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척수 좌상 후 트레드밀 운동에 의해 활성화된 Cdc2와 p-ERK1/2 단백질이 cavity 내에서 별아교세포의 증식과 축삭 재성장에 미치는 효과
서태범,김유미,최연주,김윤만,남궁욱,윤진환 한국생활환경학회 2012 한국생활환경학회지 Vol.19 No.4
Physical exercise is recommended as a therapeutic tool for improving functional and histological deficits in spinal cord contusion injury (SCI). Cell division cycle 2 (Cdc2) and Extracellular signal-regulated kinase 1/2 (ERK1/2) have been known to regulate proliferation of non-neuronal cells in both central and peripheral nervous system. Here we investigated the effect of activated Cdc2 and ERK1/2 by treadmill exercise on axonal regeneration of corticospinal tract and proliferation of astrocytes within the cavity after spinal cord contusion injury. The rats were divided into three groups: the control group (n = 20), the spinal cord injury group (n = 20), and spinal cord injury and treadmill exercise group (n = 20). We carried out Basso-Beattie-Bresnahan (BBB) test to determine functional recovery after spinal cord injury and treadmill exercise for 4 weeks significantly improved SCI-induced behavioral deficits (F = 25.457, p < .001). We also found that Cdc2 (F = 34.548, p < .001) and p-ERK1/2 expression (F = 311.507, p < .001) levels in the injured areas were further facilitated by treadmill exercise when compared to non-exercise group. Exercise-induced Cdc2 and p-ERK1/2 levels after SCI were associated with astrocyte proliferation within the cavity of the injury site. Also the results of present study suggested that treadmill exercise increased axonal sprouting of injured corticospinal tract post SCI. Our data provide evidence that treadmill exercise may be an important intervention for mediating axonal regeneration and biochemical alteration after SCI.
Non-gray Radiation with Turbulent Convection in the Entrance Region of a Smooth Tube
서태범,Seo, T.B. 대한설비공학회 1995 설비공학 논문집 Vol.7 No.4
튜브 내의 입구영역에서 난류 유동에 의한 대류와 비회복사(non-gray radiation)가 동시에 일어날 때의 열전달특성을 수치해석적으로 연구하였다. 작동유체는 이산화탄소, 수증기, 질소의 혼합가스라고 가정하였다. 지배방정식을 계산하기 위해 유한차분법이 이용되었고, 복사전달방정식을 이차편미분방정식으로 바꾸기 위해 P-1 근사법이 사용되었다. 그리고 혼합가스의 비회흡수계수(non-gray absorption coefficient)는 지수광폭밴드모형(exponential wide band model)을 이용해서 구하였다. 열전달특성에 대한 온도조건의 영향을 조사하기 위해 튜브의 축방향에 대한 평균 온도와 뉴셀트수(Nusselt number)의 변화를 몇 가지 다른 온도조건에 대해 나타내었다. 또한, 가스의 성분조성에 대한 영향을 조사하였으며, 이러한 결과에 기초해서 튜브 내에서 난류유동에 의한 대류와 비화복사가 동시에 일어날 때의 복사 뉴셀트수를 쉽게 예측할 수 있는 방법을 제시하였다.
초등 과학수업에서 KWPLC 학습전략 개발 및 적용의 효과
서태범,최선영 韓國生物敎育學會 2012 생물교육 Vol.40 No.2
The purpose of this study was to develop the KWPLC instructional strategy and explore the its effects of science process skills, science achievement and scientific attitude. The objects were conducted the third grade pupils of both an experimental group (28 students) and a control group (29 students) at the G elementary school located in Incheon City. The results of this study were as follows: First, the test on the science process skills, which was performed after the treatment of learning, was found a statistically meaningful difference (p<.05). Second, after the application of KWPLC instructional strategy, the result of science achievement was shown a statistically meaningful difference (p<.05). Third, a meaningful difference was also shown in the scientific attitude. Therefore, the KWPLC instructional strategy applied in this study might be useful to improve the science process skills, scientific attitude, achievement in elementary science class.