혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement

임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.

중년기의 스포츠 체력특성에 관한 연구

鄭升溶,崔淙洙,李鍾珏,金昌範,長鳳愚 忠北大學校 平生體育硏究所 1990 平生體育硏究所 論文集 Vol.4 No.-

The study aims to have cognizance of middle-aged mental and physiological properties by means of presenting the feature of physical strength, and to make middle-aged people try to prevent symptoms of senility and live a healthy and beneficial life for the rest of their days by means of showing a program of physical exercise suitable for middle-aged people. According to the middle-aged feature of physical strength, the decline of physical strength and physilogical function was remarkable. Individual variation in physical strength was wide and bodily organization was likely to get damaged easily as one attains an advanced age. Middle-aged people was slower in revovering and blood pressure was higher than young one after the same physical exercise. In conclusion, middle-aged people must build up his physical strength and try to prevent symptoms of senility through light physical exercises rather than heavy ones.

소아에서의 급성 파종성 뇌척수염의 임상적 고찰

조수진,박은애,유은선,김혜순,손세정,서정완,이승주,한후재 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

목적: 급성 파종성 뇌척수염은 감염이나 예방 접종 후 발생하는 중추 신경계의 급성 자가 면역 염증성 질환으로 탈수초를 일으킨다. 신경학적인 증상으로 발현되고 대부분 환전히 회복되지만 신경학적 후유증을 남기거나 사망 할 수도 있다. 이에 저자들은 본원에서 발생 한 14명을 분석하여 조기 진단과 치료에 도움을 주고자 하였다. 대상과 방법: 1998년 3월부터 2003년 8월까지 이대목동병원에서 급성 파종성 뇌척수염으로 진단 받은 14명의 의무기록을 후향적으로 조사하였다. 결과: 환자들의 평균 발생 연령은 5±7.8개월이였고, 특정계절이나 연도에 집중되어서 나타나지는 않았다. 선행질환은 주로 비특이적인 상기도 감염이 가장 많았고, 초기증상으로는 경련이 가장 많았다. 그 외에 의식저하나 운동장애도 있었다. 뇌척수액 검사에서 백혈구 증가증이 발견된 경우는 있었으나 단백이 증가된 경우는 없었다. 뇌 자기공명 촬영에서 T2 증강시 뇌백질과 기저핵에 고음영의 다발성 병소가 발견되었고 추적 촬영에서 대부분에서 소실되었다. 뇌파 검사가 시행되었던 경우 전반적인 서파가 가장 많았고 국소적인 극파가 나온 경우도 한 명 있었다. 환자들은 정맥 면역 글로블린과 메틸프레드니졸론으로 치료하였고 치료 시작 후 3~7일내 증상이 호전되었다. 모든 환자를 2달 이상 추적 관찰하였고 항경련제가 지속적으로 필요한 정도의 경련성 질환이 두 명, 신경아교증이 남아잇는 경우가 한 명, 외래에서 다발성 경화증이 의심되는 경우가 한 명 있었다. 결론: 급성 파종성 뇌척수염은 침범 부위에 따라서 다양한 임상 상으로 나타나며 면역 글로블린과 메틸프레드니졸론이 치료에 효과적이였다. 본 연구에서는 대상 환자수가 적어 신경학적 후유증의 위험요소는 밝힐 수는 없으나, 예후는 검사소견과 연관되어 있지는 않았고, 대부분에서 양호하여 완전히 회복되었으나, 신경학적 후유증이 남은 경우도 있었다. Objective:Acute disseminated encephalomyelitis(ADEM) is an acute demyelinating autoimmune inflammatory disease of the central nervous system which develops after infection of vaccination. It may be fatal, and produce a permanent residual static disability or fully recover. We retrospec-tively studied 14 cases to investigate the clinical findings and outcome of ADEM. Methods : 14cases of ADEM diagnosed at Ewha Womans University Mokdong Hospital from 1998 to 2003 were retrospectively reviewed. Results : The age of onset was 5years±7.8 months and no seasonal clustering was found. The time of onset of symptoms was between 3 to 30 days. The preceding events were nonspecific upper respiratory infections in 9 cases, aseptic meningitis in 4 cases, and gastroenteritis in one case..The initial symptoms were seizure, altered consciousness, hemiparesis, fever, headache, and vomiting. Brain MRI showed multifocal high signal intensity lesions on T2 weighted image mainly in the cerebral whith matter, basal ganglia and periventricular white matter. EEG was performed in some cases and showed generalized or focal slow waves and only one case showed focal spikes. Patients were treated with IV globulin and methylprednisolone and the symptoms improved within 3-7 days after treatment. All patients were followed up for more than 2 months and most of them fully recovered except two. Conclusion : ADEM presents in various clinical manifestations depending on its involvement of the brain lesions. Most cases recovered fully but in some cases, residual permanent neurologic sequelae remained.

철근 이음형 PC 보-기둥 내부 접합부의 구조적 거동에 관한 실험적 연구

김승훈,하상수,문정호,이리형,이강철,전병갑 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

In this study, new moment-resisting precast concrete beam-column joint is proposed for moderate seismic regions. It has the connection reinforcing bars, penetrated the joint and lap-spliced with the bottom bars of precast U-beam. An experimental study was carried out to investigate the joint behavior subjected to reverse cyclic loading and constant axial compressive load. Three precast beam-column interior were tested. The variables examined were the type of connection reinforcing bars and presence of transverse reinforcement in joint. Joint performance is evaluated on the basis of connection .strength, stiffness, energy dissipation, and drift capacity. Based on the test results, the precast connection is capable of matching or exceeding the performance of the monolithic connection and thereby provides the sufficient moment-resisting behavior to be applicable for moderate seismic regions.

고 Mn-Cr 강의 조사손상에 미치는 전자선 조사 온도의 영향

배동수,정호신,강창용,남승훈,이해무 대한금속재료학회 2004 대한금속·재료학회지 Vol.42 No.3

The effect of electron-beam irradiation temperature on irradiation damage of 12%Cr-15%Mn austenitic steel for structural material of nuclear and/or fusion reactors from the point of view of the reduced activation was investigated by using the 1,250 keV HVEM and an energy dispersed X-ray analyzer(EDX) in a 200 keV FE-TEM with beam diameter of about 0.5 nm. Void formation was not observed in irradiated specimen. The dislocation loop growth was observed and the density and size of dislocation loop were increased with irradiation dose. Irradiation-induced segregations of Cr and Mn at grain boundary were also observed by electron-beam irradiation condition. The amount of Mn segregation was increased with irradiation temperature, however, segregation phenomenon was disappeared in the case of Cr.

Redundant 2진 구조를 이용한 8 × 8-Bit 복소수 승산기의 설계

라승수,김정범 강원대학교 정보통신연구소 2003 정보통신논문지 Vol.7 No.-

A redundant binary (RB) architecture, which is optimized for the fast CMOS parallel multiplier, is proposed. This architecture enables one of to convert a pair of partial products in normal binary (NB) from to one RB number with no additional circuits. We improved the RB adder circuit so that it can make a fast addition of the RB partial products. We also simplified the converter that converts the final RB number into the corresponding NB number. The carry propagation path of the converter circuit is carried out with only a multiplexer. An 8×8-bit complex multiplier is designed with this architecture. It is fabricated by 0.6 um standard CMOS process with triple metal technology. The validity and effectiveness of the designed multiplier are verified through the MAX PLUS-Ⅱ and HSPICE simulation. The active area size is 1.55×1.45 mm2 and the number of transistors is 16,323. Under the condition of 3.3V supply voltage, the chip achieves 7.5 ns multiplication time.

편백 잎(葉) 정유 성분의 항균(抗菌)활성 물질 분석

조종수,김사익,윤승락,노정관,나종범,김동귀,최길동 진주산업대학교 산업과학기술연구소 2007 산업과학기술연구소보 Vol.- No.14

To investigate the antimicrobial effects of essential oil in the leaves of Chamaecyparis obtusa extractives by paper disc method, the extractives were fractionated into four portions. In antimicrobial test, essential oil in the leaves of Chamaecyparis obtusa was found to have strong inhibitory effects against the growth of Bacillus subtilis and Staphylococcus aureus. A part of analyzed inhibition components of essential oil in the leaves of Chamaecyparis obtusa from GC-MS was supposed to be α,β-pinene, α-terpinolene, camphor, β-myrcene, 1-α-terpinolene, 4-thujen-2-α-yl, limonene, Cardinene.

토끼에서 근육주사시 입자 크기에 따른 amoxicillin의 비교 약물동태학

박승춘,윤효인,오태광,장범수,배순이,조준형,정상희,이내경,김민규 충남대학교 수의과대학 동물의과학연구소 1998 動物醫科學硏究誌 Vol.6 No.-

To investigate the pharmacokinetic difference between the two amoxicillin (AMX) particles in rabbits after intramuscular injection (i.m.), both of AMX-S (particle size: 10 ㎍) and AMX-L (particle size: 100 ㎍) were injected into New Zealand White rabbits (1.2±0.3 ㎏) at a dose rate of 10 ㎎/㎏ of body weight. In this study, serum AMX concentrations were detected by microbiological assay with E. coli BE 1186 which shows high antibiotic sensitivity. After i.m. administration, AMX-S and AMX-L were best fitted as 1-compartment model with the absorption and elimination phase. The biological half-life (T_1/2, _k10) of AMX-S is 4.06±1.09 h and that of AMX-L 4.76±0.69 h. The serum maximal concentration time (T_max) of AMX-S and AMX-L were 0.88±0.17 h and 0.77±0.11 h, respectively. Maximal AMX concentration (C_max) (AMX-S: 5.71±0.62 ㎍/㎖, AMX-L: 5.04±0.25 ㎍/㎖) in serum showed a significant difference (p<0.05). In terms of bioequivalance, however, there was no difference between the two AMX's after i.m. injection in the basis of C_max and AUC.

회전원판 반응조를 이용한 Pseudomonas sp. KS-96에 의한 gallic acid로부터 pyrogallol의 전환

안성만,김동석,정영기,임복규,이홍수,류병호 동의대학교 기초과학연구소 1998 基礎科學硏究論文集 Vol.8 No.1

In previous paper Pseudomonas sp. KS-96 isolated from the soil to bioconversion into pyrogallol from gallic acid. Continuous bioconversion of pyrogallol was carried out using rotatory disc contactor immobilized Pseudomonas sp. KS-96. Enzyme activity of gallate decarboxylase released from Pseudomonas sp. KS-96 were shown at the highest activity on 24h incubation. Culture media containing gallic acid supplied on the flow rate of 20㎖/h until thickness of cells wall reached steady state. Bioconversion rate of pyrogallol from gallic acid showed at highest level ranging from 18hr to 36h according to time courses. Continuous bioconversion of pyrogallol using rotating disc contactor was about 81% and 80% between 6 and 8 days at the feeding rate of 30㎖ per hour in the medium containing 15g/ℓ gallic acid.

國內 물푸레나무(Fraxinus rhynchophylla)와 광릉물푸레(F. densata)의 分類學的 實體

朱勝勳,張珍成,全正壹,張桂羨,李興洙 서울大學校農業生命科學大學附屬樹木園 2003 서울大學校 樹木園 硏究報告 Vol.- No.23

물푸레나무속(Fraxinus L.)에서 소엽의 길이와 너비, 동아의 털의 밀도는 속내 종 구분에 있어 주요한 형질이다. 국내에 분포하는 물푸레나무(F. rhynchophylla)와 일본의 F. japonica, 한국의 광릉물푸레(F. densata)와 일본의 F. longucuspis 간의 분류학적인 관계는 혼란이 있어왔다. 본 연구에서는 소엽의 길이와 너비, 동아의 털의 유무를 측정하기 위하여 119개의 물푸레나무와 광릉물푸레나무 표본을 이용하였다. 형질 분석 결과 물푸레나무와 광릉물푸레는 정소엽의 길이와 폭의 비율에서 차이를 보였으나, 동아의 털의 밀도와 모양, 소엽의 개수와 같은 다른 형질에서는 차이를 보이지 않았다. 그러나 한국에서 북쪽에서 남쪽으로 갈수록 소엽의 폭이 좋아지는 경향을 보이고 있다. 또한 광릉의 개체들이 타 지역의 개체들보다 동아의 길이가 길지만, 정소엽의 폭은 남쪽에서 북쪽으로 향할수록 좁아지는 양상을 띠었다. 동아의 길이는 광릉 지단이 타 집단에 비해 긴 동아를 갖는 것으로 나타났다. 정소엽의 형태와 정소엽 및 동아의 털 밀도를 비교한 결과 상호 상관관계가 존재하지 않았다. 기존에 영양 형질을 기준으로 물푸레나무와 별개의 종으로 인식되었던 광릉물푸레는 물푸레나무의 변이체인 것으로 판단되며, 일본의 F. japonica와 F. longicuspis, 한국의 물푸레나무와 광릉물푸레 역시 형태적인 차이에 있어서 변이에 대한 충분한 인식이 없었던 것으로 여겨지지만, 이에 대한 더 많은 연구가 수행되어야 한다. The characters of leaflet length, width, and hair density of winter bud are important to recognize many taxa of Fraxinus. The systematic relationships between F. rhynchophylla in Korea and F. japonica in Japan, and F. densata in Korea and F. longucuspis in Japan were confused and were not clarified yet. One hundred nineteen specimens of F. rhychophylla and F. densata were used to evaluate the correlation between the length and width of leaflet, and absence/presence of trichome in bud. From this study, the morphological discontinuity between F. rhynchophylla and F. densata was partially present only in the ratio of length and width of terminal leaflet, but other characters, such as hair density on winter bud, bud shape, and the number of leaflet, were not useful for delimitation. However, the ratio of length and width of terminal leaflet appeared to show clinal variation with changes from north to south in Korea. In general, there Although the length of winter bud was longer in Gwangneung than those in other area, there was no correlation between the morphology of terminal leaflet and hair density of terminal leaflet and winter bud. The previous species, F. densata in Korea were indistinguishable from the typical form of F. rhynchophylla on the basis on vegetative characters, rejecting continued recognition of this taxon as a distinctive species. The morphological differentiation between F. japonica and F. oongicuspis in Japan and F. rhynchophylla and F. densta in Korea was not considered sufficient to warrant recognition of either specific or varietal status, but should be further examined.