제 3형 급성 견봉-쇄골 관절 분리 환자의 수술적 치료 결과

한성호,양보규,이승림,정선욱,이동호,김민석 대한골절학회 2003 대한골절학회지 Vol.16 No.2

목적 : 본 연구를 통하여 Rockwood 제 3형 급성 견봉-쇄골 관절 분리 환자에서 Phemister 술식과 modified Phemister 술식의 치료 결과를 비교하고자 한다. 대상 및 방법 : 1992년 2월부터 2001년 8월까지 제 3형 급성 견봉-쇄골 관절 분리로 수술적 치료를 받고 1년 이상 추시 가능하였던 45명, 45예의 환자를 대상으로 하였다. 평균 연령은 28.1세였으며, 남자가 42명, 여자가 3명이었다. 진단은 이학적 검사와 단순 방사선 부하 촬영법을 이용하였으며, 수상일로부터 수술적 치료까지의 평균 기간은 7.8일이었다. 술장 소견상 오구-쇄골인대 봉합술이 어려운 15예에서는 Phemister 술식을 시행하였고 (Ⅰ군), 인대 봉합이 가능한 30예에서는 modified Phemister 술식을 시행하였다(Ⅱ군). 수술 후 추시 기간은 평균 16.2개월이었고, 결과 판정은 최종 추시 때의 임상 소견과 이학적 검사 및 방사선 촬영을 통해 UCLA shoulder scoring system과 acromio-clavicular separation scoring system을 이용하였다. 결과 : 술후 합병증은 Ⅱ군에만 표재성 감염이 2예, K-강선 이주가 1예에서 발생하였다. 최종 추시상 전예에서 동통, 관절 운동 범위의 제한은 없었고 , Ⅱ군에서만 방사선 촬영상 2예에서 아탈구가 관찰되었다. UCLA shoulder scoring system은 Ⅱ군에서 우수 93.3%, 양호 6.7%였고, acromio-clavicular shoulder scoring system은 Ⅱ군에서 우수 90%, 양호 10%였다. 결론 : 활동적인 연령에서 발생한 제 3형 급성 견봉-쇄골 관절 손상의 환자에서 Phemister 술식만으로도 좋은 결과를 보일 수 있을 것으로 사료된다. Purpose : The purpose of this study is to compare the Phemister technique with the modified Phemister technique for the patients with Rockwood type 3, acromio-clavicular separation. Materials and Methods : The 45 cases of 45 patients received surgical treatment for Rockwood type 3, acute acromio-clavicular separation in our hospital from Feb. 1992 to Aug. 2001 later with the follow-up study were selected as subjects. The average ages were 28.1 years old, male and female were 42, 3 persons, respectively. Physical examination and plain radiography were used for their diagnosis and the intervals between injury and surgical treatment were 7.8 days. In intraoperative finding, we performed Phemister technique in 15 cases according not to be able to repair coraco-clavicular ligament (groupⅠ), modified Phemister technique in 30 cases according to be able to repair that (groupⅡ). The average follow up period was 16.2 months, and the UCLA shoulder scoring system and the acromio-clavicular separation scoring system were used to obtain clinical results. Results : Only in Group Ⅱ, the complication after surgery were associated with superficial infection in two cases and K-wire migration in one case. At last follow up, there were no pain and limitation of range of motion in all cases, and two cases in Group Ⅱ were found to be subluxation in radiography. Clinical results revealed excellent was 93.3%, good was 6.7% in UCLA shoulder scoring system in both groups, and excellent was 90%, good was 10% for group Ⅱ in acromio-clavicular separation scoring system. Conclusion : The results are considered to be food with only Phemister technique in type 3, acute injury occurred in working ages.

새로운 Acetylcholinesterase inhibitors의 합성

최순규,김형민,조승환,최학기,박유미,이용균,정대일,김인식,한정태 동아대학교 부설 기초과학연구소 2004 基礎科學硏究論文集 Vol.21 No.1

노인성 치매의 일종인 alzheimer's disease의 효과적인 억제제를 합성하기 위해 우리는 분자 모델링에 의한 가장 적합한 물질인 m-[(N,N,N-trimethylammonio)phenyl]boronic acid를 합성하였다. 출발물질인 3-aminophenylboronic acid monohydrate의 경우 boronic acid의 작용기인 hydroxyl group을 protecting시킴으로써 반응의 안정성을 기하였다. Quarternary ammonium salt는 과량의 methyliodide와 염기 촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시켜 상당히 높은 수율을 얻을 수 있었다. 또한 과량의 methyliodide와 염기촉매인 potassium hydrogen carbonate를 사용하여 용매인 methanol에서 반응시킨 결과 boronic acid의 protection없이도 안정하게 반응이 진행되어짐을 확인할 수 있었다. In order to syntheisize a effective inhibotor for alzheimer's disease, we synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 which is designed by molecular modeling form. We protected the hydroxyl group of 3-aminophenylboronic acid monohydrate 1 with ethlyne glycol to remove the reactivity if hydroxyl group. To synthesize m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4, we reacted 3-aminophenylboronic acid monohydrate 1 with ezcess methyl iodide and potassium hydrogen carbonate as a base-catalyst in methanol. but On executed reaction without protection on hydroxyl group, we found out the result that the hydroxyl group of boronic acid group at 3-aminophenylboronic acid monohydrate 1 didn't react with excess methyliodide. Synthesized m-[(N,N,N-trimethylammonio)phenyl]boronic acid 4 is in progress about biological tests as a plausible acetylcholinesterase inhibitor.

파라콰트 중독 흰쥐에서 항산화제 U-74389G 의 치료 효과

오진호,정성필,임훈,노성훈,김혜영,김승호,이한식,민진식 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: This study was conducted to verify the hypothesis that the suppression of lipid peroxidation with the antioxidant, U-74389G, could improve the survivability of paraquat intoxicated rats. Methods: First, we obtained the 24-h mortality by using several paraquat dosages and calculated the 24-h LD5O in 24 male Wistar rats(250~350 g). To examine the effect of U-74389G, we divided the rats in 4 groups: a control group and U-74389G only group, a paraquat only group, and a paraquat plus U-74389G group(n=10 each). Paraquat, 35 mg/kg, was injected intraperitoneally at 0 h. U-74389G, 10mg/kg, was administered intraperitoneally at 0, 12 h or at 1, 12 h in the respective groups. The rats were observed for 24 hours. At 24 h, plasma and lung, liver, and kidney tissues were obtained after sacrificing the surviving rats to determine the degree of lipid peroxidation by using a thiobarbituric acid reactive substances (TBARS ) quantitative analysis. Results: The 24-h LD50 of paraquat was calculated as 40 mg/kg in our rats. The 24-h mortality was as follows: control group and U-74389G group 0%, paraquat group 30%, and paraquat plus U-74389G group 10%. The TBARS analysis showed no differences between the U-74389G and the control groups. The paraquat group showed significantly increased TBARS levels in the serum and in the kidney and lung tissue compared to the control group(p<0.05). With U-74389G, the increased TBARS levels were significantly decreased in the plasma, kidney, and lung tissues compared to the paraquat group(p<0.05). However, in the liver tissue, there were no significant differences among the groups. Conclusion: A 21-aminosteroid antioxidant, U-74389G, improved the survivablity of paraquat-intoxicated rats through the suppression of lipid peroxidation. Our result suggests the possibility of clinical application of this drug as an antidote for paraquat poisoning.

비호지킨 림프종에서 CMV 대장염에 의한 대장 천공 1례

한승혁,한지숙,이승태,장준호,민유홍,고윤웅,김남규,김호근 大韓血液學會 1999 大韓血液學會誌 Vol.34 No.4

c-kit Ligand가 Transforming Growth-Factor-β1(TGF-β1)에 의한 CD34^(+) 급성 골수성백혈병세포의 Apoptosis에 미치는 영향

민유홍,김성철,이승태,한지숙,고윤웅 한국BRM학회 1995 한국 BRM학회지 Vol.5 No.2

Excavation of Lead Compounds that Inhibit Mast Cell Degranulation by Combinatorial Chemistry and Activity-Guided

Hahn, Hoh-Gyu,Oh, Heong-Sub,Cheon, Seung-Hoon,Oak, Min-Ho,Kim, Young-Ran,Kim, Kyeong-Man The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.5

An allergic reaction ensues after antigen binds to mast cell or basophil high affinity IgE receptor, Fc$\varepsilon$RI, resulting in degranulation of various inflammatory mediators that produce various allergic symptoms. In this study, i) we isolated the active component for the inhibition of mast cell degranulation from the extract of leaves of Castanea crenata and identified it as quercetin; ii) we established the total synthesis procedure of quercetin; iii) using quercetin as positive control, we excavated some lead compounds that possess inhibitory activities for mast cell degranulation by screening the chemical libraries of 1,3-oxazolidine derivatives prepared by solid phase combinatorial chemistry. Some of 1,3-oxazolidine compounds possessing acetyl and 3',4'-dichlorophenyl group displayed strong inhibitory activities on Fc$\varepsilon$RI-mediated mast cell degranulation, suggesting that they can be used as lead compounds for the development of anti-allergic agents.

Experimental Study on Hysteresis of Screening-Current-Induced Field in an HTS Magnet for NMR Applications

Min Cheol Ahn,Jeongwoo Jang,Woo Seung Lee,Seungyong Hahn,Haigun Lee IEEE 2014 IEEE transactions on applied superconductivity Vol.24 No.3

<P>This paper presents a research on magnetic hysteresis of an HTS magnet comprising a stack of pancake coils wound with GdBCO-coated conductors. The hysteresis during a typical charging and discharging process of an HTS magnet occurs mainly due to the screening-current-induced field (SCF). To investigate the hysteresis, an HTS magnet, comprising 16 single-pancake coils with the respective winding i.d., o.d., and height of 100, 124, and 4 mm, was constructed. Magnetic field distributions in a 10-mm cold bore of the HTS magnet were measured by a three-dimensional field mapper, and their spatial harmonics, axial and radial, were obtained using associated Legendre equations. Field mappings were conducted at every 10 A during charging up to 90% of the magnet critical current, and repeated at every 10 A during discharging. The hysteresis loops were obtained in terms of major field gradients, axial of Z1 and Z2 and radial of X and ZX. As a result, strong hysteresis was observed that the magnetic fields were not linearly proportional to the operating current even at the beginning of charging. Even at the identical operating currents of the coil during charging and discharging, a significant difference in the spatial field distribution was observed. The residual field, a primary source to the field discrepancy, was measured 2.11% of the magnet center field at its peak operating current of 50 A, which is significant for some applications including NMR (nuclear magnetic resonance) magnets. More importantly, the residual gradients in some major axial gradients, Z1 and Z2, were much more noticeable, about -9.4% and 10.2%, respectively, of those measured at 50 A. A recommended charging protocol, called “current-sweep-reversal,” in terms of minimizing the hysteresis of SCF was investigated and discussed in detail.</P>

Efficacy and side effect of ritodrine and magnesium sulfate in threatened preterm labor

( Min Kyoung Kim ),( Seung Mi Lee ),( Jung Won Oh ),( So Yeon Kim ),( Hye Gyeong Jeong ),( Sun Min Kim ),( Chan Wook Park ),( Jong Kwan Jun ),( Seo-kyung Hahn ),( Joong Shin Park ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.1

Objective In terms of efficacy, several previous studies have shown that the success rate in inhibiting preterm labor was not different between magnesium sulfate and ritodrine. However, there is a paucity of information regarding the efficacy of both medications after consideration of intra-amniotic infection, which is one of the most important prognostic factors in patients of threatened preterm birth. The objective of this study was to compare the efficacy and safety of magnesium sulfate with that of ritodrine in preterm labor. Methods In this retrospective cohort study, we included patients who were admitted and treated with either ritodrine or magnesium sulfate with the diagnosis of preterm labor at 24-33.6 weeks of gestational age between January 2005 to April 2015. Patients were divided into 2 groups according to the first-used tocolytics (ritodrine group and magnesium sulfate group). We compared the efficacy and prevalence of side effect in each group. The efficacy of both tocolytics was evaluated in terms of preterm delivery within 48 hours, 7 days, or 37 weeks of gestation and need for 2nd line therapy. Results A total number of 201 patients were enrolled including 177 cases in ritodrine group and 24 cases in magnesium sulfate group. The efficacy of both tocolytics (preterm delivery within 48 hours, 7 days, or 37 weeks of gestation and need for 2nd line therapy) was not different between the 2 groups of cases. In multivariate analysis, gestational age at treatment, twin gestation, intra-amniotic infection and maternal C-reactive protein (CRP) was associated with treatment failure (preterm delivery within 48 hours), but the type of tocolytics was not significantly associated with treatment failure. The type of side effect was different in the 2 groups, but the frequency of total adverse effect, need for discontinuation of therapy because of maternal adverse effect, and severe adverse effect were not different between the two groups of cases. Conclusion The efficacy and safety of magnesium sulfate was similar to ritodrine, and can be a substitute tocolytics. Additionally, failure of tocolytic therapy was determined by gestational age at treatment, twin gestation, intra-amniotic infection, and maternal CRP, not by the type of tocolytics.

비호지킨 림프종에서 발생한 급성 종양용해 증후군

민유홍,김대중,한지숙,이승태,장준호,고윤웅 대한내과학회 2000 대한내과학회지 Vol.58 No.3

Background : Acute tumor lysis syndrome(TLS) has been defined as the metabolic abnormalities that occur after rapid tumor breakdown. In this study, we have evaluated the types or degrees of metabolic abnormalities and clinical characteristics in patients with non-Hodgkin's lymphoma(NHL) who developed TLS. Methods : Patients were considered to have 'laboratory TLS(LTLS)' if any two of the following metabolic abnormalities occurred spontaneously or within 4 days of treatment: hyperphosphatemia, hyperkalemia, hyperuricemia, azotemia, and hypocalcemia. 'Clinical TLS(CTLS)' was defined as LTLS plus one of the following: a serum potassium level greater than 6.0mEq/L, a creatinine level greater than 2.5mg/dL, a calcium level less than 6.0mg/dL, the development of a life-threatening arrhythmia, or sudden death. Results : Of 111 cases with NHL, TLS occurred in 16(14.4%), LTLS in 11(9.9%), and CTLS in 5(4.5%). There was a significant difference of gender, histologic type, clinical stage, performance status, extranodal involvement, serum lactate dehydrogenase(LDH), LDH index, β2-microglobulin, uric acid, and blood urea nitrogen(BUN) level in the TLS versus control group. In multiple regression analysis, TLS occurred more frequently in patients with pre-treatment azotemia, aggressive histologic type, and elevated serum LDH level(p$lt;0.05, respectively). Pre-treatment and post-treatment TLS occurred in 8 cases(50%) respectively. The common metabolic abnormalities included hyperphosphatemia(87.5%), azotemia(81.3%), and hypocalcemia(75%). Of 11 cases with conservative care, 8 cases recovered within several days, but 3 cases died with multi-organ failure from disease progression. All 5 cases after hemodialysis for TLS recovered without any significant complications. Conclusion : The current study suggests that all patients with high-grade lymphomas and pre-treatment azotemia or a high serum LDH level be carefully monitored for at least 4 days after chemotherapy.(Korean J Med 58:301-309, 2000)

Rock Weathering and Geochemical Characteristics in the KURT

Seung Yeop Lee,Min-Hoon Baik,Won Jin Cho,Pil-Soo Hahn 한국방사성폐기물학회 2006 방사성폐기물학회지 Vol.4 No.4

한국원자력연구소 내 부지에 건설된 지하처분연구시설(KURT, KAERI Underground Research Tunnel)에 대한 기초적인 광물 풍화 및 지화학적 특성을 살펴보았다. 분석 대상 시료는 건설 과정중에 노출된 암석에 대해서 화학적 풍화에 따른 암석의 미시적인 변화를 현미경 및 화학성분 분석 등을 통해 관찰하였다. 풍화가 진행된 화강암의 경우 암석을 구성하고 있는 광물들 주변에 미세하고 작은 균열들이 발달하였다. 특히, 장석 광물의 풍화가 특징적으로 관찰되었고 광물 용해에 따른 Ca 성분의 선택적 용출 현상이 심하였다. 또한, 를 함유한 흑운모의 용해에 의한 성분의 용출에 의해 주변 광물의 미세균열에 이차생성물로 철산화물 침전이 두드러졌다. 광물내부로 부터 발생된 미세균열은 풍화가 진행되면서 점차 그 규모가 커지고 grain boundary를 따라 매우 먼 거리까지 확장되는 특성을 보여 주었다. 신선한 암석 이 풍화됨에 따라 암석 내에 존재하거나 용출된 화학 성분들은 이러한 미세 균열들을 통해 새로운 이차광물 생성에 관여하거나 그들과 상호 반응하면서 이동하는 것으로 추정된다. A basic research was conducted on the mineral weathering and geochemical characteristics in the KURT (KAERI Underground Research Tunnel), which was recently constructed at a site in KAERI. Some rock samples exposed during the KURT construction were examined using a microscope and chemical analysis for some micro-changes of the rocks caused by the chemical weathering. The weathered granite has some small and fine cracks around the rock-forming minerals. In particular, there are a characteristic weathering of feldspar mineral and a preferential leaching of Ca component from the mineral dissolution. In addition, by the dissolution of biotite containing component there were iron-oxides precipitates as secondary products into the microcracks of around minerals. The results also show that the micro-cracks initiated from the mineral interior are extended and connected into the larger cracks along the grain boundary with the progress of the weathering. Thus, it is considered that some chemicals dissolved from the fresh rock would be involved in the formation of secondary minerals and migrate interacting with them.