청심연자탕(淸心蓮子湯)으로 호전된 뇌내출혈에 고혈압이 동반된 태음인 환자 치험 1례

오정민,엄태민,최고은,허종원,유호룡,설인찬,김윤식,Oh, Jeong-Min,Eom, Tae-Min,Choi, Ko-Eun,Heo, Jong-Won,Yoo, Ho-Ryong,Seol, In-Chan,Kim, Yoon-Sik 대한중풍순환신경학회 2014 대한중풍.순환신경학회지 Vol.15 No.1

■ Objectives The purpose of this case study is to report that a hypertension with intracerebral hemorrhage of tae-eumin was treated with 'Cheongsim Yeunja-tang' and then the symptoms were improved and blood pressure was decreased. ■ Methods Although the patient who had hypertension with intracerebral hemorrhage took antihypertension drugs, intermittent increase of blood pressure was shown. We diagnosed him as Tae-eumin and treated with Cheongsim Yeunja-tang. We daily checked blood pressure and evaluated the symptoms. ■ Results After the treatment with Cheongsim Yeunja-tang, blood pressure was decreased and symptoms were improved. ■ Conclusion The result shows Cheongsim Yeunja-tang has antihypertensive effect and improve hypertension symptoms of Tae-eumin patient with intracerebral hemorrhage.

Monte Carlo 방법을 이용한 대기오염 배출률 예측의 불확실성 평가

정효준,김은한,서경석,황원태,한문희 한국환경과학회 2006 한국환경과학회지 Vol.15 No.4

한국판 사건충격척도 수정판의 신뢰도 및 타당도 연구

은헌정,권태완,이선미,김태형,최말례,조수진 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.3

Objectives : The present study was conducted to explore the reliability and validity of the "Impact of Event Scale-RevisedKorean version" (IES-R-K). Methods : The subjects were college students who visited a college counseling center and patients who were admitted to a general hospital and two orthopedic local clinics.Those subjects who experienced catastrophic traumatic events were tested for CAPS, BDI, STAI-I, II, and MMPI-PTSD scale. Results : The range of correlations between item-total were .45 -.89. The coefficients of internal consistency were .69 -.83, of them were the Split-half reliability was .71 and the test-retest reliability was .89, all within expected ranges. Inter-corre-lations of IES-R-K, CAPS, BDI, STAI-I, II, and MMPI-PTSD scale were high. CAPS showed the highest correlation Coef-ficient. Factor analysis indicated 4 factors in IES-R ; avoidance, hyperarousal, intrusion, and sleep problem & numbness. IES-R-K can be a useful self-rating diagnostic instrument for PTSD symptoms to be a clinical concern by using 24/25 cutoff in total score. The partial PTSD cutoff score is 17/18. Conclusion : The IES-R-K was confirmed in it's reliability and validity. IES-R-K could be applied for screening of PTSD.

Resin infiltration을 시행한 법랑질 초기 우식 병소의 특성

김은영,권민석,김신,정태성 大韓小兒齒科學會 2012 大韓小兒齒科學會誌 Vol.39 No.1

The concept of resin infiltration which was born in an innovative philosophy to arrest the incipient caries. However, the structural changes of resin infiltrated lesions have not yet explained completely. The liquid resin might contribute not only to maximizing the penetration but to deteriorating physical stability. This study was performed to examine some physical and histological features of resin infiltrated incipient carious lesions. With the specimen of resin infiltrated lesions, microhardness by nanoindentation in depth profile, morphology of resin tags were revealed after HCl dissolution, and degree of microleakage were assessed. The percentage of microhardness of surface layer and lesion body of untreated specimen to sound enamel was 64.6% and 24.6% respectively, while that of resin-infiltrated lesions was 72.1%, showing significant difference (p<0.05). The resin tags observed under SEM had relatively homogeneous length of 433(282~501) ㎛ on the average. Among 20 specimens for microleakage assessment, 13 specimens showed no leakage while 5 and 2 showed leakage into outer and inner half of lesion respectively. It was thought the infiltrant resin penetrates deeply and homogeneously into lesion body and improves its hardness with relatively good physical stability. 본 연구는 infiltrant resin을 침투시킨 초기 우식 병소의 특성을 평가하기 위해 법랑질의 깊이에 따른 경도를 측정하고, 병 소 내로의 레진 침투양상을 분석하며, 미세누출 정도를 관찰하여 다음의 결과를 얻었다. 건전 법랑질에 대한 초기 우식 법랑질의 경도 백분율은 표층(5~40 ㎛) 64.6%, 병소본체(60~350 ㎛) 24.6%였으며, infiltrant resin을 침투시킨 병소의 경도 백분율은 72.1%로 나타났다. 5~350 ㎛의 전 깊이에서, infiltrant resin을 침투시 킨 병소는 비처치 우식 병소보다 경도가 유의하게 높았지만 정상 법랑질에 비해서는 경도가 유의하게 낮았다(p<0.05). FESEM 관찰 결과 탈회된 법랑질 내부로 비교적 균일하게 침투한 레진 테그가 관찰되었으며, 침투깊이는 433 ㎛(282-501)로 측정되었다. 열순환 처리 후 13개의 치아에서 미세누출이 관찰되지 않았고, 5개에서 병소 외측 절반, 2개에서 병소 내측 절 반까지 미세누출이 관찰되었다.

형질전환 제초제저항성 벼 밀양 204호의 농업적 특성

정응기,이기환,원용재,박향미,전남수,최준호,구연충,한창덕,은무영,김태산,남민희 Plant molecular biology and biotechnology research 2005 Plant molecular biology and biotechnology research Vol.2005 No.

This study was conducted to investigated the major characteristics of genetically modified rice of "Milyang 204" originated from Dongjinbyeo compared to a non-transgenic rice varieties Dongjinbyeo and Junambyeo. Basta resistant transgenic rice lines carrying bar gene produced by the Yeongnam Agricultural Research Institute were evaluated for their agronomic characters. The transgenic Japonica rice of "Milyang 204" showed inferior phenotypic traits compared to a non-transgenic rice variety Dongjinbyeo and Junambyeo. On the basis of UPOV (Union Internationale Pour la Protaection des Obtentions Vegetables) and NSMO(National Seed Management Office) the transgenic "Milyang 204" showed difference in some traits out of some agronomic traits, such as leaf color, angle of flag leaf, number of spikelets, culm length, white core and white belly compared to the nontransgenic varieties rice.

간질 환자의 인구학적 특성, 임상 특성, 정신병리 및 대처방식과 심리사회적 적응과의 관계

은헌정,최관호,이선미,김태형,최말례 대한간질학회 2004 대한간질학회지 Vol.8 No.1

Helm-Holtz coil裝置 초파리集團의 選擇不利에 관한 遺傳學的 硏究

鄭勝文,朴泰永,朴殷圭 圓光大學校 基礎自然科學硏究所 1990 基礎科學硏究誌 Vol.9 No.2

In order ot elucidate the genetic behavior of sexually selective disadvantage between visible mutants and wild type of Drosophila melanogaster in the Helm-Holtz coil apparatus without the ambient magnetic filed, this study was carried out From the result of the present experiment, the frequencies of all the flies between in the apparatus and .in the ambient field showed that the mutants decreased and the wild type increased according to the process of the generations. The whole average frequencies of the + gene-bearing chromosomes on the selective advantage through initial to twenty five generations in the apparatus and in the field were 72.84%, and 73.60%, respectively. It was observed that the sexually selective disadvantage of the + gene of wild type in the apparatus were higher than 'hat in the field. Each frequency on the sexually selective advantage rates of the yw gene-bearing chromosomes showed as 2.56% in the apparatus and as 1.91% in the field. Thus the selective disadvantage of the farmer was lower thatn that of the latter. The average frequencies of the w and the y gene-bearing chromosomes in the selective advantage rates were nearly the same under both conditions of the apparatus and the field showing 0.07%, 0.08% and 0.03%, 0.03%, respectively. The percentage of progeny due to eggs Lying by mated females on a complete food in the apparatus and in the field was found that each frequency in the whole average frequencies revealed 35.23% in the apparatus and 64.77% in the field. This suggested that the frequencies of all the flies in the apparatus decreased to nearly half of that of them in the field. The average frequency of each gene through initial to twenty five generations in the apparatus and in the field was calculated to be 72.84% and 73.60% in + gene. 2.56% and 1.91% in yw gene, 0.07% and 0.08% in w gene, 0.03% and 0.03% in y gene, respectively. From these data, the yellow bodied mutant was the highest in selective disadvantage and weakened in order of wild, yellow-white and white eyed mutant And summarized are that, as to the gene frequencies of wild, yellow-white, white, and yellow of Drosophila melanogaster, strength and weakness of selective disadvantage was varied due to X-linked genes.

일 도시 지역의 외상후 스트레스 장애 역학 조사

은헌정,이선미,김태형 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 이 연구는 DSM-IV에 근거한 외상후 스트레스 장애(Posttrauamatic Stress disorder : 이하PTSD)의 평생 유병률 및 현재 유병률을 평가하고, PTSD와 관련된 외상 사건의 유형과 사회인구학적 특성을 조사하고 한다. 방 법 : 조사를 위해, 전체 인구가 611,921명인 한 도시가 선택되었고, 도시 내 15세에서 65세 이상인 850명을 표집하여, 가정 방문을 통해 외상사건 조사표와 임상가 실시용PTSD척도(CAPS)를 적용하여 실시하였다. 결 과 : 연구 지역내에서 PTSD의 평생 유병률은 4.71%, 현재 유병률은 2.12%이었다. 평생 및 현재 유병률에서 남녀간에 통계적으로 유의한 차이가 없었다. (p>.05). 또한 나이, 교육에 따른 평생 유병률도 통계적으로 유의한 차이가 없었다.(p<.001). 단지 결혼 상태에 따른 평생 유병률에서 통계적으로 유의한 차이가 있었다. 외상사건에 평생 동안 노출될 확률은 78.79%이었다. 갑작스럽고 예기치 않았던 친지의 죽음이 가장 흔히 발생하는 사건이었다(51.06%). 자연재해, 화재 및 폭발, 교통사고, 가정 및 직장에서의 심각한 사고, 신체적폭력, 무기로 공격함, 전쟁, 생명을 위협하는 질병, 누군가를 심하게 다치게 하거나 죽음에 이르도록 함과 같은 사건은 남성에서 여성들보다 더 자주 발생하였고, 여성들에게는 성폭행이 더 자주 발생하였다. PTSD발병과 상관이 높은 외상사건은 자연재해, 화재 및 폭발, 교통사고, 가정 및 직장에서의 심각한 사고, 신체적 폭력, 성폭행, 생명을 위협하는 질병 등 이었다. 결 론 : 조사 지역 내에서 PTSD의 유병율은 다른 대부분의 선행 연구들에 비해 낮았다. 본 연구에서는 성별에 따라 흔히 경험한 외상사건의 유형에 차이가 있으며, PTSD와 관련된 외상사건들도 차이가 있음을 발견했다. 앞으로 역학 연구에서 외상 사건들로부터 PTSD를 일으킬 확률을 알기 위해서는 회고적으로 보고한 제한된 소수의 외상사건들을 조사하기 보다는 평생 경험하는 모든 외상사건들을 평가해야 할 것이며, 전국전인 표집을 해야 할 필요가 있을 것으로 생각된다. Objectives : This study was designed to assess the epidemiology of DSM-IV posttraumatic stress disorder(PTSD), including information on lifetime and current prevalence, the kinds of traumas most often associated with PTSD, and sociodemographic correlates. Method : For this survey, an urban area with total population of 611,921 persons was chosen. Modified version of traumatic event checklist and Clinician Administered PTSD Scale were administrated to a representative sample of 850 persons aged 15 o 65 years above through home visiting. Results : The lifetime and current prevalence of PTSD in survey area was 4.71% and 2.12%. the lifetime and current prevalence in male and female were of no significant statistical differences(p>.05). And the lifetime prevalence by age, and education were of no significant statistical differences. Only the lifetime prevalence by marital status was of significant statistical differences(p<.001). The lifetime prevalence to any traumatic exposure was 78.79%. Sudden unexpected death of a close person was the most prevalent traumatic event(51.06%). Among the traumas, natural disaster, fire and explosion, motor vehicle accident, serious accident at work or home, physical assault, assault with a weapon, combat, life-threatening illness, and serious injury to death you caused to someone else were more commonly associated with male sex, and sexual assault was more commonly associated with female sex. The traumas commonly associated with PTSD were natural disaster, fire and explosion, motor vehicle accident, serious accident at work or home, physical assault, sexual assault, combat, and life-threatening illness. Conclusion : The lifetime and current prevalence in survey area were lower than those of previous studies. This study found differences between men and women on the type of trauma experienced, and the type of trauma associated with PTSD. Future epidemiological studies to assess PTSD from all lifetime traumas rather than from only a small number of retrospectively reported ones will be required, and larger sample size covering the country will be required for better estimation.

(±)-Camphor가 ICR 마우스 수컷의 간 cytochrome P450 효소 활성에 미치는 영향

오은경,박형건,배기현,최옥진,최은경,최창근,한진희,정태천 한국환경독성학회 2002 환경독성보건학회지 Vol.17 No.4

Effects of (±)-camphor on liver cytochrome P450 enzymes were investigated in male ICR mice. Mice were treated intraperitoneally with 0, 200, 400 and 800 mg/kg of (±) -camphor in corn oil for 3 consecutive days. Twenty four hr after the final treatment, the animals were subjected to necropsy. The activities of serum aspartate aminotransferase and serum alanine aminotransferase were slightly changed by the treatment with (±)-camphor at the doses used. Administration o(±)-camphor to mice significantly induced the hepatic activities of pentoxyresorufin O-depentylase and benzyloxyresorufin O-debenzylase and weakly induced ethoxyresorufin O-deethylase in dose-dependent manners. The present results suggested that (±)-camphor might act as a relatively specific inducer of hepatic cytochrome P450 213 in male ICR mice.

결핵성 수막염 환자에서 결핵균 30 kDa 및 32 kDa 단백항원에 대한 항체반응의 비교

백태현,김선영,이건수,김화중,김성호,조은경,박정규 충남대학교 의과대학 지역사회의학연구소 1996 충남의대잡지 Vol.23 No.2

The 30 and 32 kDa antigens from Mycobacterium tuberculosis H37Rv culture filtrates, identified as biologically important proteins in the immune responses against mycobacterial infection, were purified and used in enzyme linked ummunosorbent assay (ELISA) for the determination in specific IgG and IgM levels in cerebrospinal fluids of 15 patients with tuberculous meningitis and 17 controls with nontuberculous diseases. High reactivity to both antigens was observed in tuberculous meningitis. Mean IgG and IgM antibody levels differed significantly (P < 0.001) between patients and con trols. Mean IgG antibody levels were also higher than IgM levels in tuberculous meningitis. A comparison of the antibody levels against the 30 and 32 kDa antigen within the tuberculous meningitis patients showed higher IgG reactivity to the 30 kDa than to the 32 kDa antigen, suggesting that the antibody response of these patients is directed predominantly against the 30 kDa protein. However, the patterns of reactivity to 30/32 kDa, 30 kDa and 32 kDa antigen in individual subjects were similar. By the cut-off value adding 2 stsndard deviation to the mean absorbance of controls, the sensitivity and specificity of the IgG antibody to the 30 kDa antigen were 100% and 94.4%, respectively. These values were higher than those obtained by 30/ 32 kDa and 32 kDa antigen. From the above results, it is suggested that the 30 kDa antigen may be dominant antigen and more valuable in the diagnosis of tuberculous meningitis than 32 kDa antigen.