정보산업 전문기술인력 양성에 관한 조사연구 -대학 정보산업 관련 학과의 교과과정 검토-

정순기, 조용환 忠北大學校 1986 論文集 Vol.32 No.-

-본문참고-

프레탈정 (실로스타졸 100mg)에 대한 실로스탄정 (한국유나이티드 제약)의 생물학적 동등성

용철순,이경희,최진석,박병주,정세현,김용일,박상만,유봉규,이종달,최한곤 한국병원약사회 2003 병원약사회지 Vol.20 No.2

Bioequivalence of one cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and Cilostan^(R)(Korea united Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Sixteen normal male volunteers(age 20~30 years old)were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 100㎎ of cilostazol were orally administered, blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameter. The results showed that the differences in C_(max), T_(max) and AUC_(t) between one tablet were 16.08%, 18.88% and 17.57%, respectively. The powers (1-β) for C_(max), T_(max) and AUC_(t) were 85.03%, 83.92% and 80.12%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilostan^(R) tablet is bioequivalent to Pletaal^(R) tablet.

부산지역 사무소 건물의 연면적에 따른 냉방설비 시스템의 라이프 사이클 코스트 분석

정순성,김동완,조용수 동아대학교 건설기술연구소 1997 硏究報告 Vol.21 No.1

This study is aimed at proposing an economic Cooling System by total area using Life Cycle Costing, a general economical efficiency analysis method considering total amount of investment, service life, salvage value and the change of price caused by interest rate or inflation. LCC elements of Cooling System are Initial costs, Operations costs, Maintenance costs, Replacement/Alteration costs, Tax costs, Salvage costs etc., and considerable factors are Discount or Interrest rate, Escalation, Service life etc. In order to compare design alternatives, both present and future costs for each alternative must be brought to a common point in time. Costs may be converted to today's cost by the present-worth method, or may be converted to an annual series of payments by the annualized method.

3-Cyano 및 3-Carbomethoxy Chromone과 Allenylstannane과의 반응

鄭大一,宋有淨,崔舜圭,李龍均,安賢淑,윤구식 東亞大學校附設基礎科學硏究所 1998 基礎科學硏究論文集 Vol.15 No.2

t-Butyldimethylsilyl triflate 존재에서 3-Cyano 및 3-Carbomethoxy Chromone(1a,b)과 Allenylstannane(2) 과의 반응에서 Chromone의 C-2위치에 propargyl기가 도입된 유도체(3a,b)를 합성하였다. 합성한 유도체의 상대적 구조는 ¹H-NMR을 통해 분석하였으며, T.S구조의 모델을 통하여 가능한 메카니즘을 제시하였다. Reaction of 3-Cyano and 3-Carbomethoxy Chromone(1a,b) with Allenylstannane(2) in the presence of tert-butyldimethylsilyl triflate afforded the corresponding the propargylation product(3a,b) in the moderate yield. The relative stereochemistry of 3a,b are obtained on the basis of ¹H-NMR analysis. And the possible reaction mechanism are suggested by the molecular models in the transition state.

TiO₂를 이용한 프로필렌 가스의 광촉매 산화반응

정대일,이동희,김용환,김현숙,이용균,박유미,최순규,김동현 동아대학교 환경문제연구소 2001 硏究報告 Vol.24 No.1

Photocatalyzed degradation of propylene gas was carried out over precoated titanium dioxide(anatase) illuminated W light in a flow reactor. photocatalytic oxidation of propylene gas indicated high conversion rates (78.0%) to CO₂ gas. And photocatalytic oxidation of gas according to a fold, twofold, and threefold of titanium dioxide(anatase) respectively gave high conversion rate. The longer reaction time was, the higher conversion rate to CO₂ gas showed.

폴록사머를 이용한 디클로페낙 고형 좌제의 개발

용철순,오유경,김정애,김용일,박상만,양준호,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

To develop a poloxamer-based solid suppository with poloxamer mixtures, the melting points of various formulations composed of P 124 and P 188 were investigated. To investigate the effect of poloxamer to the dissolution and dissolution mechanism of diclofenac sodium from the suppository the dissolution of diclofenac sodium delivered by the poloxamer-based suppository was performed. Furthermore, to investigate the mucoadhesive property of the poloxamer-based solid suppository, the identification test in the rectum was carried out after its rectal administration in rats. The poloxamer mixtures composed of P 124 and P 188 were homogeneous. Very small amounts of P 188 affected the melting points of poloxamer mixtures. In particular, the poloxamer mixture [P 124/P 188 (97/3%)] with the melting point of about 32℃ was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, very small amounts of P 188 in the poloxamer-based suppository hardly affected the dissolution rates of diclofenac sodium from the suppository. Dissolution mechanism analysis showed the dissolution of diclofenac sodium was proportional to the time. At 4 h after administration, the blue color of poloxamer-based suppository [diclofenac sodium/poloxamer mixture (2.5/97.5%)] with the P 124/P 188 ratio of (97/3%) and blue lake in the rectum was faded. However, the position of suppository in the rectum did not significantly change with time. Thus, it retained in the rectum for at least 4 h. Our results indicated that the poloxamer-based solid suppository with P 124 and P 188 would be a candidate of rectal dosage from for diclofenac sodium.

牛乳및 乳製品中의 異種脂肪 檢出에 關한 硏究

정은자,이용억,김을상,신광순 韓國營養學會 1978 Journal of Nutrition and Health Vol.11 No.2

The ice cream, a type of freezing food of condensed state of milk, richer in nutritions and easily available in all seasons, is one of luxuary items. The fatty acids in the milk is the most important component of ice cream which not only improve the nutritional value but also is easier digestive, more rapidly absorbed than those of plant and also has influence up the quality of the goods. In order to see the fatty acid distribution of the fats in the ice cream on the market, the ice creams on the market were selected in accordance with things most in demands of each manufacture divided into the shape. and analyzed for the concentration of total lipid, acid value, iodine value and saponification value. For the compositional analysis of fatty acid of milk as basis and those gas liquid chromatography was also used. The following were the results obtained. 1) The average total lipids in milk and, the 3 kind of ice creams shaped carton, cone and bar were 3.04, 8.34, 6.41, and 5.4% respectively. 2) The average acid values of milk and each of 3-different type of ice creams shaped carton, cone and bar were 0.72, 0.62, 0.76, and 0.95 respectively. 3) The soponification values. Ranged from 180 to 260, varied great degree depending upon. the different manufactures, the average saponification value of the milk and each type of ice cream shaped carton, cone and bar were 208, 226, 226 and 215 respectively. 4) The iodine values varying great degree upon the different manufactures ranged from 10 to 32, the average values of milk and each type of ice cream shaped carton, cone and bar were 29, 20, 19 and 22 respectively. 5) The fatty acids analyzed for milk and ice cream, were 17-different kind, for the milk palmitic acid appeared principal constituents which valued 29.8%, whereas oleic acid were 27.1%. Since the compositions of fatty acid in ice creams for each different manufacture varied so great degree from manufacture to manufacture that the average values of those for the same shaped ice creams seems to have no meaning, if the compositions of fatty acid in the ice cream were considered according to the manufactures such as A, B, C, D and E companies. 27.4% lauric acid which was principal constituents, 17.8% palmitic acid and 11.8% oleic acid which was equal to 1/2 of that in the milk were found in the product of A company, 28.2% oleic acid and 27.8% palmitic acid which had similar pattern with the composition as that of milk in the product of B company, 25.5% palmitic acid, 22.7% oleic acid and 11.6% lauric acid in the product of C company, 34.4% lauric acid, 15.6% palmitic acid and 8.6% oleic acid which amounts to 1/3 of that in the milk in the product of D company, and 24.6% lauric acid and 18% palmitatic acid in the product of E company respectively. For the ratio of saturated to unsaturated fatty acid, these were 84 : 16 in the product of At 62 : 38 in the product of B, 68 : 32 in the product of C, 88 : 12 in the product of D, 79 : 21 in the product of E respectively, while this ratio for milk was 63 : 37. Although the compositional characteristic of fatty acids in the ice creams varied great degree according to the manufactures, all kinds of different shaped product showed the same pattern in composition regardless of the type of ice cream shaped in provided they were made in the same company. The lauric acid was more exuberant, however oleic acid, unsaturated fatty acid, was of less quantity than in the milk fat. In general, there was less quantity of unsaturated fatty acid in the ice creams compared with in milk.

Paraquat에 의한 급성 폐 손상에서 Vitamin E의 영향

용석중,송광선,정순희 연세대학교 원주의과대학 1999 원주의대논문집 Vol.12 No.1

鐵筋콘크리트 構造物의 最適設計

鄭哲源,朴熙淳,孫鎔雨,崔圭文 圓光大學校 1989 論文集 Vol.23 No.2

이 論文에서는 最適化問題를 해결한다 : 彈牲設計에 비해 最大效率로 주어진 形態의 構造를 設計하여 모든 可能한 荷重組合下에서 그 構造의 崩壞와 그것의 臨界斷面의 first yield에 대한 어떤 지정된 最小荷重係數를 측정한다. 目的函數를 線形化하고, 모든 limit equilibrium constraint를 算出해 내는 方法을 개발하여 線形計劃法과 콤퓨터技法의 도움으로 그 問題를 해결한다. 관계되는 원리와 대응되는 最適解는 鐵筋콘크리트 連續보와 뼈대 構造를 例로서 설명되어 있다. The following optimization problem is solved in the paper : design a structure of given geometry for maximum efficiency vs. elastic design, so that under any possible load combination certain specified minimum load factors be guaranteed against both the collapse of the structure and the first yield of its critical sections. By linearizing the objective function and developing a method to generate all limit equilibrium constraints the problem is solved with the help of linear programming and computer techniques. The principles involved and corresponding optimal solutions are illustrated by the examples of a reinforced concrete continuous beam and frame.

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.