원발성 중추신경계 임파종 : 치료 및 생존율 Treatment and Survival Rate

남도현,이상형,김동규,정희원,지제근,왕규창,김현집,최길수,한대희 대한신경외과학회 1993 Journal of Korean neurosurgical society Vol.22 No.3

The authors report on 17 patients having primary central nervous system(CNS) lymphomas between January, 1981 and August, 1992. All patients were treated at Seoul National University Hospital. Only three cases underwent surgery only and fourteen cases underwent surgery and radiation therapy with or without chemotherapy. There were no immunosuppressive patients. Sixteen patients were analyzed for survival studies, because one case was lost during follow-up. The median survival time(MST) was 26 months and one- and two-year survival rates for the 16 patients were 87.5% and 65.6% respectively. The rate of survival was analyzed according to possible prognostic factors ; age and sex, multiplicity and location of tumors, preoperative Karnofsky performance score(KPS), pathological subclassification, type of surgery, preoperative steroid therapy, postoperative adjuvant therapy, extent of radiation, chemotherapy and the degree of response to treatment at three months follow-up. Postoperative adjuvant therapy and the degree of response to the treatment correlated with survival. Fourteen patients who underwent postoperative adjuvant therapy had a median survival time of 63 months. The one- and two-year survival rates were 100% and 75% respectively compared to the MST of 1.5 months with survival rates of 0% and 0% retrospectively for the two patients who did not. A higher long term survival rate was observed in the group with better immediate responses. In nine of 16 patients with complete responses, the MST, one-, and two-year survival rates were 63 months, 100%, and 83% respectively. The authors suggest that preoperative application of steroids may be considered in case of clinically suspected primary CNS lymphomas. It is concluded that after obtaining the tissue diagnosis of primary CNS lymphomas, radiotherapy with or without chemotherapy should be performed until the complete response.

^(131)I 전신스캔 음성 재발 분화 갑상선암에서 EDG PET의 임상적 의의 : ^(99m)Tc-MIBi Scintigraphy와 비교분석

원종철,이성진,이태윤,남궁일성,이시열,김하영,한정희,류진숙,문대혁,안일민 대한내분비학회 2001 Endocrinology and metabolism Vol.16 No.4-5

MWPC 위치검출기의 X-선 천체물리학에의 응용

남욱원,최철성,문신행,강희동 경북대학교 센서기술연구소 1990 센서技術學術大會論文集 Vol.1 No.1

1983 년경 국내에서도 과학탐사 로케트와 인공위성이 발사될 예정에 있으며 이에 따라 X-선 천체물리학을 위한 방사선 센서의 국내 개발이 시급히 요청되는 바이다. 따라서 현재 방사선계측에 많이 이용되고 있는 방사선 센서들 중 국내에서 개발되어온 MWPC위치검출기를 소개하고 인공위성 혹은 과학탐사로케트에 탑재되어 X-선 천체물리학연구에 이용될 경우 연구 개발되어 나가야 할 방향을 제시하고자 한다. Domestic sounding rocket and scientific satellite are scheduled to launch around 1993. The development of radiation sensor is required to observe X-rays coming from celestial bodies by the use of those space vehicleS. In this study we introduce the multi-wire position sensitive detector and the future works of onboard detector for X-ray astrophysics.

人體 胃癌 및 胃炎에서의 CEA의 表現에 對한 免疫酵素 組織學的 硏究

元南熙,李大一,白承龍 고려대학교 의과대학 1982 고려대 의대 잡지 Vol.19 No.3

Carcinoembryonic antigen (CEA) isolated from adenocarcinomata of human digestive system and fetal or embryonic gut tissue is one of tumor associated antigens. In recent years, extensive studies to detect CEA in the blood as well as in the tissue of various conditions have been reported. However, characterization of CEA in the tissue of stomach cancer, common malignant tumor in Korea, has rarely been investigated. The author performed peroxidase-antiperoxidase immunohistologic study with anti-CEA antibody to determine the presence of CEA in 51 cases of gastric adenocarcinoma and 18 cases of chronic gastritis. All tissues examined were obtained with endoscopic biopsy, fixed in 10% formalin and embedded in paraffin. The findings were analysed and results obtained are as following. 1. CEA positive reaction to anti-CEA antibody was noted in 45 of the 51 cases with gastric cancer (88.2%). 2. Patterns of positive reaction to anti-CEA antibody of 45 CEA positive adenocarcinomas were focal in 9 cases (20.0%), moderate in 10 cases (22.2%) and diffuse in 26 cases (57.8%). 3. Comparing the pattern of CEA positive reaction with histologic differentiation of cancer cell, the differentiated type showed diffuse linear pattern along membrane the surface and undifferentiated type revealed focal positive pattern in the cytoplasm. 4. Of 18 cases with chronic gastritis, 8 cases of non-specific gastritis and 10 cases of intestinal metaplasia, CEA poistive reaction to anti-CEA antibody was noted in 4 cases at the lesion of intestinal metaplasia. The results obtained above suggest that presence of CEA in gastric cancer is detected 88% of cases, variable in pattern, partly depending on morphologic differentiation, and even exhibit in goblet cells in some intestinal metaplasia which is believed to be a precancerous condition of stomach cancer.

한국인 지원자에서 니모디핀의 생체이용율연구

강원호,심희옥,남진경,김동출 忠南大學校 生命科學硏究院 醫藥品開發硏究所 2006 藥學論文集 Vol.21 No.-

A reversed phase HPLC method was developed and validated for the determination of nimodipine in human plasma. Nitrendipine was used as an internal standard. Calibration curves were linear in the concentration range of 5~300 ng/ml. The coefficient of variation of the intra- and inter-day precision was below 15%. The coefficient of variation of the accuracy was below 15% in the concentration range investigated. A bioavailability study was performed using the validated HPLC method. Eight healthy male volunteers were orally administered 30 mg of nimodipine. The pharmacokinetic parameters were calculated using WinNonlin. The mean values of AUC_(24hr) was 64.0±31.3 ng·hr/ml, C_(max) was 46.5±31.2 ng/ml, T_(max) was 0.54±0.17 hr and t_(1/2) was 3.03±2.26 hr. The pharmacokinetic parameters and the HPLC method can be used for the design of bioequivalence study of nimodipine.

우울증 환자에서 Lamotrigine의 항우울 효과

박영남,김희철,이원우 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.2

초 록 이 연구는 4주간의 항우울약물 단독 혹은 기분안정약물과 병합치료에 호전되지 않았던 양극성장애 우울증 4명과 주요 우울증 4명에게 lamotrigine을 항우울약물 과/혹은 기분안정약물과 함께 치료하여 항우울 효과를 평가하였다. 대상환자 8명중 7명은 3주간 치료후 HRSD점수가 50%이상 감소하였으며 HRSD로 평가한 우울증상은 치료 제1주에 기저치에 비하여 54%, 제2주에 63%, 제3주에 66%, 제4주에 70% 감소되었다. 이 연구는 소수의 환자를 대상으로 한 단기 연구로 이 결과를 일반화하는데는 한계가 있으나, lamotrigine과 항우울약물을 함께 치료할 때 상승효과로 치료의 효과가 빠르게 나타난다고 추정되어 향후 통제된 연구로 검증하는 것이 필요하다고 생각된다.This study evaluated antidepressant effect of adjunctive lamotrigine treatment in 8 depressed patients, 4 bipolar depressed and 4 major depression, who did not respond to 4 weeks treatment with antidepressant alone or combined with mood stabilizer. In seven (88%) of 8 patients HDRS decreased over 50% at end of 3 weeks treatment. The serial HRSD showed progressive decrement, 54% decrease in week 1, 63% in week 2, 66% in week 3, and 70% in week 4. This result suggests synergistic effect between lamotrigine and antidepressants and further controlled study is warranted.

중소기업에서의 중역정보시스템 개발 프레임웍에 관한 연구

허남원,박학희 啓明專門大學 産業開發硏究所 2002 啓明硏究論叢 Vol.20 No.1

The goal of this study is to develop a strategy of the "D" leasing company and an experimental prototype as analyzing feasibility and necessity of implementing EIS(Executive Information System) in a Leasing Company through the investigation of the general EIS development process. We suggest an actual system as a result of literature survey and many interviews with people on the job. On the way of reaching our purpose of this study, we find the fact that it will be desirable to make more correct diagnoses on internal conditions and external environment and information systems of the given firm in establishing EIS appropriate the surrounds of the company. We also find that it will be desirable to obtain the more accurate information required by executives to establish more suitable EIS for a company.

고혈압과 정상혈압쥐에서의 식이지방 변화에 따른 혈청과 간의 지질대사 동향

조성희,신응남,서미영,이원정 대구효성가톨릭대학교 응용과학연구소 1991 응용과학연구논문집 Vol.1 No.-

혈압에 영향을 주는 식이요인 중에서 섭취지방이 상당히 중요하다는 것은 일찍부터 거론이 되어왔으며, 식이지방 중에서 다불포화지방이 혈압을 낮추는 효과가 있다고 대체적으로 요약할 수 있겠다. 그러나 다불포화지방산의 종류에 따라서도 차이가 지적되고 있으며, 그 중에서 n-6계열의 식물성다불포지방과 n-3계열의 어유 다불포화지방간의 비교가 최근 10년간 많은 연구의 대상이 되어왔고, eicosapentaenoicacid(EPA)와 docosahexaenoic acid(DHA)가 주다불포화지방산이 되는 어유가, 오랫동안 필수지방산으로 중요시해 왔던 식물유의 linolic acid보다 혈압강하작용이 크다는 결과들이 주목을 끌고 있다.

압력센서식 수위계측 시스템의 개발과 GIS에의 적용

박찬원,박희석,남현식 강원대학교 산업기술연구소 2005 産業技術硏究 Vol.25 No.B

This peper presents a development of the Data Logger System to transmit the outcome of the waterlevel measuring instrument using the pressure sensor by means of the CDMA network. In or order to set up the real time monitoring the waterlevel measurement system, we have designed the waterlevel sensor, communication terminal and repeater, and data logger. Furthermore, its application for the GIS(Geographical Information System) with management server system and software solutions have also developed to minimize the property damages from the flood disaster which occurs every year in the river.

Carbamazepine에 의해 발생한 다형 홍반, 독성 간염, 백혈구 및 혈소판 감소증 1례

김희철,정성원,박영남,정철호,김정범 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.1