비만세포주에서 Histamine 유리에 관한 연구

김형룡,국윤아,신민,이홍수,원진숙,김형민,이영미,정헌택,이혜숙,안녕형 원광대학교 생명공학연구소 1995 생명공학연구소보 Vol.3 No.1

요구르트를 이용한 구강간호가 경관영양환자의 설태 제거와 구강안위에 미치는 효과

이형란,강현숙 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: This study examined the effect of the oral care using yogurt on the reduction of the tongue coating and the level of oral comfort in patients being tube feeding. Method: There were 64 tube feeding patients at the S medical center(experimental group : 31, control group : 33). The subjects in the experimental group received oral care using yogurt containing Lactobacillus acidophilus. The control group received oral care using 0.02% chlorhexidine gluconate. Oral care was performed twice daily for 1 week in both groups. The scores for the tongue coating, oral dryness, and the level of oral comfort were used to measure the effect of the oral care. The data were analyzed by the SPSS WIN 11.5. Result: the degree of the tongue coating and oral dryness were significantly lower in the experimental group than in the control group. The degree of oral comfort was significantly higher in the experimental group than in the control group. Conclusion: Oral care using yogurt is effective in reducing the tongue coating, oral dryness, and oral discomfort. Therefore this oral care method can be used to improve the level of oral comfort in patients who are tube feeding.

철 결핍성빈혈이 혈청 지질 및 렙틴농도에 미치는 영향

이근일,김혜영A,강형숙 龍仁大學校 2003 용인대학교 논문집 Vol.21 No.-

The purpose of this study was to investigates the changes in serum lipid and leptin of iron deficiency anemia female gymnasts who excessive training and weight control. The mean age of subject was 17.6 years old. Their mean height was 158.4±4.76cm and mean weight 48.7±4.70kg. Mean body fat percent was 21.2±3.01%, and body mass index was 19.5±1.30 kg/m^2. The mean value of energy and iron intake were 1367.2±360.9 kcal(74±38.0% of the Recommended Dietary Allowance) and 7.1±2.7 mg(38.6±15.8% of RDA), The rate of te 3 major nutrition (P : F : C) was 63 : 26 : 11%. It showed that high fat intake rate. The hemtological status showed hemoglobin(2.3±1.0g/dl), Ferritin(46.7±32.l ng/ml), sTfR(2.8±1.4 mg/L) was low, but in a normal range. Mean serum triglyceride concentration and LDL-cholesterol, Atherogenic index was normal rage, but iron deficient group was higher than normal group(P<.05). Mean Insuin concentration was significantly lower than normal group(P<.05).

PGE_2와 DBcAMP가 골조직 세포의 생리적 활성에 미치는 영향

이준기,채한정,강장숙,김형룡 원광대학교 생체재료·매식연구소 1998 원광생체재료·매식 Vol.7 No.2

One of the primary functions for which bones have evolved is to act as structural support. To achieve this goal, bones are remodeling throughout life so that their structure remains optimal for the prevailing mechanical environment. Bone remodeling consists of an initial phase of osteoclastic bone resorption followed by a bone formation period. Prostaglandins are potent regulators of bone formation and bone resorption that can have both stimulatory and inhibitory effects. Elevation of intracellular cAMP is an important intracellular signaling mechanism involved in the regulation of the expression of many proteins. In this study, the author examined whether PGE_2 or DBcAMP affected osteoblastic activation or osteoclastic differentiation in mouse bone marrow cells and osteosarcoma ROS 17/2.8 cells. The effect of PGE_2 and DBcAMP on the cell proliferation was measured by the incorporation of [^3H]-thymidine into DNA. From the result, PGE_2( 0.5-1 ㎍/ml ) and DBcAMP(0.1-0.5 mM) inhibited the [^3H]-thymidine incorporation into DNA. The effect of PGE_2 and DBcAMP on the induction of alkaline phosphatase(ALP) was investigated in ROS 17/2.8 cells cultured in medium containing 0.4% fetal bovine serum. PGE_2 and DBcAMP stimulated ALP activity in the cells. PGE_2 also increased the intracellular cAMPs contents with a maximal effect at 0.5 ㎍/ml. ROS 17/2.8 cells released nitric oxide upon stimulation of PGE2 or DBcAMP with interferon-γ. PGE_2 and DBcAMP increase the phosphorylation level of CREB(cAMP response element binding protein) without any change on the amount of CREB protein. Also, PGE_2 (10^-6 M) and DBcAMP (10^-4 M) significantly increase the generation of osteoclast-like cell in mouse bone marrow cell culture system. In conclusion, the results of this study suggested that PGE_2 and cAMP should appear to be an important regulatory molecule in the processes of bone formation and resorption.

Peripheral odontogenic fibroma에 관한 증례보고

이제호,최형준,이종갑,장태숙 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.3

The peripheral odontogenic fibroma (WHO type) is a relatively rare and characteristically benign and unencapsulated, exophytic gingival mass of fibrous connective. Odontogenic epithelium is found within the gingival mass, but usually appears to play a minor role when compared to the fibrous component. The connective tissue is ranged from markedly cellular to relatively acellular and well collagenized. but the connective tissue in this case report appears less cellular. Peripheral odontogenic fibroma must be differentiated histologically from peripheral ossifying fibroma, Peripheral cemental epithelial odontogenic tumor and Peripheral ameloblastoma. The author reports the following conclusions after clinical and radiological examination, excisional biopsy and reviewing literatures. 1. Peripheral odontogenic fibroma is rare lesion and frequently occurs in interdental papila as a form of fibroblastic connective tissue including odontogenic epithelium within the lesion. 2. Peripheral odontogenic fibroma must be differentially diagnosed with Peripheral ossifying fibroma by including less cellular connective tissue, odontogenic epithelium and dysplastic dentin. 3. Treatment consists of surgical excision including removal of alveolar bone which is eroded under the lesion.

삼차신경 감각핵의 세포활성도와 Substance P 유리에 대한 Capsaicin, Paradol 및 Shogaol의 전통작용기전에 관한 연구 : Ⅰ. 유해자극에 의한 개구반사와 삼차신경 척수감각핵의 Substance P에 미치는 영향 Ⅰ. EFFECTS ON JAW OPENING REFLEX BY NOXIOUS STIMULUS AND RELEASE OF SUBSTANCE P

이종흔,김중수,송형근,박수정,함진숙 대한구강생물학회 1990 International Journal of Oral Biology Vol.14 No.1

The purpose of this investigation was to determine the relative analgesic effectiveness of paradol and shogaol compared with capsaicin, and effects of capsaicinoids on substance P of trigeminal spinal sensory nucleus. Under anesthesia, anterior belly of digastric muscle was exposed and a pair of electrodes was inserted to record the electromyograms. Noxious electrical stimulus was applied to oral mucosa around the mental foramen. Inferior alveolar nerves (IAN) and saphenous nerves were carefully exposed for application of vehicle and drugs to evaluate the effects on digastric EMG (dEMG) and neural conduction, and caudal part of brainstem was exposed to determine the substance P. Vehicle and 1.5% of capsaicin, paradol and shogaol were applied to IAN and saphenous nerves for 30 minutes, respectively. EMG_s of digastric muscle evoked by noxious electrical stimulus were recorded before application of drugs or vehicle, immediately after removal and washing of drugs and at 30 minutes after washing. To examine the effects of the peripheral stimulation on the action potential, stimulating electrodes were placed on the peripheral side of drugs application site and recording electrodes were on the proximal side. Substance P of trigeminal spinal sensory nucleus was collected by push-pull perfusion technique and determined by radioimmunoassay. Capsaicin application on IAN could not influence on dEMG, but paradol and shogaol decrease the amplitude of dEMG. Capsaicin applied locally to nerve decreased amplitude and conduction velocity of only C-fiber, while paradol and shogaol inhibited the neural conduction of C-fiber and Aδ-fiber. Substance P in the trigeminal spinal nucleus was reduced by capsaicin but not by paradol and shogaol.

부가적 산부식 시간에 따른 자가 산부식 접착제의 법랑질 전단결합강도

이형숙,김성기,이동수,김신,정태성 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.4

이 연구의 목적은 유치와 영구치의 법랑질에 자가 산부식 접착제 적용 전 부가적인 산부식 시간을 달리 하였을 때, 전단결합강도에 미치는 영향을 알아보기 위함이다. 각각 65개의 발거된 건전한 유치와 영구치 협, 설면 법랑질 시편을 제작하고 두 종류의 자가 산부식 접착제를 적용하였다. 실험군은 Clearfil SE bond, Adper Prompt L-pop으로 처리한 두 개 군으로 나누고, 이를 다시 산부식 시간에 따라 여섯 군(0, 5, 10, 15, 20, 30초)으로 분류하였다. 대조군으로는 total-etching system인 Multi-purpose plus를 사용하였다. 접착제 처리면을 복합레진으로 충전하고 24시간 경과 후 전단결합강도를 측정하고 Mann-Whitney test와 Kruskal-Wallis test를 사용하여 통계분석 하였다. 결과는 자가 산부식 접착제를 적용한 군은 유치, 영구치 모두에서 total etching system에 비해 낮은 전단 결합강도를 보였다. 자가 산부식 접착제 사용 군내에서 산부식을 추가로 시행하였을 때 유치와 영구치 모두에서 결합강도가 증가하였으며, 10초 이상 산부식을 시행한 경우 결합력의 차이는 없는 것으로 나타났다. 유치와 영구치간 결합력의 차이는 인정되지 않았다. 결론적으로, 자가 산부식 접착제의 법랑질에 대한 전단결합강도는 유치, 영구치 모두에서 10초 이상의 부가적 산부식이 결합력의 증가에 유리하게 작용하는 것으로 나타났다. The aim of this study was to evaluate the bonding ability of two self etch systems to human primary and permanent enamel and the effect of additional acid etching time. Exfoliated, caries free human primary molar(n=65) and permanent molar extracted (n=65) were used. prepared enamel specimens were randomly divided into 2 test groups and a control group. The control group(n=10) were treated with 35% phosphoric acid gel and Scotchbond Multi-purpose adhesive. Experimental groups(self-etching systems) were subdivided into 6 groups(each n=10) according to additional etching time(0s, 5s, 10s, 15s, 20s, 30s). The result were as follows : 1) The shear bond strengths of the self-etching adhesives(Clearfil SE Bond, Adper Prompt L-pop) without additional etching were lower than control group(Scotch Bond Multipurpose). 2) Between the same self-etch adhesive groups, additional etched groups showed higher shear bond strength 3) There was no significant difference between primary and permanent enamel. In conclusion, bond strength of self-etch adhesives to enamel could be increased with additional etching.

어린이 영구치에 나타난 국소적 치아 이형성증의 관리

이형숙,김재문,김신,정태성 大韓小兒齒科學會 2008 大韓小兒齒科學會誌 Vol.35 No.4

국소적 치아 이형성증(Regional Odontodysplasia)은 치아 경조직에 비교적 드물게 나타나는 발육성 장애로 치열궁의 특정 사분악에 국한되어 나타나며 이환치 경조직의 모든 구성요소가 발육 부전이나 석회화 부전을 보인다. 국소적 치아 이형성증에 대한 장기적 치료와 관리를 위해서는 여러 분야에 걸친 체계적 접근이 요구되며,치료 계획은 환자의 저작기능과 심미성의 회복,정상적인 수직고경과 공간의 유지,악골의 정상적인 성장과 이환치의 맹출관리를 도모할 목적으로 수립되어야 한다. 본 증례보고에서는 부산대학교병원 소아치과에서 국소적 치아 이형성증으로 진단받고, 2~5년간 정기적인 관찰을 받아온 5세 8개월~10세 9개월 어린이 3명을 대상으로 그 간의 치료 내용과 치아 발육과정을 검토해 보았다. 관찰 기간 동안 12개 이환치 중 심한 염증과 이형성으로 발거된 1개 치아를 제외한 모든 치아에서 석회화의 진행 또는 치조골 상방으로의 맹출성 이동을 보이긴 하였으나 그 정도와 속도는 개개 치아마다 매우 다양하였다. 그러므로 치료는 악골의 정상 발육과 공간 유지를 도모하고 치아의 조기 상실에 따른 부작용을 차단하기 위해서 이환치에 대하여 최대한으로 보존적인 접근을 하는 것이 추천된다. 또한 치아마다 그 발육정도가 다양하므로 개개 치아의 맹출 관리를 위한 독립적인 치료 계획을 수립하는 것이 바람직할 것으로 판단된다. Regional odontodysplasia is a relatively rare developmental anomaly of dental hard tissue with characteristic clinical. radiographic and histologic features. It requires a continuous and multidisciplinary approaches, and the aim of treatment for these patients should include aiding mastication. improving aesthetics. maintaining normal vertical dimension and space, allowing normal jaw growth and eruptional management of affected teeth. This report describes three cases of regional odontodysplasia with 2-5 years of follow-up. Conservative treatment is chosen to preserve the affected teeth as long as possible, and periodic radiographic and clinical examination was done. During this time, all teeth except one showed progressive development. An interesting finding observed in our cases was that each tooth even in the same person showed different degree of tooth development and eruption rate. Thus, we colcluded that the treatment plan for regional odontodysplasia should be conservative and individualized and based on the assessment of each tooth.

부산지역 모 공단 및 인근지역 사업체의 산업보건 실태에 관한 조사연구

이동영,손혜숙,이채언,박형종,김대환,엄상화,최성용,유병철 인제대학교 1993 仁濟醫學 Vol.14 No.4

부산지역 공단 및 인근지역 사업체의 산업보건실태를 파악하기 위하여 205개 사업체의 보건담당자를 대상으로 1990년도의 보건실태에 관한 설문조사를 하였다. 조사내용을 일반사항, 보건관리실태에 관한 사항, 작업장 유해환경 및 보호구 지급사항, 건강관련 사항 및 근무조건에 관한 사항 등으로 대별하여 분석ㆍ관찰하였다. In order to obtain the fundamental data for developing more effective and acceptable programs of public health manegement in an industrial complex, 205 health manager in the plants answered the questionaire of the status of industrial health during 1990. The questionaire consisted of general charateristics, health care status, environmental problems, health problems, and others. 72.4% of 205 plants had less than 100 workers. Fabricated metal manufacture was 32.4%. Although Footwear manufacture was 6.4%, the percentage of workers was 33.1% of total workers. The percentage(56.2) of retired women was higher than that(38.2) of men. 51.9% of total plants has recieving group health care services. 85.4% of plants was exposed to noise, 66.5% was exposed to dust. Ear plug and mask were given to prevent noise and dust in 69.2% and 68.6%, respectively. Among 22,299 workers, 618(2.8%) were diagnosed as suspected non-occupatinal disease. 85.9% of them worked on continuously and had their disease treated. The cases suspected for occupational disease was 100 workers. 82.5% of them changed their post. 45% had the compensation for their occuaptional disease. The rate of working: accidents was 2.3%.

정신분열증 음성증상에 대한 단기 토큰경제의 효과와 치료인자

안정숙,이연덕,방형석,박정은,신정호 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.5

연구목적 : 정신분열증의 음성증상은 약물치료에 잘 반응하지 않은 채로 남아 재활을 어렵게 한다. 본 연구는 정신분열증환자의 음성증상을 개선시키는데 토큰경제치료(TET)가 효과가 있는 지를 조사하고, 종합병원의 정신과병동 여건에 맞는 TET 프로그램을 개발하고자 시행되었다. 연구방법 : 정신과병동에 입원치료중 음성증상이 주문제가 되어 삼개월 이하의 단기 TET를 받은 정신분열증환자 35사례를 대상으로, PANSS음성증상척도를 사용하여 TET의 효과를 조사하였다. 또한 목표행동의 각 수준별로 성공집단과 실패집단의 환자 변인과 프로그램 변인을 비교함으로써 치료인자를 규명하고자 하였다. 연구결과 : 1) 음성소척도 총점은 기저선 관찰기간의 31.57±4.32점에서 TET 종료시 20.66±4.63점으로 낮아졌다. TET종료시 음성소척도의 7개 증상 모두 감소하였으나 추상적 사고의 장애와 상동적 사고는 다른 5개 소척도 증상에 비해 상대적으로 덜 개선되었다. 또한 TET 기간 동안 항정신증약물의 용량은 487.58±372.79mg/day로부터 291.21±287.74mg/day로 감소하였다. 2) 자조기술 수준(Ⅰ)에 속한 항목들의 성공률은 75%, 병동활동 수준(Ⅱ)에서는 78%, 사회기술 및 작업 수준(Ⅲ)에서는 68%로서, 전체 목표행동에 대한 TET의 성공률은 74%였다. 3) 수준 Ⅱ의 성공집단은 실패집단보다 TET 종료시 항정신병약물의 투약용량이 유의하게 낮았으며, 수준 Ⅲ의 성공집단은 실패집단보다 입원경력이 유의하게 적었다(p<.05). 수준 Ⅰ에서는 간식신청, 면회, 가족외출 등이, 수준 Ⅱ에서는 면회가 강화물로 적용되었을 때 성공률이 유의하게 높았다. 결 론 : 이러한 결과는 TET가 정신분열증환자의 음성증상에 효과적인 치료법임을 보여준다. TET의 효율향상과 원할한 운용을 위해서는 개별화된 프로그램을 개발하려는 지속적인 연구가 필요할 것이다. Objective : The negative symptoms of schizophrenia usually are not responsive to drug therapy to persist and make schizophrenics more difficult in their rehabilitation. The authors investigated the therapeutic effect of token economy(TET) for negative symptoms of schizophrenic patients, and attempted to develop a TET program for psychiatric wards in general hospital. Methods : Negative subscale of PANSS was rated for 35 schizophrenics with negative symptoms as their main problems before and after short-term TET(less than 3 months). Therapeutic factors were identified by comparing patient and program variables between the achieved and the non-achieved group of each level of target behaviors. Results : 1) Subtotal of negative subscale of PANSS was decreased from 31.57±4.32 at baseline to 20.66±4.63 after treatment. With TET, symptoms of 'difficulty in abstract thinking' and 'stereotypic thinking' were less responsive than the other 5 items of the scale. Also the dose of antipsychotics prescribed was reduced to 291.21±287.74mg/day from 487.58±372.79mg/day. 2) The achievement rate of level Ⅰ(self-help) was 75%, level Ⅱ(ward-activity) 78%, and level Ⅲ(social activity/occupation) 68%, resulting in average 74% for all target behaviors. 3) On level Ⅱ, dose of antipsychotics was lower, and on level Ⅲ, number of admission was fewer and female sex was more frequent in achieving patient group than nonachieving group. The rate of achievement was higher in case of special food, reception, and outing with family applied as a reinforcer on level Ⅰ, and reception on level Ⅱ. Conclusion : These results showed that TET was effective for schizophrenic patients with negative symptoms in psychiatric ward. Further investigations to refine the individual program of TET will be needed for enhancement of it's therapeutic efficacy and smart application of it.