Targeting Multiple Myeloma Cell Death with Polyphenol EGCG

Tae‐Hoon Lee,Hee‐Young Yang,Hoon‐In Choi,Ung Yang,Kyoung‐Jin Chung,Lina Ren 한국동물생명공학회(구 한국동물번식학회) 2011 발생공학 국제심포지엄 및 학술대회 Vol.2011 No.1

(‐)‐Epigallocatechin 3‐gallate (EGCG) is a potent antioxidant polyphenol in green tea that acts as an anticancer agent via both direct and indirect pathways. Although the relationship between EGCG’s anticancer effects and its antioxidant activity is not fully understood, it is known that EGCG stimulates production of reactive oxygen species (ROS), which induce oxidative stress leading to cell death. In IM9 multiple myeloma cells, EGCG acted in a dose‐ and time‐dependent manner to induce apoptotic cell death. Among the antioxidant enzymes expressed in IM9 cells, levels of peroxiredoxin (Prdx) V were selectively and significantly reduced by EGCG. Moreover, the ROS scavenger NAC completely inhibited EGCG‐induced apoptosis and PrdxV reduction, while overexpression of PrdxV, but not a PrdxVC48S mutant, protected IM9 cells from EGCG‐induced apoptosis. EGCG‐induced reductions in cell viability and PrdxV levels were also observed in primary CD138+ multiple myeloma cells from patients. These results suggest that PrdxV is a key target via which EGCG mediates its anticancer effects.

韓國의 名目換率의 變動行態分析 : 1980년대를 중심으로 The Case Study For Korea

梁太碩,金鎭玉 제주대학교 1993 논문집 Vol.37 No.1

This paper employs the equilibrium approach to exchange rate determination model(Stockman, 1987) and the Sims' innovation accounting technique to asses the relative contributions of the determinants of the foreign currency(U.S. Dollar, Japan Yen) value in terms of the Korean Won. Monthly data during the period January 1980 through December 1990 are used in the analysis. Unlike the monetary approach to exchange rates, the equilibrium approach may incorporate the purchasing power disparity as a determinant of the nominal exchange rate. Furthermore it argues that any government policy can not create the correlation between changes in the real and nominal exchange rate. This may imply that the change in the nominal exchange rate in duced by government policy can not affect the real exchange rate. Causality runs from the change in the real exchange rate to the nominal exchange rate. For U. S. vs Korea VAR system, the real exchange rate is affected by the relative money supply ratio and the relative production ratio at the significance level of 8% and 10 % respectively. On the other hand the nominal exchange rate is affected only by its own past. The variance decomposition result is that the innovations in the real exchange rates(deviation from the relative purchasing power parity) may account for about 55% of the forecast error variance in the nominal exchange rates. In contrast, the innovations in the nominal exchange rate may explain 8% of the forecast error variance in the real exchange rate. For japan vs Korea VAR system, the causality test is that both the real and nominal exchange rate are completely autonomous. the variance decomposition result is that the real exchange rate may account for about 67% of the forcast error variance in the nominal exchange rate. On the contrary the innovations in the nominalexchange rate may explain 7% of the forecast error varaince in the real exchange rates. To sum, the change in the nominal exchange rate is caused by the nonmonetary factors, such as the presence of the nontradables, trade restrictions, government spending. In contrast, the change in nominal exchange rate induced by the government policy can not affect the real exchange rate.

쾌적한 캠퍼스 조성을 위한 기본계획 기초적 연구

梁富弘,朴碩鉉,崔生吉,孫泰鎭,金基洙 충주대 2003 産業科學論文集 Vol.11 No.-

In this study, the potential energy and limitation of the facility of Chungju national university are analyzed in the respect of human knowledge, nature, and visual environment. In addition, the effctiveness and problem of the existing master plan are evaluated through the investigation on the main hart and development procedure of the previous master plan of CJU. These results are compared and reflected to the plan of Vision 2003, e-STRR2010 and effective campus development plans of CJU are presented.

大學校 敎職員의 健康實態에 관한 基礎的 調査硏究

양점홍,황철문,남태호,백영호,윤양진,황영성 부산대학교 사범대학 1993 교사교육연구 Vol.26 No.-

The purpose of this study was to analyze the staffs' health of P. University through survey research. Also, the staffs's health problem was analyzed by the regular health test's result and their lifestyle. The results were as following: 1. The analysis of lifestyle (1) A habit of smoking 1. It was presented the male smokers(55.9%) and females smokers(0.6%) of P. university staffs were found in this study. 2. It was presented the male smokers smoked average 18.2 pieces a day. Also, they began to smoke cigarette 21.5 years old. 3. The persistent smokers were 24.6% and 52.2% of smokers be going to quit smoking cigarette someday in the future. (2) A habit of drinking 1. It was presented 85.7% of males and 59.1% of females subject drinking normally. 2. It was presented 3.7% of male subjects were drinking alcohol almost everyday in a week. 3. The most frequent kind of alcohol is as following order a beer(males 67.6% & females 79.6%) and a soju(males 28.3% & females 4.3%). Males drunken average amount of beer was 2 bottles(640ml) and females drunken average amount of beer was 0.8 bottles in a week. (3) A habit of exercise 1. It was presented males (29.0%) and females (15.1%) were exercising regularly, but males (23.3%) and females (38.6%) of staffs were not exercise at all. 2. It was found males' regular kind of exercise was as following order mountain-climbing, tennis, and jogging and females' regular kind of exercise was as order swimming, free handing exercise, and mountain-climbing. 3. It was presented 25.1% of staffs exercised 6 times a week regularly. And each times of exercise, 37.3% of staffs spent less than 30 minutes. 4. It was presented staffs exercised for health (72.4%) and 48.4% of staffs could not exercise as following reasons of not enough times, home work, research.... 5. Male staffs prefer as following order kind of sport tennis, swimming, and golf and female staffs prefer as following order kind of sport swimming, tennis, and bowling in the future. (4) A habit of eating 1. It was presented 5.5% of males and 16.6% of females did not have a breakfast regularly. 2. Concerning balance of food content: do not concerning food (males 34.7% & females 23.8%) and subjects like vegetables 9males 25.7% & females 32.7%) were found. 3. It was presented 8.5% of males and 5.4% of females took the vitamin regularly. (5) Health condition 1. In present evaluation for subject's health condition, very healthy (males 7.5% & females 6.0%) and poor health (males 2.0% & females 1.8%) were found in this study. 2. In present evaluation criterion for subject's health condition, the ability of adaptation on fatigue was appeared the most (males 35.9% & females 40.7%). 3. It was presented subjects have a digestive trouble (males 23.5% & females 33.1%) which were the best health problem in subjects. 2. A analysis of result of regular health test (1) Physique test 1. It was presented height (males 169.5cm & females 158.6cm) and body weight (males 65.9kg & females 53.1kg) were found in this study. 2. According to this study, obesity (males 11.2% & females 5.6%) and low body weight (males 8.8% & females 14.8%) were found in this study. 3. A high blood pressure subject (males 8.7% & females 2.5%) over than a contraction blood pressure 140mmHg and A high blood pressure subject (males 8.5% & females 1.9%) over than a expansion blood pressure 90mmHg were found in this study. (2) A blood test 1. Normal hemoglobin of subject (males 99.8% & females 62.3%) and 37.7% of females less than normal hemoglobin were found in this study. 2. 5.3% of males and 2.5% of females have greater than a concentration of glucose 140mg/dl, but there was anyone less than a concentration of glucose 50mg/dl. 3. The greater than 251mg/dl staff''s T.C.(males 7.1% & females 4.9%) and the less than 130mg/dl staffs' T.C.(males 2.0% & females 3.7%) were found in this study. 4. It was found males 5.3%, 11.6% & females 1.9%, 4.3% were presented greater than GOT and GPT 341U/L. (3) Hepatitis, Urinary Sugar, and Urinary Protein test 1. According to this study result, positive hepatitis was presented males (6.5%) and female(4.3%). 2. Urinary sugar is greater than +- males (1.8%) and females (2.4%) were found in this study. 3. Urinary protein is greater than +- males (1.6%) and females (1.8%) were found in this study. (4) Chest X-ray test 1. It was found male (1.6%) suffered from tuberculosis of the lungs. (5) Dental test 1. It was presented 77.3% of males and 88.9% of females was not existed the upper caries. Also, 75.7% of males and 90.7% of females was not existed the bottom caries. 2. It was presented 96.8% of males and 99.4% of females had the non-deficit of teeth in the upper part of teeth. Also, 93.9% of males and 98.1% of females had the non-deficit of teeth in the bottom part of teeth. 3. It was presented 19% of males and 3.7% of females have the periodontal disease. (6) General report and judgment 1. In general report, it was found 75.3% of males and 91.4% of females were the normal health condition. It was presented 9.1% of males and 4.9% of females were the liver disease, 4.9% of males and 1.2% of females were the sugar diabetes, 4.9% of males and 0.6% of females were the high blood pressure, and 1.4% of males and 1.9% of females were high arrest of bleeding. 2. In general judgment, it was presented 75.5% of males and 91.4% of females were the normal health condition. However, it was presented 17.8% of males and 7.4% of females were required high observation, 6.7% of males and 1.2% of females were required simple observation. As presented P. University staffs' lifestyle, it was found still many staffs have not right living habit. It is necessary to be wellness of lifestyle and satisfaction of life through correction of self responsibility and management in their life. Therefore, it is possible to live with healthy in better quality of life which is high quality of life and new concept of health were offered. Also, researcher expected the regular health examination be more practical contents than informal contents. Researcher recommended that it is necessary to support the university administration to be more flexibility of the regular health examination day than set the certain day of regular health examination and it required to create a way of using the P. university hospital.

건강보험의 재정전망과 정책과제

양봉민,김진현,이태진 한국사회복지정책학회 2002 사회복지정책 Vol.15 No.-

건강보험의 재정전망을 낙관적 전망(복지부 계획)과 중립적 전망의 두 가지 시나리오에 의해 추계해 본 결과 어느 쪽도 2006년까지 재정적자를 면하기 어려운 것으로 예상되며 별도의 재정대책이 없이 현재와 같은 추세로 간다면 건강보험은 수년내 또다시 재정파탄의 가능성이 잇는 것으로 사료된다. 장기적 재정안정을 위해 두 가지 종류의 방안이 거론될 수 있는데, 하나는 약가인하나 수가통제와 같이 재정지출을 출발부터 줄이는 방법이고, 다른 하나는 건강보험의 목적적 가치인 의료이용의 형평성을 견지하면서 거시 경제적 차원에서 재정지출의 크기를 조절하는 장치로서 제도화하는 것이다. 위의 두 가지 방안, 즉 의료전달상의 미시적 효율과 거시적 재정조정장치가 동시에 추구되고 작동되면서 건강보험제도는 원래의 목적을 상실하지 않으면서 장기적 재정안정을 기할 수 있을 것으로 판단된다. 건강보험의 장기 재정안정은 재정안정을 위한 구조적 틀의 구성이 중요하다. 의료비 및 보험급여 증가 요인들은 지불보상제, 전달체계, 의료의 공공성, 그리고 각종 지침(진료, 처방, 고가장비 등)의 사용이라는 네 가지의 매개체를 통하여 의료비 증가로 이어지게 된다. 따라서 이들 네 가지 매개체를 정책적으로 잘 관리함으로써 장기재정안정의 제도적 기전을 마련할 수 있다. 구체적으로는 건강보험제도를 통해 의료이용의 적절성 및 형평성이란 정책목표를 어느 정도 달성한 상황에서, 이런 정책 목표를 훼손시키지 않으면서 거시적 효율성 달성을 위해 한 걸음 더 전진할 수 있는 좋은 대안으로 총액예산제를 들 수 있다. The purpose of this paper is to analyze long-term financial prospects of the national health insurance(NHI) and to suggest health policy instruments for financial stabilization of the Korean NHI. The financial crisis in the NHI is still on debate. The current deficit in the income statement of the NHI was increased by more than 870 billion won during 2002, which resulted in a total deficit of 2.6 trillion won. Based on two scenarios of optimistic and neutral assumptions, this paper predicted financial balance for the year 2003-2006. All possible predictions show a huge deficit in financial balance of the NHI until the end of 2006. Therefore the NHI is, without a new health reform plan, destined to be in a bankruptcy by the year 2006. Experiences in advanced countries show that the most effective health policy reform to cope with financial crisis is considered to be a change in payment system, a shift from the current fee-for-service to a global budget system. According to our analysis, a global budget system coupled with pharmaceutical price control, health care delivery system, clinical guideline, public health resources is the key variable to establish an efficient and equitable health care system in terms of both micro and macro level.

시각 특성을 고려한 웨이브릿 변환 비디오 압축

양해권,김진태 群山大學校 情報通信技術硏究所 1998 情報通信技術硏究論文集 Vol.2 No.-

In this paper, we will compress the data of video signal using motion compensation and wavelet transform method. It is abbreviate to process have not large gain that analysing human visual characteristic for video signal and is compressed to the high portion without low resolution for video signal by abbreviated unsensitive information for human visual. In the result of simulation with 'Football' and 'People', we get high resolution under compress of frame per 30:1.

우리나라 法院의 建築計劃的 特性에 관한 硏究

조영태,이진우,양동양 대한건축학회 2003 대한건축학회논문집 Vol.19 No.4

Despite a hundred year long history of the planning and construction of modern courthouse in Korea, the adequate evaluations thereof are overdue. This study aimed to prevent uniformity in courthouse designs and to suggest desirable direction of planning for the public-use, through the investigation of the domestic(including Seoul District Court Complex) and 27 foreign instances. Architectural factors were analyzed in 1)site plans and outdoor space, 2)external appearance, 3)internal space program, 4)circulations. Especially, internal space program of floor with courtrooms and circulations of users are important analysing factors in this paper. As the result of this study, most of domestic courthouses are very much similar in site planning, massing, appearance, and judge oriented circulation plans. These characteristics of planning are purposed to express the equity and dignity of law. But the instances of European and USA have various type of spatial composition and the general public-oriented planning.

조기위암의 임상적 연구

박태준,양은수,류종철,박태군,이희승,신원창,이진호,김관엽 인제대학교 1994 仁濟醫學 Vol.15 No.1

1989년 9월부터 1993년 7월까지 인제대학교 의과대학 상계백병원에서 실시한 위내시경 소견이 조기위암이며 내시경 직시하 생검결과 선암으로 판명되어, 근치적 위절제술을 시행받은 23명의 환자에서 임상적 특징을 알아보고, 문헌고찰과 함께 보고하는 바이다. The incidence and mortality rate of stomach cancer ranks well ahead of all malignancies in Korea. The prognosis is excellent in early gastric cancer of which the overall 5 years survival rate of 85∼95% is comparative with that of advanced gastric cancer of 15∼49%. So early detection with very sensitive mordality of gastroscope and surgery is the only premise to decrease the mortality rate of gastric cancer. This report deals with the clinical aspects of 23 cases of early gastric cancer, which were confirmed with histopathologic examination of resected stomach during the 4 years from September 1989 to July 1993 at Sanggye Paik hospital, Seoul, Korea. Out of 23 cases of early gastric cancer, 14 cases were male, 9 cases were female, and the male to female ratio was 1.6 : 1. The most common type of early gastric cancer was talc type(43.5%), IIc and its combined type comprised most of them(87.0%). The most prevalent sloe of lesion was gastric angle(43.5%) and the most common direction was lesser curvature(73.9%) 19 cases of 23(78.3%) were between 1∼3cm in size, and there was no statistical significance between the size of the lesion and lymph node metastasis. Of the 9 cases with mucosal lesion, there were 2 cases with lymph node metastasis(22.2%), but 7cases(50.0% ) of 14 cases with submucosal lesion presented lymph node metastasis. Diagnostic accuracy of endoscopy on detection of early gastric cancer was 17 cases(73.9%) of total 23 cases in our study. As with other report, histopathulogic examination of resected stomach revealed adenocarcinoma, tubular type as the most common type. Frequent complaint of patients with early gastric cancer was epigastric pain(65.2%), and duration of the symptom was less than 12 months in 17 cases(73.1%) of 23 patients with early gastric cancer.

디자인 실기교육 방법에 관한 연구 : A Vision of 21C展을 통한 작품제시를 중심으로

김태진,김윤희,정승혜,홍철순,양재범 경남정보대학 1999 論文集 Vol.27 No.1

응급실을 내원한 65세 이상 노인 환자의 분석

김진년,김태훈,강양욱,오명,김상철,김성훈,권계형,남홍우,이홍순,유형준 대한노인병학회 2001 대한노인병학회지 Vol.5 No.3