TNBS에 의해 유도된 대장염에서 ERK의 역할에 관한 연구

유민욱,권영미,장성조 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

플륨 모니터링에 의한 SM45C 레이저 용접특성 평가

유영태,김재열,노경보,양동조,오용석,임기건,김지환 한국공작기계학회 2003 한국생산제조학회지 Vol.12 No.6

With the increased use of lasers in industrial welding applications, techniques for monitoring and controlling these processes become increasingly important. It is very important that we understand the dynamic behaviors of the laser induced plume in welding because the laser induced plume has considerable effects on welding efficiency and the quality of materials. As the plume fluctuation was associated with keyhole instability, unstable vapor plume indicated the process was unstable and would result in poor welds. An Infrared Themal-vision Camera can be utilized compensate for incurracies encountered in real-time monitoring during laser welding. We have results that instabilities of plume are closely dated with hot cracking and defect of laser welding.

Siriraj Stroke Score 따른 뇌졸중 환자 감별의 적합성

유병대,이명갑,서영조,조준,박찬상,이동필 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: The differentiation between hemorrhagic(HS) and norhemorrhagic(NHS) stroke is the most important first step in the management of acute stroke because clinical management of the two disorders differs substantially. Neuroimaging studies are useful in diagnosing and distinctioning between HS and NHS. The use of clinical variables, such as Siriraj stroke scores(SSS), has led to good sensitivity, specificity and predictive values. The aim of our study was to evaluate the use of the SSS in the Korean population and assess whether it could aid to expedite treatment decisions. Methods: We reviewed 111 cases of stroke patients admitted to our hospital via the emergency department over a 6 months period from July to December 1998. Levels of consciousness, vomiting, headache, and atheroma markers used in the SSS were applied to these patients who met the criteria for a stroke. Results: Of the 111 patients, the SSS classified 83 with sensitivities of 81.1%(NHS) and 73.3%(HS) and positive predictive values of 84.3% and 68.8%, respectively. The overall accuracy rate was 78.3%. Conclusion: Our results suggest that the SSS is not reliable in distinguishing stroke types in the Korean population. Definite neuroimaging studies are needed prior to thrombolytic therapy.

유산소 운동에서의 뇌파·혈중 β-엔돌핀의 동태 분석

조규상,유영창,전유정 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

The present study was designed to examine the effects of aerobic exercise on the change of alpha wave component in electroencephalogram (EEG) and plasma β-endorphin. Exercise consisted of 30-min cycling on an ergometer with the load adjusted to elicit a heart rate rise of 50% between resting and predicted maximal value. The EEG signals and blood samples were obtained before and after 30-min exercise. The EEG signal was digitized at a sampling frequency of 64㎐ and analyzed by means of computer-aided decomposition algorithm and frequency power spectral analyses, respectively. The blood samples were immediately centrifuged for 15-min for quantitative analysis of β-endorphin by means of radioimmunoassay method. Results indicated that β-endorphin was significatly (p<.05) greater after exercise as compared to that of the resting contorol. It was also found that the larger the changes in β-endorphin following exercise, the higher the appearance rate of alpha wave in EEG. There was a positive and signifcant correlation (r=.563, p<0.05) between that increase in alpha wave component and that of the plasma β-endorphin. There results suggest that traquilizer effects of aerobic exercise could be explained, at least in part, by the increase of alpha wave component and plasma β-endorphin which in turn bring about the relaxation effects upon the central nervous system.

Sezary증후군과 병발된 용혈성 빈혈 1예

유광하,진춘조,김홍승,이종인,심영학,정순희,이창훈 건국대학교 의과학연구소 1997 건국의과학학술지 Vol.7 No.-

저자등은 전신적인 소양감을 동반한 홍반성 판상의 피부 병변과 자가 면역성 용혈성 빈혈이 동반된 Sezary 증후군을 진단하고 복합 화학 요법 CHOP으로 치료하여 피부 증상과 빈혈이 호전된 예를 문헌고찰과 함께 보고하였다. Sezary syndrome(SS), a leukemic variant of cutaneous T-cell lymphoma(CTCL), is monoclonal proliferation of CD4 T-cell having cerebriform nuclei in the skin and the peripheral blood. It is associated with erythroderma, pruritis, lymphadenopathy with protracted clinical course and systemic spread. We present a case of SS i a 38-year-old woman with generalized exfoliative erythroderma, plaques, and pruritus. Histopathologic findings of the skin lesions revealed infiltration of atypical lymphocytes in the dermis and epidermis. Electron microscopic findings of peripheral blood and skin showed atypical lymphocytes with cerebriform nuclei. Laboratory findings revealed direct Coombs' positive autoimmune hemolytic anemia, a rare association of SS. Chemotherapy with CHOP produced improvement of the skin manifestation and anemia.

Electrically conductive graphene/polyacrylamide hydrogels produced by mild chemical reduction for enhanced myoblast growth and differentiation

Jo, Hyerim,Sim, Myeongbu,Kim, Semin,Yang, Sumi,Yoo, Youngjae,Park, Jin-Ho,Yoon, Tae Ho,Kim, Min-Gon,Lee, Jae Young Elsevier 2017 Acta Biomaterialia: structure-property-function re Vol.48 No.-

<P><B>Abstract</B></P> <P>Graphene and graphene derivatives, such as graphene oxide (GO) and reduced GO (rGO), have been extensively employed as novel components of biomaterials because of their unique electrical and mechanical properties. These materials have also been used to fabricate electrically conductive biomaterials that can effectively deliver electrical signals to biological systems. Recently, increasing attention has been paid to electrically conductive hydrogels that have both electrical activity and a tissue-like softness. In this study, we synthesized conductive graphene hydrogels by mild chemical reduction of graphene oxide/polyacrylamide (GO/PAAm) composite hydrogels to obtain conductive hydrogels. The reduced hydrogel, r(GO/PAAm), exhibited muscle tissue-like stiffness with a Young’s modulus of approximately 50kPa. The electrochemical impedance of r(GO/PAAm) could be decreased by more than ten times compared to that of PAAm and unreduced GO/PAAm. <I>In vitro</I> studies with C2C12 myoblasts revealed that r(GO/PAAm) significantly enhanced proliferation and myogenic differentiation compared with unreduced GO/PAAm and PAAm. Moreover, electrical stimulation of myoblasts growing on r(GO/PAAm) graphene hydrogels for 7days significantly enhanced the myogenic gene expression compared to unstimulated controls. As results, our graphene-based conductive and soft hydrogels will be useful as skeletal muscle tissue scaffolds and can serve as a multifunctional platform that can simultaneously deliver electrical and mechanical cues to biological systems.</P> <P><B>Statement of Significance</B></P> <P>Graphene-based conductive hydrogels presenting electrical conductance and a soft tissue-like modulus were successfully fabricated via mild reduction of graphene oxide/polyacrylamide composite hydrogels to study their potential to skeletal tissue scaffold applications. Significantly promoted myoblast proliferation and differentiation were obtained on our hydrogels. Additionally, electrical stimulation of myoblasts via the graphene hydrogels could further upregulate myogenic gene expressions. Our graphene-incorporated conductive hydrogels will impact on the development of new materials for skeletal muscle tissue engineering scaffolds and bioelectronics devices, and also serve as novel platforms to study cellular interactions with electrical and mechanical signals.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

전기화상 환자에 대한 임상적 고찰

유병대,김성진,이명갑,서영조,강재구,이동필 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: Good documentation of electrical injuries at the time of presentation is very important to emergency management, so this study was designed to investigate the clinical characteristics and the outcomes of patients with electrical injury. Methods: A review of 75 cases of electrical injuries admitted to our hospital via the emergency department over a 4 year period from 1996 to 1999 was conducted. Results: There were 49 patients with high-voltage injuries and 19 patients with low-voltage injuries. All but 4 patients were males, with a mean age of 29.5 years. The most common type of injury was electrothermal burn. The most common point of entry was hand. The average size of burn wounds was 14.5% TBSA in the high-voltage group and 2.5% in the low-voltage group. Forty-nine(72.1%) of the injuries were work related. The number of patients with compartment syndrome was 19, and fasciotomies were performed in all but one patient. Myoglobinuria was noted in 22 patients, but no patient developed acute renal failure due to myoglobinuria. In the high-voltage group, 10 limb amputations were performed. Complication were observed in 12 patients. The most common complication was neurological injury. The average length of hospital stay was 50.7 days in the high-voltage group and 13.8 days in the low-voltage group. The overall mortality rate was 4.3%. Couclusion: Prevention of electrical injuries is very important. Education and compliance with safety measures, as well as basic knowledge and precaution in dealing with electricity, are essential to avoid these injuries.

그레이브스병에서 방사성 요오드 치료에 따른 갑상선 자극 호르몬 수용체 결합억제 면역글로불린(Thyrotropin Binding Inhibitory Immunoglobulin, TBII)의 변화

조영석,권기현,이준철,나소영,이효진,홍우정,이유선,김군순,송민호,김영건,노흥규 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

Prediction of thrapeutic response to radioiodine in Graves' disease is poorly understood. Although thyrotropin binding inhibitor immunoglobulin(TBII) level is a strong index for relapse after antithyroid drug medication, conflicting results are reported regarding its prognostic significance in Graves' disease treated with RAI. This study is dengned to evaluate possible relationship between post-treatment hypothyroidism and TBII in Graves' disease treated with RAI. Fourty two patient with Graves' disease after radioiodine treatment were studied retrospectively. The subject were divided into hypothyroid group and euthyroid or hyperthyroid group. We evaluated the association of hypothyroidism and TBII with radioiodine treatment dose. The mean age of hypothyroid group was 48±11 years and euthyroid or hyperthyroid group was 47±12 years. There was no difference in two groups. And there was no significant difference in post- treatment TBII between two groups(49.9±28.5%, 29.9±14.3%, p-value >0.05). The treatment-dose had no influence on post-treatment thyroid state. Euthyroid or hyperthyroid group was done with 13.6±6.9mCi and hypothyroid group was 17.0±10.4mCi(p-value > 0.05). TBII had no prognostic significance on long-term hypothyrodism in Graves' disease treated with radioiodine. And, treatment-dose had no influence on post-treatment thyroid state.

이중외피 파사드의 운전모델 개발에 관한 연구

박유영,조재훈,여명석,김광우 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1

The objective of this study is to develop the operation model of the double-skin facade for energy conservation and user comfort. This study proposes development process of the operation model in three steps. A case study is used to investigate the feasibility of the process. The G building in Kungkido is chosen. The main contents of this study are as follows. 1) The operation objectives and standards are established. And the operation factors classified according to the objectives and standards. 2) Correlation of the operation factors are clarified. And Individual models. The operation model is essential to building which has the double-skin facade and logical operation would be improved by this model. For the practical application of this operation model, it will be needed to connect the building management system.

삼부이론을 적용한 창의적 사고 배양 수업안의 개발 : 지구과학 분야를 중심으로 Especially for High School Earth Science Education

최임조,임영구,강용희,유계화 慶北大學校 科學敎育硏究所 2003 科學敎育硏究誌 Vol.27 No.-

The enrichment triad model(Renzulli, 1977) which was originally developed for teaching and learning of gifted and talented children consists of three types of enrichment activities. Type Ⅰ enrichment activities build knowledge for later use in 'gifted behaviors', and type Ⅱ enrichment activities focus on the 'how-to skills,' attitudes and values the student must develop to become and effective investigator, problem solver and producer. Type Ⅲ enrichment activities, the pursuit of real problems and realization of gifted behavior, are the fundamental goal for this model. In this study we developed enrichment activities for high school earth science class. We could summarize enrichment activities as follows: In studying the fossil section, after reporting their research activities on fossil data, students can understand the fossil theory through questioning and answering their homeworks. They can enhance their interest and curiosity by watching the movie 'Jurassic Part'(type Ⅰ enrichment activities). After making replica of fossil samples(type Ⅱ), they can write their research reports or articles concerning fossils(type Ⅲ). Students can extend their knowledge about fossils through these types of enrichment activities. In studying weather map section, after collecting newspaper clippings or searching internet, students present their knowledge about weather and weather maps(type Ⅰ enrichment activities). Learning how to make weather maps and investigating how to analyze them, student can extend their knowledge(type Ⅱ). Through these activities, students can apply their knowledge to everyday life experience(type Ⅲ). The third program is 'igneous rock' section. Students investigate the fossil formation in Korea(type Ⅰ enrichment activities). They can understand the principle of volcanic activities through experiment of volcano eruption model type Ⅱ. Through drawing pictures, writing assignment of experiment activities and playing the role play of igneous rocks, teachers can help students to acquire cause or interest to study the igneous rocks(type Ⅲ). In conclusion, within a classroom instruction teachers would be utilizing all three types of activities, moving from one to the other as class, and individual needs, demand. By selecting what students want to do and making them to produce results of their activities, we are expecting that teachers can cultivate creative thinking and enhance problem solving ability of students.