관동화로부터 분리한 sesquiterpene의 nitric oxide synthase 저해활성

정연수,류재하 숙명여자대학교 약학연구소 2004 약학논문집-숙명여자대학교 Vol.20 No.-

Nitric Oxide (NO), derived from L-arginine, is produced by two types of nitric oxide synthases (constitutive NOS: cNOS, inducible NOS: iNOS). The NO produced in large amounts by the iNOS is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. The inhibitors of iNOS, thus, may be useful candidates for the treatment of inflammatory diseases accompanied by the overproduction of NO. The activity guided fractionation of the hexane soluble fraction obtained from the methanol extract of Tussilago farfara gave an inhibitory active compound of NO synthesis in LPS-activated macrophages (IC_(50) value was 8.9 μM). The structure of active compound was elucidated as la, 5a-bisacetoxy-8-angeloyloxy-3β, 4β-epoxybisabola-7(14), 10-dien-2-one by spectral analysis. This compound can be a useful candidate for the development of new drugs to treat endotoxemia and inflammation accompanied by the overproduction of NO.

학령기 아동을 위한 통합적 독서치료 프로그램 개발

채혜정,이재연 숙명여자대학교 아동연구소 2004 兒童硏究 Vol.17 No.2

The purpose of this study was to design and perform the program for school age children. The program was designed to help children understand and express their feeling, and to learn communication skills through the fairy tales. The subjects were 23 children who were 3th graders of M elementary school in Keungkido. These children, teacher and their parents were evaluated to examine the need of elementary school counselling, there children before developing the program. The Bilio-counselling program for elementary school children consisted of a total of 43 sessions in three parts. The present program developed for this study consisted of 20 60-minute sessions by counselor, 18 20-minute sessions in the class by teacher, and 5, 20-minute sessions in home by parents. The content of the program was employed the children counselling approaches such as a biblio therapy, play therapy, art therapy, theraplay, and drama therapy. And the 33 fairy tales were used in the program. The biblio-counselling program employed in the present study was developed and implemented as a multiple counselling program in elementary school to foster the psychological growth of children. However, it is expected that the present program will prove to be useful in effectiveness for elementary school.

선천성 결손치에 관한 임상적 연구

정해경,양연미,김재곤,백병주,정진우,김하나,김미아 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.2

The congenital missing of teeth is common, which takes place since the proliferation and differentiation are not allowed in that tooth bud fail to start development. The purpose of this study is to research incidence rate, number, and missing part of congenital missing teeth, and to study whether a person who has missing teeth has other abnormality of teeth or not. For this study, 1,520 subjects(aged 2.9~17) who had visited pediatric dentist department of Chonbuk national university dental hospital within 2 years were examined with an panoramic radiograph ; exempting third molar missing state. The obtained results are as follows. 1. 8.88% among total subjects show missing teeth ; male 9.05%, female 8.64% 2. The most frequently missing permanent teeth were the mandibular second premolars(22.3%). The most frequently missing primary teeth are mandibular lateral incisors(50%). 3. 43.3% patients have one permanent missing tooth, 34.3% have two, and 10.4% have more than six, respectively. In primary teeth, 86.7% patients have one missing tooth, and 13.3% have two missing teeth. 4. 18 patients(13.3%) have missing teeth as well as hyperdontia, while some patients have microdont, ectopic eruption, and fusion teeth. 치아의 선천성 결손은 치배의 발육이 시작되지 못하여 치아의 증식, 분화가 일어나지 못함으로서 발생하는 흔한 치아의 발육 이상이다. 이 연구의 목적은 선천성 결손치의 발생률, 결손치의 수, 발생부위와 결손치 환자에게서 나타난 다른 치아이상의 발생여부를 조사하는 것이다. 본 연구는 2006년 7월부터 2008년 6월까지 전북대학교 소아치과에 내원하여 파노라마를 촬영한 1,520명의 환자(2.9~17세)를 대상으로 제 3 대구치를 제외한 선천성 결손치의 분포를 조사하여 다음과 같은 결과를 얻었다. 1. 전체 1,520명 중 총 8.88%에서 결손치가 관찰되었으며, 남자가 9.05%, 여자가 8.64%에서 결손치가 관찰되었다. 2. 총 350개의 영구 결손치 중 하악 제 2 소구치가 22.3%로 가장 발생률이 높았고, 하악 측절치, 상악 제 2 소구치, 하악 중절치, 상악 측절치 순이었다. 또한 총 18개의 유치 결손치 중 하악 유측절치가 가장 높은 발생률(50%)을 보였다. 3. 1개의 영구치 결손치를 가지는 환자는 43.3%, 2개는 34.3%, 3개는 6,7%, 4개는 1.5%, 5개는 3.7%, 6개 이상은 10.4%이었다. 또한 유치 결손치의 수는 1개는 86.7%, 2개는 13.3%이었다. 4. 결손치가 있는 환자 중 과잉치를 가지는 환자는 18명(13.3%)이 있었으며, 왜소치, 이소맹출, 융합치 등의 치아이상을 지닌 환자도 관찰되었다.

제1대구치의 석회화와 맹출 양상

정해경,양연미,김재곤,백병주,소유려 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.3

Among the permanent teeth, the first permanent molars play the greatest role in occlusion and function. So, early diagnosis for congenital missing, abnormal eruption and abnormal formation is very important to the first permanent molars in the course of arch development. The aim of this study is to analyse the differences between right and left first permanent molar's formation and eruption and between upper and lower one. A total of 545 children were selected am ong children who had visited our clinic, investigate eruption and calcification stage of permanent first molar, based on Gleiser and Hunt criteria for this study. 1. Gingival emergence of mandibular first molar is faster than maxillary first molar by 0.75~0.8 years, gingival emergence of maxillary first molar in girls faster than boys by 0.45 years, and that of mandibular first molar in girls faster than boys by 0.5 years. 2. There is the significant difference between right and left first molar on the eruption score and the calcification stage ; 5 year old children show the significant difference on the eruption score. 7 year old children show the significant difference on both the eruption score and calcification stage. 3. It shows the most active eruption movement of crown on the maxilla while the root is rapidly widening its furcation and completing root formation to 2/3, on the other hand, the most active crown emerging on mandible is shown when the root formation completed to 1/4 to 1/2. 제1대구치는 치열의 교합 및 발육에 중요하게 관여하며 기능적, 형태적으로 건전한 교합의 발육 및 유지에 필수적인 치아이다. 치열의 발육과정에 있어서 제1대구치의 형성, 맹출 및 형태의 이상이나 선천결손의 발생여부를 조기에 진단하는 것은 매우 중요하다. 이 연구의 목적은 제1대구치의 맹출과 석회화 양상에 대해 조사하여 형성과 맹출의 상, 하악과 좌, 우 차이에 대해 평가하는 것이다. 2007년 7월부터 2008년 6월까지 전북대학교 치과병원 소아치과에 내원하여 파노라마 방사선사진을 촬영한 545명의 어린이를 대상으로, 제1대구치의 맹출 위치와, Gleiser and Hunt의 석회화단계의 분류를 이용하여 제1대구치의 석회화에 대해 연구한 결과 다음과 같은 결론을 얻었다. 1. 제1대구치의 구강내 출은은 하악 제1대구치의 구강내 출은이 상악 제1대구치의 출은보다 0.75~0.8년 빠르게 일어났으며, 여성은 남성에 비해 상악은 약 0.45년, 하악은 약 0.5년 먼저 출은했다. 2. 제1대구치의 석회화단계와 맹출 정도의 좌, 우 차이는, 5세에서 상악 좌, 우측 맹출 정도와, 7세에서 상악 좌, 우측 맹출정도, 하악 좌, 우측 석회화단계가 유의한 차이를 보였다. 3. 상악은 치근 분지부의 급속한 확대단계와 치근 2/3완성단계 사이에서, 하악은 치근 1/4완성단계와 치근 1/2완성단계 사이에 가장 많은 맹출 이동량을 보였다.

신경회로망을 이용한 이면비드 폭 예측에 관한 연구

정재원,김일수,박창언,김학형,서주환,김인주,심지연 한국공작기계학회 2008 한국공작기계학회 춘계학술대회논문집 Vol.2008 No.-

The development of robotic welding process is a very complex assignment because the system is affected by a number of process parameters which are very difficult to determine or predict in practice. The full automation welding has not yet been achieved partly because the mathematical model for the process parameters of a given welding task is not fully understood and quantified. Several mathematical models to control welding quality, Productivity, micro structure and weld properties in arc welding processed have been studied. However, it is not an easy task to apply them to the various practical situations because the relationship between the process parameters and the bead geometry is non-linear and also they are usually dependent on specific experimental result. Practically, it is difficult, but important to know how to establish a mathematical model that can predict the result of the actual welding process and how to select the optimum welding condition under a certain constraint. In this paper, an attempt has been made to develop an neural network model to predict the back-bead width as a function of key process parameters in the GMA (Gas Metal Arc) welding and to compare the developed models with the experimental results

개에서 발생한 추간판 탈출증의 수술적 치료 1례

조재금,이재연,정성목,김명철 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2011 動物醫科學硏究誌 Vol.18 No.1

Seven-year old, castrated male pekingese was presented with sudden onset of pain and tetraparesis. He was diagnosed with multiple intervertebral disc disease (lesion: C6-7 [mild], T12-13 [mild], L2-3 [moderate] via MRI in 2006. After undergoing conservative therapy at local hospital, he had more severe symptom in December 2009 than before. In order to identify exact site, he had been taken second MRI and transferred to CNU VMTH. Definitive diagnosis is also multiple intervertebral disc disease (IVDD) with the same lesion except C3-4 (+++). The spinal cord between C3 and C4 is ventrally compressed by intervertebral disc and the compression is much more severe than other lesions. Since the symptoms were severe and took place rapidly and didn't respond to medical treatment, surgical treatment, ventral slot for new lesion(C3-4) was planned. After the ventral compression of spinal cord between C3 and C4 was achieved, he showed enhancement which is gradual return to normal neurologic response, sternal recumbency, and occasional standing. After postoperative treatment at local hospital, he fully recovered to the normal. It was considered that accurate diagnosis timely adequate treatment are essential for the cure of IVDD.

數學敎育의 現況分析과 改善方案 (Ⅱ) : 中·高校 數學科 運營과 敎師 現況分析 Analysis of administrations and teachers of today's math. department in the middle and high schools

林在圭,奇宇恒,金演哲,金正遠 慶北大學校 師範大學 1981 敎育硏究誌 Vol.23 No.-

Owing to the curriculum's revision of primary and high school in the beginning of 1970, several elementary concepts of modern mathematics were introduced as new teaching contents. So the efficient ways to reeducate the present teachers and to publish a desirable textbook have been badly needed. In this paper, we investigate the present situations of administration and teachers of mathematics department in the city and rural area. On the basis of these results, we find out the better ways of mathematics education from the following points of view: 1. The general administrations of mathematics department. 2. The reeducation and education for mathematics teachers. 3. Mathematics textbooks. 4. Evaluations and tests.

Hydrogen Peroxide 농도와 적용시간이 Hydroxyapatite discs의 미백과 물리적 성질에 미치는 영향

양연미,이두철,백병주,김재곤,신정근 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.1

법랑질의 주성분인 hydroxyapatite 분말을 성형하고 소결하여 착색을 유발한 다음 과산화수소의 농도와 적용 기간의 변화에 따라 나타나는 미세 조직과 기계적 성질의 변화 및 미백 효과 등에 관한 연구를 통해 다음과 같은 결론을 얻었다. 1. 과산화수소의 농도와 적용시간이 증가함에 따라 미백 효과가 증가되었다. 2. 표면조도는 15% 과산화수소 10일, 30% 과산화수소 7, 10일 적용 시 유의한 차이로 증가하였다(p<0.05). 3. X-선회절 분석결과 미백처리 전·후의 결정상의 변화는 관찰되지 않았으나, 주사전자현미경 관찰시 표면의 미세구조는 과산화수소 농도와 적용시간의 증가에 따라 미세기공이 증가하였다. 4. 2축 굽힘강도는 30%농도의 과산화수소로 7, 10일 적용하였을 때 유의한 차이로 감소되었다(p<0.05). 5. 미소 경도값은 15% 과산화수소 10일과 30% 과산화수소 3, 7, 10일 적용 후 유의한 차이로 감소되었다(p<0.05) The purpose of this study was to evaluate the effect that various concentration and application time of hydrogen peroxide had on tooth whitening and physical properties. The hydroxyapatite (HA) discs of 12 mm (Φ) x 1.2 mm (t) in dimensions were made by compression (100 kg/㎠) and sintering (at 1350℃ for 2 hours). All specimens were polished sequentially with #240 through #2000 emery paper and one side of each specimen was polished finally with 0.3 ㎛ alumina paste. The discs were placed in sterile whole stimulated saliva overnight at 37℃ in order to form an in vitro pellicle layer. Then the discs were rinsed with distilled water and soaked into staining broth at 37℃ for 7 days. These stained specimens were bleached with hydrogen peroxide according to the change of concentration (3∼30%) and application time (3∼10 days). The specimens were analyzed with a spectrophotometer, X-ray diffractometer (XRD), scanning electron microscope (SEM), surface roughness tester, microhardness tester and biaxial flexural strength. The results of present study can be summarized as follows: 1. The bleaching effect was increased with the increased concentration and the extended application time of hydrogen peroxide. 2. The surface roughness was significantly increased from the specimen bleached with 15% hydrogen peroxide for 10 days and with 30% for 7 and 10 days respectively (p<0.05). 3. The changes of crystal phase observed by XRD between before and after bleaching weren' t shown of any difference, but microporous structure of surface observed by SEM was shown of increase with the increased concentration and the extended application. 4. The biaxial flexural strength was significantly decreased from bleaching of specimen with 30% hydrogen peroxide for 7 and 10 days respectively (p<0.05). 5. Microhardness was significantly decreased from bleaching with 15% hydrogen peroxide for 10 days and with 30% for 3, 7 and 10 days respectively (p<0.05). Although the tooth bleaching effect was greater when the high concentration was applied, further in vivo experiment will be needed to prove it s safety.

생약추출물 유도형 Nitric Oxide Synthase 저해활성 검색

류재하,이소영,박재현,이화진,장세란,은진희,김남이,정연수,장미경,최영은,이숙현,손행자,안한나,고혜진 숙명여자대학교 약학연구소 2001 약학논문집-숙명여자대학교 Vol.17 No.-

Nitric Oxide (NO), derived from L-arginine, is produced by two types (constitutive and inducible) of nitric oxide synthase (NOS: cNOS and iNOS). The NO produced in large amounts by the iNOS is known to be responsible for the vasodilation and hypotension observed in septic shock and inflammation. The inhibitors of iNOS, thus, may be useful candidate for the treatment of inflammatory diseases accompanied by the overproduction of NO. We prepared alcoholic extracts of herbal drugs which have been used for the treatment of inflammation in oriental medicine. We have screened the inhibitory activity of NO production in lipopolysaccharide (LPS)-activated macrophages after the treatment of these extracts. Among the 81 kinds of extracts of herbal drugs, 34 extracts showed potent inhibitory activity of NO production above 50% at the concentration of 50 (μg/ml. The inhibitory activities of NO production were also evaluated for several solvent fractions at three different concentrations. Especially, hexane soluble fractions of Agrimonia pilosa, Hydrangea serrata, Machilus thunbergii, Prunella vulgaris, Saussurea lappa, Tussilago farfara, and ethyl acetate soluble fractions of Angelica gigas, Ostericum koreanum, Torilis japonica, Perilla frutescence showed moderate activity at 10 and/ or 25 (μg/ml. These fractions are promising candidates for the study of the activity-guided chromatographic purification of active compounds.

치위생과 학생들의 전공교육 및 직업관에 대한 의식 조사 연구

정재연,최정이 韓國學校保健學會 2000 韓國學校保健學會誌 Vol.13 No.1

For the fBfose of strer]gthening Derltal Hygiene studerlts'confidence and nutivation in the Deltal Hygiene Deparaent and helping consant Wer pffssionalisf survey on Derltal Hygiene studnlts' consciousness of attitude to and satigfEction of the coursE career plan and occupation mind set was carried out 530 ttuee year students in 8 Derltal Hygiene academies in Seoul and Kyonggi pvince were WuestionaE The results of the survny are as follows:. 1. Derltal Hygiene students'rretives consisted pimarily of gieloyrnerlt and a desire fer professionalism 25% of them entered the course after one feilure in the entrance semination and 17% had family mernbns algeing in the dentistry field 84%, the largest portiorL were from an academic high school. 24% had senne howledge of Dental Hygiene, which they had aeluired from seniors, friends, and teachers. 2. Patient car and IreatmBrlt assistance related mattns were not considned important in the cgurst. The weak pints of the course hkned out to be ecUcation in computaT and frreign languages, but the weakest was the ability of patient care during dinical 03inine. S3% had experiences had thought of changing their major while in the course because it didn't rmtch their aptitude and intarst. 3. As for a career after graduatiof 49% worried about it Most students wanted to work at a dental hospital or genafl hospital, The rmst favored duty was coordination or recoption or oral disease reventive wnt They wanted to work untill they had a stable living. 68% answered they would get a job at an oral clinic and 70% said they would continue studying for self-realization. 4. Satisfaction with the rmjor was high in studerlts whose aptitude and interest rmtched the course, who had background hlowledge of the major, and who didn't think of changing the major but would continue studying resulting in statistically slight difference (p$lt;0.001). As to satisfaction with the flrulties, itwas high in the studnlts whose aptitude and intenfst rmtched the major and who didn't think about a career after graduation showing a slight difference (P$lt;05, p$lt;01). As for satisfEction with clinical trainine, studnlts whose aptitude and interest matched the imjor and who didn't consider changing the major answned positively showing a statistically slight difference (p$lt;.001, p$lt;.01). As to satisfaction with the course, it was high in the students who entered with aptitude and interest who had peliminary Dowledge who didn't consider changing the major, and who didn't think about a career after graduation showing a statistically slight difference (p$lt;.001, p$lt;.05). 5. Occupation mind-set w3s positive for students who entned with interest and aptitude, who had reliminary Cowledge, and who had not considered changing the rmjor showing a statistically slight diffennce (p$lt;.001). The higher the satisfaction with the major, feculty and clinical training was, the mme positive the oRrpation mind-set was(p$lt;.001).