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최강원,오명돈,배현주,백경란,박선양,김병국,신완식,강문원,진종률,박종원,김춘추,김동집,한지숙,민유홍,이선주,고윤웅 대한화학요법학회 1993 대한화학요법학회지 Vol.11 No.2
Fluconazole의 진균 감염증 예방 효과와 안전성에 관하여 3개 대학병원에서 관해유도화학요법을 받는 급성 백혈병환자를 대상으로 무작위 배정법과 너도나도 누가림법에 의하여 연구하였다. 모두 62명의 환자에게 fluconazole(100㎎ bid) 또는 nystatin(1,000,000IU/day)을 무작위로 투여하였다. 투약은 관해유도화학요법과 같은 날짜에 시작하여 호중구수가 1,000㎣이상으로 회복되거나 진균 감염증이 확인되거나 의심되어 Amphotericin-B를 시작하거나, 약과 관련된 부작용이 나타날 때까지 계속하였다. 진균 colonization은 fluconazole군에서 감소하였으나 nystqatin군에서는 증가하였다, 표재성 진균감염증으로 nystatin군에서 C. albicans 진균혈증 1례와 C.parasilosis 진균혈중 1례가 발생하였다. 경험적 항진균요법으로 Amphotericin-B를 투여한 경우는 fluconazolerns 34명중 7례(21%), nystatinrns 28명중 10례(36%)였다(p<0.05). Fluconazole군과 nystatin군 사이에 부작용이나 사망률에 차이는 없었다. 결론적으로, fluconazole은 관해유도화학요법을 받는 급성 백혈병환자에서 진균의 colonization을 줄이는데 효과적이고 안전한 항진균제이다. We made a randomized, double-blind, multicenter trial to compare the efficacy and safety of fluconazole with nystatin for prevention of fungal infections in patients with acute leukemia. Sixty-two adult undergoing remission induction chemotherapy for cute leukemia were enrolled. Patients were randomly assigned to receive either fluconazole (100㎎ bid) or nystatin(1,000,000IU×6/day) with corresponding placebo. The study drug was started in initiation of chemotherapy and continued until recovery of neutrophil counts(>1,000/㎣), development of proven or suspected invasive fungal infection, or the occurrence of drug-related toxicity. Fungal colonization decreased in fluconazole(F) group, however increased in nystain(n) group. Superficial fungal infection occurred in 1 of 34 F group, whereas invasive fungal infection developed in 3 of 28 N group. Empirical amphotericin-B therapy was given in 7 of 34(21%) F group and 10 of 28(36%) N group(p>0.05). The incidence of drug-related side effects and overall moratlity were similar in both study groups.
성장기 아동과 성인에서의 Ⅱ급 1류 부정교합치료양상에 관한 두부방사선 계측학적 비교연구 : ADOLESCENTS CONTRASTED WITH ADULTS
강보선,양원식 대한치과교정학회 1995 대한치과교정학회지 Vol.25 No.3
본 연구는 Ⅱ급 1류 부정교합의 치료에 있어 치료전의 환자연령에 따른 부정교합치료의 양적 차이를 알아보고, Johnston analysis를 통해 협측 치열군의 교정이 어떤 방법으로 이루어지는지, 즉, 두개저에 대한 또한 상호간에 대한 상, 하악 각각의 성장양과 기저골에 대한 구치의 이동양을 측정하여 구치부의 교정이 어떻게 이루어지는지를 알아보고자 했으며 서울대학교병원 치과진료부 교정과에 내원하여 Ⅱ급 1류 부정교합으로 진단되어 상, 하악 제1소구치를 발치하여 치료를 받은 여자환자 52명중 치료전의 연령을 기준으로 성장기 아동군과 성인군으로 대별하여 치료전,후 두부방사선사진을 계측, 비교분석하여 다음과 같은 결론을 얻었다. 1. 치료전,후의 상악골의 전후방적인 위치변화에 대한 비교를 통해서 성장기 아동군과 성인군간의 유의한 차는 없었다. 그러나 하악골의 전후방적 위치변화에 있어서는 두 군간에 유의한 차이를 보였다.(p<0.05) 2. 치료 전,후 수직고경의 변화에 있어, 성장기 아동군에서는 전안면고경, 후안면 고경, 하안면고경 등이 성장과 치료의 효과로 유의성있게 증가하였으며(p<0.001), 성인군에서는 유의성있는 변화가 없었다. 3. 치료전,후 교합평면의 변화에 있어, 성장기 아동군에서는 교합평면의 경사도의 유의성있는 변화가 발견되지 않았으나, 성인군에서는 교합평면의 경사도가 유의성있게 증가하였다.(p<0.05) 4. Johnston analysis를 이용한 분석으로, total molar correction의 양에 있어서 성장기 아동군과 성인군에서 유의한 차이를 보였다.(p<0.05) 5. Johnston analysis를 이용한 분석에 의해 성장기 아동군에서는 total molar correction의 63%가 하악골성장에 의해, 37%가 치아이동에 의해 이루어짐을 관찰했다. 성인군에서는 total molar correction의 99%가 치아이동에 의해 이루어졌다. The purpose of this study was to quantitate differences in the nature of the correction of Angle's Class Ⅱ div 1 malocclusion dependent on the patient's age at the time of treatment. The sample consisted of 27 female patients in the adolescent group with a mean initial records age of 11.8 years and 25 female patients in the adult group with a mean starting age of 21.1 yrs. Lateral cephalometric head films were taken before and after orthodontic treatment with four bicuspid extraction. The results were obtained as follows. 1. None of maxillary skeletal parameters exhibited a significantly different in tretment change between adolescents and adults. But, in mandibular skeletal measurements, there were significant differences between two groups.(p<0.05) 2. Measures of vertical dimension in the adults remained unchanged during treatment, reflecting the effective absence of growth. 3. The steepness of occlusal plane in the adults changed significantly.(p<0.05) In contrast, the adolescents displayed stability of the occlusal plane. 4. According to the Johnston analysis, there was a significant difference in the total molar correction between two groups.(p<0.05) 5. According to the Johnston analysis, differential mandibular growth in the adolescents contrubuted 63% of the total molar correction, with orthodontic tooth movement accounting for the remaining 37%. In the adults, dental movements comprised 99% of the correction.
플루옥세틴 캅셀제의 지원자에 대한 생체이용율 및 대사율 비교
강원구,박용순,조규행,최준식,권광일 충남대학교 약학대학 의약품개발연구소 1998 藥學論文集 Vol.14 No.-
Fluoxetine is a nontricyclic antidepressant which blocks serotonin reuptake selectively. Its N-demethyl metabolite, norfluoxetine is also selective inhibitor of serotonin uptake. This study was carried out to compare the bioavailability of Myung-in fluoxetine (20 ㎎/cap with that of Prozac?. The bioavailability was conducted on 24 healthy volunteers who received a single dose (80 ㎎) of each drug in the fasting state, in a randomized balanced 2-way crossover design. After dosing, serial blood samples were collected for a period of 48 hours. plasma was analyzed for fluoxetine and norfluoxetine by a sensitive and validated HPLC assay. The major pharmacokinetic parameters (AUC_0-48hr, Cmax, Tmax. AUC_inf.. MRT. T_1/2. Vd and Cl) were clculated from the plasma fluoxetine concentration-time data of each volunteer. The microcomputer program. "WinNonlin' was used for compartmental analysis. A two-compartment model with first-order inpot, first-order output and no lag time was chosen as the most appropriate phamacokinetic model. The data were best described by using a weighting factor of 1/y^2. Though the plasma fluoxetine concentrations of Myung-in fluoxetine were higher than those of Prozac® at all observed time from 7.9% to 16.9% (P<0.05 at 6, 7 and 10 hr), the bioavailability of Myung-in fluoxetine appeared to be bioequivalent with that of Prozac®. There were no statistical significant differences between the two drugs in al pharmacokinetic parameters including AUC_0-48hr of norfluoxetine.
Pbo-B₂O₃계 저융점유리에 코디어라트 Filler 첨가에 따른 특성에 관한 연구
강원호,이헌식,홍유식,이경희 明知大學校 産業技術硏究所 1989 産業技術硏究所論文集 Vol.8 No.-
On sealing glass for Joining with the ceramic substrate of which the coefficient of thermal(C.T.E) expansion is ??, the properties of sealing glass due to change the content and particle size of filler were studyed. Mother glass used PbO-B₂= 3 system glass and Ceramic filler used cordierite that have low dielectric constance and C.T.E. of ?? Optimum content of filler cordierite for matching C.T.E. withe ceramic substrate is 15 ∼ 17 wt.% and MOR in maximum at 15 wt.%. Sealing glass which prepared with coarse filler in average particle size have a good flowbility, but have a poor resistance to acid and high dielectric contance. The particle size range of cordierite in optimum properties is 270 - 400 mesh.