소화관내 이물에 대한 고찰

윤한덕,류진호,박주경,허탁,조석주,김성근,민용일 大韓應急醫學會 1997 대한응급의학회지 Vol.8 No.1

We analyzed records at Chonnam university hospital from Sep. 1. 1993 to Aug. 31. 1996 to assess clinical significance of the foreign body in the gastrointestinal tract. There were 133 episodes consisting of 79 pediatric and 54 adult patients as possible to review. In the pediatric patients, the coin was the most common cause of foreign body ingestion, while adult patients were usually caused by bones and meat. We removed foreign bodies in the oral cavity and oropharynx in 12 cases using direct laryngopharyngoscpy and forcep. Endoscopy was performed successfully in 47 of 51 patients in which was attempted; there were two complications composed of an aspiration pneumonia and a mediastinitis due to esophageal perforation. There were spontaneous passage of foreign bodies in 48 cases. We observed complications in 6 cases in which 4 cases needed operations due to complications. Foreign bodies which pass into the stomach can be observed for development of complications, as 94% of foreign bodies which reach the stomach spontaneously pass. Only 4 patients required interventions, which was done without mortality.

Tetracyclic Isoquinoline유도체의 합성

조수동,정윤성,김정주,안철진,신동수 Institute of Genetic Engineering Changwon National 1998 Gene and Protein Vol.2 No.1

To develop new pharmacological charactization of isoquinoline derivatives, we have synthesized 3-benzyl-9,10-dimethoxy-6,7,11b,12-tetrahydropyridazino [4',5': 5,6] [1,4] -oxazino [3,4-а]isoqinolin-4(3H) -one. We have developed a convenient cyclization of novel isoquinoline derivatives starting from 3,4-dimethoxy phenethylamine using boron trifluoride diethyl etherate.

Clostridium difficile 장염에 의한 속발성 유전분증에서 발현된 독성 장염

조형원,정혜경,강현주,이윤표,강혜원,심기남,정성애 Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1

Amyloidosis is characterized by extracellular deposition of protein fibrils in one or multiple organs. AA amyloidosis is secondarily occurred to be related with chronic infections or inflammatory diseases. We report a 67-year-old man suffered from secondary AA amyloidosis related with chronic Clostridium difficile colitis after repeated total hip replacement surgery. Infection control is the most important treatment of AA amyloidosis secondary to chronic infection. However, the patient’s C. difficile colitis was not controlled well, eventually toxic megacolon with sepsis was developed. Consequently, he had to take total colectomy, but he expired with multi-organ failures. We suggested that early surgical procedure might be one option for intractable C. difficile colitis complicated with secondary amyloidosis.

대학교 대형강의실의 조명조건별 조명환경평가

최윤정,이상운,조현주 충북대학교 교육 ·생활연구소 생활과학연구센터 2003 생활과학연구논총 Vol.7 No.1

The purposes of this study are to evaluate the lighting environment of a university assembly hall and to make clear the problems of conditions of lighting operation. The field measurement on the illumination level and the questionnaire survey on subject response of the lighting environment with students were carried out at an assembly hall in C university, Cheongju. These survey were taken on 4th and 9th of December, 2002. The illumination levels of the assembly hall in the condition A (157∼403 lux) were lower than standard (400lux). The illumination levels of the condition B (16∼372 lux) and condition C (0∼1 lux) were poor. The illumination levels of the condition D (231∼510 lux) were somewhat lower than standard. It was found that the present condition of the lighting environment of the university assembly hall is inappropriate illumination level and uniformity for lecture.

저체중 또는 과체중 청소년에서 캠프 프로그램을 이용한 영양 교육효과에 관한 연구

성미경,승정자,류화춘,박재년,박동연,최미경,조경옥,최선혜,이윤신,김유경,이은주 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.4

This study was performed to evaluate the effectiveness of a nutrition education program developed for nutritionally imbalanced adolescents. A summer nutrition camp was held for 23 overweight and 16 underweight subjects. Its effectiveness with regard to was evaluated at the end of the camp and 6 months later. Nutrition knowledge, nutritional attitude, food behavior, nutrient intake, exercise habit and ideal body figures desired by the subjects. The results showed significantly higher nutrition knowledge scores at the end of the camp as compared to those obtained prior to the camp program, and these scores were maintained for at least six months. Nutrition attitude scores also improved after the education program, and these improved scores also lasted for 6 months. However, the food behavior scores measured 6 months after the education program were not significantly different from those obtained prior to the camp. Also, the exercise habit, the ideal body figures and the body figures desired by the subjects remained unchanged. When nutrient intakes of subjects were assessed before the program and 6 months later, the mean daily vitamin C intake was significantly increased after the education program. Also, the intake of iron from plant food sources increased in the overweight subjects, while less iron from animal source were consumed by the underweight subjects. Both groups tended to consume more vegetables and fruits 6 months after the education program which may have contribute to the higher vitamin C and plant-based iron intakes. These results indicate that a 4-day nutrition education camp program sustained changes in nutrition knowledge and nutrition attitude for 6 months. The increased intake of vegetables and fruits was also achieved through this education program. However, changes in dietary behavior in adolescents may require repeated education.

Impaired Diastolic Recovery after Acute Myocardial Infarction as a Predictor of Adverse Events

Yoon, Hyun Ju,Kim, Kye Hun,Kim, Jong Yoon,Cho, Jae Young,Yoon, Nam Sik,Park, Hyung Wook,Hong, Young Joon,Kim, Ju Han,Ahn, Youngkeun,Jeong, Myung Ho,Cho, Jeong Gwan,Park, Jong Chun Korean Society of Echocardiography 2015 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.23 No.3

<P><B>Background</B></P><P>To investigate the impact of left ventricular (LV) diastolic functional recovery on major adverse cardiac events (MACE) 6 months after acute myocardial infarction (AMI) in patients with preserved LV systolic function.</P><P><B>Methods</B></P><P>A total 463 patients with preserved LV systolic function at 6 months after an AMI were divided into two groups based on the extent of diastolic recovery assessed by echocardiography: group I (n = 241) showed improving diastolic function and group II (n = 222) did not. MACE included death, recurrent myocardial infarction, and rehospitalization due to heart failure, and these events were compared with the patients' characteristics at baseline.</P><P><B>Results</B></P><P>Compared with group I, the patients in group II were older and had a higher prevalence of hypertension and diabetes. Blood levels of hemoglobin and triglyceride were lower in group II, whereas the levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and of high-sensitivity C-reactive protein were higher in this group than in group I. MACE were significantly more frequent in group II than in group I. Age, elevated NT-proBNP, and impaired diastolic recovery were significant independent predictors of MACE.</P><P><B>Conclusion</B></P><P>Despite improvement in LV systolic function, LV diastolic function had not improved in 222 patients (47.9%) by the 6-month follow-up after the index AMI, and impaired diastolic functional recovery was found to be an independent predictor of MACE. Evaluation of diastolic function would be a useful way to stratify risk in patients discharged after an index AMI.</P>

Modified AS1411 Aptamer Suppresses Hepatocellular Carcinoma by Up-regulating Galectin-14

( Hyeki Cho ),( Yun Bin Lee ),( Yuri Cho ),( Jeong-hoon Lee ),( Dong Hyeon Lee ),( Jeong-ju Yoo ),( Young Youn Cho ),( Eun Ju Cho ),( Su Jong Yu ),( Yoon Jun Kim ),( Jong In Kim ),( Jong Hun Im ),( Ju 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Aims: Aptamers are small synthetic oligonucleotides that bind to target proteins with high specificity and affinity. AS1411 is an aptamer that binds to the protein nucleolin, which is overexpressed in the cytoplasm and occurs on the surface of cancer cells. We investigated the therapeutic potential of aptamers in treating hepatocellular carcinoma (HCC) by evaluating anti-tumor effects and confirming the affinity and specificity of AS1411 and modified AS1411 aptamers in HCC cells. Methods: Cell growth was assessed using the MTS assay, and cell death signaling was explored by immunoblot analysis. Fluore- scence-activated cell sorting was performed to evaluate the affinity and specificity of AS1411 aptamers in SNU-761 HCC cells. We investigated the in vivo effects of the AS1411 aptamer using BALB/c nude mice in a subcutaneous xenograft model with SNU-761 cells. Results: Treatment with a modified AS1411 aptamer significantly decreased in vitro (under normoxic [P=0.035] and hypoxic [P=0.018] conditions) and in vivo (under normoxic conditions, P=0.041) HCC cell proliferation compared to control aptamers. AS1411 and control aptamers failed to control HCC cell proliferation. However, AS1411 and the modified AS1411 aptamer did not induce caspase activation. Decrease in cell growth by AS1411 or modified AS1411 was not prevented by caspase or necrosis inhibitors. In a microarray, AS1411 significantly enhanced galectin-14 expression. Suppression of HCC cell proliferation by the modified AS1411 aptamer was attenuated by galectin-14 siRNA transfection. Conclusions: The modified AS1411 aptamer suppressed HCC cell growth in vitro and in vivo by up-regulating galectin-14 expression. Modified AS1411 aptamers may have therapeutic potential as a novel targeted therapy for HCC.

Hospitalized Cases of Adolescent and Adult H1N1 Influenza in a University Hospital in Korea, September 2009-January 2010

Yoon, So Yoon,Ryu, Yon Ju,Kang, Hye Won,Baek, Doo Hyun,Kim, Soo Hyun,Choi, Min Young,Park, Hye Sung,Lee, Jin Hwa,Chun, Eun Mi,Chang, Jung Hyun,Cho, Young Joo,Jun, Yoon Hee,Shim, Sung Shine,Lee, Mi Ae 이화여자대학교 의과학연구소 2010 EMJ (Ewha medical journal) Vol.33 No.2

연구배경:2009년 4월 새로운 인플루엔자 A(H1N1) 바이러스에 의한 감염은 전세계적으로 대유행이 시작되었다. 본 연구에서는 대한민국의 한 대학병원에서 발생한 H1N1 인플루엔자 감염환자 중에서 청소년과 성인 입원 환자를 대상으로 임상적 특성과 예후에 대하여 2009년 9월부터 2010년 1월까지 조사하여 알아보고자 하였다. 방 법:대유행 H1N1 인플루엔자로 확진된 13세 이상의 환자의 의무기록을 후향적으로 분석하였으며 대유행 H1N1 인플루엔자는 real-time reverse transcriptase-polymerase chain reaction 시행하여 확진하였다. 결 과:43명의 대유행 인플루엔자 입원 환자 중에서 7명(16%)은 중환자실 치료를 받았으며 이중 1명(2%)은 사망하였다. 평균 연령은 45세였고 기저질환으로 천식, 당뇨, 허혈성 심장질환, 기관지 확장증, 암의 순서로 많은 빈도수를 보였다. 임상증상으로 발열이 가장 주된 증상이었으며 그 외에 기침, 호흡곤란, 콧물, 근육통 또는 관절통, 인후통을 호소하였다. 입원 시 42명 중 25명의 환자에서 흉부 방사선 검사 결과 폐렴을 동반하였고 만성호흡기 질환의 악화를 보인 경우가 11명의 환자에서 관찰 되었다. 또한 23명의 Fish환자에서 산소공급이 필요하였으며 이중 2명은 급성 호흡부전으로 인하여 기계 환기가 필요하였다. 중환자실 입원을 요한 7명의 환자들은 모두 기저질환을 가지고 있었으며 이중 5명은 천식, 3명은 허혈성 심장 질환이 있었고 임신 상태와 당뇨가 각각 1명으로 나타났다. 확진된 모든 환자들은 증상 발현으로부터 평균 2일 내에 항바이러스제를 처방 받았다. 결 론:천식은 입원치료를 요하는 대유행 인플루엔자 감염환자에서 가장 흔하게 동반된 내과적 질환이었으며 특히 허혈성 심장질환 동반하는 환자의 경우 중환자실 입원을 필요로 함을 알 수 있으며 연구 결과 대부분의 환자에서 항바이러스제 치료에 효과적인 것으로 나타났다.

Introduction of KULARC’s Animal Biosafety Level 3 Facility

Yoon Ju Cho,Young AH Lee,Jin Uk Lee,Eun Ki Baik,Young Duk Ju,Jin Soo Han 한국실험동물학회 2007 한국실험동물학회 학술발표대회 논문집 Vol.2007 No.-

Effects of Combined Therapy with Ezetimibe Plus Simvastatin After Drug-Eluting Stent Implantation in a Porcine Coronary Restenosis Model

Cho, Jung Sun,Jeong, Myung Ho,Sim, Doo Sun,Hong, Young Joon,Lim, Kyung Seob,Kim, Jung Ha,Kim, Hyoung Doo,Baek, Ju Yeal,Yoon, Hee Jeoung,Her, Sung-Ho,Jin, Seung Won,Kim, Ju Han,Ahn, Youngkeun,Cho, Jeon The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.5

<P>The aim of this study was to examine the anti-proliferative and anti-inflammatory effects of ezetimibe/simvastatin (E/S) after drug-eluting stent (DES) implantation in a porcine coronary restenosis model. Pigs were randomized into two groups in which the coronary arteries (23 pigs) had DES. Stents were deployed with oversizing (stent/artery ratio 1.3:1) in porcine coronary arteries. Fifteen pigs were taken 10/20 mg of E/S and eight pigs were not taken E/S. Histopathologic analysis was assessed at 28 days after stenting. In neointima, most inflammatory cells were lymphohistiocytes. Lymphohistiocyte count was not different between two groups (337±227 vs. 443±366 cells, <I>P</I>=0.292), but neointima area was significantly smaller (1.00±0.49 mm<SUP>2</SUP> vs. 1.69±0.98 mm<SUP>2</SUP>, <I>P</I>=0.021) and percent area stenosis was significantly lower (23.3±10% vs. 39±19%, <I>P</I>=0.007) in E/S group compared with control group. There were no significant differences in fibrin score (1.99±0.79 vs. 1.81±0.88, <I>P</I>=0.49), endothelial score (1.75±0.66 vs. 1.80±0.59, <I>P</I>=0.79), and the percent of endothelium covered lumen (43±21% vs. 45±21%, <I>P</I>=0.84) between E/S group and control group. Combined therapy with ezetimibe and simvastatin inhibits neointimal hyperplasia, but does not inhibit inflammatory infiltration and arterial healing after DES implantation in a porcine coronary restenosis model.</P>