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창의성 관점에서 본 제 7차 초등 수학과 교육과정 : 규칙성과 함수를 중심으로 Focusing on Patterns and Functions
서경혜,유솔아,정진영 한국수학교육학회 2003 初等 數學敎育 Vol.7 No.1
The present study examined the 7th national elementary school mathematics curriculum from a perspective of mathematical creativity. The study investigated to what extent the activities in the Pattern and Function lessons in the national elementary school mathematics textbooks promoted the development of mathematical creativity. The results indicated that the current elementary school mathematics curriculum was limited in many ways to promote the development of mathematical creativity. Regarding the activities in Pattern lessons, for example, most activities presented closed tasks involving finding and extending patterns. The lesson provided little opportunities to explore the relationships among various patterns, apply patterns to different situations, or create ones own patterns. In regard to the Function lessons, the majority of activities were about computing the rate. This showed that the function was taught from an operational perspective, not a relational perspective. It was unlikely that students would develop the basic understanding of function through the activities involving the computing the rate. Further, the lessons had students use exclusively the numbers in representing the function. Students were provided little opportunities to use various representation methods involving pictures or graphs, explore the strengths and limitations of various representation methods, or to choose more effective representation methods in particular contexts. In conclusion, the lesson activities in the current elementary school mathematics textbooks were unlikely to promote the development of mathematical creativity.
review : Role of intestinal microflora in xenobiotic-induced toxicity
( Hye Gwang Jeong ),( Mi Jeong Kang ),( Hyung Gyun Kim ),( Do Gyeong Oh ),( Jin Sung Kim ),( Sang Kyu Lee ),( Tae Cheon Jeong ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
In addition to its role in digestion of food in the gastrointestinal tract, the intestinal microflora is also capable of biotransforming numerous drugs. Likewise, the intestinal microflora may significantly modulate xenobiotic-induced toxicity by either activating or inactivating xenobiotics via metabolism. To date, most investigations of xenobiotic metabolism have focused not only on metabolism in host tissues, but the modulation of the pharmacological activity of drugs by the intestinal microflora. Despite its importance, the presumed role of intestinal microflora metabolism inxenobiotic-induced toxicity has been understudied. Therefore, it is appropriate to briefly review our current situation, and state which research in xenobiotic metabolism by intestinal microflora, particularly in the field of toxicology, is needed.
Jeong, Young-IL,Cha, Byungyoul,Lee, Hye Lim,Song, Yeon Hui,Jung, Yun Hye,Kwak, Tae Won,Choi, Changyong,Jeong, Gyeong-Won,Nah, Jae Woon,Kang, Dae Hwan Elsevier/North Holland 2017 International journal of pharmaceutics Vol.532 No.1
<P><B>Abstract</B></P> <P>The polysaccharide chitosan has abundant cationic amine groups, and can form ion-complexes with anionic molecules such as the strong photosensitizer chlorin e6 (Ce6). In this study, water-soluble chitosan (WSC) was used to fabricate Ce6-incorporated nanophotosensitizers (Abbreviated as ChitoCe6 nanophotosensitizer) via a self-assembling process. This was accomplished by dissolving WSC in pure water and then directly mixing the solution with solid Ce6 causing ion complex formation between WSC and Ce6. The resulting nanophotosensitizer was spherical in shape and had a particle size of less than 300nm. The photodynamic effect of ChitoCe6 nanophotosensitizer was evaluated using gastrointestinal (GI) cancer cells. At <I>in vitro</I> study using SNU478 cholangiocarcinoma cells, ChitoCe6 nanophotosensitizer showed improved Ce6 uptake by tumor cells, reactive oxygen species production, and cellular phototoxicity. An <I>in vivo</I> study using SNU478-bearing nude mice showed that the ChitoCe6 nanophotosensitizer efficiently accumulated in the tumor tissue and inhibited tumor growth more than treatment with Ce6 alone. Furthermore, ChitoCe6 nanophotosensitizer was also efficiently absorbed through tissue layers in an <I>ex vivo</I> study using porcine bile duct explants. ChitoCe6 nanophotosensitizer showed enhanced photosensitivity and photodynamic effects against cancer cells <I>in vitro</I> and <I>in vivo</I>. We present ChitoCe6 nanophotosensitizer as a promising candidate for photodynamic therapy of GI cancer.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Up-to-Date Knowledge on Osteoporosis Treatment Selection in Postmenopausal Women
Hye Gyeong Jeong,Min Kyung Kim,Hee Jeung Lim,Seul Ki Kim 대한폐경학회 2022 대한폐경학회지 Vol.28 No.3
The concept of a super-aged society has led to a steady increase in the average lifespan and hence, interest in a healthy life has increased. Aging is a major risk factor for many diseases, including osteoporosis. Osteoporotic fractures have a significant impact on the quality of life of the elderly and hence, it is pivotal to provide effective treatment of osteoporosis after menopause. Osteoporosis requires proper management and the treatment must be centered on long-term goals. New drugs with diverse mechanisms have been developed for treating osteoporosis. Current management of osteoporosis generally focuses on the importance of risk-based strategies to maximize the effectiveness of existing treatments and mitigate potential negative side-effects. Additionally, there is a need for sequential treatment of osteoporosis in the future. This review discusses the dynamic strategies for osteoporosis treatment and the importance of long-term management in postmenopausal women.
( Hye Gyeong Jeong ),( Min Jung Lee ),( Jung Ryeol Lee ),( Byung Chul Jee ),( Seul Ki Kim ) 대한폐경학회 2021 대한폐경학회지 Vol.27 No.1
Uterine leiomyoma is a very common gynecological tumor in the reproductive years. Recent studies have shown that surgical treatment of uterine leiomyoma using robotic-assisted laparoscopic myomectomy (RALM) is associated with significantly fewer complications, lower estimated blood loss, fewer conversions, and less bleeding than conventional laparoscopic myomectomy. This study reports the case of a giant uterine leiomyoma treated using RALM. A 50-year-old woman was referred to our outpatient clinic with progressive abdominal distension. Ultrasonography and magnetic resonance imaging were performed and showed a markedly enlarged uterus containing a 28-cm uterine myoma. RALM confirmed the 28-cm subserosal myoma on the posterior wall of the uterus. The myoma was enucleated, and the myometrial and serosal defect was repaired with a continuous suture using barbed suture materials. The entire myoma was removed using an electric morcellator. The operation lasted for 190 minutes. The total weight of the removed myoma was 3,262 g, and uterine leiomyoma was pathologically diagnosed. There were no postoperative complications. Although the treatment of huge myomas using RALM is controversial and technically demanding, we successfully performed RALM in a patient with a large myoma. This case confirms the efficiency, reliability, and safety of a robotic-assisted laparoscopic approach for removing a huge myoma. In a well-selected case, RALM can be performed by experienced surgeons regardless of the size of fibroids.
Jeong, Hye Gyeong,Kim, Seul Ki,Lee, Jung Ryeol,Jee, Byung Chul The Korean Society for Reproductive Medicine 2022 Clinical and Experimental Reproductive Medicine Vol.49 No.3
Objective: The aim of this study was to assess the correlation of oocyte number with serum anti-Müllerian hormone (AMH) levels measured by two automated methods (Access or Elecsys) in fresh stimulated in vitro fertilization (IVF) cycles. Methods: In this retrospective study at a university hospital, data were collected from 243 fresh stimulated IVF cycles performed from August 2016 to December 2020. The serum AMH level was measured by Access in 120 cycles and by Elecsys in 123 cycles. The cut-off of serum AMH for prediction of poor responders (three or fewer oocytes) or high responders (15 or more oocytes) was calculated by the receiver operating characteristic curve analysis. Results: For the two automated methods, the following equations were derived: total oocyte number=2.378+1.418×(Access-AMH) (r=0.645, p<0.001) and total oocyte number=2.417+2.163×(Elecsys-AMH) (r=0.686, p<0.001). The following combined equation could be derived: (Access-AMH)=0.028+1.525×(Elecsys-AMH). To predict poor responders, the cut-off of Access-AMH was 1.215 ng/mL (area under the curve [AUC], 0.807; 95% confidence interval [CI], 0.730-0.884; p<0.001), and the cut-off of Elecsys-AMH was 1.095 ng/mL (AUC, 0.848; 95% CI, 0.773-0.923; p<0.001). To predict high responders, the cut-off of Access-AMH was 3.450 ng/mL (AUC, 0.922; 95% CI, 0.862-0.981; p<0.001), and the cut-off of Elecsys-AMH was 2.500 ng/mL (AUC, 0.884; 95% CI, 0.778-0.991; p<0.001). Conclusion: Both automated methods for serum AMH measurement showed a good correlation with oocyte number and good performance for predicting poor and high responders in fresh stimulated IVF cycles. The Access method usually yielded higher measured serum AMH levels than the Elecsys method.
‘아랍의 봄’ 이후 시리아 난민에 관한 연구 -주변 중동 국가로의 유입을 중심으로-
정혜경 ( Jeong Hye-gyeong ),조희선 ( Cho Hee-sun ) 부산외국어대학교 지중해연구소 2016 지중해지역연구 Vol.18 No.3
The ‘Arab Spring’ which has reached to Syria developed into a bloody civil war into which the whole country plunged. As the result, Syrian people tried to escape to neighboring countries and Europe to produce a massive Syrian refugees. As Syrian civil war continued, Syrian refugees en masse first flowed into neighboring countries like Turkey, Lebanon, Jordan, Iraq and Egypt. And as rapidly increased refugees caused various economic and social problems in neighboring countries, Syrian refugee issue could not be limited to a matter of Syria, but became a matter of whole Arab and Middle Eastern countries. The study on Syrian refugee problem is important today because it became one of the main and key issues of the international community including Korea, not to mention of the Middle Eastern countries. Therefore, in Chapter 1 of this study, we dealt with the generation and diffusion background of Syrian refugees; in Chapter 2, Syrian refugees` influx and residence in neighboring countries; and in Chapter 3, various economic and social problems in neighboring countries occurred due to Syrian refugees. As well as its timeliness, this study also has its limits in terms that Syrian refugees issue is a relatively recent situation and the issue is still ongoing. Initially, the temporal scope of this study was limited between 2011, when Syrian people first displaced, and January 2016; but later added the situation occurred by May 2016. This study limited its regional scope to five neighboring countries(Turkey, Jordan, Lebanon, Iraq, and Egypt) where the majority of Syrian refugees flowed in, although Syrian refugees flow into European countries and even into Korea. The human extent of this study is limited to registered refugees by the UNHCR whose documents and materials are traceable. Although we admit that Syrian Refugees issue is still ongoing and is not a matter limited to five neighboring countries, and that the number of unregistered refugees may exceed the registered refugees, this study may serve as a groundwork for future research on the Syrian refugee.
Paraquat에 의한 백서의 폐섬유화증에서 비선택적 Endothelin-1 receptor blocker (Bosentan(R))의 치료효과
정혜철 ( Jeong Hye Cheol ),정기환 ( Jeong Gi Hwan ),김병규 ( Kim Byeong Gyu ),이승헌 ( Lee Seung Heon ),김민경 ( Kim Min Gyeong ),김정열 ( Kim Jeong Yeol ),박상면 ( Park Sang Myeon ),이신형 ( Lee Sin Hyeong ),신철 ( Sin Cheol 대한결핵 및 호흡기학회 2001 Tuberculosis and Respiratory Diseases Vol.50 No.2