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Optical packet and burst switched networks: a review
Jue, J.P.,Yang, W.-H.,Kim, Y.-C.,Zhang, Q. IET 2009 IET COMMUNICATIONS Vol.3 No.3
<P>Over the past several years, a significant amount of research has been conducted in the areas of optical packet switching (OPS) and optical burst switching (OBS). This research has been motivated by the need for techniques that are capable of supporting the demanding requirements of emerging dynamic high-bandwidth network applications in a flexible and efficient manner. Although optical packet and burst switching have yet to be widely deployed in commercial settings, recent research progress indicates that such deployments are not infeasible in the near future. The authors review the literature on OPS and OBS. Basic concepts are discussed and an overview of current and emerging research issues and challenges for optical packet and burst switched networks is presented. The authors attempt to cover issues that are essential for the practical deployment of such networks and highlight promising research directions that are likely to facilitate such deployments.</P>
Yang, Kwang-Heon,Lee, Jue-Yeon,Jung, Jin-Hyung,Shin, Hyun-Seung,Cho, In-Woo The Korean Dental Association 2015 대한치과의사협회지 Vol.53 No.9
Purpose : The purpose of this clinical study was to evaluate the effect of chelating and deproteinizing agent containing dental conditioning gel on alleviation of peri-implant mucosa inflammation. Methods: 36 patients with functionally loaded implants for at least 1 year and have clinical signs of peri-implant mucositis were recruited. At baseline, all implants received subgingival prophylaxis with ultrasonic scaler. In the test group, patients were provided a chelating and deproteinizing agent dental conditioning gel (Clinplant$^{(R)}$) and were given instructions to applicate it around the implants using an interdental brush for 2 weeks. Chlorhexidine and saline were provided to the positive control group and negative control group, respectively. The modified sulcus bleeding index (mSBI), modified plaque index (mPI), and probing pocket depth (PPD) were evaluated at baseline, 1 week, and 2 weeks. Results: In the Clinplant$^{(R)}$ and chlorhexidine group, mSBI (-0.81, -0.85 respectively; p<0.01), mPI (-0.46, -0.5 respectively; p<0.01), and PPD (-0.58, -0.48 respectively; p<0.01) at 2 weeks were significantly reduced from baseline. In the saline group, all the clinical parameters were reduced but there was no statistical significance. The saline may be attributed to the influence of prophylaxis at baseline. Conclusions: The present study demonstrated the beneficial clinical effects of chelating and deproteinizing agent containing dental conditioning gel to decrease peri-implant mucosa inflammation equivalent to chlorhexidine. This dental conditioning gel might be useful for alleviation of peri-implant mucosa inflammation.
Clinical Outcomes of Metachronous Gastric Cancer after Endoscopic Resection for Early Gastric Cancer
( Jue Lie Kim ),( Sang Gyun Kim ),( Jung Kim ),( Jae Yong Park ),( Hyo-joon Yang ),( Hyun Ju Kim ),( Hyunsoo Chung ) 대한간학회 2020 Gut and Liver Vol.14 No.2
Background/Aims: Patients treated with endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) are at risk of developing metachronous gastric cancer (MGC). The aim of this study was to evaluate the clinical outcomes of MGC after ESD for EGC between the re-ESD and surgery groups. Methods: In total, data from 1,510 patients who underwent ESD for EGC from January 2005 to May 2014 were retrospectively reviewed, and data from 112 patients with MGC were analyzed according to the type of treatment, namely, re-ESD and surgery. The clinicopathological factors affecting the subsequent treatment and outcomes of MGC were evaluated. Results: The median duration to the development of MGC was 47 months. In multivariate analysis, lower body mass index (BMI) (p=0.037) and multiplicity (p=0.014) of index cases were significantly associated with subsequent surgery for MGC. In cases of MGC, a diffuse or mixed-type Lauren classification (p=0.009), the depth of tumor mucosal invasion (p=0.001), and an upper stomach location (p=0.049) were associated with surgery. Overall survival was significantly shorter in the surgery group than in the re-ESD group after treatment for MGC (log-rank test, p=0.01). Conclusions: Lower BMI and multiplicity of index cancers were significantly associated with the surgical resection of MGC. Close follow-up is needed to minimize additional treatment for cases at high risk of advanced MGC after ESD for EGC. (Gut Liver 2020;14:190-198)
Breast Cancer Diagnosis Using Cluster-based Undersampling and Boosted C5.0 Algorithm
Jue Zhang,Li Chen,Jian-xue Tian,Fazeel Abid,Wusi Yang,Xiao-fen Tang 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.5
Learning from imbalanced data set is relatively new challenge for breast cancer diagnosis, where the diseases cases are often quite rare relative to normal population. Although traditional algorithms are all accuracyoriented which result biased towards the majority class. The combinations of sampling methods with ensemble classifiers have shown certainly good performance. In this paper, a hybrid of cluster-based undersampling and boosted C5.0 is proposed. The proposed classification model consists of two phases: cluster analysis and classification. In cluster analysis, affinity propagation algorithm is used to define the number of clusters, and then the k-means clustering is utilized to select the border and informative samples. In the classification phase, C5.0 algorithm is used in conjunction with boosting technical, owing to leverage the strength of the individual classifiers. The proposed algorithm is assessed by 14 benchmark imbalanced data sets taken from UCI dataset repository. The extensive experimental results on different imbalanced datasets demonstrated that the proposed algorithm can achieve better classification performance in terms of Matthews’ Correlation Coefficient (MCC) as compared to other existing imbalanced dataset classification algorithms.
양대현,이종수,이창균,김나영,이계희,임선희,고재중,고영희,오주현,최신은 대한소화기내시경학회 1997 Clinical Endoscopy Vol.17 No.5
Pseudolymphoma or benign lymphoid hyperplasia is an unusual pathologic entity representing lymphoid hyperplasia, which is sometimes not easily classified as reactive or neoplasic. It occurs in a wide variety of sites, including the orbit, salivary glands, skin, thyroid, gastrointestinal tract and lung. Within the gastrointestinal tract, stomach, small intestine and large intestine, particulary rectum, can be involved, but intestine including rectum has been rarely reported in Korea to the best of our knowlege. We experienced a case of focal lymphoid hyperplasia of the rectum presented with hematochezia in a 33-year old male. It was diagnosed by histopathology with sigmoidoscopic biopsy and molecular genetic study. Rectal lesion as well as hematochezia was improved by prednisolone and mesalamine enema therapy. Hence, we report this case with a brief review of literatures.
Cell‐penetrating chitosan/doxorubicin/TAT conjugates for efficient cancer therapy
Lee, Jue‐,Yeon,Choi, Young‐,Suk,Suh, Jin‐,Sook,Kwon, Young‐,Min,Yang, Victor C.,Lee, Seung‐,Jin,Chung, Chong‐,Pyoung,Park, Yoon‐,Jeong Wiley Subscription Services, Inc., A Wiley Company 2011 International journal of cancer: Journal internati Vol.128 No.10
<P><B>Abstract</B></P><P>In this study, a cell‐penetrating peptide, the transactivating transcriptional factor (TAT) domain from HIV, was linked to a chitosan/doxorubicin (chitosan/DOX) conjugate to form a chitosan/DOX/TAT hybrid. The synthesized chitosan/DOX/TAT conjugate showed a different intracellular distribution pattern from a conjugate without TAT. Unlike both free DOX and the conjugate without TAT, the chitosan/DOX/TAT conjugate was capable of efficient cell entry. The chitosan/DOX/TAT conjugate was found to be highly cytotoxic, with an IC<SUB>50</SUB> value of approximately 480 nM, 2 times less than that of chitosan/DOX (980 nM). The chitosan/DOX/TAT provided decreases in tumor volume of 77.4 and 57.5% compared to free DOX and chitosan/DOX, respectively, in tumor‐bearing mice. Therefore, this study suggests that TAT‐mediated chitosan/DOX conjugate delivery is effective in slowing tumor growth.</P>
Biological effects of a root conditioning agent for dentin surface modification in vitro
Lee, Jue-Yeon,Seol, Yang-Jo,Park, Jang-Ryul,Park, Yoon-Jeong,Chung, Chong-Pyoung Korean Academy of Periodontology 2010 Journal of Periodontal & Implant Science Vol.40 No.6
Purpose: Connective tissue reattachment to periodontally damaged root surfaces is one of the most important goals of periodontal therapy. The aim of this study was to develop a root conditioning agent that can demineralize and detoxify the infected root surface. Methods: Dentin slices obtained from human teeth were treated with a novel root planing agent for 2 minutes and then washed with phosphate-buffered saline. Smear layer removal and type I collagen exposure were observed by scanning electron microscopy (SEM) and type I collagen immunostaining, respectively. Cell attachment and lipopolysaccharides (LPS) removal demonstrated the efficiency of the root conditioning agent. Results: SEM revealed that the smear layer was entirely removed and the dentinal tubules were opened by the experimental gel. Type I collagen was exposed on the surfaces of the dentin slices treated by the experimental gel, which were compared with dentin treated with other root planing agents. Dentin slices treated with the experimental gel showed the highest number of attached fibroblasts and flattened cell morphology. The agar diffusion assay demonstrated that the experimental gel also has effective antimicrobial activity. Escherichia coli LPS were effectively removed from well plates by the experimental gel. Conclusions: These results demonstrated that this experimental gel is a useful tool for root conditioning of infected root surfaces and can also be applied for detoxification of ailing implant surface threads.
Lee, Jue-Yeon,Choo, Jung-Eun,Choi, Young-Sook,Shim, In-Kyong,Lee, Seung-Jin,Seol, Yang-Jo,Chung, Chong-Pyoung,Park, Yoon-Jeong Wiley (John WileySons) 2009 Biotechnology and Applied Biochemistry Vol.52 No.1
<P>Two cell-binding domains from FGF-2 (fibroblast growth factor-2) were shown to increase cell attachment and osteoblastic differentiation. Two synthetic peptides derived from FGF-2, namely residues 36-41 (F36; PDGRVD) and 77-83 (F77; KEDGRLL), were prepared and their N-termini further modified for ease of surface immobilization. Chitosan membranes were used in the present study as mechanical supportive biomaterials for peptide immobilization. Peptides could be stably immobilized on to the surface of chitosan membranes. The adhesion of mesenchymal stem cells to the peptide (F36 and F77)-immobilized chitosan membrane was increased in a dose-dependent manner and completely inhibited by soluble RGD (Arg-Gly-Asp) and anti-integrin antibody, indicating the existence of an interaction between F36/F77 and integrin. Peptide-immobilized chitosan supported human bone-marrow-derived mesenchymal-stem-cell differentiation into osteoblastic cells, as demonstrated by alkaline phosphate expression and mineralization. Taken together, the identified peptide-immobilized chitosan membranes were able to support cell adhesion and osteoblastic differentiation; thus these peptides might be useful as bioactive agents for osteoblastic differentiation and surface-modification tools in bone regenerative therapy.</P>