만성신부전증 환자의 HLA 동종항체 분석

김대원,양윤선,김선희,오하영 대한임상병리학회 1997 대한임상병리학회지 Vol.17 No.1

근원 불명 전이암의 예후인자와 생존율

원종호,박성규,홍대식,박희숙,김은석,최두호 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.1

Purpose : Patients with cancer of unknown primary site represent 5% to 10% of all cancer patients. This study was to evaluate survival and prognostic factors of patients with malignancy of unknown origin. Materials and Methods : A retrospective analysis was done for one hundred and two patients with malignancy of unknown origin who were treated from January 1989 to December 1998. There were 52 male and 50 female patients. Age of patients ranged from 20 to 94 years (mean 58 years). Clinical presentation depended on the site of metastases. In cases of multiple metastatic sites, we selected the first apparent metastasis or the symptomatic one for which the patient was first seen. The three most frequent initial metastatic sites were peritoneum, lymph node, and liver. Median follow up period was 4 months(0-100 months) and survival rate measured form the time of diagnosis. Results : The two years survival rate was 13.6% with a median survival time of 4 months. The factors associated with the overall survival rate were the tumor marker CEA(p=0.0061), smoking history(p=0.0039), and histologic type(squamous cell carcinoma versus non-squamous cell carcinoma, p=0.0295). Marginal statistical difference was found according to performance status. No statistical differences were found according to sex, weight loss, initial metastatic site and numbers, primary lesion site, and treatment modality. Conclusion : Squamous cell carcinoma was associated with survival rate. In squamous cell carcinoma of unknown origin with good prognostic factor, especially cervical lymph node metastasis, we suggest an approach of extensive initial workup for staging and aggressive treatment.

원발성 위장관 악성 림프종의 임상적 고찰 : 치료 결과를 중심으로

원종호,백승호,홍대식,오도연,박희숙 순천향대학교 1994 논문집 Vol.17 No.4

저자들은 1984년 3월부터 1992년 12월까지 순천향 대학교 부속병원에서 원발성 위장관 악성 림프종으로 진단되었던 23명을 대상으로 다음과 같은 결론을 얻었다. 1. 대상 환자의 나이의 중앙치는 44(23-75)세로 남녀비가 2.8 : 1이었다. 2. 원발병소는 위 10예(43.5%), 소장 8예(34.8%) 및 회맹장 이행부위 5예(21.7%)였고, 병기 Ⅰ??기 8예(34.8%), Ⅱ??기 12예(52.2%), Ⅲ기 2예(8.7%), Ⅳ기 1예(4.3%)였다. 동반된 다른 장기는 주로 복부 임파절이었으며 폐 임파절 침범이 1예 있었고, 간을 침범한 경우가 1예, 위장과 소장에 병발한 경우가 1예 있었다. 조직학적 분류로는 중등도 19예(82.6%) 및 고도 4예(17.4%)였고 10예(43.5%)에서 B 증후가 있었다. 3. 치료를 시행한 20예중 Ⅰ??기 7예는 수술적 치료후 보조항암화학요법을 시행하였으며, Ⅱ??기 13예중 진단적 개복술후 완전절제가 확인된 3예는 보조항암화학요법을, 불완전절제로 확인된 7예는 관해유도 항암화학요법을 시행하였고, 3예는 항암화학요법만을 시행하였다. 4. 치료를 시행한 20예의 생존기간은 중앙치 43(4-100??개월이었으며, 3년 생존율 60.9%, 5년 생존율 40.6%였다. 5. Ⅰ??기 7예의 생존기간은 중앙치 42(11-100??개월이었으며, Ⅱ??, Ⅲ기 13예에서 치료에 대한 완전 관해가 9례(70%), 부분관해(15%), 무반응이 2례(15%)로 관해율은 85%였으며, 생존기간은 중앙치 44(4-52??개월이었다. 6. 완전관해자가 진행시까지의 관해지속기간은 중앙치 43(10-56??개월이었으며, 3년 무병생존율 79.1%, 5년 무병생존율 36.2%였다. Over a 8-year period(March 1984 through December 1992), 23 patients with primary gastrointestinal non-Hodgkin's lymphoma treated at Soonchunhyang University Hospital were analyzed with the following results; 1. The mean age of the patients was 43(23-75) years with male to female ratio of 2.8 : 1. 2. The primary sites of lymphoma were stomach in 10(43.5%), small intestine in 8(34.8%), and ileocecal area in 5(21.7%) and by modified Ann Arbor system, stage Ⅰ?? was 8(34.8%), stage Ⅱ?? was 12(52.2%), stage Ⅲ was 2(8.7%), and stage Ⅳ was 1(4.3%). Histologic classification by Working formulation revealed 19 cases(82.6%) of intermediate grade and 4 cases(17.4%) of high grade. B symptoms were observed in 10 cases(43.5%). 3. Treatments were performed in 20 cases as follows : In 7 cases with stage Ⅰ, complete surgical resection with systemic combined chemotherapy was performed. In 13 cases with stage ⅡE and Ⅲ, complete resection with systemic combined chemotherapy in 3 cases, incomplete resection with combined chemotherapy in 7 cases, and combined chemotherapy only in 3 cases. 4. Median survival duration of 20 treated patients was 43(4-100?? months and 3-year survival rate and 5-year survival rate were 60.9% and 40.6%, respectively. 5. Median survival duration of 7 cases with stage Ⅰ?? was 42 months(11-100??. In 13 cases with stage Ⅱ??, Ⅲ, response to treatment was complete remission in 9(70%), partial remission in 2(15%), and no response in 2(15%) resulting 85% of response rate and median survival duration was 44(4-52?? months. 6. Disease free survival rate of achieving a complete remission was 43(10-56?? months and 3-year disease-free survival rate and 5-year disease-free survival rate were 79.1% and 39.2%, respectively.

용융침투법으로 제조한 알루미나-유리 복합체의 동적 피로 특성 평가

원대희,안승근,배태성,강동완,진영철 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.3

The fatigue characteristics of alumina-glass composites were evaluated by biaxial flexure test under the dynamic loading conditions. 88 specimens were tested by tested by testing 22 samples at each of four loading rates : 0.01, 0.1, 1, and mm/min. A Vickers-produced indentation crack was made at the center of the tensile surface with load of 49.0 N, and the microstructural aspects of crack propagation was investigated under statically loaded state in distilled water at 37℃. The results obtained were summarized as follows; 1. The fatigue parameter of alumina-glass composite containing 6 mol % yttria was n=22.2, σf0=319.6 MPa. 2. 10-year failure stress of alumina-glass composite containing 6 mol% yttria was 171.7 MPa. 3. Fracture surface of alumina-glass composite indicated the frictional interlocking of jogs having the tendency of toughening by crack deflection, rather than by crack bridging.

이트리아 첨가 붕규산염 유리로 제조한 알루미나-유리 복합체의 파괴인성 평가

원대희,이민호,박주미,배태성,진영철 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.2

The study was performed to evaluate the fracture toughness of dental alumina-glass. Alumina compacts were prepared by press 150㎏/㎠ and sintering at 1100℃ for 2hrs. Dense composites were made by infiltrating partially sintered alumina with four different borosilicate glasses containing 1, 3, 6, 9 mol% Yttria(Y₂O₃) at 1200℃ for 6hrs. Apparent porosity was measured by the KS L 3114 principle method. Fracture toughness values were about ∼4.72 MPa·m½. Porosity rates of alumina-glass composites were about 0.2%. The fracture surface of the alumina-glass composites showed a Palmqvist crack pattern at the fracture origin and indicated a tendency by the frictional interlocking between the microstructurally rough fracture surfaces.

열가압 성혈 글라스 세라믹의 파괴인성에 미치는 반복 열가압 성형의 영향

원대희 大韓齒科器材學會 2002 대한치과재료학회지 Vol.29 No.4

This study was performed to evaluate the effects of repeating the heat pressing procedure on the fracture toughness of heat-pressable glass-ceramics. Three commercially available ingots of Authentic(Ceramay GmbH), Empress and Empress 2(deutsche Ivoclar Dental GmbH) were used. Crystal phases of these glass-ceramics were investigated by means of X-ray diffraction analysis (XRD) and morphology and microstructure were studied using scanning electron microscopy (SEM). Fracture toughness was calculated using the length of radial crack formed on the Vickers-produced indentation crack by means of the indentation fracture method. According to the result of X-ray diffraction analysis, the test groups of Authentic and Empress did not show the change in crystal peak intensity, but the test group of Empress 2 showed increase in crystal peak intensity after repeating the heat pressing procedure. Fracture toughness values of the test groups of Authentic and Empress showed the aspect of increase after repeating the heat processing procedure but that of Empress 2 group showed decrease.

^(131)I 전신스캔 음성 재발 분화 갑상선암에서 EDG PET의 임상적 의의 : ^(99m)Tc-MIBi Scintigraphy와 비교분석

원종철,이성진,이태윤,남궁일성,이시열,김하영,한정희,류진숙,문대혁,안일민 대한내분비학회 2001 Endocrinology and metabolism Vol.16 No.4-5

노즐 직경이 충돌제트에 의하여 열전달에 미치는 영향

이대희,원세열,이영민,조헌노 인제대학교 1999 仁濟論叢 Vol.14 No.3

본 연구는 축대칭 난류원형제트가 평판에 충돌하는 경우에 노즐직경이 국소 Nusselt 수 분포에 미치는 영향을 연구하였다. 노즐출구에서의 유동은 완전 발달된 속도형상을 지니고 있다. 그리고, 금박막이 된 Intrex를 사용하여 평판에는 등열유속 경계조건을 형성시켰다 또한, 액정은 평판의 벽면온도를 측정하기 위하여 사용하였다. 실험시 Reynolds 수는 Re=23,000으로 고정하였으며, 노즐과 평판사이의 거리는 L/d=2~14 까지, 노즐 직경은 d=1.36, 2.16, 3.40으로 변화시켰다. 실험결과 정체점과 정체점 영역에서의 Nusselt 수는 노즐 직경이 증가함에 따라 증가함을 알았다. The effect of nozzle diameter on the local Nusselt number distributions has been investigated for an axisymmetric turbulent jet impinging on the flat Plate surface. The flow at the nozzle exit has a fully developed velocity profile. A uniform heat flux boundary condition at the plate surface was created using gold film Intrex. Liquid Crystal was used to measure the plate surface temperature. The experiments were made for the jet Reynolds number (Re) 23,000, the dimensionless nozzle to surface distance (L/d) from 2 to 14., and the nozzle diameter (d) from 1.36 to 3.40 cm. The results show that the Nusselt number at and near the stagnation point increase with an increasing value of the nozzle diameter.

기능성 Catechol-O-Methyltransferase 유전자 다형성과 한국인 정신분열병의 관련성

박태원,홍영준,박임순,김형섭,최인미,배수영,윤경식,강대희 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : Catechol-O-Methyltransferase(COMT)는 카테콜아민 신경전달물질의 불활성화를 담당하는 효소로서, 정신분열병과 관련된 후보 유전자로서 알려져 왔다. 최근, 기능성 COMT유전자 다형성과 정신분열병의 관련성이 제기되었는데, 한국인 정신분열병에서도 이러한 관련성이 있는지를 살피기 위해 본 연구를 시행하였다. 방 법 : 정신분열병으로 진단된 환자군 103명과 성별 및 연령별로 1:1 짝짓기 대조군 사이에 유전자형과 대립유전자의 분포를 비교하였다. 또한, 환자군은 공격적 행동, 가족력, 아동기 발병 여부에 따라 두 군으로 나누어 비교하였다. DNA의 다형성 부의를 중합효소연쇄반응에 의해 증폭한 후 ,NlaⅢ제한효소법과 전기영동을 실시하여 유전자형을 판별하였다. 결 과 : 환자군 전체와 대조군 사이에 유전자형과 대립유전자 빈도의 차이가 없었다. 가족력이 있는 환자군을 대조군과 비교하였을 때는, 대립유전자 L을 포함하는 유전자형과 그렇지 않은 유전자형의 분포에 있어 유의한 차이를 보였다(p=0.02, OR=3.9, 95% Cl=1.1∼14.3). 결 론 : 한국인 정신분열병과 기능성 COMT 유전자 다형성 사이에 유의한 관련성이 없었다. 따라서, 기능성 COMT 유전자 다형성이 한국인 정신분열병의 발병에 영향을 주지 못한다. 그러나, 정신분열병 가족력과 기능성 COMT유전자 다형성의 관련성이 시시돠어, 향후 본 연구에서 나타난 방법론적인 문제점을 보완하고 추가 대상자를 확보한 연구가 필요하다. Objectives : Catechol-O-methyltransferase(COMT) is involved in the degradation of catecholamine meurotransmitters and has been investigated as a candidate gene in schizophrenia. Recently, possible relationship between functional COMT gene polymorphism and schizophrenia has been suggested. To address the possible role of functional COMT gene polymorphism in the predisposition to schizophrenia, we carried out an association study in Korean schizophrenic patients and controls. Methods : One hundred and three Korean inpatients diagnosed as schizophrenia and 103 age and sex matched controls were selected as study subjects. Patients were subgrouped into two groups on the basis of history of aggressive behavior, family history of schizophrenia and related disorders, and age at onset. We determined COMT genotypes using PCR of the relevant region followed by digestion with NlaⅢ and electrophoresis. Results : No significant differences of allele and genotype frequencies were noted between patients and controls. However, when patients were categorized by the presence of family history of schizophrenia and related disorders, patients with family history showed almost 4 fold higher frequency of having COMT L allele containing genotype compared to controls(p=0.02, OR=3.9, 9.5% CI=1.10-14.33). Conclusion : Although our results do not support an association between functional polymorphism of COMT gene and schizophrenia overall, the findings suggest an association between functional COMT gene polymorphism and familial schizophrenia. Further studies with large samples are needed to confirm this association.

Junctional Rhythm을 보인 한국형 출혈열 1례

이성원,이수훈,최대현,손영기,차광수,손춘희,정원태,김성은,김종성 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.1