism may be caused by damages of output pathways downstream to the nigrostriatal dopminergic system.

Effect of Phellinus linteus Extract Supplementation on Cortisol and Related Cytokines in Young Male Adults

Jeong-Beom Lee,신영오,Jun-Sang Bae,Young-Ki Min,Hun-Mo Yang,Hyung-Seok Seo,권대근,강준용,Young-ju Song 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.3

This study investigated the anti-inflammatory effects of Pellinus linteus (PL) extract supplementation in healthy young men. The subjects were 18 healthy young males 20 years of age that were given 1.5 L of 0.12% PL extract orally (n=8) or a placebo (control group, n=10)daily for 4 weeks. The body composition, the white blood cell (WBC) count and differential as well as the serum cortisol, interleukin (IL)-1β, and IL-6 concentrations were measured before and after the supplementation. Serum concentrations of cortisol and IL-1β at rest after oral supplementation were significantly decreased compared to before treatment (p<0.01, p<0.05, respectively). However,there was no change in the IL-6. And also, these factors in PL extract supplement group were significantly reduced after performing the exercise compared to control group. These results suggest that oral PL extract supplements for 4 weeks had a significant effect on inhibition of inflammatory markers in healthy young men.

토마토 여름 육묘시 어린묘 정식과 육묘방법이 생육 및 수량에 미치는 영향

이희경,이문행,박권서,이은모,전낙범,서상덕,조평화,김영식,김성은,조숙경,Lee, Hee-Keyung,Lee, Mun-Haeng,Park, Guen-Se,Lee, Eun-Mo,Jeon, Nak-Beom,Seo, Sang-Deag,Cho, Pyeng-Hwa,Kim, Young-Shik,Kim, Seng-Eun,Cho, Suk-Keyung 한국유기농업학회 2015 韓國有機農業學會誌 Vol.23 No.1

고온기 토마토 육묘 시 발생하는 묘의 도장 및 연약화 등의 문제점을 최소화하기 위하여 어린 묘 정식과 육묘방법에 따른 토마토 생육과 수량에 미치는 영향을 구명하고자 수행하였다. 고온기인 7월 20일부터 9월 7일까지 실생묘, 삽목묘, 접목묘로 육묘하였고 어린 묘는 다른 묘보다 20일 정식하였다. 어린묘의 묘소질은 다른 묘에 비해 연약했으며 생체중은 실생묘보다 1/10 정도로 적어 큰 차이를 나타냈다. 정식 20일 후의 어린 묘의 생육은 다른 육묘방법에 비해 양호하였고 생체중은 36.1 g으로 실생묘에 비해 약 3배 정도 증가되었다. 정식 2개월 후의 어린 묘에서 이상줄기는 발생하지 않았고 화방출현도 빨랐다. 어린 묘에서 총 수량과 상품수량이 각각 8,535 kg/10a, 7,575 kg/10a로 가장 많았다. 과실품질은 어린 묘와 육묘방법별로 큰 차이가 없었으며 이상의 결과로 판단해 볼 때 토마토 고온기 육묘 시 어린 묘를 정식함으로써 생육을 촉진하고 과실 수확량을 높여 토마토를 안정적으로 생산 할 수 있을 것으로 판단된다. Effect of seedling type and early transplanting of summer grown seedling on the growth and yield of tomato was investigated to minimize problems caused by legginess of seedling in summer. Grafted seedling, 20 days seedling (young seedling), 40 days seedling, and rooted cutting were raised from July 20 to Sept. 7 and young seedling was transplanted 20 days earlier than other seedling types. Young seedling growth was weaker than other seedling types and fresh weight was only 1/10 of 40 days seedling. Growth of young seedling at 20 days after transplanting was better than other seedling types and fresh weight was 3 times higher than 40 days seedling. Creased stem did not appear and trusses developed faster in young seedling. Total yield and commercial yield were highest in young seedling as 8,535 kg/10a, and 7,575 kg/10a. There is no significant difference among seedling types in fruit quality. This result shows that early transplanting of summer grown seedling is more effective to attain stable growth and yield in tomato.

Relationship of the Lodging of Corn Hybrids and Wet Stress in Field Condition

Young-Son Cho,Byeong-Jin Lee,Daniel Son,Young-Hwan Yoon,Won-Ha Yang,Jong-Ho Seo,Chung-Kook Kim,Beom-Young Son 한국국제농업개발학회 2011 韓國國際農業開發學會誌 Vol.23 No.4

포장조건에서 22종의 옥수수교잡종을 과습조건에서 도복관련형질들의 상호관련성을 검정하였는데 좌절중 (1.0 m, 1.5 m)과 좌절부위등을 평가하였고 주요한 도복 저항성 형질인 좌절중, 간직경, 뿌리건물중, 중심고등의 상호 관련성을 함께 평가하였다. 본시험은 포트시험에서 일차 스크린 한 것을 논에 경사지를 만들어 경사지별로 수분함량과 도복저항성을 비교하기 위하여 관수시기(과습조건)를 파종후 20일, 5엽기, 출웅기, 출사기로 구분하였고 관수량은 100 mm/일 씩 5일간 처리하였으며 조사는 수확기에 수행 하였다. 본시험의 결과 출사기에 1.0 m, 1.5 m 높이에서 좌절중과 중심고는 정의 상관을 보였으며 파종후 20일차에 관수처리구에서는1.0m, 1.5m 모두 좌절강도와 간직경이 정의 상관을 나타냈다. 관수처리 5엽기에서는 높이 1.0 m에서 좌절강도와 간직경간의 강한 정의 상관을 나타냈으며 도복관련 형질인 간직경, 뿌리건물중,지상부 중심고, 좌절중, 좌절고등이지만 관수처리시 이들을 가장쉽게 판별 할 수 있는 방법은 5엽기에 관수처리구가 가장 효율적으로 사료된다. Under field conditions, 22 corn hybrids(CHs) were tested for several characteristics related to lodging resistance and excessive water stress, such as pushing resistance on 1.0 and 1.5 m hights of the corns and breaking point. The 22 corn CHs were selected because they showed strongest pushing resistance and breaking resistance of culm as well as the highest thickness of basal culm, leaf greenness, leaf area, and plant height based on two pre-pot experiments performed in phytotron. To make excess water condition, water irrigation was done at 1) 20-d after seeding, 2) 5th leaf stage, 3) tasseling stage, and 4) silking stage with 100 mm/day for 5 days. Lodging-related characteristics were measured: culm diameter, root dry weight, weight balance of above-ground plant, breaking resistance, and breaking height in field experiment. Among all the characteristics tested, we explained in the two critical points for lodging resistance: 1) breaking resistance and breaking point, 2) culm diameter with breaking resistance and breaking point, and they were further evaluated for the relationships with the 1.0 and 1.5m height of above-ground plant. In the corn hybrids, there was a positive correlation between breaking resistant and weight balance of corn at the silking stage water treatment at 1.0 and 1.5-m height. And breaking resistant and culm diameter had a positive relationship at the 20-d water treatment at both measuring height. In conclusion, selection for lodging resistant hybrids or germplasms to excess soilwater should be made at the 5th leaf stage water treatment, and basal culm thickness should be considered to evaluate the resistance of the corn hybrid plants to lodging.

Microelectromechanical-System-Based Variable-Focus Liquid Lens for Capsule Endoscopes

Seo, Sang Won,Han, Seungoh,Seo, Jun Ho,Kim, Young Mok,Kang, Moon Sik,Min, Nam Ki,Choi, Woo Beom,Sung, Man Young IOP Publishing 2009 Japanese journal of applied physics Vol.48 No.r5

Growth-promoting activity of Hominis Placenta extract on regenerating sciatic nerve1

SEO, Tae-beom,HAN, In-sun,YOON, Jin-hwan,SEOL, In-chan,KIM, Yun-sik,JO, Hyun-kyung,AN, Joung-jo,HONG, Kwon-eui,SEO, Young-bae,KIM, Dong-hee,PARK, Seung-kiel,YANG, Deok-chun,NAMGUNG, Uk Springer Science and Business Media LLC 2006 Acta pharmacologica Sinica. Vol.27 No.1

<P>AIM: Extract of Hominis Placenta (HP) has been used in oriental medicine as an agent for improving physiological function. The present study was conducted to investigate whether HP treatment in an experimental sciatic nerve injury animal model produces growth-promoting effects on regenerating peripheral nerve fibers after injury. METHODS: After HP was injected into a sciatic nerve injury site, changes in protein levels were analyzed in the regenerating nerve area by Western blotting and immunofluorescence staining analyses. For quantitative assessment of axonal regeneration, a retrograde tracing technique was used to identify the neuronal cell bodies corresponding to regenerating axons, and the extent of neurite outgrowth in cultured dorsal root ganglia (DRG) sensory neurons prepared from animals that had experienced a sciatic nerve crush injury 7 d before neuron collection was analyzed. RESULTS: Induction levels of axonal growth-associated protein (GAP-43) in the injured sciatic nerves were elevated by HP treatment. HP treatment also upregulated cell division cycle 2 (Cdc2) protein levels in the distal stump of the injured sciatic nerve. Induced Cdc2 protein was detected in Schwann cells, suggesting that Cdc2 kinase activity may be involved in the growth-promoting activity of regenerating axons via Schwann cell proliferation. Cell body measurement by retrograde tracing indicated that HP treatment produced significant increases in regenerating motor axons. Finally, HP treatment of cultured DRG sensory neurons significantly increased neurite arborization and elongation. CONCLUSION: HP promotes the regeneration of injured sciatic axons by upregulating the synthesis of regeneration-related protein factors such as GAP-43 and Cdc2.</P>

새로운 베스타틴 유사체의 입체선택적 합성

서영란 ( Young Ran Seo ),이수범 ( Soo Beom Lee ),김영규 ( Young Gyu Kim ) 한국공업화학회 2015 공업화학 Vol.26 No.1

Two new analogs of bestatin were prepared from D-leucine and D-valine in a stereoselective and efficient way. An aminopeptidase inhibitor bestatin shows significant biological effects on immunomodulation and is marketed for the treatment of acute myelocytic leukemia. The key intermediates, trans-oxazolidine methyl esters 2a and 2b, were obtained with more than 20 to 1 stereoselectivity in a one-pot procedure by the three cascade reactions between N-hydroxymethyl protected α-amino aldehydes (4a and 4b) and phenylsulfonylnitromethane (PhSO2CH2NO2) and the following in-situ ozonolysis. Basic hydrolysis of 2a and 2b, and then the peptide coupling with L-Leu-OMe produced the protected derivatives of two new bestatin analogs, 3a and 3b, respectively. The new isobutyl and isopropyl analogs of bestatin (1a and 1b) were produced in overall 51% and 38% yields, respectively, with high stereoselectivity from the corresponding protected α-amino aldehydes 4 in a six-step process.

대관령 풍력발전 단지의 집중관측을 활용한 WRF 모형의 검증

서범근(Beom-Keun Seo),변재영(Jae-Young Byon),구해정(Hae-Jung Koo),김근회(Geun-Hoi Kim),정현숙(Hyun-Sook Jung),박영산(Young-San Park),최영진(Young-Jean Choi) 한국신재생에너지학회 2013 한국신재생에너지학회 학술대회논문집 Vol.2013 No.05