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α- Phenyl - cysteine 유도체의 합성에 관한 연구
권순경 한국약제학회 1981 Journal of Pharmaceutical Investigation Vol.11 No.1
Through hydrolysis of hydantoin with barium hydroxide amino acid can be prepared. By applying this method new four α-phenyl-cysteine derivatives were synthesized.
(-)-5-(p-Chlorobiphenyl)-3,4-dihydroxy-2(5H)-furanone의 합성
권순경 德成女子大學校 藥學硏究所 1996 藥學論文誌 Vol.7 No.1
A new method for the synthesis of chiral (-)-5-(p-chlorobiphenyl)-3,4- dihydroxy-2(5H)-furanone (5) is described. The object compound was synthesized from corresponding aldehyde. 4-Hydroxy-2(5H)-furanone is a α,β-unsaturated β-hydroxybutyrolactone, which is also named as a tetronic acid. In many natural products the tetronic acid component was found. The best known of which is ascorbic acid(vitamin C). The new compound (5) that can be construed as a "lipophilic vitamin C analogue", is expected to show antilipidemic and antiaggregatory activities as well as 5-(p-chlorophenyl)-3, 4-dihydroxy-2(5H)-furanone.
Benzazepinylalkanoic acids 유도체의 염소도입반응
권순경,박영남 德成女子大學校 藥學硏究所 2003 藥學論文誌 Vol.14 No.1
The immunological determination method is one of the best method for accuracy and convenience to detect small amount of abused drugs in urine. To develop a rapid in vitro detecting method for benzodiazepine drugs or their metabolite in urine, chlorobenzazepinyalkanoic acid derivatives as haften were synthesized.
3-Alkylthio-6-allylthiopyridazine 유도체 합성 및 SK-Br3 인간유방암세포와 Hep-G2 인간간암세포에 대한 항암작용
권순경,박명숙,박해선 德成女子大學校 2005 德成女大論文集 Vol.34 No.-
Allylthio group of allicin and other organosulfur compounds which are isolated from garlic is considered as a pharmacophore, a key structure component of the molecule which is due to biological activities. In the foregoing studies various 3-alkoxy-6-allylthiopyridazine derivatives (K-compounds) were synthesized and their biological activities were tested in test animals. They showed good hepatoprotective activities on the carbon tetrachloride-treated mouse and aflatoxin B1-treated rats and chemopreventive activities on hepatocarcinoma cells in rat as expected. Now two pyridazine derivatives whose oxygen atom at 6-position of 3-alkoxy-6-allylthiopyridazine is displayed by sulfur(S) were synthesized and their activities were synthesized and their activities were tested in vitro against SK-Br3 human breast cancer cells and Hep-G2 human liver cancer cells. Thio-K6 and Thio-K16 showed good chemopreventive activities on hepatocarcinoma and breast cancer.
(-)-α-(p-Chlorobiphenyl)-α-(tert-butyl-dimethylsilyloxy)acetaldehyde의 합성
권순경 德成女子大學校 1996 德成女大論文集 Vol.26 No.-
Aldehydes play often an important role in organic synthesis. Although a number of synthetic methods have been reported to date, none seems to be generally applicable to all kinds of compounds. Especially transformation of carboxylic esters to aldehydes has been known among synthetic organic chemists. In this study a direct reduction of (-)-methyl α-(p-chlorobiphenyl)-α-(tert-butyldimethylsilyloxy) acetate to(-)-(α)-(p-chlorobiphenyl)-α-(tert-butyldimethylsilyloxy ) acetaldehyde using DIBAL-H was successful. The prepared aldehyde is a key intermediate, which can be used to synthesize potential anti-inflammatory tetronic acid derivatives.
Aryloxyallylthiopyridazine 유도체 합성
권순경,김미경 德成女子大學校 藥學硏究所 2002 藥學論文誌 Vol.13 No.1
Allylthio group of the sulfur compounds of garlic oil plays an important role for prevention and treatment of hepatic diseases induced by toxic substances or carbon tetrachloride. Thus allylthio group as pharmacologically active group was introduced into pyridazine heterocycle ring. Aryloxyallylthiopyridazine derivatives were synthesized and their hepatoprotective activities were screened in rat. The activities of these compounds were weaker than alkoxyallylthiopyridazine derivatives, which exhibit a superior hepatprotective effect.
1,5-Diphenylhydantoins을 위한 새로운 Methyl α-Anilinophenylacetate 유도체의 합성
권순경,최희전,박명숙 德成女子大學校 藥學硏究所 2001 藥學論文誌 Vol.12 No.1
For the development of new COX-2 inhibitor, novel key intermediates (2∼4) synthesized through esterification, bromination and α-substitution from phenylacetic acid. The methyl phenylacetate 2 was synthesized through reflux phenylacetic acid with sulfuric and methanol. The methyl α-bromophenylacetate 3 was produced through radical bromination using N-bromosuccinimide from 2. The optical amination to introduce anilino group was contolled under 80℃ in DME. The bromo intermediate was converted to the final methyl α-anilinophenylacetate 4 through reaction with aniline.
권순경 德成女子大學校 藥學硏究所 2000 藥學論文誌 Vol.11 No.1
Although the first pyridazine was obtained in 1886, this heterocycle was not thoroughly investigated such isomers as pyrimidine and pyrazine especially in the field of drug development because pyridazine derivatives do not occur as natural products. Recently medicinal chemists have an growing interest in the pyridazine derivatives, since many pyridazine derivatives were found to possess various potential therapeutic activities. In this paper sixty-eight pyridazine derivatives, which are already introduced as medicines or are being developed as drugs were classified according to their pharmacological activities, reviewed since 1995 and the relationship of structure-activities was discussed.
권순경,박영남,박해선 德成女子大學校 藥學硏究所 2004 藥學論文誌 Vol.15 No.1
Compounds with an oxygen-oxygen single bond, are called peroxides, which undergo homolysis readily by heating or irradiation with light, because the oxygen-oxygen bond is weak. The formed products are radicals, which are short-lived and highly reactive. This property is used as initiator in radical chain reaction such as halogenation and many kinds of polymerization. Peroxides are one of the important oxidants and initiators. In this paper synthetic methods of peroxides and mechanisms are reviewed.
Induction of Coriolus versicolor Laccase by Phenolic Compounds
권순경,윤민호,최우영 한국응용생명화학회 1992 한국응용생명화학회 학술발표회 Vol.1992 No.-
Phenolic compounds were tested by adding to growing cultures of the lignin-degrading basidiomycete, Coriolus versicolor CV3 for growth and laccase (benzenediol : oxygen oxidoreductase, EC 1.10.3.2) formation. Addition of various compounds at the concentration of 4×10^(-4) M stimulated the extraccllular lactase, whereas the mycelial growth was repressed. Enzyme induction was marked by o-toluidine (2.3-fold), 2,5-xylidine (3.1-fold) and p-cresoi (2.5-fold), however the influence of substitutes and/or position on those phenolic rings was not clear. An enzyme component which have apparent molecular mass of 68,000 was intensively induced by 2,5-xylidine, and the other component of Mr 46,000 was not affected: these results appeared to be different from the report by Dollag and Leonowicz(1984), because their results indicated that only low molecular weight component was inducible and the higher one was noninducible. Protein synthesis inhibitors(actinomycin D and puromycin) were also tested and compared with phenolic compounds.