In Vitro Fertilization and Embryo Cleavage in Canine Oocytes

Hae }ung Kim,Sang Ryeul Lee,Sin Hae Park,Sung Hyun Kim,Bong Soo Kim,Dong Hun Yoo,Sin Hae Park,Mi Jung Shin,Jae Wook Kim,Zae Young Ryoo 한국동물생명공학회(구 한국동물번식학회) 2006 Reproductive & developmental biology Vol.30 No.2

Voice Mismatch Meets Neurolinguistics

Gui-Sun Moon,Sun-Woong Kim,Jeong-Ah Shin,Hae-Kyung Wee,Jong Un Park,Myung-Kwan Park,Wonil Chung 현대문법학회 2018 현대문법연구 Vol.99 No.-

Gui-Sun Moon, Sun-Woong Kim, Jeong-Ah Shin, Hae-Kyung Wee, Jong Un Park, Myung-Kwan Park, and Wonil Chung. 2018. Voice Mismatch Meets Neurolinguistics. Studies in Modern Grammar 99, 85-115. This paper aims to investigate Korean advanced L2 English learners’ strategies for ellipsis resolution during sentence processing. Ellipsis resolution is known to involve several stages of information processing from the initial step of detecting an ellipsis-licensing element by the parser to the final stage of integrating the ellipsis site with the information retrieved from the antecedent of the ellipsis site. In examining these steps, we have manipulated three factors: (i) TP vs. VP-ellipsis; (ii) two types of discourse coherence relations (resemblance(-contrast) vs. cause-effect relations); (iii) voice match vs. mismatch. We found through the ERP recordings that voice mismatch in TP ellipsis elicited N400, followed by P600, irrespective of discourse coherence relations. In contrast, voice mismatch in VP-ellipsis registered N400 only in resemblance(-contrast) relation, but not in cause-effect relation. These findings lead us to conclude that Korean advanced L2 learners of English seem to undergo the full sequence of processing stages required for ellipsis resolution.

원발성 폐암의 CT상 병기 결정:새로 재정된 TNM 체계와의 비교

신현준,최영칠,전혜정,박정희,김요한,이원진 건국대학교 의과학연구소 1998 건국의과학학술지 Vol.8 No.-

Accurate staging of lung cancer is essential for defining operability, selecting treatment regimens, predicting survival, and reporting comparable end results. Revisions in stage grouping of the TNM subsets in the International System for Staging Lung Cancer have been adopted by the American Joint Committee on Cancer and the Union Internationale le Cancer at 1996. We compared the previous TNM systems with revised stage grouping rules, and tried to applicate the new size-criteria for metastatic lymph nodes in mediastinum. Twenty-two patients were undergone CT stagings by using three different systems of previous, revised, and modified TNM subsets. Ten patients showed different TNM stage by the revised stage grouping rules and seven patients were altered in lymph node stage by the new size-criteria. Recognition of revised stage grouping rules is very important for treatment plan and predicting the correct prognosis.

COX-2 Inhibitors를 위한 새로운 1,2-치환된 피롤리딘 유도체의 합성

박명숙,신혜순 德成女子大學校 藥學硏究所 2000 藥學論文誌 Vol.11 No.1

For the development of new COX-2 inhibitor, novel compounds were synthesized through induction an arylsulfony group to 1-position, an arylcarboxamidyl group to 2-position and an aralkyl group to 4-position of L-proline. The 4-aralkyloxy-1-(4-methylphenylsulfonyl)-L-prolines 5a-d were synthesized through N-tosylation, esterification, O-alkyl-(or aryl)ation, base-hydrolysis (deprotection of carboxylic acid) from 4-hydroxy-L-proline. Final 4-aralkyloxy-1-(4-methylphenylsulfonyl)-2-phenylcarboxamidyl-L-prolines 6a-d were synthesized through the condensation of aniline with 5a-d using DCC.

시계열분석을 이용한 한국 오징어 어업의 어획량 분석과 예측

박해훈,신형호 麗水水産大學校 産業技術硏究所 1996 産業基術硏究所 論文集 Vol.5 No.-

한국 오징어 어업에서의 22년간이 월별 어획량 자료에 시계열 분석을 이용하여 어획량을 분석, 예측하였다. 시계열 분석은 다른 생물학적, 해양학적, 사회 경제적인 요소가 없어도 단지 어획량 자료만으로 분석과 예측이 가능하다. 1971∼1990년 사이의 월별 오징어 어획량의 자료를 ARIMA 시계열 모형에 적응시켜 분석한 결과, 다음과 같은 계절 ARIMA 모형식을 구하였다. 로그(대수)변환때 : ?? Box-Cox 변환때 : ?? 위의 두 모형중 로그변환시킨 경우보다 Box-Cox 변환시킨 것이 예측오차가 적었으며, BOX-COX변환식은 ??이었다. 위의 두 모형 중 후자의 모형으로 1991∼1992년에 대해 오징어의 월별 어획량을 예측하였다. 예측 어획량과 실제 어획량과의 월별 오차범위는 0.9∼203%였다. 실제 어획량이 1991년과 1992년에 각각 109,902M/T, 139,792M/T이고, 예측어획량은 78,585M/T과 86,968M/T이었다(1991년의 오차는 24.6%, 1992년에는 27.4%). 2년 동안의 총어획톤수에 대한 오차는 26.2%였다. 또한, 스펙트럼 분석은 순환변동의 주기가 12.5개월, 2.2년 및 5.5년인 성분에서 상대적으로 큰 값을 나타내었으며, 순환변동 성분은 적절한 ARIMA 모형을 결정하는데도 도움을 준다. The seasonal Autoregressive Integrated Moving Average (ARIMA) model and spectral analysis were described to forecast the monthly landings of squid in Korea. The prediction error by the Box-Cox transformation on monthly squid catches in Korea was less than that by the logarithmic transformation. The equation of Box-Cox transformation was ??. the seasonal ARIMA model is presented ?? where : ??=value at month t: ?? is a backward shift operator, that is, ??: and ??=error term at month t, which is to forecast 24 month ahead the squid landing in Korea. Forecast of the monthly squid landings for 1991∼1992 which were compared with the actual landings had an absolute percentage error(APE) range of 11.2∼207.7%. Total observed annual landings in 1991 and 1992 were 109,902M/T and 139,792M/T respectively, while the model predicted 82.816M/T and 101,479M/t (APE 24.6% and 27.4%, respectively). And spectrum analysis of the monthly catches of squid showed some dominant flutuations in the periods of 12.5 month, 2.2 and 5.5 years. The spectrum analysis was also useful for selecting better ARIMA model.

Cyclooxygenase-2 저해제로서의 benzothiazine 유도체 합성과 항염작용 평가

신혜순,박명숙,권순경 德成女子大學校 藥學硏究所 2000 藥學論文誌 Vol.11 No.1

The antiinflammatory mechanism of NSAIDs is attributed to the reduction of prostaglandin synthesis by the direct inhibition of cyclooxygenase. Inhibition of prostaglandin production in organs such as stomach and kidney can result in gastric lesions, nephrotoxicity and increased bleeding. In this study, newly designed COX-2 inhibitors, synthesized 1,2-benzothiazine derivatives, were screened in vitro for selectivity of COX-1 and COX-2 inhibition properties. Lead compounds in the structure-activity relationship were studied to synthesize new highly selective COX-2 inhibitors. To determine inhibitory effect of COX-2, synthesized 1,2-benzothiazine derivatives were screened with accumulation of prostaglandin by lipopolysaccharide (LPS) in aspirin-treated macrophages and murine macropharge cell. Some of synthesized 1,2-benzothiazine derivatives were shown to be effective as selective COX-2 inhibitory activity. Others exhibited a preferential inhibition of COX-2, although some COX-1 inhibitory activity was still present. As a conclusion, simple monomer derivatives were more active than dimer derivatives. Substitution of halogen (Br, Cl) on the benzothiazine nucleus slightly enhanced inhibition activity.

간외담관 폐쇄에서의 초음파소견 : 담관벽 경계소실의 중요성 Significance of Decreased Echotexture of Bile Duct Wall-Interface

신현준,손은주,이창희,최영칠,전혜정,박정희,이태의 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-

Ultrasound is very useful in evaluation of obstructive jaundice. We retrospectively evaluated the useful findings of ultrasonography in differentiating benign extrahepatic duct obstruction from malignant diseases. Among the 36 patients, 25 patients were benign extrahepatic obstruction and 11 patients were malignant obstruction. The shapes of extrahepatic dilatation were classified into fustiform, meniscus, and abrupt cut off by bowel gas. The diameter, length, and bile duct wall-interface were compared between benign and malignant groups and serum bilirubin and alkaline phosphatase were also compared between two groups retrospectively. The results were as follows. The most common form of extrahepatic dilatation was meniscus(10 of 26 patients, 38%) in benign obstruction, and fusiform(8 of 11 patients, 73%) in malignant obstruction. No significant difference was noted in diameter, length, serum bilirubin, and alkaline phosphatase between benign and malignant groups. Only one case showed decreased bile duct wall-interface in benign obstruction, but loss or decrease of bile duct wall-interface were 8 patients in malignant obstruction. The combined findings of fusiform dilatation and loss of bile duct wall-interface in ultrasonography will be helpful in differential diagnosis of malignant extrahepatic bile obstruction from benign conditions.

두경부 암환자의 항암화학요법에 따른 삶의 질 변화

신혜숙,박혜자,박명희,연기순,김훈교,문한림,송혜향 가톨릭대학교 가톨릭대학교 간호대학 호스피스 교육연구소 1999 호스피스논집 Vol.4 No.-

The purpose of this study was to assess the changes in quality of life wish elapse of chemotherapy in head and neck cancer patients. This study was a longitudinal descriptive design. The subjects were 9 patients who had stage III and stage IV head and neck cancer and received neoadjuvant cisplatin and 5-fluorouracil chemotherapy. Linear Analogue Self Assessment Scale (LASA) of the QOL which it includes eleven items(seven physical items appetite, nausea/vomiting, physical well-being, vigor activity, energy, sleepiness, fatigue and four mental items anger, anxiety, depression & vital power) were used to assess the quality of life eleven times(once in the prechemotherapy period and from the 1st day to 10th day postchemotherapy). The means of scores at each time were analyzed by repealed measures of ANOVA and Bonferroni multiple comparison method. The results are as follows : 1. The degree of appetites decreased significantly on the period between third and sixth day compared with that of appetites on the prechemotherapy day (p<0.001). 2. The degree of physical well-being decreased significantly on the period between first and fifth day compared with that of physical well-being on the prechemotherapy day (p<0.001). 3. The degree of nausea/vomiting decreased significantly on the period between first and fourth day compared with that of appetites on the prechemotherapy day (p<0.001). 4. The degree of anger decreased significantly on the second, fourth, eighth and ninth day after chemotherapy compared with that of anger on the prechemotherapy day(p<0.001). 5. The degree of fatigue decreased significantly on the fourth day compared with that of fatigue on the prechemotherapy day(p<0.001). 6. The increment of nausea/vomiting and poor appetite started on the 2.89th day and 3.67th day after chemotherapy, respectively. 7. The increment of sleepiness started on the 2.56th day after chemotherapy. 8. The increment of depression and anxiety started on the 2.33th day and 3.33th day after chemotherapy, respectively. 9. The lowest degrees of nausea/vomiting and poor appetite were 37.00±17.9 % and 28.64±14.94 % after chemotherapy compared with those of nausea/vomiting and poor appetite on the prechemotherapy day, respectively. 10. The lowest degrees of anger and vigor activity were 48.12±28.3 % and 39.83±24.9 % after chemotherapy compared with those of anger and vigor activity on the prechemotherapy day, respectively. 11. The recovery rates of eight items of quality of life (appetite, vigor activity, energy, fatigue, anger, anxiety, depression & vital power) were shown to reach a peak on the tenth day after chemotherapy and be reached to almost 84 % compared with those of quality of life on the prechemotherapy day. 12. The recovery rates of physical well-being and sleepiness were shown to reach to 67.75 % and 95.68 % on the 10th day after chemotherapy compared with those of physical well-belong and sleepiness on the prechemotherapy day. 13. The recovery rates of seven physical items were faster than those of four mental items on the 10th day after chemotherapy. In conclusion, it is suggested that nursing care strategies to improve the quality of life in patients with chemotherapy would be established both physically and mentally, and be extended at least ten days when patients stayed their home after chemotherapy.

Comet assay를 이용한 Ferric Sulfate의 유전자 독성에 대한 연구

박혜련,정태성,김신,강호승 大韓小兒齒科學會 2000 大韓小兒齒科學會誌 Vol.27 No.1

치수절단술은 유치의 치수치료 방법 중 사용빈도가 높은 시술 중 하나로 치수절단 술식에 사용되는 약제는 치수나 주위조직에 무해하여야 하며, 감염이나 내흡수 등의 부작용이 없어야 한다. 본 연구는 임상에서 유치의 지혈적 치수절단 술식의 약제로 사용되는 ferric sulfate의 유전자 독성을 평가할 목적으로 human gingival fibroblast에 ferric sulfate를 다양한 농도와 접촉시간을 설정한 후 comet assay를 이용하여 유전자 독성을 평가하여 보았다. 그 결과는 다음과 같다. 1. 농도에 따른 세포의 유전자 손상정도의 변화는 ferric sulfate의 농도에 비례하여 유전자 손상이 증가하는 양상을 나타내었다. 2. 농도에 따른 세포의 유전자 손상정도는 0.1,mM이상의 농도에서 대조군과 유의한 차이를 나타내었다.(p<0.05) 3. 시간경과에 따른 세포의 유전자 독성의 변화는 대조군과 유의한 차이를 보이지 않았다(P>0.05). Although ferric sulfate has been proposed as an alternative to formocresol in pulpotmy treatment in primary teeth, it has been given little concern regarding its cytotoxicity and mutagenicity. In the present study, we assessed the in vitro genotoxic effect of a ferric sulfate on human gingival fibroblast cell line (HGF-1), DNA damage was evaluated using comet assay (single cell alkaline gel electrophoresis) and obtained the results as follows: 1. A dose-response relationship was found between ferric sulfate concentrations (0 to 5mM)and DNA damages. 2. Above the concentration of 0.1mM, DNA damage was significantly increased than those of the control (p<0.05). 3. At the fixed concentration of 0.05mM, no significant difference was found between exposure time and DNA damage. These findings suggest that ferric sulfate as a pulpotomy agent can induce DNA damage in human gingival fibroblasts.

전방 십자인대의 파열시의 자기공명영상:직접소견의 중요성

신현준,이창희,최영칠,전혜정,박정희,김동헌 건국대학교 의과학연구소 2001 건국의과학학술지 Vol.11 No.-

It is Important to know the normal size, shape, and signal intensity of anterior cruciate ligament in the evaluation of knee injury Many studies have reported findings of tear or rupture as well as normal anatomy of these structure, especially with MR images. To our knowledge, there are few studies about normal structures of anterior cruciate ligament in MR images. The purpose of this study is to compare normal finding with tear of anterior cruciate ligament on MRI. Twenty-three cases with rupture of anterior cruciate ligament were evaluated on MRI, measuring the length, thickness, width of anterior cruciate ligament, and angles of anterior and posterior cruciate ligaments. Mean length, thickness, and width of anterior cruciate ligament in patients with rupture were 37.7±4.8mm, 9.0±1.2mm, 8.0±0.8mm, and mean angles of anterior cruciate ligament, and posterior cruciate ligament were 48.1±9.6˚, 118.8±13.1˚. Curvature ratio of posterior cruciate ligament was 0.25±0.09. The results showed significant differences between normal persons and patients with complete or partial rupture, and the mean angle and curvature ratio of posterior cruciate ligament which are known to related with indirect sign in tear of anterior cruciate ligament showed significant differences between ours and that of western countries. These results will be useful in the evaluation of patient wish rupture of anterior cruciate ligament, especially on MRI.