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오주현,신동현 대한간암학회 2024 대한간암학회지 Vol.24 No.1
Management of hepatocellular carcinoma (HCC) is challenging due to the complex relationship between underlying liver disease, tumor burden, and liver function. HCC is also notorious for its high recurrence rate even after curative treatment for early-stage tumor. Liver transplantation can substantially alter patient prognosis, but donor availability varies by each patient which further complicates treatment decision. Recent advancements in HCC treatments have introduced numerous potentially efficacious treatment modalities. However, high level evidence comparing the risks and benefits of these options is limited. In this complex situation, multidisciplinary approach or multidisciplinary team care has been suggested as a valuable strategy to help cope with escalating complexity in HCC management. Multidisciplinary approach involves collaboration among medical and health care professionals from various academic disciplines to provide comprehensive care. Although evidence suggests that multidisciplinary care can enhance outcomes of HCC patients, robust data from randomized controlled trials are currently lacking. Moreover, the implementation of a multidisciplinary approach necessitates increased medical resources compared to conventional cancer care. This review summarizes the current evidence on the role of multidisciplinary approach in HCC management and explores potential future directions.
적심 및 Daminozide 처리가 가든멈 신품종 ‘Candy Ball’과 ‘Fancy Ball’의 생장 및 개화에 미치는 영향
오주현,민병훈,김동찬,김종윤 한국화훼학회 2015 화훼연구 Vol.23 No.3
This study was conducted to investigate the optimal number of pinching and daminozide spray application rates for a quality crop production of two newly bred garden mum cultivars (Chrysanthemum × morifolium ‘Candy Ball’ and ‘Fancy Ball’) from Floriculture Research Institute, Chungchungnam-do Agricultural Research & Extension Services, Yesan, Korea. To investigate the optimal number of pinching treatment, one-, two-, three-times pinching treatments were conducted one week after transplanting with 2 weeks intervals. Pinching treatments caused no considerable decrease in plant heights, but increased the number of flowers in both ‘Candy Ball’ and ‘Fancy Ball’ garden mum cultivars as the number of pinching increased, thus improving product quality. To find the optimal concentration of daminozide application for quality garden mum production, daminozide were sprayed three times at the concentration of 0, 1000, 2500, and 5000 mg • L−1. Both ‘Candy Ball’ and ‘Fancy Ball’ cultivars displayed shorter plant heights and peduncle lengths with increasing concentration of daminozide. Although flower sizes of both cultivars were not affected by daminozide treatment regardless of the concentration, ‘Fancy Ball’ cultivar displayed lighter red flower color with increasing daminozide concentration. In both cultivars the number of flowers increased with increasing daminozide concentration, which increased the total flower dry weight and shoot dry weight, thus improving the product quality. Overall, daminozide spray treatment with the concentration at 2500-5000 mg • L−1 was more effective than pinching treatment for the height and flowering control to improve product quality of the two newly bred garden mum cultivars ‘Candy Ball’ and ‘Fancy Ball’. 본 연구는 충청남도농업기술원 화훼연구소에서 새롭게 육성된 가든멈 신품종 Chrysanthemum × morifolium ‘Candy Ball’과 ‘Fancy Ball’의 고품질 생산을 위한 최적 적심 처리횟수와 식물생장조절제 daminozide 살포 최적 농도를 알아보고자 수행하였다. 적심 처리횟수를 정식 1주 후 2주 간격으로 1, 2, 3회 하였을때 ‘Candy Ball’과 ‘Fancy Ball’ 두 품종 모두 적심 처리에 의하여 초장이 크게 줄어들지는 않았으나 적심횟수가 많을수록 개화수가 증가하는 경향을 보여 생산 품질을 향상할 수 있을 것으로 판단되었다. Daminozide 처리 농도 실험에서는 0, 1000, 2500, 5000mg • L−1의 농도로 3회 엽면 살포시 두 품종 모두 daminozide 처리 농도가 증가함에 따라 초장과 화경장이 감소하였다. 두 품종 모두 daminozide 처리에 의한 꽃 크기 변화는 없었으나, ‘Fancy Ball’ 품종의 경우 daminozide 처리 농도가 높아질수록 붉은 화색이 옅어짐을 보였다. 두 품종 모두 daminozide 처리 농도가 증가함에 따라 개화수가 증가하는 결과로 전체 화기 건물중 및 지상부 건물중이 증가하여 가든멈 품질이 향상됨을 알 수 있었다. 결과적으로 가든멈 신품종 ‘Candy Ball’과‘Fancy Ball’의 고품질 생산을 위하여 단독 적심 처리보다는 2500-5000mg • L−1 농도의 daminozide 처리가 초장을 줄이고 개화수를 높이는데 효과적인 것으로 나타났다.
오주현,김성훈,한은지,최은경,채병주,박용규,최우희 대한핵의학회 2013 핵의학 분자영상 Vol.47 No.4
Purpose We evaluated whether the maximum standardized uptake values (SUVmax) of primary tumor from the initial staging by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) of patients with breast cancer could identify patients at risk for early recurrence within 2 years, particularly in comparison to the American Joint Committee on Cancer (AJCC) stage. Methods We reviewed the staging 18F-FDG PET/CT images of patients with primary breast cancer and their medical records. The SUVmax of the primary tumor was measured. The presence or absence of FDG uptake in the axillary lymph node (ALN) was also assessed. The patient’s pathologic primary tumor stage (pT), pathologic regional lymph node stage (pN),stage grouping, age, estrogen receptor (ER) and progesterone receptor (PR) status, and neoadjuvant chemotherapy history were evaluated with the FDG uptake parameters for recurrence within 2 years following the end of first-line therapy. Results Recurrence within 2 years was present in 9.1%(n =40)out of the 441 patients assessed. The FDG uptake in ALN, pT,pN, stage grouping and neoadjuvant chemotherapy history were prognostic for early recurrence, while primary tumor SUVmax, age, and ER or PR status were not significant on logistic regression. On multivariate analysis, only the stage grouping (odds ratio 2.79; 95 % CI 1.73, 4.48; p <0.0001)and neoadjuvant chemotherapy history (odds ratio 2.70; 95 %CI 1.22, 5.98; p =0.0141) could identify patients at increased risk for recurrence within 2 years. Conclusions Primary tumor FDG uptake measured by SUVmax, and visual assessment of FDG uptake in the ALN in the initial staging PET/CT of patients with breast cancer may not have additional prognostic value compared with the AJCC stage grouping for early recurrence.
오주현,김봉근 서울大學校經濟硏究所 2011 經濟論集 Vol.50 No.2
본 논문은 한국의 세대내 소득이동성(earnings mobility)을 추정한다. 패널자료의 문제점인 비무작위적 탈락( non-random attrition) 과 측정오차(measurement error)를 보정하기 위해 가패널 방법론(pseudo-panel approach) 을 사용하고, 통상패널자료의 추정편의를 빈곤함정(poverty trap)에 적용해 논의한다.